Physicochemical modification of the excretion product of Saccharomyces cerevisiae killer strains results in fungicidal activity against Candida albicans and Tricophyton mentagrophytes.

Abstract:

:It is known that certain yeast strains, so called 'killers', can produce and excrete proteinaceous toxins that can induce death of other sensitive strains. We obtained a stable fungicidal factor (SKF) through concentration and stabilization of the excretion product of certain killer strains of Saccharomyces cerevisiae (K1 and K2). The isolated proteinaceous complex exhibited activity at broad ranges of pH (4-7.5) and temperatures (20-37.5 degrees C). It was significantly lethal against Candida albicans and Tricophyton mentagrophytes. SKF showed stability and activity after storage, with a mean half-life of 6 months at 4 degrees C or at -20 degrees C.

journal_name

FEMS Microbiol Lett

authors

Bracesco N,Salvo VA,Carrau FM,Nunes E

doi

10.1111/j.1574-6968.2006.00113.x

keywords:

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

132-6

issue

1

eissn

0378-1097

issn

1574-6968

pii

FML113

journal_volume

256

pub_type

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