Artificial organs: a new option for treating osteoarthritis.

abstract：:Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an e...

journal_title：Current drug delivery

authors： Mishra N,Singh D,Sharma S,Baldi A

更新日期：2014-01-01 00:00:00

abstract：:Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly difficult. One problem has been that antibiotics commonly used were designed for...

journal_title：Current drug delivery

authors： El-Zahaby SA,Kassem AA,El-Kamel AH

更新日期：2014-01-01 00:00:00

abstract：:The mucosal administration of vaccines is an area currently receiving a high level of interest due to potential advantages offered by this technique. These advantages include the ability to administer vaccines without need for needles, thus improving patient compliance with vaccination schedules, and the capacity to i...

journal_title：Current drug delivery

authors： Moyle PM,McGeary RP,Blanchfield JT,Toth I

更新日期：2004-10-01 00:00:00

abstract：:The aim of this study was to design a silica-supported solid dispersion of lacidipine (LCDP) to enhance the dissolution rate and oral absorption using supercritical CO2 (scCO2) as a solvent. The formulation was characterized using differential scanning calorimetry, powder X-ray diffraction, scanning electron microscop...

journal_title：Current drug delivery

authors： Geng Y,Fu Q,Guo B,Li Y,Zhang X,Wang X,Zhang T

更新日期：2016-01-01 00:00:00

abstract：:The objective of this study was to investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant. The result showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HCl from aged PEO matri...

journal_title：Current drug delivery

authors： Shojaee S,Nokhodchi A,Cumming I,Alhalaweh A,Kaialy W

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:A ceftiofur hydrochloride long-acting oily suspension with no irritation was prepared by testing and optimizing the types and amounts of organic solvents, suspending agents, and surfactants.

Methods: Its properties, stability, injection site irritation, in vitro release, and pharmacokinetics in pigs were...

journal_title：Current drug delivery

authors： Xie S,Zhang X,Luo W,Meng K,Chen D,Pan Y,Tao Y,Huang L,Liu Z,Wang Y,Yuan Z

更新日期：2020-09-03 00:00:00

abstract：:A palpable need for the optimization of therapeutic agents, due to challenges tackled by them such as poor pharmacokinetics and chemoresistance, has steered the journey towards novel interdisciplinary scientific field for emergence of nanostructure materials as a carrier for targeted delivery of therapeutic agents. Am...

journal_title：Current drug delivery

authors： Chaudhary HM,Duttagupta AS,Jadhav KR,Chilajwar SV,Kadam VJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Hesperetin (HSP) is a low water-soluble flavanone aglycone with low bioavailability. OBJECTIVES:This study aimed at enhancing the hepatoprotective effects of HSP by a combinatory technique based on solid dispersions of co-crystals of HSP. METHODS:Co-crystals were prepared using citric acid, tartaric acid, ...

journal_title：Current drug delivery

authors： Varshosaz J,Jalali M,Hosseini-Sharifabad A

更新日期：2018-01-01 00:00:00

abstract：:Since its discovery in 1796 by Edward Jenner, vaccines have been an integral aspect of therapeutics, combating a number of infectious diseases with remarkable success. In recent years, due to rapid advances in proteomics, genomics, biotechnology and immunology and the plethora of knowledge amassed in related fields, i...

journal_title：Current drug delivery

authors： Azad N,Rojanasakul Y

更新日期：2006-04-01 00:00:00

abstract：:Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validate...

journal_title：Current drug delivery

authors： de Almeida PA,Alves MC,Polonini HC,Calixto SL,Braga Gomes TB,Barros Lataliza AA,da Silveira Ramos CD,Barbosa Raposo NR,de Oliveira Ferreira A,Fernandes Brandão A

更新日期：2015-01-01 00:00:00

abstract：:Curcumin as an antioxidative agent which has been widely used medicinally in India and China. However, rapid metabolism coupled with the instability of curcumin under physiological conditions has greatly limited its applications in vivo. In the present study, a thermosensitive hydrogel with high payload of curcumin wa...

journal_title：Current drug delivery

authors： Lu C

更新日期：2016-01-01 00:00:00

abstract：:Metformin (MTF) improves hyperglycemia primarily by suppressing glucose production by the liver. The objective of our investigation was to evaluate nanoemulsion as a promising carrier for MTF for sustained hypoglycemic effect. The drug was incorporated into oil phase of nanoemulsion, which finally improved biopharmace...

journal_title：Current drug delivery

authors： Akhtar J,Siddiqui HH,Badruddeen,Fareed S,Aqil M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The present work aimed to develop an ethosomal gel of naproxen sodium for the amelioration of rheumatoid arthritis. OBJECTIVE:In the present work, we have explored the potential of ethosomes to deliver naproxen into deeper skin strata. Further, the anti-inflammatory efficacy of naproxen ethosomal formulatio...

journal_title：Current drug delivery

authors： Anjum F,Zakir F,Verma D,Aqil M,Singh M,Jain P,Mirza MA,Anwer MK,Iqbal Z

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate Quality by Design (QbD) principle for the preparation of hydrogel products to prove both practicability and utility of executing QbD concept to hydrogel based controlled release systems. Product and process understanding will help in decreasing the variability of ...

journal_title：Current drug delivery

authors： Dalwadi C,Patel G

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to prepare and evaluate hydrogels containing 0.1% isosorbide mononitrate (ISMN) for topical treatment of anal fissure. The hydrogels were prepared on the base of Carbopol 940, Poloxamer 407 or their combination. The highest viscosity and significant thyxotropy were observed for the com...

journal_title：Current drug delivery

authors： Yoncheva K,Doytchinova I,Tankova L

更新日期：2012-09-01 00:00:00

abstract：:The use of different drug classes as host modulating agents has been postulated to have significance as an adjunctive remedy curing chronic periodontitis. In this study nano-structured films containing doxycyclin (DOX) were evaluated for such purpose. Nano DOX/chitosan particulate system was prepared using spray dryin...

journal_title：Current drug delivery

authors： Mahmoud MM,Samy WM

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:The main objective of this novel study was to develop midazolam hydrochloride fast dissolving oral films (FDFs) using solvent casting method and to evaluate the characteristics of the optimum formulation through in vitro and in vivo analysis. The FDFs are new favorable solid dosage forms that deliver drugs r...

journal_title：Current drug delivery

authors： Soroushnai A,Ganji F,Vasheghani-Farahani E,Mobedi H

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Cystic Fibrosis (CF) is a genetic disease which affects the patient's lungs, pancreas, liver, kidney and intestine and lacks sulfatase enzyme, leading to mucopolysaccharidosis. Colistin sulfate acts by interacting with phospholipids of bacterial cell membranes. Sulfatase enzyme reduces the high levels of sul...

journal_title：Current drug delivery

authors： Solanki NR,Patel DH,Talele DR

更新日期：2020-01-01 00:00:00

abstract：:In recent years, Poloxamers had attracted a particular interest in the design of dermal and transdermal delivery systems in order to improve or retard drug permeation through the skin. In the present study, the influence of different parameters, such as, temperature, storage time, type of polymer (Lutrol(®) F-127 and ...

journal_title：Current drug delivery

authors： Almeida H,Amaral MH,Lobão P,Lobo JM

更新日期：2013-12-01 00:00:00

abstract：:Hydrogels can constitute reliable delivery systems of drugs, including those based on nucleic acids (NABDs) such as small interfering ribonucleic acid (siRNA). Their nature, structure, and response to physiological or external stimuli strongly influence the delivery mechanisms of entrapped active molecules, and, in tu...

journal_title：Current drug delivery

authors： Dalmoro A,Abrami M,Galzerano B,Bochicchio S,Barba AA,Grassi M,Larobina D

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Tuberculosis is an infection and caused by gentle growing bacteria. The Internet provides opportunities for people with tuberculosis (TB) to connect with one another to address these challenges. OBJECTIVE:The aim of this paper is to introduce readers to the platforms on which Tuberculosis participants inter...

journal_title：Current drug delivery

authors： Singh G,Kesharwani P,Srivastava AK

更新日期：2018-01-01 00:00:00

abstract：:The stratum corneum (SC) is a primary rate limiting barrier to permeation of drug molecules through the skin. Small molecular weight lipophilic drugs that are effective at low doses can be effectively delivered by passive transdermal delivery. The SC does not permit passage of polar/hydrophilic and macromolecules. Pas...

journal_title：Current drug delivery

authors： Charoo NA,Rahman Z,Repka MA,Murthy SN

更新日期：2010-04-01 00:00:00

abstract：:The interaction of a series of amphiphilic 2-alkyl aminoacids (lipoamino acids, LAAs) with different cell cultures and biomembrane models was investigated. LAAs can be useful promoieties to modify the physico-chemical properties of many drugs, and in particular their lipophilicity. Tests were performed in vitro on mam...

journal_title：Current drug delivery

authors： Pignatello R,Noce C,Campisi A,Acquaviva R,Bucolo C,Puglisi G,Toth I

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:A new tumor targeted polymer-coated gold/graphene hybrid has been developed for achieving simultaneously thermoablation and chemoterapy of folate receptor-positive cancer cells. METHODS:The gold/graphene hybrid was prepared by depositing gold nanospheres onto graphene oxide and coating it with an inulin-fola...

journal_title：Current drug delivery

authors： Mauro N,Volsi AL,Scialabba C,Licciardi M,Cavallaro G,Giammona G

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:The present study reports the use of MicrofluidizerTM technology to form a stable nanosuspension of atovaquone (ATQ) using quality by design (QbD) approach. METHODS:The patient-centric quality target product profile and critical quality attributes (CQAs) were identified. A Box-Behnken design was employed for...

journal_title：Current drug delivery

authors： Kakade P,Gite S,Patravale V

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease is a chronic progressive neurodegenerative disorder associated with depletion of acetylcholine. Oral treatment with tacrine hydrochloride; a reversible inhibitor of acetylcholinesterase, finds limited use in Alzheimer's disease due to frequent dosing, hepatotoxicity and extensive pre-syst...

journal_title：Current drug delivery

authors： Setya S,Madaan T,Razdan BK,Farswan M,Talegaonkar S

更新日期：2019-01-01 00:00:00

abstract：:The dermal delivery characteristics of hydrophilic silica nanoparticle coated medium chain triglyceride oil-in-water emulsions are reported and correlated with the physicochemical and interfacial properties of the emulsion based drug carriers. The synergistic drug/stabiliser/nanoparticle interactions are demonstrated ...

journal_title：Current drug delivery

authors： Eskandar NG,Simovic S,Prestidge CA

更新日期：2009-08-01 00:00:00

abstract：:The objective of this investigation was to prepare mucoadhesive microspheres of ketorolac for nasal delivery to avoid gastrointestinal side effects of conventional dosage form. Mucoadhesive microspheres were prepared using carbopol, polycarbophil and chitosan as polymer by spray drying method. The process and formulat...

journal_title：Current drug delivery

authors： Nagda CD,Chotai NP,Nagda DC,Patel SB,Patel UL

更新日期：2012-03-01 00:00:00

abstract：:Fast-dissolving drug delivery systems have been developed as an alternative to conventional dosage form as an oral means of drug delivery in case of chronic conditions. Now a day's fast dissolving films are preferred over conventional tablets and capsules for masking the taste of bitter drugs to increase the patient c...

journal_title：Current drug delivery

authors： Chaturvedi A,Srivastava P,Yadav S,Bansal M,Garg G,Sharma PK

更新日期：2011-07-01 00:00:00

abstract：AIM:This study aimed to investigate the influence of the preparation process and composition on the microstructure of the O/W primary emulsions and the corresponding impact on the formation of oil-in-water-in-oil (O/W/O) multiple emulsions. OBJECTIVES:Multiple emulsions were prepared by a two-step emulsification metho...

journal_title：Current drug delivery

authors： Zhang Q,Qin Y,Duan G,Ou W,Wang Y,Zhang W

更新日期：2020-12-31 00:00:00