Betulinic acid nanogels: rheological, micro structural characterization and evaluation of their anti-inflammatory activity.

abstract：AIM:This study was focused on the formulation of the multi-unit extended-release peroral delivery device of lamotrigine for better management of epilepsy. BACKGROUND:The single-unit extended-release peroral preparations often suffer from all-or-none effect. A significant number of multi-unit delivery systems have been...

journal_title：Current drug delivery

authors： Jain D,Sodani A,Ray S,Ghosh P,Nandi G

更新日期：2020-01-01 00:00:00

abstract：:Biphenyl Dimethyl Dicarboxylate (BDD) is insoluble in aqueous solution and the bioavailability after oral administration is low. Self-nanoemulsifying drug delivery system (SNEDDS) containing BDD has been successfully prepared using carefully selected ingredients which are less affected by pH and ionic strength changes...

journal_title：Current drug delivery

authors： El-Laithy HM

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The aim of this research was to engineer solid dispersion lipid particles (SDSLs) in which a solid dispersion (SD) was encapsulated to form the core of solid lipid particles (SLs), thereby achieving an efficient enhancement in the dissolution of a poorly water-soluble drug. METHODS:Ultrasonication was intro...

journal_title：Current drug delivery

authors： My Tran KT,Vo TV,Lee BJ,Duan W,Ha-Lien Tran P,Truong-Dinh Tran T

更新日期：2018-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environment...

journal_title：Current drug delivery

authors： Sharma P,Pandita A,Murthy RS

更新日期：2013-11-24 00:00:00

abstract：:Paclitaxel (taxol, 1a) and docetaxel (taxotere, 1b) have established themselves as an important class of antitumor drugs currently available to the oncologist. While the great contribution of these drugs to the management of the disease and their effect on the improvement of the patient quality of life could not be ov...

journal_title：Current drug delivery

authors： Safavy A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Mesoporous bioactive glass (MBG) has been widely studied because of its excellent histocompatibility and degradability. However, due to the lack of good osteoinductive activity, the pure MBG scaffold is not effective in repairing large-scale bone defects. OBJECTIVE:To observe the repair effect of MBG scaffo...

journal_title：Current drug delivery

authors： Wu L,Wei Z,He S,Bi Y,Cao Y,Wang W

更新日期：2020-09-15 00:00:00

abstract：:Motivated by the success and exhaustive research on carbon nanotubes (CNTs) based drug delivery, graphene, a two-dimensional; honey-comb crystal lattice has emerged as the rising star in recent years. Graphene is a flat monolayer of carbon atoms that holds many promising properties such as unparalleled thermal conduct...

journal_title：Current drug delivery

authors： Muthoosamy K,Bai RG,Manickam S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Cabazitaxel (CBZ) is a new taxane approved by FDA for treatment of castration- resistant prostate cancer not responding to docetaxel. However, CBZ is not a suitable substrate for p-glycoprotein 60, an efflux pump which transports anticancer drugs out of malignant cells and is therefore a promising drug for t...

journal_title：Current drug delivery

authors： Khoeeniha MK,Esfandyari-Manesh M,Behrouz H,Amini M,Varnamkhasti BS,Atyabi F,Dinarvand R

更新日期：2017-01-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 has spread rapidly since its discovery in December 2019 in the Chinese province of Hubei, reaching this day, all the continents. This scourge is, unfortunately, in lineage with various dangerous outbreaks such as Ebola, Cholera, Spanish flu, American seasonal flu. Until ...

journal_title：Current drug delivery

authors： Sofiane F,Lamia T,Mohamed S,Mokrane IO

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:Wound healing is a biological process that can get in a state of pathologic inflammation, requiring the use of specific medications able to promote proper tissue repair. OBJECTIVE:The study describes the production and characterization of nanoparticle based gel for wound healing treatment designed to delive...

journal_title：Current drug delivery

authors： Esposito E,Pecorelli A,Sguizzato M,Drechsler M,Mariani P,Carducci F,Cervellati F,Nastruzzi C,Cortesi R,Valacchi G

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present work was to evaluate alginate hydrogels in the form of spherical beads as carrier for antithrombotic drugs for future use in artificial grafts. The ionotropic gelation technique was employed to prepare beads from the L. hyperborea stipe of alginate with two different alginate concentrations and ...

journal_title：Current drug delivery

authors： Jämstorp E,Bodin A,Gatenholm P,Jeppsson A,Strømme M

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...

journal_title：Current drug delivery

authors： Varol M,Koparal AT,Benkli K,Bostancioglu RB

更新日期：2018-01-01 00:00:00

abstract：:The objective of the present research is to prepare stable nano suspensions of Valsartan (VAL) with high solubility and dissolution. VAL is an orally administered anti-hypertensive drug with lower bio-availability of 25%, this is attributed to its lower aqueous solubility (0.082 mg/ml). VAL nano suspensions were prepa...

journal_title：Current drug delivery

authors： Vuppalapati L,Cherukuri S,Neeli V,Yeragamreddy PR,Kesavan BR

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To develop and evaluate the suitability of lecithin organogels containing aceclofenac for topical application and compare its In vitro and In vivo effects with conventionally used hydrogels. METHODS:The components and their concentration necessary for organogels formation were evaluated using phase diagram. So...

journal_title：Current drug delivery

authors： Shaikh IM,Jadhav SL,Jadhav KR,Kadam VJ,Pisal SS

更新日期：2009-01-01 00:00:00

abstract：:The objective of this investigation was aimed to explore the cancer targeting potential of folate conjugated dendrimer (polypropylene imine, PPI) under strategic influence of folate receptor up-regulators (all trans Retinoic acid, ATRA and Dexamethasone, DEXA). The folate conjugated dendrimer nanoconjugate (FPPI) was ...

journal_title：Current drug delivery

authors： Dhakad RS,Tekade RK,Jain NK

更新日期：2013-08-01 00:00:00

abstract：:Fast-dissolving drug delivery systems have been developed as an alternative to conventional dosage form as an oral means of drug delivery in case of chronic conditions. Now a day's fast dissolving films are preferred over conventional tablets and capsules for masking the taste of bitter drugs to increase the patient c...

journal_title：Current drug delivery

authors： Chaturvedi A,Srivastava P,Yadav S,Bansal M,Garg G,Sharma PK

更新日期：2011-07-01 00:00:00

abstract：:The objective of this study was to develop and evaluate mucoadhesive microsphere of diclofenac sodium with natural gums for sustained delivery. Guar gum and tragacanth were used along with sodium alginate as mucoadhesive polymers. Microspheres were formulated using orifice-ionic gelation method. Particle size, surface...

journal_title：Current drug delivery

authors： Amin ML,Jesmeen T,Sutradhar KB,Mannan MA

更新日期：2013-12-01 00:00:00

abstract：:ImmunoPET is a non-invasive imaging technology based on tracking and quantification of radiolabeled monoclonal antibodies, antibody fragments and peptides in vivo. The knowledge of distribution and expression levels of a given receptor is a key for successful receptor targeted cancer therapy. ImmunoPET performed with ...

journal_title：Current drug delivery

authors： Marik J,Junutula JR

更新日期：2011-01-01 00:00:00

abstract：:The low bioavailability and consequently the poor therapeutic response of traditional ophthalmic formulations is caused by reduced pre-corneal residence time of the formulation in contact with the ocular surface. The use of colloidal carrier systems, namely lipid nanoparticles in combination with in situ gelling polym...

journal_title：Current drug delivery

authors： Almeida H,Lobão P,Frigerio C,Fonseca J,Silva R,Palmeira-de-Oliveira A,Lobo JM,Amaral MH

更新日期：2016-01-01 00:00:00

abstract：:Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulos...

journal_title：Current drug delivery

authors： Duttagupta DS,Jadhav VM,Kadam VJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Polyionic Complex (PIC) nanogels are promising delivery systems with numerous attractions such as simple, fast, and organic solvent-free particle formation and mild drug loading conditions. Among polyelectrolytes, poly (L-amino acid) copolymers such as poly (ethylene glycol)-block-poly (L-glutamic acid) copo...

journal_title：Current drug delivery

authors： Salmanpour M,Saeed-Vaghefi M,Abolmaali SS,Tamaddon A

更新日期：2020-11-03 00:00:00

abstract：:The aim of the present study was to formulate a combined patch containing salicylic (SA) acid and nicotinamide (NA), useful for the treatment of mild acne, and to verify their mutual effect on drug permeation and skin retention. The performance of the patch was tested in vitro in permeation experiments using pig ear s...

journal_title：Current drug delivery

authors： Padula C,Ferretti C,Nicoli S,Santi P

更新日期：2010-12-01 00:00:00

abstract：:Skin, the most significant protective organ in the body, may face serious problems, including cancer, infectious diseases, etc., requiring different drugs for the treatment. However, most of these drugs have poor chemical and physical stability, and insufficient penetration through the skin layers. In recent years, wi...

journal_title：Current drug delivery

authors： Khailnezhad B,Hadjizadeh A

更新日期：2020-08-20 00:00:00

abstract：:Gene therapy has the potential to treat both acquired and inherited genetic diseases. Generally, two types of gene delivery vectors are used - viral vectors and non-viral vectors. Non-viral gene delivery systems have attracted significant interest (e.g. 115 gene therapies approved for clinical trials in 2018; clinical...

journal_title：Current drug delivery

authors： Begum AA,Toth I,Hussein WM,Moyle PM

更新日期：2019-01-01 00:00:00

abstract：:Polar lipids and various surfactants exhibit rich phase behavior depending on the composition of the lipids and the physicochemical conditions. Lamellar (L(alpha)), hexagonal (Inverted [H(II)]) and normal or inverted cubic (bicontinuous or micellar) structures are some of the most common lyotropic liquid crystalline p...

journal_title：Current drug delivery

authors： Hirlekar R,Jain S,Patel M,Garse H,Kadam V

更新日期：2010-01-01 00:00:00

abstract：:Hydrogels can constitute reliable delivery systems of drugs, including those based on nucleic acids (NABDs) such as small interfering ribonucleic acid (siRNA). Their nature, structure, and response to physiological or external stimuli strongly influence the delivery mechanisms of entrapped active molecules, and, in tu...

journal_title：Current drug delivery

authors： Dalmoro A,Abrami M,Galzerano B,Bochicchio S,Barba AA,Grassi M,Larobina D

更新日期：2017-01-01 00:00:00

abstract：:The placenta has traditionally been considered as a highly permeable organ for a large variety of substances with diverse molecular structures that are readily able to cross it from the maternal blood to reach the foetus. This has recommended limiting the use of drugs during pregnancy as far as possible. However, our ...

journal_title：Current drug delivery

authors： Marin JJ,Briz O,Serrano MA

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Cystic Fibrosis (CF) is a genetic disease which affects the patient's lungs, pancreas, liver, kidney and intestine and lacks sulfatase enzyme, leading to mucopolysaccharidosis. Colistin sulfate acts by interacting with phospholipids of bacterial cell membranes. Sulfatase enzyme reduces the high levels of sul...

journal_title：Current drug delivery

authors： Solanki NR,Patel DH,Talele DR

更新日期：2020-01-01 00:00:00

abstract：:The aim of this work is to study liposomes as carriers of nutrients and therapeutic agents in aquaculture with Venerupis decussatus and Venerupis pullastra larvae. Multilamellar (MLVs) and large unilamellar (LUVs) vesicles were prepared from a commercial mixture of soy phosphatidylcholine, rich in unsaturated and poly...

journal_title：Current drug delivery

authors： Lai F,Valenti D,Sinico C,Manconi M,Mendez JB,Fadda AM

更新日期：2004-04-01 00:00:00

abstract：:Osteoarthritis is usually regarded as a localized disease whose optimal treatment is a therapy applied directly to the affected joint. Unfortunately, current local therapies such as repeated intraarticular injections or constant infusions are associated with a higher risk of infection. One way to overcome this would b...

journal_title：Current drug delivery

authors： Stöve J,Lehmann L,Fickert S,Aigner T,Brenner R

更新日期：2007-01-01 00:00:00