Studies with emulsion containing trans-resveratrol: in vitro release profile and ex vivo human skin permeation.

abstract：BACKGROUND:Gemcitabine (GEM) is found effective in the treatment of many solid tumors. However, its use is restricted due to its small circulation half-life, fast metabolism and low capacity for selective tumor uptake. Folate receptors (FRs) have been recognized as cellular surface markers, which can be used for cancer...

journal_title：Current drug delivery

authors： Unnam S,Panduragaiah VM,Sidramappa MA,Muddana Eswara BR

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...

journal_title：Current drug delivery

authors： Varol M,Koparal AT,Benkli K,Bostancioglu RB

更新日期：2018-01-01 00:00:00

abstract：:The aim of this work is to study liposomes as carriers of nutrients and therapeutic agents in aquaculture with Venerupis decussatus and Venerupis pullastra larvae. Multilamellar (MLVs) and large unilamellar (LUVs) vesicles were prepared from a commercial mixture of soy phosphatidylcholine, rich in unsaturated and poly...

journal_title：Current drug delivery

authors： Lai F,Valenti D,Sinico C,Manconi M,Mendez JB,Fadda AM

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease is a chronic progressive neurodegenerative disorder associated with depletion of acetylcholine. Oral treatment with tacrine hydrochloride; a reversible inhibitor of acetylcholinesterase, finds limited use in Alzheimer's disease due to frequent dosing, hepatotoxicity and extensive pre-syst...

journal_title：Current drug delivery

authors： Setya S,Madaan T,Razdan BK,Farswan M,Talegaonkar S

更新日期：2019-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environment...

journal_title：Current drug delivery

authors： Sharma P,Pandita A,Murthy RS

更新日期：2013-11-24 00:00:00

abstract：:Serrapeptase is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia sp. HY-6. Very few methods are available for the quantification of serrapeptase. The activity of the enzyme is determined by an ELISA assay, colorimetric method using casein as substrate or by HPLC method. These methods ...

journal_title：Current drug delivery

authors： Sandhya KV,Devi SG,Mathew ST

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Essential oils are poor aqueous solubility and high volatility compounds. The encapsulation of essential oils with cyclodextrins (CDs) can protect them from the adverse environmental conditions and improve their stability. Therefore, increasing the functional capabilities of essential oils when they were use...

journal_title：Current drug delivery

authors： Li Z,Wen W,Chen X,Zhu L,Cheng G,Liao Z,Huang H,Ming L

更新日期：2020-07-31 00:00:00

abstract：:The objective of present investigation was the characterization of chitosan films after in vivo implantation. Chitosan films were prepared at three dose loadings of paclitaxel by classical casting method. They were implanted subcutaneously in Swiss mice in the neck region and were removed at 7, 15, 21 and 30 days post...

journal_title：Current drug delivery

authors： Panchagnula R,Dhanikula RS,Dhanikula AB

更新日期：2006-07-01 00:00:00

abstract：:The objective of this work was to investigate the main theological features of vaginal hydrophilic polymer gels and to elucidate about the relationship between these characteristics and gels composition, and their general influence in therapeutic/usage purpose. Flow and dynamic oscillatory properties of four commercia...

journal_title：Current drug delivery

authors： das Neves J,da Silva MV,Gonçalves MP,Amaral MH,Bahia MF

更新日期：2009-01-01 00:00:00

abstract：:Osteoarthritis is usually regarded as a localized disease whose optimal treatment is a therapy applied directly to the affected joint. Unfortunately, current local therapies such as repeated intraarticular injections or constant infusions are associated with a higher risk of infection. One way to overcome this would b...

journal_title：Current drug delivery

authors： Stöve J,Lehmann L,Fickert S,Aigner T,Brenner R

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Nanoparticles (NPs) suffer from rapid clearance from body and require frequent dosing if long treatment is required. METHOD:In order to solve this problem for solid lipid nanoparticles (SLN) and prolong their action, SLNs were incorporated into thermo-responsive Poloxamer sol-gels and their fate was investi...

journal_title：Current drug delivery

authors： Dorraj G,Dadashzadeh S,Erfan M,Moghimi HR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Amphotericin B eye drops are widely used in the treatment of ocular infections. However, amphotericin's toxicity leads to low patient compliance and aggravation of symptoms. This work describes the development of a microemulsion system containing amphotericin B, aiming for its use in ocular applications. ME...

journal_title：Current drug delivery

authors： da Silveira WL,Damasceno BP,Ferreira LF,Ribeiro IL,Silva KS,Silva AL,Giannini MJ,da Silva-Júnior AA,de Oliveira AG,do Egito ES

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Colloidal systems are most prominent delivery systems mainly used as vehicles for the transportation, targeting the various types of biomolecules, proteins, peptides, synthetic medicinal agents. OBJECTIVE:To provide concise information on patents that are directly or indirectly related to the nanoemulsions....

journal_title：Current drug delivery

authors： Patel RB,Thakore SD,Patel MR

更新日期：2016-01-01 00:00:00

abstract：:Gelrite is an ion-activated polymer prepared by partial acetylation of gellan gum, an exogeneous polysaccharide present in Pseudomonas elodea. Its unique cation-dependent gelling property at 33 degrees C has been exploited for the formulation of in situ gelling hydrogels for ophthalmic and oral drug delivery. Gelrite ...

journal_title：Current drug delivery

authors： Rastogi R,Aqil M,Ali A,Sultana Y

更新日期：2008-04-01 00:00:00

abstract：:Reactive oxygen species (ROS) and free radicals have been implicated in a number of diseases and disorders, and the skin, for its localization, is exposed to a large number of environmental threats. Free radical scavengers and antioxidants have thus been proposed as protective or therapeutic agents against ROS-mediate...

journal_title：Current drug delivery

authors： Ascenso A,Ribeiro HM,Marques HC,Simoes S

更新日期：2011-11-01 00:00:00

abstract：AIM:This study was focused on the formulation of the multi-unit extended-release peroral delivery device of lamotrigine for better management of epilepsy. BACKGROUND:The single-unit extended-release peroral preparations often suffer from all-or-none effect. A significant number of multi-unit delivery systems have been...

journal_title：Current drug delivery

authors： Jain D,Sodani A,Ray S,Ghosh P,Nandi G

更新日期：2020-01-01 00:00:00

abstract：:Metformin (MTF) improves hyperglycemia primarily by suppressing glucose production by the liver. The objective of our investigation was to evaluate nanoemulsion as a promising carrier for MTF for sustained hypoglycemic effect. The drug was incorporated into oil phase of nanoemulsion, which finally improved biopharmace...

journal_title：Current drug delivery

authors： Akhtar J,Siddiqui HH,Badruddeen,Fareed S,Aqil M

更新日期：2014-01-01 00:00:00

abstract：:Tablets are still the most commonly used dosage form because of the ease of manufacturing, convenience in administration, accurate dosing and excellent stability. Direct compression is the preferred method for the preparation of tablets. However, it has been estimated that less than 20 percent of the active pharmaceut...

journal_title：Current drug delivery

authors： Mirani AG,Patankar SP,Borole VS,Pawar AS,Kadam VJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The present work aimed to develop an ethosomal gel of naproxen sodium for the amelioration of rheumatoid arthritis. OBJECTIVE:In the present work, we have explored the potential of ethosomes to deliver naproxen into deeper skin strata. Further, the anti-inflammatory efficacy of naproxen ethosomal formulatio...

journal_title：Current drug delivery

authors： Anjum F,Zakir F,Verma D,Aqil M,Singh M,Jain P,Mirza MA,Anwer MK,Iqbal Z

更新日期：2020-01-01 00:00:00

abstract：:The objective of this study was to develop and evaluate mucoadhesive microsphere of diclofenac sodium with natural gums for sustained delivery. Guar gum and tragacanth were used along with sodium alginate as mucoadhesive polymers. Microspheres were formulated using orifice-ionic gelation method. Particle size, surface...

journal_title：Current drug delivery

authors： Amin ML,Jesmeen T,Sutradhar KB,Mannan MA

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Mesoporous bioactive glass (MBG) has been widely studied because of its excellent histocompatibility and degradability. However, due to the lack of good osteoinductive activity, the pure MBG scaffold is not effective in repairing large-scale bone defects. OBJECTIVE:To observe the repair effect of MBG scaffo...

journal_title：Current drug delivery

authors： Wu L,Wei Z,He S,Bi Y,Cao Y,Wang W

更新日期：2020-09-15 00:00:00

abstract：:Percutaneous coronary intervention (PCI) has become a highly effective alternative for the treatment of coronary artery disease. The use of stents has reduced the rates of restenosis by preventing elastic recoil and negative remodeling, however neointima formation still remains an issue. Local drug delivery is an attr...

journal_title：Current drug delivery

authors： Kennedy KL,Lucas AR,Wan W

更新日期：2011-09-01 00:00:00

abstract：:The aim of the present study was to prepare and evaluate hydrogels containing 0.1% isosorbide mononitrate (ISMN) for topical treatment of anal fissure. The hydrogels were prepared on the base of Carbopol 940, Poloxamer 407 or their combination. The highest viscosity and significant thyxotropy were observed for the com...

journal_title：Current drug delivery

authors： Yoncheva K,Doytchinova I,Tankova L

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Polyionic Complex (PIC) nanogels are promising delivery systems with numerous attractions such as simple, fast, and organic solvent-free particle formation and mild drug loading conditions. Among polyelectrolytes, poly (L-amino acid) copolymers such as poly (ethylene glycol)-block-poly (L-glutamic acid) copo...

journal_title：Current drug delivery

authors： Salmanpour M,Saeed-Vaghefi M,Abolmaali SS,Tamaddon A

更新日期：2020-11-03 00:00:00

abstract：:ADMET Chemoinformatics multi-output models are useful for a parallel prediction of multiple experimental parameters related the absorption (A), distribution (D), metabolism (M), excretion (E), and toxicity (T) process of drugs, pollutants, and NPs with a single QSPR model. Here we present one state-of-art review about...

journal_title：Current drug delivery

authors： González-Díaz H

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is considered as a violent disease with high rate of morbidity and mortality. Early brain injury (EBI) and delayed vasospasm are the two aspects of this disease that are becoming research hotspots. OBJECTIVE:We aim to update the role of oxidative stress in the development of EB...

journal_title：Current drug delivery

authors： Yang Y,Chen S,Zhang JM

更新日期：2017-09-06 00:00:00

abstract：:Alternative formulations of paclitaxel were developed in order to improve its aqueous solubility, and characterized in vitro. A methacrylic acid based nanoconjugate of paclitaxel was synthesized by a simple esterification reaction with molecular weight of 1657 Da. The in vitro hydrolysis study on the prodrug of paclit...

journal_title：Current drug delivery

authors： Dhanikula AB,Panchagnula R

更新日期：2005-01-01 00:00:00

abstract：:The development of oral insulin using the eligen technology represents a significant advance in insulin administration which is expected to improve the quality of life of diabetic patients. As clinical studies progress, a great deal of interest has focused on the process by which this technology enables insulin absorp...

journal_title：Current drug delivery

authors： Malkov D,Angelo R,Wang HZ,Flanders E,Tang H,Gomez-Orellana I

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Cystic Fibrosis (CF) is a genetic disease which affects the patient's lungs, pancreas, liver, kidney and intestine and lacks sulfatase enzyme, leading to mucopolysaccharidosis. Colistin sulfate acts by interacting with phospholipids of bacterial cell membranes. Sulfatase enzyme reduces the high levels of sul...

journal_title：Current drug delivery

authors： Solanki NR,Patel DH,Talele DR

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:In this study, central composite factorial design was used for the preparation and optimization of chitosan/Na-alginate hydrogel films containing metformin via solvent evaporation technique. METHODS:Low and high molecular weight (MW) chitosan was used as a polymer in different concentrations while genipin w...

journal_title：Current drug delivery

authors： Ubaid M,Murtaza G

更新日期：2018-01-01 00:00:00