Mucosal immunisation: adjuvants and delivery systems.

abstract：:Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an e...

journal_title：Current drug delivery

authors： Mishra N,Singh D,Sharma S,Baldi A

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The present study reports the use of MicrofluidizerTM technology to form a stable nanosuspension of atovaquone (ATQ) using quality by design (QbD) approach. METHODS:The patient-centric quality target product profile and critical quality attributes (CQAs) were identified. A Box-Behnken design was employed for...

journal_title：Current drug delivery

authors： Kakade P,Gite S,Patravale V

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeu...

journal_title：Current drug delivery

authors： Khondee S,Chittasupho C,Tima S,Anuchapreeda S

更新日期：2018-01-01 00:00:00

abstract：:A number of Polycyclic Aromatic Hydrocarbons (PAHs) have been shown to be toxicants, and induce carcinogenic and immunotoxic effects. Since PAHs are often present in low concentrations and it may be difficult to determine them in complex matrices, it is therefore essential to use powerful analytical tools to separate ...

journal_title：Current drug delivery

authors： Şentürk Z

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Tuberculosis is an infection and caused by gentle growing bacteria. The Internet provides opportunities for people with tuberculosis (TB) to connect with one another to address these challenges. OBJECTIVE:The aim of this paper is to introduce readers to the platforms on which Tuberculosis participants inter...

journal_title：Current drug delivery

authors： Singh G,Kesharwani P,Srivastava AK

更新日期：2018-01-01 00:00:00

abstract：:Percutaneous coronary intervention (PCI) has become a highly effective alternative for the treatment of coronary artery disease. The use of stents has reduced the rates of restenosis by preventing elastic recoil and negative remodeling, however neointima formation still remains an issue. Local drug delivery is an attr...

journal_title：Current drug delivery

authors： Kennedy KL,Lucas AR,Wan W

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Atenolol has been used to treat angina and hypertension, either alone or with other antihypertensives. Despite its usefulness, it shows some side effects such as diarrhea and nausea in some patients. A method for slow release of atenolol in intestine is helpful to prevent such side effects. METHODS:A facile...

journal_title：Current drug delivery

authors： Mortazavi-Derazkola S,Naimi-Jamal MR,Ghoreishi SM

更新日期：2016-01-01 00:00:00

abstract：:Conventional dosage forms such as tablets, capsules and syrups are prescribed in the normal course of practice. However, concerns about patient preferences and market demands have given rise to the exploration of novel unconventional dosage forms. Among these, confectionery-based dose forms have strong potential to ov...

journal_title：Current drug delivery

authors： Tangso KJ,Ho QP,Boyd BJ

更新日期：2015-01-01 00:00:00

abstract：:Relief of chronic pain is an important clinical problem requiring special care and approaches. The present study was designed for the construction of a controlled release system for local application of analgesics (hydromorphone (HM), morphine (M), and codeine (C)) and a local anesthetic, bupivacaine (BP). An interpen...

journal_title：Current drug delivery

authors： Keskin DS,Wise DL,Hasirci V

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Fluoroquinolones, the synthetic antibacterial agents are being successfully utilized against bacterial infections, since the time immemorial. Despite of enormous useful features, these drugs are associated with some limitations also. Large number of efforts has been made by various scientists to improve phar...

journal_title：Current drug delivery

authors： Sharma PC,Piplani M,Rajak H

更新日期：2018-02-14 00:00:00

abstract：:Gelrite is an ion-activated polymer prepared by partial acetylation of gellan gum, an exogeneous polysaccharide present in Pseudomonas elodea. Its unique cation-dependent gelling property at 33 degrees C has been exploited for the formulation of in situ gelling hydrogels for ophthalmic and oral drug delivery. Gelrite ...

journal_title：Current drug delivery

authors： Rastogi R,Aqil M,Ali A,Sultana Y

更新日期：2008-04-01 00:00:00

abstract：:The objective of this investigation was to prepare mucoadhesive microspheres of ketorolac for nasal delivery to avoid gastrointestinal side effects of conventional dosage form. Mucoadhesive microspheres were prepared using carbopol, polycarbophil and chitosan as polymer by spray drying method. The process and formulat...

journal_title：Current drug delivery

authors： Nagda CD,Chotai NP,Nagda DC,Patel SB,Patel UL

更新日期：2012-03-01 00:00:00

abstract：AIM:This study aimed to investigate the influence of the preparation process and composition on the microstructure of the O/W primary emulsions and the corresponding impact on the formation of oil-in-water-in-oil (O/W/O) multiple emulsions. OBJECTIVES:Multiple emulsions were prepared by a two-step emulsification metho...

journal_title：Current drug delivery

authors： Zhang Q,Qin Y,Duan G,Ou W,Wang Y,Zhang W

更新日期：2020-12-31 00:00:00

abstract：OBJECTIVE:The label free ultrasmall fluorescent ferrite clusters have been engineered in a controlled fashion which was stabilized by serum protein and functionalized by folic acid for the application of targeted multimodal optical and Magnetic Resonance (MR) cancer imaging. METHODS:The ultra-small manganese ferrite n...

journal_title：Current drug delivery

authors： Haribabu V,Sharmiladevi P,Akhtar N,Farook AS,Girigoswami K,Girigoswami A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cystic Fibrosis (CF) is a genetic disease which affects the patient's lungs, pancreas, liver, kidney and intestine and lacks sulfatase enzyme, leading to mucopolysaccharidosis. Colistin sulfate acts by interacting with phospholipids of bacterial cell membranes. Sulfatase enzyme reduces the high levels of sul...

journal_title：Current drug delivery

authors： Solanki NR,Patel DH,Talele DR

更新日期：2020-01-01 00:00:00

abstract：:Methylene blue (MB) has been shown to slow down the progression of the Alzheimer's disease (AD) and other tauopathies; however distribution of MB into the brain is limited due its high hydrophilicity. In this study, we aimed to prepare novel hydrophobic glutathione coated PLGA nanoparticles to improve bioavailability ...

journal_title：Current drug delivery

authors： Jinwal UK,Groshev A,Zhang J,Grover A,Sutariya VB

更新日期：2014-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) and free radicals have been implicated in a number of diseases and disorders, and the skin, for its localization, is exposed to a large number of environmental threats. Free radical scavengers and antioxidants have thus been proposed as protective or therapeutic agents against ROS-mediate...

journal_title：Current drug delivery

authors： Ascenso A,Ribeiro HM,Marques HC,Simoes S

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...

journal_title：Current drug delivery

authors： Varol M,Koparal AT,Benkli K,Bostancioglu RB

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To develop and evaluate the suitability of lecithin organogels containing aceclofenac for topical application and compare its In vitro and In vivo effects with conventionally used hydrogels. METHODS:The components and their concentration necessary for organogels formation were evaluated using phase diagram. So...

journal_title：Current drug delivery

authors： Shaikh IM,Jadhav SL,Jadhav KR,Kadam VJ,Pisal SS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is considered as a violent disease with high rate of morbidity and mortality. Early brain injury (EBI) and delayed vasospasm are the two aspects of this disease that are becoming research hotspots. OBJECTIVE:We aim to update the role of oxidative stress in the development of EB...

journal_title：Current drug delivery

authors： Yang Y,Chen S,Zhang JM

更新日期：2017-09-06 00:00:00

abstract：:The most common feature for antigen-delivery systems is their particulate nature. Together with a certain depot effect, it is the particulate nature that primarily dictates whether the antigen-delivery system will be successful in inducing a certain type and strength of immune response. In this article, we will summar...

journal_title：Current drug delivery

authors： Liang MT,Davies NM,Blanchfield JT,Toth I

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:The main objective of this novel study was to develop midazolam hydrochloride fast dissolving oral films (FDFs) using solvent casting method and to evaluate the characteristics of the optimum formulation through in vitro and in vivo analysis. The FDFs are new favorable solid dosage forms that deliver drugs r...

journal_title：Current drug delivery

authors： Soroushnai A,Ganji F,Vasheghani-Farahani E,Mobedi H

更新日期：2018-01-01 00:00:00

abstract：:Biphenyl Dimethyl Dicarboxylate (BDD) is insoluble in aqueous solution and the bioavailability after oral administration is low. Self-nanoemulsifying drug delivery system (SNEDDS) containing BDD has been successfully prepared using carefully selected ingredients which are less affected by pH and ionic strength changes...

journal_title：Current drug delivery

authors： El-Laithy HM

更新日期：2008-07-01 00:00:00

abstract：:The objective of this study was to investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant. The result showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HCl from aged PEO matri...

journal_title：Current drug delivery

authors： Shojaee S,Nokhodchi A,Cumming I,Alhalaweh A,Kaialy W

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Realgar, a traditional Chinese medicine, has shown antitumor efficacy in several tumor types. We previously showed that realgar nanoparticles (nano-realgar) had significant antileukemia, anti-lung cancer and anti-liver cancer effects. In addition, the anti-tumor effects of nanorealgar were significantly bett...

journal_title：Current drug delivery

authors： Xiaoxia X,Jing S,Dongbin X,Yonggang T,Jingke Z,Yanying Z,Hulai W

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:In the present work, we report for the first time the therapeutic potential of talazoparib (BMN 673)-SLNs for the treatment of BRCA1 deficient Triple Negative Breast Cancer (TNBC). BMN 673-SLNs were produced by hot-homogenization technique and then characterized. METHODS:The cytotoxic and apoptotic effects o...

journal_title：Current drug delivery

authors： Eskiler GG,Cecener G,Dikmen G,Egeli U,Tunca B

更新日期：2019-01-01 00:00:00

abstract：:Camptothecins are a family of alkaloids originally extracted from the Chinese tree Camptotheca acuminata, Nyssaceae, exhibiting a strong activity against colorectal cancer (CRC). CRC is a common malignancy worlwide. Despite significant developments in the treatment of this disease, it still causes considerable morbidi...

journal_title：Current drug delivery

authors： Mollica A,Stefanucci A,Feliciani F,Cacciatore I,Cornacchia C,Pinnen F

更新日期：2012-03-01 00:00:00

abstract：:Motivated by the success and exhaustive research on carbon nanotubes (CNTs) based drug delivery, graphene, a two-dimensional; honey-comb crystal lattice has emerged as the rising star in recent years. Graphene is a flat monolayer of carbon atoms that holds many promising properties such as unparalleled thermal conduct...

journal_title：Current drug delivery

authors： Muthoosamy K,Bai RG,Manickam S

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:A new tumor targeted polymer-coated gold/graphene hybrid has been developed for achieving simultaneously thermoablation and chemoterapy of folate receptor-positive cancer cells. METHODS:The gold/graphene hybrid was prepared by depositing gold nanospheres onto graphene oxide and coating it with an inulin-fola...

journal_title：Current drug delivery

authors： Mauro N,Volsi AL,Scialabba C,Licciardi M,Cavallaro G,Giammona G

更新日期：2017-01-01 00:00:00

abstract：:Atherosclerosis is the primary cause of coronary heart disease, which is characterized by a narrowing (stenosis) of the arteries that supply blood to tissues of the heart. Over the past decade, the use of "Bare metallic stents" during Percutaneous Transluminal Coronary Angioplasty (PTCA) has become a common practice f...

journal_title：Current drug delivery

authors： Hirlekar R,Patel M,Jain S,Kadam V

更新日期：2010-12-01 00:00:00