Abstract:
:The use of nanoparticles as platforms or vehicles for applications in nanomedicine, such as drug delivery and medical imaging, has been widely reported in the literature. A key area of potential improvement in the development and implementation of nanoparticles is the design of surface treatments to maximize residence time in the bloodstream. Major obstacles to the prolonged circulation of nanoparticles include complement activation and opsonization, both of which contribute to the removal of foreign matter from the vasculature. A greater understanding of the mechanisms through which nanoparticles interact with the complement system of innate immunity may be necessary in future endeavours to optimize nanoparticle design. The range of experimental techniques available for measuring complement interaction is presented. In particular, an in vitro hemolytic complement consumption assay called the CH(50) method is compared with alternative complement measurement techniques and cellular uptake studies in order to demonstrate its effectiveness as a quantitative evaluation of overall complement interaction. Moreover, establishing the usefulness of CH(50) results as predictors of in vivo behaviour is identified as a critical area for future research.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Meerasa A,Huang JG,Gu FXdoi
10.2174/156720111795256165subject
Has Abstractpub_date
2011-05-01 00:00:00pages
290-8issue
3eissn
1567-2018issn
1875-5704pii
BSP/CDD/E-Pub/00078journal_volume
8pub_type
杂志文章,评审abstract::In this study we developed and evaluated a prototype of an effective occlusive mucoadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and gelatine models together with nystatin as a prophylactic agent incorporated into the formulation and investigated drug release in-vitro. Results of...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201811310010020
更新日期:2013-02-01 00:00:00
abstract::The aim of the present study was to prepare and evaluate hydrogels containing 0.1% isosorbide mononitrate (ISMN) for topical treatment of anal fissure. The hydrogels were prepared on the base of Carbopol 940, Poloxamer 407 or their combination. The highest viscosity and significant thyxotropy were observed for the com...
journal_title:Current drug delivery
pub_type: 杂志文章,随机对照试验
doi:10.2174/156720112802650635
更新日期:2012-09-01 00:00:00
abstract::Conventional eye drops show relatively low bioavailability due to poor precorneal contact time. In situ hydrogels are of great importance in providing sustained ocular drug delivery. By exhibiting elastic properties they resist ocular drainage of the drug leading to longer contact times. In the present study an in sit...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720110791560928
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:This study aimed to develop and evaluate chitosan (CTS) solid dispersion particulate matrix (SDPM) for sustained oral delivery of ketorolac tromethamine (KT). METHODS:SDPM formulations were prepared by freeze drying method and characterized for their effectiveness and biological activities via in vitro and ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201812666151012114006
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:One of the major abundant proteins in the nucleous is nucleolin that overexpressed on the cytoplasmic membrane of malignant and endothelial cells and makes it as a promising condidate for targeted drug delivery. OBJECTIVES:In this study, doxorubicin (Dox) as a chemotherapy drug was entrapped into the Poly l...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180724104451
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeu...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201814666170712122508
更新日期:2018-01-01 00:00:00
abstract::The objective of this study was to investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant. The result showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HCl from aged PEO matri...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201812666150326113052
更新日期:2015-01-01 00:00:00
abstract::The aim of this work is to study liposomes as carriers of nutrients and therapeutic agents in aquaculture with Venerupis decussatus and Venerupis pullastra larvae. Multilamellar (MLVs) and large unilamellar (LUVs) vesicles were prepared from a commercial mixture of soy phosphatidylcholine, rich in unsaturated and poly...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201043479957
更新日期:2004-04-01 00:00:00
abstract::Percutaneous coronary intervention (PCI) has become a highly effective alternative for the treatment of coronary artery disease. The use of stents has reduced the rates of restenosis by preventing elastic recoil and negative remodeling, however neointima formation still remains an issue. Local drug delivery is an attr...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720111796642282
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Realgar, a traditional Chinese medicine, has shown antitumor efficacy in several tumor types. We previously showed that realgar nanoparticles (nano-realgar) had significant antileukemia, anti-lung cancer and anti-liver cancer effects. In addition, the anti-tumor effects of nanorealgar were significantly bett...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200115105633
更新日期:2020-01-01 00:00:00
abstract::Hydrogels can constitute reliable delivery systems of drugs, including those based on nucleic acids (NABDs) such as small interfering ribonucleic acid (siRNA). Their nature, structure, and response to physiological or external stimuli strongly influence the delivery mechanisms of entrapped active molecules, and, in tu...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160721142202
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:An injectable long acting In-Situ Forming Gel (ISFG) of human Growth Hormone (hGH) was prepared by using triblock PCL-PEG-PCL (Mw 1500-1500-1500). Ring-Opening Polymerization (ROP) of triblock using microwave was applied. METHODS:The BCA protein assay Kit was used to determine the concentration of hGH in the...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200120120105
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The present work aimed to develop an ethosomal gel of naproxen sodium for the amelioration of rheumatoid arthritis. OBJECTIVE:In the present work, we have explored the potential of ethosomes to deliver naproxen into deeper skin strata. Further, the anti-inflammatory efficacy of naproxen ethosomal formulatio...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200724170203
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The scope of nanotechnology has been extended to almost every sphere of our daily life. As a result of this, nanocarriers like Carbon Nanotubes (CNTs) are gaining considerable attention for their use in various therapeutic and diagnostic applications. OBJECTIVE:The objective of the current article is to rev...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200508092821
更新日期:2020-01-01 00:00:00
abstract::The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The present study was carried out to develop a gastroretentive drug delivery system using isabgol as an exci...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/15672018113106660065
更新日期:2014-01-01 00:00:00
abstract::ADMET Chemoinformatics multi-output models are useful for a parallel prediction of multiple experimental parameters related the absorption (A), distribution (D), metabolism (M), excretion (E), and toxicity (T) process of drugs, pollutants, and NPs with a single QSPR model. Here we present one state-of-art review about...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:
更新日期:2016-04-19 00:00:00
abstract::Fast-dissolving drug delivery systems have been developed as an alternative to conventional dosage form as an oral means of drug delivery in case of chronic conditions. Now a day's fast dissolving films are preferred over conventional tablets and capsules for masking the taste of bitter drugs to increase the patient c...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720111795768022
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Essential oils are poor aqueous solubility and high volatility compounds. The encapsulation of essential oils with cyclodextrins (CDs) can protect them from the adverse environmental conditions and improve their stability. Therefore, increasing the functional capabilities of essential oils when they were use...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200731164902
更新日期:2020-07-31 00:00:00
abstract::Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulos...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666150310151657
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:A new tumor targeted polymer-coated gold/graphene hybrid has been developed for achieving simultaneously thermoablation and chemoterapy of folate receptor-positive cancer cells. METHODS:The gold/graphene hybrid was prepared by depositing gold nanospheres onto graphene oxide and coating it with an inulin-fola...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160520113804
更新日期:2017-01-01 00:00:00
abstract::Metformin (MTF) improves hyperglycemia primarily by suppressing glucose production by the liver. The objective of our investigation was to evaluate nanoemulsion as a promising carrier for MTF for sustained hypoglycemic effect. The drug was incorporated into oil phase of nanoemulsion, which finally improved biopharmace...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720181102140411160817
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The management of TB is difficult due to the resistance developed by Mycobacterium tuberculosis against anti-tubercular drugs causes the new challenges for treating and managing the disease. OBJECTIVE:The objective of the study was to combat multiple drug resistance (MDR) exhibited by mycobacterium species ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160502124811
更新日期:2016-01-01 00:00:00
abstract::The objective of this investigation was aimed to explore the cancer targeting potential of folate conjugated dendrimer (polypropylene imine, PPI) under strategic influence of folate receptor up-regulators (all trans Retinoic acid, ATRA and Dexamethasone, DEXA). The folate conjugated dendrimer nanoconjugate (FPPI) was ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201811310040012
更新日期:2013-08-01 00:00:00
abstract::Camptothecins are a family of alkaloids originally extracted from the Chinese tree Camptotheca acuminata, Nyssaceae, exhibiting a strong activity against colorectal cancer (CRC). CRC is a common malignancy worlwide. Despite significant developments in the treatment of this disease, it still causes considerable morbidi...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720112800234558
更新日期:2012-03-01 00:00:00
abstract::Reactive oxygen species (ROS) and free radicals have been implicated in a number of diseases and disorders, and the skin, for its localization, is exposed to a large number of environmental threats. Free radical scavengers and antioxidants have thus been proposed as protective or therapeutic agents against ROS-mediate...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720111797635487
更新日期:2011-11-01 00:00:00
abstract::Several groups have shown that vaccine antigens can be encapsulated within polymeric microparticles and can serve as potent antigen delivery systems. We have recently shown that an alternative approach involving charged polylactide co-glycolide (PLG) microparticles with surface adsorbed antigen(s) can also be used to ...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720106775197565
更新日期:2006-01-01 00:00:00
abstract::Paclitaxel (taxol, 1a) and docetaxel (taxotere, 1b) have established themselves as an important class of antitumor drugs currently available to the oncologist. While the great contribution of these drugs to the management of the disease and their effect on the improvement of the patient quality of life could not be ov...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720108783331005
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:Present investigation was aimed to fabricate nanocrystal of exemestane, an anticancer drug with poor dissolution properties and oral bioavailability. METHODS:Influence of various process parameters on the formulation of exemestane nanosuspension using media milling technique were investigated in the trial batc...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201818999210112190716
更新日期:2021-01-12 00:00:00
abstract:BACKGROUND:The aim of this research was to engineer solid dispersion lipid particles (SDSLs) in which a solid dispersion (SD) was encapsulated to form the core of solid lipid particles (SLs), thereby achieving an efficient enhancement in the dissolution of a poorly water-soluble drug. METHODS:Ultrasonication was intro...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201814666170606101138
更新日期:2018-01-01 00:00:00
abstract::The objective of this study was to develop and evaluate mucoadhesive microsphere of diclofenac sodium with natural gums for sustained delivery. Guar gum and tragacanth were used along with sodium alginate as mucoadhesive polymers. Microspheres were formulated using orifice-ionic gelation method. Particle size, surface...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/15672018113109990054
更新日期:2013-12-01 00:00:00