Abstract:
:Polar lipids and various surfactants exhibit rich phase behavior depending on the composition of the lipids and the physicochemical conditions. Lamellar (L(alpha)), hexagonal (Inverted [H(II)]) and normal or inverted cubic (bicontinuous or micellar) structures are some of the most common lyotropic liquid crystalline phases. Hexosomes are the reverse hexagonal phases comprised of hexagonally close-packed infinite water layers covered by surfactants monolayer. Hexosomes (dispersed HII phases) due to their special structural properties have potential to be used as alternative delivery vehicle for pharmaceuticals. Biologically active molecules can either be accommodated within the aqueous domains or can be directly coupled to the lipid hydrophobic moieties oriented radially outwards from the centre of the water rods. Due to these special properties of hexosomes, they are used to improve solubility of poorly water soluble drugs and to transport therapeutic peptides and proteins by oral, transdermal, and parenteral routes. This article includes various methods of preparation of hexosomes and their application in drug delivery through various routes.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Hirlekar R,Jain S,Patel M,Garse H,Kadam Vdoi
10.2174/156720110790396526subject
Has Abstractpub_date
2010-01-01 00:00:00pages
28-35issue
1eissn
1567-2018issn
1875-5704pii
CDD Epub -33journal_volume
7pub_type
杂志文章abstract::Paclitaxel (taxol, 1a) and docetaxel (taxotere, 1b) have established themselves as an important class of antitumor drugs currently available to the oncologist. While the great contribution of these drugs to the management of the disease and their effect on the improvement of the patient quality of life could not be ov...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
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journal_title:Current drug delivery
pub_type: 杂志文章,评审
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journal_title:Current drug delivery
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journal_title:Current drug delivery
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abstract:BACKGROUND:One of the major abundant proteins in the nucleous is nucleolin that overexpressed on the cytoplasmic membrane of malignant and endothelial cells and makes it as a promising condidate for targeted drug delivery. OBJECTIVES:In this study, doxorubicin (Dox) as a chemotherapy drug was entrapped into the Poly l...
journal_title:Current drug delivery
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abstract:BACKGROUND:PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE:The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded t...
journal_title:Current drug delivery
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journal_title:Current drug delivery
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abstract:BACKGROUND:Nasal delivery of 20 (R) -ginsenoside Rg3 (Rg3) has a short-lived anti-fatigue effect owing to rapid clearance by nasal cilia. Thus, in order to extend the residence time of Rg3 in the nasal cavity, a new drug delivery system is needed. METHODS:Chitosan microspheres loaded with Rg3 were prepared using a mul...
journal_title:Current drug delivery
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doi:10.2174/1567201814666161109121151
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abstract::Skin, the most significant protective organ in the body, may face serious problems, including cancer, infectious diseases, etc., requiring different drugs for the treatment. However, most of these drugs have poor chemical and physical stability, and insufficient penetration through the skin layers. In recent years, wi...
journal_title:Current drug delivery
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journal_title:Current drug delivery
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journal_title:Current drug delivery
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Current drug delivery
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doi:10.2174/1567201815666180503120113
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更新日期:2014-01-01 00:00:00
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journal_title:Current drug delivery
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更新日期:2013-06-01 00:00:00
abstract::Curcumin as an antioxidative agent which has been widely used medicinally in India and China. However, rapid metabolism coupled with the instability of curcumin under physiological conditions has greatly limited its applications in vivo. In the present study, a thermosensitive hydrogel with high payload of curcumin wa...
journal_title:Current drug delivery
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更新日期:2016-01-01 00:00:00
abstract::Relief of chronic pain is an important clinical problem requiring special care and approaches. The present study was designed for the construction of a controlled release system for local application of analgesics (hydromorphone (HM), morphine (M), and codeine (C)) and a local anesthetic, bupivacaine (BP). An interpen...
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更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Cystic Fibrosis (CF) is a genetic disease which affects the patient's lungs, pancreas, liver, kidney and intestine and lacks sulfatase enzyme, leading to mucopolysaccharidosis. Colistin sulfate acts by interacting with phospholipids of bacterial cell membranes. Sulfatase enzyme reduces the high levels of sul...
journal_title:Current drug delivery
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abstract::The present study performed by preparation and evaluation of floating tablets of Acyclovir as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose K 4M, K 15M, psyllium husk, swelling agent as crospovidone and micro...
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更新日期:2009-10-01 00:00:00
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journal_title:Current drug delivery
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journal_title:Current drug delivery
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abstract::Camptothecins are a family of alkaloids originally extracted from the Chinese tree Camptotheca acuminata, Nyssaceae, exhibiting a strong activity against colorectal cancer (CRC). CRC is a common malignancy worlwide. Despite significant developments in the treatment of this disease, it still causes considerable morbidi...
journal_title:Current drug delivery
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abstract::Methylene blue (MB) has been shown to slow down the progression of the Alzheimer's disease (AD) and other tauopathies; however distribution of MB into the brain is limited due its high hydrophilicity. In this study, we aimed to prepare novel hydrophobic glutathione coated PLGA nanoparticles to improve bioavailability ...
journal_title:Current drug delivery
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abstract::The objective of present investigation was the characterization of chitosan films after in vivo implantation. Chitosan films were prepared at three dose loadings of paclitaxel by classical casting method. They were implanted subcutaneously in Swiss mice in the neck region and were removed at 7, 15, 21 and 30 days post...
journal_title:Current drug delivery
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abstract::Biphenyl Dimethyl Dicarboxylate (BDD) is insoluble in aqueous solution and the bioavailability after oral administration is low. Self-nanoemulsifying drug delivery system (SNEDDS) containing BDD has been successfully prepared using carefully selected ingredients which are less affected by pH and ionic strength changes...
journal_title:Current drug delivery
pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
abstract::Hydrogels can constitute reliable delivery systems of drugs, including those based on nucleic acids (NABDs) such as small interfering ribonucleic acid (siRNA). Their nature, structure, and response to physiological or external stimuli strongly influence the delivery mechanisms of entrapped active molecules, and, in tu...
journal_title:Current drug delivery
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更新日期:2017-01-01 00:00:00
abstract::Since its discovery in 1796 by Edward Jenner, vaccines have been an integral aspect of therapeutics, combating a number of infectious diseases with remarkable success. In recent years, due to rapid advances in proteomics, genomics, biotechnology and immunology and the plethora of knowledge amassed in related fields, i...
journal_title:Current drug delivery
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abstract:BACKGROUND:Hesperetin (HSP) is a low water-soluble flavanone aglycone with low bioavailability. OBJECTIVES:This study aimed at enhancing the hepatoprotective effects of HSP by a combinatory technique based on solid dispersions of co-crystals of HSP. METHODS:Co-crystals were prepared using citric acid, tartaric acid, ...
journal_title:Current drug delivery
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更新日期:2018-01-01 00:00:00
abstract::Motivated by the success and exhaustive research on carbon nanotubes (CNTs) based drug delivery, graphene, a two-dimensional; honey-comb crystal lattice has emerged as the rising star in recent years. Graphene is a flat monolayer of carbon atoms that holds many promising properties such as unparalleled thermal conduct...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811666140605151600
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To develop and evaluate the suitability of lecithin organogels containing aceclofenac for topical application and compare its In vitro and In vivo effects with conventionally used hydrogels. METHODS:The components and their concentration necessary for organogels formation were evaluated using phase diagram. So...
journal_title:Current drug delivery
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更新日期:2009-01-01 00:00:00