A gastroretentive drug delivery system of lisinopril imbibed on isabgol-husk.

abstract：:Therapeutic drug monitoring (TDM) is a valuable tool for tailoring the dosage of the prescribed medication(s) to the individual pharmacokinetic characteristics of a patient. In psychiatry and neurology, however, proven evidence that TDM should be used for treatment with the multiple neuropsychiatric medications is res...

journal_title：Current drug delivery

authors： Hiemke C

更新日期：2016-01-01 00:00:00

abstract：:The most common feature for antigen-delivery systems is their particulate nature. Together with a certain depot effect, it is the particulate nature that primarily dictates whether the antigen-delivery system will be successful in inducing a certain type and strength of immune response. In this article, we will summar...

journal_title：Current drug delivery

authors： Liang MT,Davies NM,Blanchfield JT,Toth I

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...

journal_title：Current drug delivery

authors： Varol M,Koparal AT,Benkli K,Bostancioglu RB

更新日期：2018-01-01 00:00:00

abstract：:Hydrogels can constitute reliable delivery systems of drugs, including those based on nucleic acids (NABDs) such as small interfering ribonucleic acid (siRNA). Their nature, structure, and response to physiological or external stimuli strongly influence the delivery mechanisms of entrapped active molecules, and, in tu...

journal_title：Current drug delivery

authors： Dalmoro A,Abrami M,Galzerano B,Bochicchio S,Barba AA,Grassi M,Larobina D

更新日期：2017-01-01 00:00:00

abstract：:A review with 93 references. Heparins are high molecular weight, hydrophilic polyanions, which are unstable under acidic conditions; and therefore they exhibit poor oral bioavailability. Consequently they must be administered via the parenteral route which is expensive, inconvenient, and limits use by outpatients. The...

journal_title：Current drug delivery

authors： Ross BP,Toth I

更新日期：2005-07-01 00:00:00

abstract：:Since the discovery of Helicobacter pylori (H. pylori) in the early 1980s, its eradication has been one of the most important global challenges in gastroenterology. Various circumstances make the treatment with antimicrobials particularly difficult. One problem has been that antibiotics commonly used were designed for...

journal_title：Current drug delivery

authors： El-Zahaby SA,Kassem AA,El-Kamel AH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is considered as a violent disease with high rate of morbidity and mortality. Early brain injury (EBI) and delayed vasospasm are the two aspects of this disease that are becoming research hotspots. OBJECTIVE:We aim to update the role of oxidative stress in the development of EB...

journal_title：Current drug delivery

authors： Yang Y,Chen S,Zhang JM

更新日期：2017-09-06 00:00:00

abstract：:The placenta has traditionally been considered as a highly permeable organ for a large variety of substances with diverse molecular structures that are readily able to cross it from the maternal blood to reach the foetus. This has recommended limiting the use of drugs during pregnancy as far as possible. However, our ...

journal_title：Current drug delivery

authors： Marin JJ,Briz O,Serrano MA

更新日期：2004-07-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 has spread rapidly since its discovery in December 2019 in the Chinese province of Hubei, reaching this day, all the continents. This scourge is, unfortunately, in lineage with various dangerous outbreaks such as Ebola, Cholera, Spanish flu, American seasonal flu. Until ...

journal_title：Current drug delivery

authors： Sofiane F,Lamia T,Mohamed S,Mokrane IO

更新日期：2020-09-17 00:00:00

abstract：:Medicated foams and film forming systems are dosage forms formulated to undergo a controlled metamorphosis when applied on the skin. Indeed, due to the presence of propellant or a particular air-spray foam pump, a liquid can generate foam when applied on the stratum corneum, or a liquid or conventional dosage form can...

journal_title：Current drug delivery

authors： Gennari CGM,Selmin F,Minghetti P,Cilurzo F

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeu...

journal_title：Current drug delivery

authors： Khondee S,Chittasupho C,Tima S,Anuchapreeda S

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:An injectable long acting In-Situ Forming Gel (ISFG) of human Growth Hormone (hGH) was prepared by using triblock PCL-PEG-PCL (Mw 1500-1500-1500). Ring-Opening Polymerization (ROP) of triblock using microwave was applied. METHODS:The BCA protein assay Kit was used to determine the concentration of hGH in the...

journal_title：Current drug delivery

authors： Khodaverdi E,Delroba K,Mohammadpour F,Khameneh B,Sajadi Tabassi SA,Tafaghodi M,Kamali H,Hadizadeh F

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate Quality by Design (QbD) principle for the preparation of hydrogel products to prove both practicability and utility of executing QbD concept to hydrogel based controlled release systems. Product and process understanding will help in decreasing the variability of ...

journal_title：Current drug delivery

authors： Dalwadi C,Patel G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Fluoroquinolones, the synthetic antibacterial agents are being successfully utilized against bacterial infections, since the time immemorial. Despite of enormous useful features, these drugs are associated with some limitations also. Large number of efforts has been made by various scientists to improve phar...

journal_title：Current drug delivery

authors： Sharma PC,Piplani M,Rajak H

更新日期：2018-02-14 00:00:00

abstract：:Selective targeting of ligand-targeted liposomes containing anticancer drugs or therapeutic genes to cell surface receptors expressed on cancer cells is a recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics or gene therapeutics. Some recent advances in the field of ligand-...

journal_title：Current drug delivery

authors： Sapra P,Tyagi P,Allen TM

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:The present study reports the use of MicrofluidizerTM technology to form a stable nanosuspension of atovaquone (ATQ) using quality by design (QbD) approach. METHODS:The patient-centric quality target product profile and critical quality attributes (CQAs) were identified. A Box-Behnken design was employed for...

journal_title：Current drug delivery

authors： Kakade P,Gite S,Patravale V

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The scope of nanotechnology has been extended to almost every sphere of our daily life. As a result of this, nanocarriers like Carbon Nanotubes (CNTs) are gaining considerable attention for their use in various therapeutic and diagnostic applications. OBJECTIVE:The objective of the current article is to rev...

journal_title：Current drug delivery

authors： Panigrahi BK,Nayak AK

更新日期：2020-01-01 00:00:00

abstract：:The objective of this study was to investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant. The result showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HCl from aged PEO matri...

journal_title：Current drug delivery

authors： Shojaee S,Nokhodchi A,Cumming I,Alhalaweh A,Kaialy W

更新日期：2015-01-01 00:00:00

abstract：:The objective of this investigation was aimed to explore the cancer targeting potential of folate conjugated dendrimer (polypropylene imine, PPI) under strategic influence of folate receptor up-regulators (all trans Retinoic acid, ATRA and Dexamethasone, DEXA). The folate conjugated dendrimer nanoconjugate (FPPI) was ...

journal_title：Current drug delivery

authors： Dhakad RS,Tekade RK,Jain NK

更新日期：2013-08-01 00:00:00

abstract：:Biphenyl Dimethyl Dicarboxylate (BDD) is insoluble in aqueous solution and the bioavailability after oral administration is low. Self-nanoemulsifying drug delivery system (SNEDDS) containing BDD has been successfully prepared using carefully selected ingredients which are less affected by pH and ionic strength changes...

journal_title：Current drug delivery

authors： El-Laithy HM

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Nanoparticles (NPs) suffer from rapid clearance from body and require frequent dosing if long treatment is required. METHOD:In order to solve this problem for solid lipid nanoparticles (SLN) and prolong their action, SLNs were incorporated into thermo-responsive Poloxamer sol-gels and their fate was investi...

journal_title：Current drug delivery

authors： Dorraj G,Dadashzadeh S,Erfan M,Moghimi HR

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present work is the development and evaluation of solid lipid nanoparticles (SLNs) as carrier system for topical delivery of benzocaine (BZC) improving its local anesthesia aiming to produce a fast acting and long lasting topical formulation. BZC loaded SLNs were prepared using a full factorial design t...

journal_title：Current drug delivery

authors： Basha M,Abd El-Alim SH,Kassem AA,El Awdan S,Awad G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Hesperetin (HSP) is a low water-soluble flavanone aglycone with low bioavailability. OBJECTIVES:This study aimed at enhancing the hepatoprotective effects of HSP by a combinatory technique based on solid dispersions of co-crystals of HSP. METHODS:Co-crystals were prepared using citric acid, tartaric acid, ...

journal_title：Current drug delivery

authors： Varshosaz J,Jalali M,Hosseini-Sharifabad A

更新日期：2018-01-01 00:00:00

abstract：:Gelrite is an ion-activated polymer prepared by partial acetylation of gellan gum, an exogeneous polysaccharide present in Pseudomonas elodea. Its unique cation-dependent gelling property at 33 degrees C has been exploited for the formulation of in situ gelling hydrogels for ophthalmic and oral drug delivery. Gelrite ...

journal_title：Current drug delivery

authors： Rastogi R,Aqil M,Ali A,Sultana Y

更新日期：2008-04-01 00:00:00

abstract：:Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulos...

journal_title：Current drug delivery

authors： Duttagupta DS,Jadhav VM,Kadam VJ

更新日期：2015-01-01 00:00:00

abstract：:The aim of the present work was to evaluate alginate hydrogels in the form of spherical beads as carrier for antithrombotic drugs for future use in artificial grafts. The ionotropic gelation technique was employed to prepare beads from the L. hyperborea stipe of alginate with two different alginate concentrations and ...

journal_title：Current drug delivery

authors： Jämstorp E,Bodin A,Gatenholm P,Jeppsson A,Strømme M

更新日期：2010-10-01 00:00:00

abstract：:Relief of chronic pain is an important clinical problem requiring special care and approaches. The present study was designed for the construction of a controlled release system for local application of analgesics (hydromorphone (HM), morphine (M), and codeine (C)) and a local anesthetic, bupivacaine (BP). An interpen...

journal_title：Current drug delivery

authors： Keskin DS,Wise DL,Hasirci V

更新日期：2004-01-01 00:00:00

abstract：:Percutaneous coronary intervention (PCI) has become a highly effective alternative for the treatment of coronary artery disease. The use of stents has reduced the rates of restenosis by preventing elastic recoil and negative remodeling, however neointima formation still remains an issue. Local drug delivery is an attr...

journal_title：Current drug delivery

authors： Kennedy KL,Lucas AR,Wan W

更新日期：2011-09-01 00:00:00

abstract：:Serrapeptase is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia sp. HY-6. Very few methods are available for the quantification of serrapeptase. The activity of the enzyme is determined by an ELISA assay, colorimetric method using casein as substrate or by HPLC method. These methods ...

journal_title：Current drug delivery

authors： Sandhya KV,Devi SG,Mathew ST

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:In the present work, we report for the first time the therapeutic potential of talazoparib (BMN 673)-SLNs for the treatment of BRCA1 deficient Triple Negative Breast Cancer (TNBC). BMN 673-SLNs were produced by hot-homogenization technique and then characterized. METHODS:The cytotoxic and apoptotic effects o...

journal_title：Current drug delivery

authors： Eskiler GG,Cecener G,Dikmen G,Egeli U,Tunca B

更新日期：2019-01-01 00:00:00