Abstract:
:The most common feature for antigen-delivery systems is their particulate nature. Together with a certain depot effect, it is the particulate nature that primarily dictates whether the antigen-delivery system will be successful in inducing a certain type and strength of immune response. In this article, we will summarize recent data on particulate delivery systems for peptide and protein antigens with a main focus on lipid or polymer-based particles, all of which possess high potential as both preventive and therapeutic vaccines for parenteral, nasal, and possibly oral administration.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Liang MT,Davies NM,Blanchfield JT,Toth Idoi
10.2174/156720106778559029subject
Has Abstractpub_date
2006-10-01 00:00:00pages
379-88issue
4eissn
1567-2018issn
1875-5704journal_volume
3pub_type
杂志文章,评审abstract::New technologies are currently investigated with the aim to improve the quality of foods by enhancing their nutritional value, freshness, safety and shelf-life, as well as by improving their tastes, flavours and textures. Moreover, new technological approaches are being explored, in this field, to address nutritional ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999201125205025
更新日期:2020-11-25 00:00:00
abstract::Previous studies suggested that caspofungin dose escalation against Candida species is more beneficial than currently used lower daily doses. Thus, we determined in vitro and in vivo activity of caspofungin against six wild-type C. albicans clinical isolates, the ATCC 10231 strain and an echinocandin resistant strain....
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201812666150623091336
更新日期:2016-01-01 00:00:00
abstract::A palpable need for the optimization of therapeutic agents, due to challenges tackled by them such as poor pharmacokinetics and chemoresistance, has steered the journey towards novel interdisciplinary scientific field for emergence of nanostructure materials as a carrier for targeted delivery of therapeutic agents. Am...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666141229104304
更新日期:2015-01-01 00:00:00
abstract::In this study we developed and evaluated a prototype of an effective occlusive mucoadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and gelatine models together with nystatin as a prophylactic agent incorporated into the formulation and investigated drug release in-vitro. Results of...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201811310010020
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate Quality by Design (QbD) principle for the preparation of hydrogel products to prove both practicability and utility of executing QbD concept to hydrogel based controlled release systems. Product and process understanding will help in decreasing the variability of ...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666150817122506
更新日期:2016-01-01 00:00:00
abstract::There are still so-called unmet needs in the treatment of epithelial and cutaneous lesions. Mucositis, ocular lesions, chronic skin wounds represent typical examples. These pathologies do not yet afford a satisfactory treatment. In particular chronic wounds represent a major health care burden, likely to increase as t...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811310010005
更新日期:2013-02-01 00:00:00
abstract:AIM:This study was focused on the formulation of the multi-unit extended-release peroral delivery device of lamotrigine for better management of epilepsy. BACKGROUND:The single-unit extended-release peroral preparations often suffer from all-or-none effect. A significant number of multi-unit delivery systems have been...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200317124022
更新日期:2020-01-01 00:00:00
abstract::Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly difficult. One problem has been that antibiotics commonly used were designed for...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811666140327145049
更新日期:2014-01-01 00:00:00
abstract::Skin, the most significant protective organ in the body, may face serious problems, including cancer, infectious diseases, etc., requiring different drugs for the treatment. However, most of these drugs have poor chemical and physical stability, and insufficient penetration through the skin layers. In recent years, wi...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200820161438
更新日期:2020-08-20 00:00:00
abstract:OBJECTIVES:In this study, central composite factorial design was used for the preparation and optimization of chitosan/Na-alginate hydrogel films containing metformin via solvent evaporation technique. METHODS:Low and high molecular weight (MW) chitosan was used as a polymer in different concentrations while genipin w...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180409102459
更新日期:2018-01-01 00:00:00
abstract::The development of oral insulin using the eligen technology represents a significant advance in insulin administration which is expected to improve the quality of life of diabetic patients. As clinical studies progress, a great deal of interest has focused on the process by which this technology enables insulin absorp...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201053586001
更新日期:2005-04-01 00:00:00
abstract::Medicated foams and film forming systems are dosage forms formulated to undergo a controlled metamorphosis when applied on the skin. Indeed, due to the presence of propellant or a particular air-spray foam pump, a liquid can generate foam when applied on the stratum corneum, or a liquid or conventional dosage form can...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201816666190118124439
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Polyionic Complex (PIC) nanogels are promising delivery systems with numerous attractions such as simple, fast, and organic solvent-free particle formation and mild drug loading conditions. Among polyelectrolytes, poly (L-amino acid) copolymers such as poly (ethylene glycol)-block-poly (L-glutamic acid) copo...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999201103195846
更新日期:2020-11-03 00:00:00
abstract::Hydrogels can constitute reliable delivery systems of drugs, including those based on nucleic acids (NABDs) such as small interfering ribonucleic acid (siRNA). Their nature, structure, and response to physiological or external stimuli strongly influence the delivery mechanisms of entrapped active molecules, and, in tu...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160721142202
更新日期:2017-01-01 00:00:00
abstract::The present study performed by preparation and evaluation of floating tablets of Acyclovir as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose K 4M, K 15M, psyllium husk, swelling agent as crospovidone and micro...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720109789941678
更新日期:2009-10-01 00:00:00
abstract::Since its discovery in 1796 by Edward Jenner, vaccines have been an integral aspect of therapeutics, combating a number of infectious diseases with remarkable success. In recent years, due to rapid advances in proteomics, genomics, biotechnology and immunology and the plethora of knowledge amassed in related fields, i...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720106776359249
更新日期:2006-04-01 00:00:00
abstract::Serrapeptase is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia sp. HY-6. Very few methods are available for the quantification of serrapeptase. The activity of the enzyme is determined by an ELISA assay, colorimetric method using casein as substrate or by HPLC method. These methods ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720108785915023
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption, and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). Transdermal route is also beneficial for dru...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201815666180605114131
更新日期:2018-01-01 00:00:00
abstract::The objective of the present study was to fabricate and evaluate a multiparticulate oral gastroretentive dosage form of baclofen characterized by a central large cavity (hollow core) promoting unmitigated floatation with practical applications to alleviate the signs and symptoms of spasticity and muscular rigidity. So...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201811666140414113838
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to design a silica-supported solid dispersion of lacidipine (LCDP) to enhance the dissolution rate and oral absorption using supercritical CO2 (scCO2) as a solvent. The formulation was characterized using differential scanning calorimetry, powder X-ray diffraction, scanning electron microscop...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666151203233232
更新日期:2016-01-01 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 has spread rapidly since its discovery in December 2019 in the Chinese province of Hubei, reaching this day, all the continents. This scourge is, unfortunately, in lineage with various dangerous outbreaks such as Ebola, Cholera, Spanish flu, American seasonal flu. Until ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200917124241
更新日期:2020-09-17 00:00:00
abstract:BACKGROUND:Osteoporosis is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteo...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201813666161230142123
更新日期:2017-01-01 00:00:00
abstract::The aim of the present study was to prepare and evaluate hydrogels containing 0.1% isosorbide mononitrate (ISMN) for topical treatment of anal fissure. The hydrogels were prepared on the base of Carbopol 940, Poloxamer 407 or their combination. The highest viscosity and significant thyxotropy were observed for the com...
journal_title:Current drug delivery
pub_type: 杂志文章,随机对照试验
doi:10.2174/156720112802650635
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Hesperetin (HSP) is a low water-soluble flavanone aglycone with low bioavailability. OBJECTIVES:This study aimed at enhancing the hepatoprotective effects of HSP by a combinatory technique based on solid dispersions of co-crystals of HSP. METHODS:Co-crystals were prepared using citric acid, tartaric acid, ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180730141556
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The management of TB is difficult due to the resistance developed by Mycobacterium tuberculosis against anti-tubercular drugs causes the new challenges for treating and managing the disease. OBJECTIVE:The objective of the study was to combat multiple drug resistance (MDR) exhibited by mycobacterium species ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160502124811
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Mesoporous bioactive glass (MBG) has been widely studied because of its excellent histocompatibility and degradability. However, due to the lack of good osteoinductive activity, the pure MBG scaffold is not effective in repairing large-scale bone defects. OBJECTIVE:To observe the repair effect of MBG scaffo...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200916091253
更新日期:2020-09-15 00:00:00
abstract::Therapeutic drug monitoring (TDM) is a valuable tool for tailoring the dosage of the prescribed medication(s) to the individual pharmacokinetic characteristics of a patient. In psychiatry and neurology, however, proven evidence that TDM should be used for treatment with the multiple neuropsychiatric medications is res...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201812666151029100909
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The scope of nanotechnology has been extended to almost every sphere of our daily life. As a result of this, nanocarriers like Carbon Nanotubes (CNTs) are gaining considerable attention for their use in various therapeutic and diagnostic applications. OBJECTIVE:The objective of the current article is to rev...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200508092821
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE:The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded t...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180108170206
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Betulinic acid (BA) is a lipophilic compound with proven beneficial results in topical inflammation. Nanogels (NG) are carriers of bioactive compounds with properties that make them good candidates to treat skin diseases. OBJECTIVE:The objective of this study was to evaluate the anti-inflammatory activity o...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200817154003
更新日期:2020-08-17 00:00:00