Photothermal Ablation of Cancer Cells Using Folate-Coated Gold/ Graphene Oxide Composite.

abstract：:Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environment...

journal_title：Current drug delivery

authors： Sharma P,Pandita A,Murthy RS

更新日期：2013-11-24 00:00:00

abstract：OBJECTIVES:This study aimed to develop and evaluate chitosan (CTS) solid dispersion particulate matrix (SDPM) for sustained oral delivery of ketorolac tromethamine (KT). METHODS:SDPM formulations were prepared by freeze drying method and characterized for their effectiveness and biological activities via in vitro and ...

journal_title：Current drug delivery

authors： Rasool BK,Aziz US,Abu-Gharbieh E,Khan SA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The basal ganglia, an important functional integrity of the brain, comprises multiple subcortical nuclei. The area is mainly supplied by the perforating branches of ipsilateral middle cerebral artery (MCA). The unilateral non-traumatic basal ganglia hemorrhage, commonly located in the putamen, most often res...

journal_title：Current drug delivery

authors： Yang Z,Chen J,Mu J

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:Osteoporosis is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteo...

journal_title：Current drug delivery

authors： Gera S,Sampathi S,Dodoala S

更新日期：2017-01-01 00:00:00

abstract：:The objective of this investigation was aimed to explore the cancer targeting potential of folate conjugated dendrimer (polypropylene imine, PPI) under strategic influence of folate receptor up-regulators (all trans Retinoic acid, ATRA and Dexamethasone, DEXA). The folate conjugated dendrimer nanoconjugate (FPPI) was ...

journal_title：Current drug delivery

authors： Dhakad RS,Tekade RK,Jain NK

更新日期：2013-08-01 00:00:00

abstract：:The stratum corneum (SC) is a primary rate limiting barrier to permeation of drug molecules through the skin. Small molecular weight lipophilic drugs that are effective at low doses can be effectively delivered by passive transdermal delivery. The SC does not permit passage of polar/hydrophilic and macromolecules. Pas...

journal_title：Current drug delivery

authors： Charoo NA,Rahman Z,Repka MA,Murthy SN

更新日期：2010-04-01 00:00:00

abstract：:The blood brain barrier protects the brain from harmful substances in the blood stream and has stopped the development of many powerful and interesting drugs candidates for central nervous system due to the low poor distribution and by efflux mechanisms. Many different approaches have been developed in order to overco...

journal_title：Current drug delivery

authors： Khalil NM,Mainardes RM

更新日期：2009-07-01 00:00:00

abstract：:Metformin (MTF) improves hyperglycemia primarily by suppressing glucose production by the liver. The objective of our investigation was to evaluate nanoemulsion as a promising carrier for MTF for sustained hypoglycemic effect. The drug was incorporated into oil phase of nanoemulsion, which finally improved biopharmace...

journal_title：Current drug delivery

authors： Akhtar J,Siddiqui HH,Badruddeen,Fareed S,Aqil M

更新日期：2014-01-01 00:00:00

abstract：:New technologies are currently investigated with the aim to improve the quality of foods by enhancing their nutritional value, freshness, safety and shelf-life, as well as by improving their tastes, flavours and textures. Moreover, new technological approaches are being explored, in this field, to address nutritional ...

journal_title：Current drug delivery

authors： Trombino S,Curcio F,Roberta C

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:The management of TB is difficult due to the resistance developed by Mycobacterium tuberculosis against anti-tubercular drugs causes the new challenges for treating and managing the disease. OBJECTIVE:The objective of the study was to combat multiple drug resistance (MDR) exhibited by mycobacterium species ...

journal_title：Current drug delivery

authors： Moin A,Raizaday A,Hussain T,Nagshubha B

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE:The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded t...

journal_title：Current drug delivery

authors： De Marco Almeida F,Silva CN,de Araujo Lopes SC,Santos DM,Torres FS,Cardoso FL,Martinelli PM,da Silva ER,de Lima ME,Miranda LAF,Oliveira MC

更新日期：2018-01-01 00:00:00

abstract：:The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The present study was carried out to develop a gastroretentive drug delivery system using isabgol as an exci...

journal_title：Current drug delivery

authors： Semwal R,Semwal RB,Semwal DK

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:The main objective of this novel study was to develop midazolam hydrochloride fast dissolving oral films (FDFs) using solvent casting method and to evaluate the characteristics of the optimum formulation through in vitro and in vivo analysis. The FDFs are new favorable solid dosage forms that deliver drugs r...

journal_title：Current drug delivery

authors： Soroushnai A,Ganji F,Vasheghani-Farahani E,Mobedi H

更新日期：2018-01-01 00:00:00

abstract：:Several groups have shown that vaccine antigens can be encapsulated within polymeric microparticles and can serve as potent antigen delivery systems. We have recently shown that an alternative approach involving charged polylactide co-glycolide (PLG) microparticles with surface adsorbed antigen(s) can also be used to ...

journal_title：Current drug delivery

authors： Singh M,Kazzaz J,Ugozzoli M,Malyala P,Chesko J,O'Hagan DT

更新日期：2006-01-01 00:00:00

abstract：:The objective of the present research is to prepare stable nano suspensions of Valsartan (VAL) with high solubility and dissolution. VAL is an orally administered anti-hypertensive drug with lower bio-availability of 25%, this is attributed to its lower aqueous solubility (0.082 mg/ml). VAL nano suspensions were prepa...

journal_title：Current drug delivery

authors： Vuppalapati L,Cherukuri S,Neeli V,Yeragamreddy PR,Kesavan BR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Colloidal systems are most prominent delivery systems mainly used as vehicles for the transportation, targeting the various types of biomolecules, proteins, peptides, synthetic medicinal agents. OBJECTIVE:To provide concise information on patents that are directly or indirectly related to the nanoemulsions....

journal_title：Current drug delivery

authors： Patel RB,Thakore SD,Patel MR

更新日期：2016-01-01 00:00:00

abstract：:Asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis, are among the most common chronic diseases and their prevalence is increasing. Each of these diseases is characterized by the secretion of cytokines and pro-inflammatory molecules which are thought to play a critical rol...

journal_title：Current drug delivery

authors： Gioia SD,Sardo C,Castellani S,Porsio B,Belgiovine G,Carbone A,Giammona G,Cavallaro G,Conese M

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Present investigation was aimed to fabricate nanocrystal of exemestane, an anticancer drug with poor dissolution properties and oral bioavailability. METHODS:Influence of various process parameters on the formulation of exemestane nanosuspension using media milling technique were investigated in the trial batc...

journal_title：Current drug delivery

authors： Parmar K,Shah J

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Wound healing is a biological process that can get in a state of pathologic inflammation, requiring the use of specific medications able to promote proper tissue repair. OBJECTIVE:The study describes the production and characterization of nanoparticle based gel for wound healing treatment designed to delive...

journal_title：Current drug delivery

authors： Esposito E,Pecorelli A,Sguizzato M,Drechsler M,Mariani P,Carducci F,Cervellati F,Nastruzzi C,Cortesi R,Valacchi G

更新日期：2018-01-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) is a valuable tool for tailoring the dosage of the prescribed medication(s) to the individual pharmacokinetic characteristics of a patient. In psychiatry and neurology, however, proven evidence that TDM should be used for treatment with the multiple neuropsychiatric medications is res...

journal_title：Current drug delivery

authors： Hiemke C

更新日期：2016-01-01 00:00:00

abstract：:psyllium, a medicinally active gel forming natural polysaccharide and a dietary fiber has been used as a medicine in myriad of conditions such as constipation and inflammatory bowel syndrome. One of its more recent uses that have received attention has been its ability to reduce blood sugar levels in diabetics. Theref...

journal_title：Current drug delivery

authors： Rathnanand M,Narkhede R,Udupa N,Kalra A

更新日期：2013-06-01 00:00:00

abstract：:Since its discovery in 1796 by Edward Jenner, vaccines have been an integral aspect of therapeutics, combating a number of infectious diseases with remarkable success. In recent years, due to rapid advances in proteomics, genomics, biotechnology and immunology and the plethora of knowledge amassed in related fields, i...

journal_title：Current drug delivery

authors： Azad N,Rojanasakul Y

更新日期：2006-04-01 00:00:00

abstract：:ADMET Chemoinformatics multi-output models are useful for a parallel prediction of multiple experimental parameters related the absorption (A), distribution (D), metabolism (M), excretion (E), and toxicity (T) process of drugs, pollutants, and NPs with a single QSPR model. Here we present one state-of-art review about...

journal_title：Current drug delivery

authors： González-Díaz H

更新日期：2016-04-19 00:00:00

abstract：:The interaction of a series of amphiphilic 2-alkyl aminoacids (lipoamino acids, LAAs) with different cell cultures and biomembrane models was investigated. LAAs can be useful promoieties to modify the physico-chemical properties of many drugs, and in particular their lipophilicity. Tests were performed in vitro on mam...

journal_title：Current drug delivery

authors： Pignatello R,Noce C,Campisi A,Acquaviva R,Bucolo C,Puglisi G,Toth I

更新日期：2007-04-01 00:00:00

abstract：:Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validate...

journal_title：Current drug delivery

authors： de Almeida PA,Alves MC,Polonini HC,Calixto SL,Braga Gomes TB,Barros Lataliza AA,da Silveira Ramos CD,Barbosa Raposo NR,de Oliveira Ferreira A,Fernandes Brandão A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Bupivacaine is the most used local anesthetic in surgical procedures, producing prolonged anesthesia. The major limiting factor for the clinical use of bupivacaine comes from its systemic toxicity. Nanostructured lipid carriers (NLC) are vehicles for sustained drug delivery that are able to minimize the toxi...

journal_title：Current drug delivery

authors： Da Silva GHR,de Morais Ribeiro LN,Guilherme VA,de Castro SR,Breitkreitz MC,de Paula E

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Amphotericin B eye drops are widely used in the treatment of ocular infections. However, amphotericin's toxicity leads to low patient compliance and aggravation of symptoms. This work describes the development of a microemulsion system containing amphotericin B, aiming for its use in ocular applications. ME...

journal_title：Current drug delivery

authors： da Silveira WL,Damasceno BP,Ferreira LF,Ribeiro IL,Silva KS,Silva AL,Giannini MJ,da Silva-Júnior AA,de Oliveira AG,do Egito ES

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present work is the development and evaluation of solid lipid nanoparticles (SLNs) as carrier system for topical delivery of benzocaine (BZC) improving its local anesthesia aiming to produce a fast acting and long lasting topical formulation. BZC loaded SLNs were prepared using a full factorial design t...

journal_title：Current drug delivery

authors： Basha M,Abd El-Alim SH,Kassem AA,El Awdan S,Awad G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cabazitaxel (CBZ) is a new taxane approved by FDA for treatment of castration- resistant prostate cancer not responding to docetaxel. However, CBZ is not a suitable substrate for p-glycoprotein 60, an efflux pump which transports anticancer drugs out of malignant cells and is therefore a promising drug for t...

journal_title：Current drug delivery

authors： Khoeeniha MK,Esfandyari-Manesh M,Behrouz H,Amini M,Varnamkhasti BS,Atyabi F,Dinarvand R

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to design an efficient delivery system with an anticipated swelling and drug release properties for a prolonged drug release as well as to target colon for various hydrophilic drugs. METHOD:For this purpose, the pH-responsive hydrogel comprising a combination of Eudragit and ...

journal_title：Current drug delivery

authors： Mahmood S,Buabeid MA,Ullah K,Murtaza G,Mannan A,Khan SA

更新日期：2019-01-01 00:00:00