Abstract:
:In this study we developed and evaluated a prototype of an effective occlusive mucoadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and gelatine models together with nystatin as a prophylactic agent incorporated into the formulation and investigated drug release in-vitro. Results of in vitro studies showed that chitosan and gelatine based gels posses properties that makes them excellent candidates for treatment of oral mucositis. These properties include not only the palliative effects of an occlusive dressing but also the potential for delivering therapeutic compounds with chitosan gels providing drug concentrations above their minimum inhibition concentration and extending the retention time in the oral cavity due to their bioadhesive properties. Chitosan also offers an advantage over suspensions because of its inherent antimicrobial properties. The performance of gelatin-based gels highlights the novel, non-toxic, in situ forming gelatine based hydrogel. The results of in vitro drug release experiments demonstrated that all the hydrogel showed sustained release properties.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Perchyonok VT,Zhang S,Oberholzer Tdoi
10.2174/1567201811310010020subject
Has Abstractpub_date
2013-02-01 00:00:00pages
144-50issue
1eissn
1567-2018issn
1875-5704pii
CDD-EPUB-20120926-1journal_volume
10pub_type
杂志文章abstract::The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The present study was carried out to develop a gastroretentive drug delivery system using isabgol as an exci...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/15672018113106660065
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Levofloxacin is a potent antibiotic with severe side effects due to its high doses. Bacterial resistance may be due to frequent use of antibiotics. Biogenic gold nanoparticles conjugated levofloxacin (Au-HSA-LvN-NPs) were developed by Human Serum Albumin (HSA) and nitrate reductasemediated pathways. METHODS...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201814666170316113432
更新日期:2017-01-01 00:00:00
abstract::Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulos...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666150310151657
更新日期:2015-01-01 00:00:00
abstract::The objective of this study was to develop and evaluate mucoadhesive microsphere of diclofenac sodium with natural gums for sustained delivery. Guar gum and tragacanth were used along with sodium alginate as mucoadhesive polymers. Microspheres were formulated using orifice-ionic gelation method. Particle size, surface...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/15672018113109990054
更新日期:2013-12-01 00:00:00
abstract::A review with 93 references. Heparins are high molecular weight, hydrophilic polyanions, which are unstable under acidic conditions; and therefore they exhibit poor oral bioavailability. Consequently they must be administered via the parenteral route which is expensive, inconvenient, and limits use by outpatients. The...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201054367968
更新日期:2005-07-01 00:00:00
abstract::The development of oral insulin using the eligen technology represents a significant advance in insulin administration which is expected to improve the quality of life of diabetic patients. As clinical studies progress, a great deal of interest has focused on the process by which this technology enables insulin absorp...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201053586001
更新日期:2005-04-01 00:00:00
abstract::The dermal delivery characteristics of hydrophilic silica nanoparticle coated medium chain triglyceride oil-in-water emulsions are reported and correlated with the physicochemical and interfacial properties of the emulsion based drug carriers. The synergistic drug/stabiliser/nanoparticle interactions are demonstrated ...
journal_title:Current drug delivery
pub_type: 杂志文章
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abstract::Selective targeting of ligand-targeted liposomes containing anticancer drugs or therapeutic genes to cell surface receptors expressed on cancer cells is a recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics or gene therapeutics. Some recent advances in the field of ligand-...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
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更新日期:2005-10-01 00:00:00
abstract::Alternative formulations of paclitaxel were developed in order to improve its aqueous solubility, and characterized in vitro. A methacrylic acid based nanoconjugate of paclitaxel was synthesized by a simple esterification reaction with molecular weight of 1657 Da. The in vitro hydrolysis study on the prodrug of paclit...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201052772861
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Present investigation was aimed to fabricate nanocrystal of exemestane, an anticancer drug with poor dissolution properties and oral bioavailability. METHODS:Influence of various process parameters on the formulation of exemestane nanosuspension using media milling technique were investigated in the trial batc...
journal_title:Current drug delivery
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更新日期:2021-01-12 00:00:00
abstract::Polar lipids and various surfactants exhibit rich phase behavior depending on the composition of the lipids and the physicochemical conditions. Lamellar (L(alpha)), hexagonal (Inverted [H(II)]) and normal or inverted cubic (bicontinuous or micellar) structures are some of the most common lyotropic liquid crystalline p...
journal_title:Current drug delivery
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更新日期:2010-01-01 00:00:00
abstract::The present study performed by preparation and evaluation of floating tablets of Acyclovir as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose K 4M, K 15M, psyllium husk, swelling agent as crospovidone and micro...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720109789941678
更新日期:2009-10-01 00:00:00
abstract::Since its discovery in 1796 by Edward Jenner, vaccines have been an integral aspect of therapeutics, combating a number of infectious diseases with remarkable success. In recent years, due to rapid advances in proteomics, genomics, biotechnology and immunology and the plethora of knowledge amassed in related fields, i...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
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更新日期:2006-04-01 00:00:00
abstract::Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly difficult. One problem has been that antibiotics commonly used were designed for...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811666140327145049
更新日期:2014-01-01 00:00:00
abstract::Metformin (MTF) improves hyperglycemia primarily by suppressing glucose production by the liver. The objective of our investigation was to evaluate nanoemulsion as a promising carrier for MTF for sustained hypoglycemic effect. The drug was incorporated into oil phase of nanoemulsion, which finally improved biopharmace...
journal_title:Current drug delivery
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
abstract::The objective of this investigation was aimed to explore the cancer targeting potential of folate conjugated dendrimer (polypropylene imine, PPI) under strategic influence of folate receptor up-regulators (all trans Retinoic acid, ATRA and Dexamethasone, DEXA). The folate conjugated dendrimer nanoconjugate (FPPI) was ...
journal_title:Current drug delivery
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Tuberculosis is an infection and caused by gentle growing bacteria. The Internet provides opportunities for people with tuberculosis (TB) to connect with one another to address these challenges. OBJECTIVE:The aim of this paper is to introduce readers to the platforms on which Tuberculosis participants inter...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201814666171120125916
更新日期:2018-01-01 00:00:00
abstract::Cutaneous gene therapy and DNA vaccination are potential applications of plasmid delivery methods where a gene for an antigen or a therapeutic protein is inserted in the plasmid and applied to the skin. However, the delivery of the DNA plasmid is a major challenge due to the unusual physicochemical properties of the D...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720106775197493
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Realgar, a traditional Chinese medicine, has shown antitumor efficacy in several tumor types. We previously showed that realgar nanoparticles (nano-realgar) had significant antileukemia, anti-lung cancer and anti-liver cancer effects. In addition, the anti-tumor effects of nanorealgar were significantly bett...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200115105633
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Osteoporosis is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteo...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201813666161230142123
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:An injectable long acting In-Situ Forming Gel (ISFG) of human Growth Hormone (hGH) was prepared by using triblock PCL-PEG-PCL (Mw 1500-1500-1500). Ring-Opening Polymerization (ROP) of triblock using microwave was applied. METHODS:The BCA protein assay Kit was used to determine the concentration of hGH in the...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200120120105
更新日期:2020-01-01 00:00:00
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journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201818666210101114517
更新日期:2020-12-31 00:00:00
abstract::The objective of this investigation was to prepare mucoadhesive microspheres of ketorolac for nasal delivery to avoid gastrointestinal side effects of conventional dosage form. Mucoadhesive microspheres were prepared using carbopol, polycarbophil and chitosan as polymer by spray drying method. The process and formulat...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720112800234503
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeu...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201814666170712122508
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to design an efficient delivery system with an anticipated swelling and drug release properties for a prolonged drug release as well as to target colon for various hydrophilic drugs. METHOD:For this purpose, the pH-responsive hydrogel comprising a combination of Eudragit and ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201816666190208165511
更新日期:2019-01-01 00:00:00
abstract::The objective of the present study was to fabricate and evaluate a multiparticulate oral gastroretentive dosage form of baclofen characterized by a central large cavity (hollow core) promoting unmitigated floatation with practical applications to alleviate the signs and symptoms of spasticity and muscular rigidity. So...
journal_title:Current drug delivery
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
abstract::The research presented in this paper discusses the potential of iontophoresis facilitated transdermal delivery of glycine. Iontophoresis has been widely investigated as a noninvasive transdermal drug delivery system. Iontophoresis is the use of a low electric current to carry ionized as well as unionized drug molecule...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720109787846207
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:A ceftiofur hydrochloride long-acting oily suspension with no irritation was prepared by testing and optimizing the types and amounts of organic solvents, suspending agents, and surfactants.
Methods: Its properties, stability, injection site irritation, in vitro release, and pharmacokinetics in pigs were...
journal_title:Current drug delivery
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更新日期:2020-09-03 00:00:00
abstract::Among the common myths in the cosmetics industry is the perception that acne only happens to teenagers, and specifically to females. However, acne is neither limited to a specific age, nor to a certain gender, it creates a stressful problem for many people. Many chemical treatments for acne were proven to be successfu...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201815666180913144145
更新日期:2019-01-01 00:00:00
abstract:AIM:This study was focused on the formulation of the multi-unit extended-release peroral delivery device of lamotrigine for better management of epilepsy. BACKGROUND:The single-unit extended-release peroral preparations often suffer from all-or-none effect. A significant number of multi-unit delivery systems have been...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200317124022
更新日期:2020-01-01 00:00:00