DNA delivery for vaccination and therapeutics through the skin.

abstract：:The blood brain barrier protects the brain from harmful substances in the blood stream and has stopped the development of many powerful and interesting drugs candidates for central nervous system due to the low poor distribution and by efflux mechanisms. Many different approaches have been developed in order to overco...

journal_title：Current drug delivery

authors： Khalil NM,Mainardes RM

更新日期：2009-07-01 00:00:00

abstract：:The objective of the present research is to prepare stable nano suspensions of Valsartan (VAL) with high solubility and dissolution. VAL is an orally administered anti-hypertensive drug with lower bio-availability of 25%, this is attributed to its lower aqueous solubility (0.082 mg/ml). VAL nano suspensions were prepa...

journal_title：Current drug delivery

authors： Vuppalapati L,Cherukuri S,Neeli V,Yeragamreddy PR,Kesavan BR

更新日期：2016-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) and free radicals have been implicated in a number of diseases and disorders, and the skin, for its localization, is exposed to a large number of environmental threats. Free radical scavengers and antioxidants have thus been proposed as protective or therapeutic agents against ROS-mediate...

journal_title：Current drug delivery

authors： Ascenso A,Ribeiro HM,Marques HC,Simoes S

更新日期：2011-11-01 00:00:00

abstract：:The aim of the present work was to evaluate alginate hydrogels in the form of spherical beads as carrier for antithrombotic drugs for future use in artificial grafts. The ionotropic gelation technique was employed to prepare beads from the L. hyperborea stipe of alginate with two different alginate concentrations and ...

journal_title：Current drug delivery

authors： Jämstorp E,Bodin A,Gatenholm P,Jeppsson A,Strømme M

更新日期：2010-10-01 00:00:00

abstract：:The research presented in this paper discusses the potential of iontophoresis facilitated transdermal delivery of glycine. Iontophoresis has been widely investigated as a noninvasive transdermal drug delivery system. Iontophoresis is the use of a low electric current to carry ionized as well as unionized drug molecule...

journal_title：Current drug delivery

authors： Dasgupta R,Banthia AK,Tibarewala DN

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Tuberculosis is an infection and caused by gentle growing bacteria. The Internet provides opportunities for people with tuberculosis (TB) to connect with one another to address these challenges. OBJECTIVE:The aim of this paper is to introduce readers to the platforms on which Tuberculosis participants inter...

journal_title：Current drug delivery

authors： Singh G,Kesharwani P,Srivastava AK

更新日期：2018-01-01 00:00:00

abstract：:Fast-dissolving drug delivery systems have been developed as an alternative to conventional dosage form as an oral means of drug delivery in case of chronic conditions. Now a day's fast dissolving films are preferred over conventional tablets and capsules for masking the taste of bitter drugs to increase the patient c...

journal_title：Current drug delivery

authors： Chaturvedi A,Srivastava P,Yadav S,Bansal M,Garg G,Sharma PK

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteo...

journal_title：Current drug delivery

authors： Gera S,Sampathi S,Dodoala S

更新日期：2017-01-01 00:00:00

abstract：:The mucosal administration of vaccines is an area currently receiving a high level of interest due to potential advantages offered by this technique. These advantages include the ability to administer vaccines without need for needles, thus improving patient compliance with vaccination schedules, and the capacity to i...

journal_title：Current drug delivery

authors： Moyle PM,McGeary RP,Blanchfield JT,Toth I

更新日期：2004-10-01 00:00:00

abstract：:The development of oral insulin using the eligen technology represents a significant advance in insulin administration which is expected to improve the quality of life of diabetic patients. As clinical studies progress, a great deal of interest has focused on the process by which this technology enables insulin absorp...

journal_title：Current drug delivery

authors： Malkov D,Angelo R,Wang HZ,Flanders E,Tang H,Gomez-Orellana I

更新日期：2005-04-01 00:00:00

abstract：:The objective of this study was to investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant. The result showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HCl from aged PEO matri...

journal_title：Current drug delivery

authors： Shojaee S,Nokhodchi A,Cumming I,Alhalaweh A,Kaialy W

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Chrysin is a strong inhibitor of breast cancer resistance protein (BCRP) but it is practically insoluble in water. Effective solubilization of chrysin is critical for its pharmaceutical application as an absorption enhancer via inhibition of BCRP-mediated drug efflux. OBJECTIVE:This study aimed to develop a...

journal_title：Current drug delivery

authors： Lee SH,Lee YS,Song JG,Han HK

更新日期：2019-01-01 00:00:00

abstract：:Osteoarthritis is usually regarded as a localized disease whose optimal treatment is a therapy applied directly to the affected joint. Unfortunately, current local therapies such as repeated intraarticular injections or constant infusions are associated with a higher risk of infection. One way to overcome this would b...

journal_title：Current drug delivery

authors： Stöve J,Lehmann L,Fickert S,Aigner T,Brenner R

更新日期：2007-01-01 00:00:00

abstract：:Asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis, are among the most common chronic diseases and their prevalence is increasing. Each of these diseases is characterized by the secretion of cytokines and pro-inflammatory molecules which are thought to play a critical rol...

journal_title：Current drug delivery

authors： Gioia SD,Sardo C,Castellani S,Porsio B,Belgiovine G,Carbone A,Giammona G,Cavallaro G,Conese M

更新日期：2017-01-01 00:00:00

abstract：:Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly difficult. One problem has been that antibiotics commonly used were designed for...

journal_title：Current drug delivery

authors： El-Zahaby SA,Kassem AA,El-Kamel AH

更新日期：2014-01-01 00:00:00

abstract：:Paclitaxel (taxol, 1a) and docetaxel (taxotere, 1b) have established themselves as an important class of antitumor drugs currently available to the oncologist. While the great contribution of these drugs to the management of the disease and their effect on the improvement of the patient quality of life could not be ov...

journal_title：Current drug delivery

authors： Safavy A

更新日期：2008-01-01 00:00:00

abstract：:Methylene blue (MB) has been shown to slow down the progression of the Alzheimer's disease (AD) and other tauopathies; however distribution of MB into the brain is limited due its high hydrophilicity. In this study, we aimed to prepare novel hydrophobic glutathione coated PLGA nanoparticles to improve bioavailability ...

journal_title：Current drug delivery

authors： Jinwal UK,Groshev A,Zhang J,Grover A,Sutariya VB

更新日期：2014-01-01 00:00:00

abstract：:The aim of this present research work was to prepare and evaluate alginate microspheres of aceclofenac by ionic gelation method for targeting the drug release in intestinal region and decrease distinct tissue protection in the stomach. This method offers to prepare microspheres which are important in controlling the r...

journal_title：Current drug delivery

authors： Khandai M,Chakraborty S,Nayak P,Krishna NB,Chakravarthi G,Acharjya B,Ghosh AK

更新日期：2012-09-01 00:00:00

abstract：:A palpable need for the optimization of therapeutic agents, due to challenges tackled by them such as poor pharmacokinetics and chemoresistance, has steered the journey towards novel interdisciplinary scientific field for emergence of nanostructure materials as a carrier for targeted delivery of therapeutic agents. Am...

journal_title：Current drug delivery

authors： Chaudhary HM,Duttagupta AS,Jadhav KR,Chilajwar SV,Kadam VJ

更新日期：2015-01-01 00:00:00

abstract：:The use of different drug classes as host modulating agents has been postulated to have significance as an adjunctive remedy curing chronic periodontitis. In this study nano-structured films containing doxycyclin (DOX) were evaluated for such purpose. Nano DOX/chitosan particulate system was prepared using spray dryin...

journal_title：Current drug delivery

authors： Mahmoud MM,Samy WM

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to prepare and evaluate hydrogels containing 0.1% isosorbide mononitrate (ISMN) for topical treatment of anal fissure. The hydrogels were prepared on the base of Carbopol 940, Poloxamer 407 or their combination. The highest viscosity and significant thyxotropy were observed for the com...

journal_title：Current drug delivery

authors： Yoncheva K,Doytchinova I,Tankova L

更新日期：2012-09-01 00:00:00

abstract：:Polar lipids and various surfactants exhibit rich phase behavior depending on the composition of the lipids and the physicochemical conditions. Lamellar (L(alpha)), hexagonal (Inverted [H(II)]) and normal or inverted cubic (bicontinuous or micellar) structures are some of the most common lyotropic liquid crystalline p...

journal_title：Current drug delivery

authors： Hirlekar R,Jain S,Patel M,Garse H,Kadam V

更新日期：2010-01-01 00:00:00

abstract：:Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validate...

journal_title：Current drug delivery

authors： de Almeida PA,Alves MC,Polonini HC,Calixto SL,Braga Gomes TB,Barros Lataliza AA,da Silveira Ramos CD,Barbosa Raposo NR,de Oliveira Ferreira A,Fernandes Brandão A

更新日期：2015-01-01 00:00:00

abstract：:New technologies are currently investigated with the aim to improve the quality of foods by enhancing their nutritional value, freshness, safety and shelf-life, as well as by improving their tastes, flavours and textures. Moreover, new technological approaches are being explored, in this field, to address nutritional ...

journal_title：Current drug delivery

authors： Trombino S,Curcio F,Roberta C

更新日期：2020-11-25 00:00:00

abstract：:The aim of the present study was to formulate a combined patch containing salicylic (SA) acid and nicotinamide (NA), useful for the treatment of mild acne, and to verify their mutual effect on drug permeation and skin retention. The performance of the patch was tested in vitro in permeation experiments using pig ear s...

journal_title：Current drug delivery

authors： Padula C,Ferretti C,Nicoli S,Santi P

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The present work aimed to develop an ethosomal gel of naproxen sodium for the amelioration of rheumatoid arthritis. OBJECTIVE:In the present work, we have explored the potential of ethosomes to deliver naproxen into deeper skin strata. Further, the anti-inflammatory efficacy of naproxen ethosomal formulatio...

journal_title：Current drug delivery

authors： Anjum F,Zakir F,Verma D,Aqil M,Singh M,Jain P,Mirza MA,Anwer MK,Iqbal Z

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:The main objective of this novel study was to develop midazolam hydrochloride fast dissolving oral films (FDFs) using solvent casting method and to evaluate the characteristics of the optimum formulation through in vitro and in vivo analysis. The FDFs are new favorable solid dosage forms that deliver drugs r...

journal_title：Current drug delivery

authors： Soroushnai A,Ganji F,Vasheghani-Farahani E,Mobedi H

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Wound healing is a biological process that can get in a state of pathologic inflammation, requiring the use of specific medications able to promote proper tissue repair. OBJECTIVE:The study describes the production and characterization of nanoparticle based gel for wound healing treatment designed to delive...

journal_title：Current drug delivery

authors： Esposito E,Pecorelli A,Sguizzato M,Drechsler M,Mariani P,Carducci F,Cervellati F,Nastruzzi C,Cortesi R,Valacchi G

更新日期：2018-01-01 00:00:00

abstract：:Conventional dosage forms such as tablets, capsules and syrups are prescribed in the normal course of practice. However, concerns about patient preferences and market demands have given rise to the exploration of novel unconventional dosage forms. Among these, confectionery-based dose forms have strong potential to ov...

journal_title：Current drug delivery

authors： Tangso KJ,Ho QP,Boyd BJ

更新日期：2015-01-01 00:00:00

abstract：:Relief of chronic pain is an important clinical problem requiring special care and approaches. The present study was designed for the construction of a controlled release system for local application of analgesics (hydromorphone (HM), morphine (M), and codeine (C)) and a local anesthetic, bupivacaine (BP). An interpen...

journal_title：Current drug delivery

authors： Keskin DS,Wise DL,Hasirci V

更新日期：2004-01-01 00:00:00