Abstract:
:A review with 93 references. Heparins are high molecular weight, hydrophilic polyanions, which are unstable under acidic conditions; and therefore they exhibit poor oral bioavailability. Consequently they must be administered via the parenteral route which is expensive, inconvenient, and limits use by outpatients. The development of an oral form of heparin is warranted. This review examined the literature, mostly published between January 2000 and January 2005, pertaining to the gastrointestinal absorption of heparin by lipidization or coadministration with penetration enhancers. A lipidization strategy that was examined involved conjugation of low molecular weight heparin with deoxycholic acid. The majority of studies examined the ability of different formulations, typically utilizing penetration enhancers, to improve heparin bioavailability. The penetration enhancers used included fatty acids, Labrasol, Gelucire 44/14, polycationic lipophilic-core dendrons, saponins, mono-N-carboxymethyl chitosan, Carbopol 934P, a combination of thiolated polycarbophil and glutathione, polymeric nanoparticles, polymeric microparticles, sodium N-[8-(2-hydroxybenzoyl) amino]caprylate (SNAC), and sodium N-[10-(2-hydroxybenzoyl)amino]decanoate (SNAD). The variety of models used and doses of heparin/penetration enhancers applied, however, made it difficult to compare the results between studies. Nevertheless, all of the reviewed drug delivery systems showed therapeutic value and confirmation of the promising results obtained from animal studies, by progression to clinical trials, is necessary. Overall, progress has been made in the quest for an oral heparin formulation.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Ross BP,Toth Idoi
10.2174/1567201054367968keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
277-87issue
3eissn
1567-2018issn
1875-5704journal_volume
2pub_type
杂志文章,评审abstract:BACKGROUND:The basal ganglia, an important functional integrity of the brain, comprises multiple subcortical nuclei. The area is mainly supplied by the perforating branches of ipsilateral middle cerebral artery (MCA). The unilateral non-traumatic basal ganglia hemorrhage, commonly located in the putamen, most often res...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201813666160607202811
更新日期:2017-09-06 00:00:00
abstract::The use of nanoparticles as platforms or vehicles for applications in nanomedicine, such as drug delivery and medical imaging, has been widely reported in the literature. A key area of potential improvement in the development and implementation of nanoparticles is the design of surface treatments to maximize residence...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720111795256165
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abstract::The aim of this study was to design a silica-supported solid dispersion of lacidipine (LCDP) to enhance the dissolution rate and oral absorption using supercritical CO2 (scCO2) as a solvent. The formulation was characterized using differential scanning calorimetry, powder X-ray diffraction, scanning electron microscop...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666151203233232
更新日期:2016-01-01 00:00:00
abstract::Alternative formulations of paclitaxel were developed in order to improve its aqueous solubility, and characterized in vitro. A methacrylic acid based nanoconjugate of paclitaxel was synthesized by a simple esterification reaction with molecular weight of 1657 Da. The in vitro hydrolysis study on the prodrug of paclit...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201052772861
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Colloidal systems are most prominent delivery systems mainly used as vehicles for the transportation, targeting the various types of biomolecules, proteins, peptides, synthetic medicinal agents. OBJECTIVE:To provide concise information on patents that are directly or indirectly related to the nanoemulsions....
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666150901111930
更新日期:2016-01-01 00:00:00
abstract::The objective of this work was to investigate the main theological features of vaginal hydrophilic polymer gels and to elucidate about the relationship between these characteristics and gels composition, and their general influence in therapeutic/usage purpose. Flow and dynamic oscillatory properties of four commercia...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720109787048294
更新日期:2009-01-01 00:00:00
abstract::In the present study, cross linked sodium carboxymethylated pea starch (SCPS) was synthesized and evaluated as tablet superdisintegrant in diclofenac sodium based tablets. SCPS was synthesized using native pea starch with monochloroacetic acid and NaOH in microwave radiation environment. Finally the dried product was ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720111794479853
更新日期:2011-03-01 00:00:00
abstract::Hydrogels can constitute reliable delivery systems of drugs, including those based on nucleic acids (NABDs) such as small interfering ribonucleic acid (siRNA). Their nature, structure, and response to physiological or external stimuli strongly influence the delivery mechanisms of entrapped active molecules, and, in tu...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160721142202
更新日期:2017-01-01 00:00:00
abstract::The aim of the present study was to prepare and evaluate hydrogels containing 0.1% isosorbide mononitrate (ISMN) for topical treatment of anal fissure. The hydrogels were prepared on the base of Carbopol 940, Poloxamer 407 or their combination. The highest viscosity and significant thyxotropy were observed for the com...
journal_title:Current drug delivery
pub_type: 杂志文章,随机对照试验
doi:10.2174/156720112802650635
更新日期:2012-09-01 00:00:00
abstract::Skin, the most significant protective organ in the body, may face serious problems, including cancer, infectious diseases, etc., requiring different drugs for the treatment. However, most of these drugs have poor chemical and physical stability, and insufficient penetration through the skin layers. In recent years, wi...
journal_title:Current drug delivery
pub_type: 杂志文章
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更新日期:2020-08-20 00:00:00
abstract::Osteoarthritis is usually regarded as a localized disease whose optimal treatment is a therapy applied directly to the affected joint. Unfortunately, current local therapies such as repeated intraarticular injections or constant infusions are associated with a higher risk of infection. One way to overcome this would b...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
abstract::Tablets are still the most commonly used dosage form because of the ease of manufacturing, convenience in administration, accurate dosing and excellent stability. Direct compression is the preferred method for the preparation of tablets. However, it has been estimated that less than 20 percent of the active pharmaceut...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
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更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Hesperetin (HSP) is a low water-soluble flavanone aglycone with low bioavailability. OBJECTIVES:This study aimed at enhancing the hepatoprotective effects of HSP by a combinatory technique based on solid dispersions of co-crystals of HSP. METHODS:Co-crystals were prepared using citric acid, tartaric acid, ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180730141556
更新日期:2018-01-01 00:00:00
abstract::Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validate...
journal_title:Current drug delivery
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doi:10.2174/1567201812666150130161736
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Chrysin is a strong inhibitor of breast cancer resistance protein (BCRP) but it is practically insoluble in water. Effective solubilization of chrysin is critical for its pharmaceutical application as an absorption enhancer via inhibition of BCRP-mediated drug efflux. OBJECTIVE:This study aimed to develop a...
journal_title:Current drug delivery
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doi:10.2174/1567201815666180924151458
更新日期:2019-01-01 00:00:00
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journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201818999210120203904
更新日期:2021-01-20 00:00:00
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journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201812666151029100909
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Gemcitabine (GEM) is found effective in the treatment of many solid tumors. However, its use is restricted due to its small circulation half-life, fast metabolism and low capacity for selective tumor uptake. Folate receptors (FRs) have been recognized as cellular surface markers, which can be used for cancer...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666181024112252
更新日期:2019-01-01 00:00:00
abstract::In recent years, Poloxamers had attracted a particular interest in the design of dermal and transdermal delivery systems in order to improve or retard drug permeation through the skin. In the present study, the influence of different parameters, such as, temperature, storage time, type of polymer (Lutrol(®) F-127 and ...
journal_title:Current drug delivery
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doi:10.2174/15672018113109990056
更新日期:2013-12-01 00:00:00
abstract::Serrapeptase is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia sp. HY-6. Very few methods are available for the quantification of serrapeptase. The activity of the enzyme is determined by an ELISA assay, colorimetric method using casein as substrate or by HPLC method. These methods ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720108785915023
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abstract::Several groups have shown that vaccine antigens can be encapsulated within polymeric microparticles and can serve as potent antigen delivery systems. We have recently shown that an alternative approach involving charged polylactide co-glycolide (PLG) microparticles with surface adsorbed antigen(s) can also be used to ...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
abstract::The objective of this investigation was to prepare mucoadhesive microspheres of ketorolac for nasal delivery to avoid gastrointestinal side effects of conventional dosage form. Mucoadhesive microspheres were prepared using carbopol, polycarbophil and chitosan as polymer by spray drying method. The process and formulat...
journal_title:Current drug delivery
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更新日期:2012-03-01 00:00:00
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journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201816666190529072914
更新日期:2019-01-01 00:00:00
abstract::The mucosal administration of vaccines is an area currently receiving a high level of interest due to potential advantages offered by this technique. These advantages include the ability to administer vaccines without need for needles, thus improving patient compliance with vaccination schedules, and the capacity to i...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201043334588
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVES:This study aimed to develop and evaluate chitosan (CTS) solid dispersion particulate matrix (SDPM) for sustained oral delivery of ketorolac tromethamine (KT). METHODS:SDPM formulations were prepared by freeze drying method and characterized for their effectiveness and biological activities via in vitro and ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201812666151012114006
更新日期:2016-01-01 00:00:00
abstract::Camptothecins are a family of alkaloids originally extracted from the Chinese tree Camptotheca acuminata, Nyssaceae, exhibiting a strong activity against colorectal cancer (CRC). CRC is a common malignancy worlwide. Despite significant developments in the treatment of this disease, it still causes considerable morbidi...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720112800234558
更新日期:2012-03-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environment...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:
更新日期:2013-11-24 00:00:00
abstract:BACKGROUND:The scope of nanotechnology has been extended to almost every sphere of our daily life. As a result of this, nanocarriers like Carbon Nanotubes (CNTs) are gaining considerable attention for their use in various therapeutic and diagnostic applications. OBJECTIVE:The objective of the current article is to rev...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200508092821
更新日期:2020-01-01 00:00:00
abstract::The present study performed by preparation and evaluation of floating tablets of Acyclovir as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose K 4M, K 15M, psyllium husk, swelling agent as crospovidone and micro...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720109789941678
更新日期:2009-10-01 00:00:00
abstract:AIM:This study was focused on the formulation of the multi-unit extended-release peroral delivery device of lamotrigine for better management of epilepsy. BACKGROUND:The single-unit extended-release peroral preparations often suffer from all-or-none effect. A significant number of multi-unit delivery systems have been...
journal_title:Current drug delivery
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00