Investigation of Drug Release from PEO Tablet Matrices in the Presence of Vitamin E as Antioxidant.

abstract：BACKGROUND:Essential oils are poor aqueous solubility and high volatility compounds. The encapsulation of essential oils with cyclodextrins (CDs) can protect them from the adverse environmental conditions and improve their stability. Therefore, increasing the functional capabilities of essential oils when they were use...

journal_title：Current drug delivery

authors： Li Z,Wen W,Chen X,Zhu L,Cheng G,Liao Z,Huang H,Ming L

更新日期：2020-07-31 00:00:00

abstract：:psyllium, a medicinally active gel forming natural polysaccharide and a dietary fiber has been used as a medicine in myriad of conditions such as constipation and inflammatory bowel syndrome. One of its more recent uses that have received attention has been its ability to reduce blood sugar levels in diabetics. Theref...

journal_title：Current drug delivery

authors： Rathnanand M,Narkhede R,Udupa N,Kalra A

更新日期：2013-06-01 00:00:00

abstract：:Gelrite is an ion-activated polymer prepared by partial acetylation of gellan gum, an exogeneous polysaccharide present in Pseudomonas elodea. Its unique cation-dependent gelling property at 33 degrees C has been exploited for the formulation of in situ gelling hydrogels for ophthalmic and oral drug delivery. Gelrite ...

journal_title：Current drug delivery

authors： Rastogi R,Aqil M,Ali A,Sultana Y

更新日期：2008-04-01 00:00:00

abstract：:Metformin (MTF) improves hyperglycemia primarily by suppressing glucose production by the liver. The objective of our investigation was to evaluate nanoemulsion as a promising carrier for MTF for sustained hypoglycemic effect. The drug was incorporated into oil phase of nanoemulsion, which finally improved biopharmace...

journal_title：Current drug delivery

authors： Akhtar J,Siddiqui HH,Badruddeen,Fareed S,Aqil M

更新日期：2014-01-01 00:00:00

abstract：:The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The present study was carried out to develop a gastroretentive drug delivery system using isabgol as an exci...

journal_title：Current drug delivery

authors： Semwal R,Semwal RB,Semwal DK

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...

journal_title：Current drug delivery

authors： Varol M,Koparal AT,Benkli K,Bostancioglu RB

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Despite therapeutics based on siRNA have an immense potential for the treatment of incurable diseases such as cancers. However, the in vivo utilization of siRNA and also the delivery of this agent to the target site is one of the most controversial challenges. The helpful assistance by nanoparticles can impr...

journal_title：Current drug delivery

authors： Shajari N,Mansoori B,Davudian S,Mohammadi A,Baradaran B

更新日期：2017-01-01 00:00:00

abstract：:The dermal delivery characteristics of hydrophilic silica nanoparticle coated medium chain triglyceride oil-in-water emulsions are reported and correlated with the physicochemical and interfacial properties of the emulsion based drug carriers. The synergistic drug/stabiliser/nanoparticle interactions are demonstrated ...

journal_title：Current drug delivery

authors： Eskandar NG,Simovic S,Prestidge CA

更新日期：2009-08-01 00:00:00

abstract：:Osteoarthritis is usually regarded as a localized disease whose optimal treatment is a therapy applied directly to the affected joint. Unfortunately, current local therapies such as repeated intraarticular injections or constant infusions are associated with a higher risk of infection. One way to overcome this would b...

journal_title：Current drug delivery

authors： Stöve J,Lehmann L,Fickert S,Aigner T,Brenner R

更新日期：2007-01-01 00:00:00

abstract：AIM:The aim of the study was to formulate, characterize, and evaluate the resveratrol-loaded cubosomes (RC) through topical application. BACKGROUND:Resveratrol (RV) is a nutraceutical compound that has exciting pharmacological potential in different diseases including cancers. Many studies of resveratrol have been rep...

journal_title：Current drug delivery

authors： Kurangi B,Jalalpure S,Jagwani S

更新日期：2020-09-02 00:00:00

abstract：:The objective of this investigation was aimed to explore the cancer targeting potential of folate conjugated dendrimer (polypropylene imine, PPI) under strategic influence of folate receptor up-regulators (all trans Retinoic acid, ATRA and Dexamethasone, DEXA). The folate conjugated dendrimer nanoconjugate (FPPI) was ...

journal_title：Current drug delivery

authors： Dhakad RS,Tekade RK,Jain NK

更新日期：2013-08-01 00:00:00

abstract：:Atherosclerosis is the primary cause of coronary heart disease, which is characterized by a narrowing (stenosis) of the arteries that supply blood to tissues of the heart. Over the past decade, the use of "Bare metallic stents" during Percutaneous Transluminal Coronary Angioplasty (PTCA) has become a common practice f...

journal_title：Current drug delivery

authors： Hirlekar R,Patel M,Jain S,Kadam V

更新日期：2010-12-01 00:00:00

abstract：:The development of oral insulin using the eligen technology represents a significant advance in insulin administration which is expected to improve the quality of life of diabetic patients. As clinical studies progress, a great deal of interest has focused on the process by which this technology enables insulin absorp...

journal_title：Current drug delivery

authors： Malkov D,Angelo R,Wang HZ,Flanders E,Tang H,Gomez-Orellana I

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:Present investigation was aimed to fabricate nanocrystal of exemestane, an anticancer drug with poor dissolution properties and oral bioavailability. METHODS:Influence of various process parameters on the formulation of exemestane nanosuspension using media milling technique were investigated in the trial batc...

journal_title：Current drug delivery

authors： Parmar K,Shah J

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:The present work aimed to develop an ethosomal gel of naproxen sodium for the amelioration of rheumatoid arthritis. OBJECTIVE:In the present work, we have explored the potential of ethosomes to deliver naproxen into deeper skin strata. Further, the anti-inflammatory efficacy of naproxen ethosomal formulatio...

journal_title：Current drug delivery

authors： Anjum F,Zakir F,Verma D,Aqil M,Singh M,Jain P,Mirza MA,Anwer MK,Iqbal Z

更新日期：2020-01-01 00:00:00

abstract：:Gene therapy has the potential to treat both acquired and inherited genetic diseases. Generally, two types of gene delivery vectors are used - viral vectors and non-viral vectors. Non-viral gene delivery systems have attracted significant interest (e.g. 115 gene therapies approved for clinical trials in 2018; clinical...

journal_title：Current drug delivery

authors： Begum AA,Toth I,Hussein WM,Moyle PM

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:In this study, central composite factorial design was used for the preparation and optimization of chitosan/Na-alginate hydrogel films containing metformin via solvent evaporation technique. METHODS:Low and high molecular weight (MW) chitosan was used as a polymer in different concentrations while genipin w...

journal_title：Current drug delivery

authors： Ubaid M,Murtaza G

更新日期：2018-01-01 00:00:00

abstract：:Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validate...

journal_title：Current drug delivery

authors： de Almeida PA,Alves MC,Polonini HC,Calixto SL,Braga Gomes TB,Barros Lataliza AA,da Silveira Ramos CD,Barbosa Raposo NR,de Oliveira Ferreira A,Fernandes Brandão A

更新日期：2015-01-01 00:00:00

abstract：:A review with 93 references. Heparins are high molecular weight, hydrophilic polyanions, which are unstable under acidic conditions; and therefore they exhibit poor oral bioavailability. Consequently they must be administered via the parenteral route which is expensive, inconvenient, and limits use by outpatients. The...

journal_title：Current drug delivery

authors： Ross BP,Toth I

更新日期：2005-07-01 00:00:00

abstract：:The aim of this study was to design a silica-supported solid dispersion of lacidipine (LCDP) to enhance the dissolution rate and oral absorption using supercritical CO2 (scCO2) as a solvent. The formulation was characterized using differential scanning calorimetry, powder X-ray diffraction, scanning electron microscop...

journal_title：Current drug delivery

authors： Geng Y,Fu Q,Guo B,Li Y,Zhang X,Wang X,Zhang T

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The present study reports the use of MicrofluidizerTM technology to form a stable nanosuspension of atovaquone (ATQ) using quality by design (QbD) approach. METHODS:The patient-centric quality target product profile and critical quality attributes (CQAs) were identified. A Box-Behnken design was employed for...

journal_title：Current drug delivery

authors： Kakade P,Gite S,Patravale V

更新日期：2020-01-01 00:00:00

abstract：:The low bioavailability and consequently the poor therapeutic response of traditional ophthalmic formulations is caused by reduced pre-corneal residence time of the formulation in contact with the ocular surface. The use of colloidal carrier systems, namely lipid nanoparticles in combination with in situ gelling polym...

journal_title：Current drug delivery

authors： Almeida H,Lobão P,Frigerio C,Fonseca J,Silva R,Palmeira-de-Oliveira A,Lobo JM,Amaral MH

更新日期：2016-01-01 00:00:00

abstract：:Curcumin as an antioxidative agent which has been widely used medicinally in India and China. However, rapid metabolism coupled with the instability of curcumin under physiological conditions has greatly limited its applications in vivo. In the present study, a thermosensitive hydrogel with high payload of curcumin wa...

journal_title：Current drug delivery

authors： Lu C

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Nasal delivery of 20 (R) -ginsenoside Rg3 (Rg3) has a short-lived anti-fatigue effect owing to rapid clearance by nasal cilia. Thus, in order to extend the residence time of Rg3 in the nasal cavity, a new drug delivery system is needed. METHODS:Chitosan microspheres loaded with Rg3 were prepared using a mul...

journal_title：Current drug delivery

authors： Zhang W,Wang X,Zhang M,Xu M,Tang W,Zhang Y,Lu L,Gao J,Gao S

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE:The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded t...

journal_title：Current drug delivery

authors： De Marco Almeida F,Silva CN,de Araujo Lopes SC,Santos DM,Torres FS,Cardoso FL,Martinelli PM,da Silva ER,de Lima ME,Miranda LAF,Oliveira MC

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Colloidal systems are most prominent delivery systems mainly used as vehicles for the transportation, targeting the various types of biomolecules, proteins, peptides, synthetic medicinal agents. OBJECTIVE:To provide concise information on patents that are directly or indirectly related to the nanoemulsions....

journal_title：Current drug delivery

authors： Patel RB,Thakore SD,Patel MR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is considered as a violent disease with high rate of morbidity and mortality. Early brain injury (EBI) and delayed vasospasm are the two aspects of this disease that are becoming research hotspots. OBJECTIVE:We aim to update the role of oxidative stress in the development of EB...

journal_title：Current drug delivery

authors： Yang Y,Chen S,Zhang JM

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:Cabazitaxel (CBZ) is a new taxane approved by FDA for treatment of castration- resistant prostate cancer not responding to docetaxel. However, CBZ is not a suitable substrate for p-glycoprotein 60, an efflux pump which transports anticancer drugs out of malignant cells and is therefore a promising drug for t...

journal_title：Current drug delivery

authors： Khoeeniha MK,Esfandyari-Manesh M,Behrouz H,Amini M,Varnamkhasti BS,Atyabi F,Dinarvand R

更新日期：2017-01-01 00:00:00

abstract：:Paclitaxel (taxol, 1a) and docetaxel (taxotere, 1b) have established themselves as an important class of antitumor drugs currently available to the oncologist. While the great contribution of these drugs to the management of the disease and their effect on the improvement of the patient quality of life could not be ov...

journal_title：Current drug delivery

authors： Safavy A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Chrysin is a strong inhibitor of breast cancer resistance protein (BCRP) but it is practically insoluble in water. Effective solubilization of chrysin is critical for its pharmaceutical application as an absorption enhancer via inhibition of BCRP-mediated drug efflux. OBJECTIVE:This study aimed to develop a...

journal_title：Current drug delivery

authors： Lee SH,Lee YS,Song JG,Han HK

更新日期：2019-01-01 00:00:00