Cell Surface Nucleolin as a Promising Receptor for Effective AS1411 Aptamer-Mediated Targeted Drug Delivery into Cancer Cells.

abstract：:Gelrite is an ion-activated polymer prepared by partial acetylation of gellan gum, an exogeneous polysaccharide present in Pseudomonas elodea. Its unique cation-dependent gelling property at 33 degrees C has been exploited for the formulation of in situ gelling hydrogels for ophthalmic and oral drug delivery. Gelrite ...

journal_title：Current drug delivery

authors： Rastogi R,Aqil M,Ali A,Sultana Y

更新日期：2008-04-01 00:00:00

abstract：:The dermal delivery characteristics of hydrophilic silica nanoparticle coated medium chain triglyceride oil-in-water emulsions are reported and correlated with the physicochemical and interfacial properties of the emulsion based drug carriers. The synergistic drug/stabiliser/nanoparticle interactions are demonstrated ...

journal_title：Current drug delivery

authors： Eskandar NG,Simovic S,Prestidge CA

更新日期：2009-08-01 00:00:00

abstract：:Methylene blue (MB) has been shown to slow down the progression of the Alzheimer's disease (AD) and other tauopathies; however distribution of MB into the brain is limited due its high hydrophilicity. In this study, we aimed to prepare novel hydrophobic glutathione coated PLGA nanoparticles to improve bioavailability ...

journal_title：Current drug delivery

authors： Jinwal UK,Groshev A,Zhang J,Grover A,Sutariya VB

更新日期：2014-01-01 00:00:00

abstract：AIM:The aim of the study was to formulate, characterize, and evaluate the resveratrol-loaded cubosomes (RC) through topical application. BACKGROUND:Resveratrol (RV) is a nutraceutical compound that has exciting pharmacological potential in different diseases including cancers. Many studies of resveratrol have been rep...

journal_title：Current drug delivery

authors： Kurangi B,Jalalpure S,Jagwani S

更新日期：2020-09-02 00:00:00

abstract：BACKGROUND:Despite therapeutics based on siRNA have an immense potential for the treatment of incurable diseases such as cancers. However, the in vivo utilization of siRNA and also the delivery of this agent to the target site is one of the most controversial challenges. The helpful assistance by nanoparticles can impr...

journal_title：Current drug delivery

authors： Shajari N,Mansoori B,Davudian S,Mohammadi A,Baradaran B

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Polyionic Complex (PIC) nanogels are promising delivery systems with numerous attractions such as simple, fast, and organic solvent-free particle formation and mild drug loading conditions. Among polyelectrolytes, poly (L-amino acid) copolymers such as poly (ethylene glycol)-block-poly (L-glutamic acid) copo...

journal_title：Current drug delivery

authors： Salmanpour M,Saeed-Vaghefi M,Abolmaali SS,Tamaddon A

更新日期：2020-11-03 00:00:00

abstract：OBJECTIVE:The aim of the present study was to design an efficient delivery system with an anticipated swelling and drug release properties for a prolonged drug release as well as to target colon for various hydrophilic drugs. METHOD:For this purpose, the pH-responsive hydrogel comprising a combination of Eudragit and ...

journal_title：Current drug delivery

authors： Mahmood S,Buabeid MA,Ullah K,Murtaza G,Mannan A,Khan SA

更新日期：2019-01-01 00:00:00

abstract：:Serrapeptase is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia sp. HY-6. Very few methods are available for the quantification of serrapeptase. The activity of the enzyme is determined by an ELISA assay, colorimetric method using casein as substrate or by HPLC method. These methods ...

journal_title：Current drug delivery

authors： Sandhya KV,Devi SG,Mathew ST

更新日期：2008-10-01 00:00:00

abstract：:The objective of this study was to investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant. The result showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HCl from aged PEO matri...

journal_title：Current drug delivery

authors： Shojaee S,Nokhodchi A,Cumming I,Alhalaweh A,Kaialy W

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cabazitaxel (CBZ) is a new taxane approved by FDA for treatment of castration- resistant prostate cancer not responding to docetaxel. However, CBZ is not a suitable substrate for p-glycoprotein 60, an efflux pump which transports anticancer drugs out of malignant cells and is therefore a promising drug for t...

journal_title：Current drug delivery

authors： Khoeeniha MK,Esfandyari-Manesh M,Behrouz H,Amini M,Varnamkhasti BS,Atyabi F,Dinarvand R

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption, and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). Transdermal route is also beneficial for dru...

journal_title：Current drug delivery

authors： Kumar L,Verma S,Singh M,Chalotra T,Utreja P

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The basal ganglia, an important functional integrity of the brain, comprises multiple subcortical nuclei. The area is mainly supplied by the perforating branches of ipsilateral middle cerebral artery (MCA). The unilateral non-traumatic basal ganglia hemorrhage, commonly located in the putamen, most often res...

journal_title：Current drug delivery

authors： Yang Z,Chen J,Mu J

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:Wound healing is a biological process that can get in a state of pathologic inflammation, requiring the use of specific medications able to promote proper tissue repair. OBJECTIVE:The study describes the production and characterization of nanoparticle based gel for wound healing treatment designed to delive...

journal_title：Current drug delivery

authors： Esposito E,Pecorelli A,Sguizzato M,Drechsler M,Mariani P,Carducci F,Cervellati F,Nastruzzi C,Cortesi R,Valacchi G

更新日期：2018-01-01 00:00:00

abstract：:Relief of chronic pain is an important clinical problem requiring special care and approaches. The present study was designed for the construction of a controlled release system for local application of analgesics (hydromorphone (HM), morphine (M), and codeine (C)) and a local anesthetic, bupivacaine (BP). An interpen...

journal_title：Current drug delivery

authors： Keskin DS,Wise DL,Hasirci V

更新日期：2004-01-01 00:00:00

abstract：:Previous studies suggested that caspofungin dose escalation against Candida species is more beneficial than currently used lower daily doses. Thus, we determined in vitro and in vivo activity of caspofungin against six wild-type C. albicans clinical isolates, the ATCC 10231 strain and an echinocandin resistant strain....

journal_title：Current drug delivery

authors： Domán M,Kovács R,Kardos G,Gesztelyi R,Juhász B,Bozó A,Kardos T,Saleh Q,Majoros L

更新日期：2016-01-01 00:00:00

abstract：:Polar lipids and various surfactants exhibit rich phase behavior depending on the composition of the lipids and the physicochemical conditions. Lamellar (L(alpha)), hexagonal (Inverted [H(II)]) and normal or inverted cubic (bicontinuous or micellar) structures are some of the most common lyotropic liquid crystalline p...

journal_title：Current drug delivery

authors： Hirlekar R,Jain S,Patel M,Garse H,Kadam V

更新日期：2010-01-01 00:00:00

abstract：:Conventional dosage forms such as tablets, capsules and syrups are prescribed in the normal course of practice. However, concerns about patient preferences and market demands have given rise to the exploration of novel unconventional dosage forms. Among these, confectionery-based dose forms have strong potential to ov...

journal_title：Current drug delivery

authors： Tangso KJ,Ho QP,Boyd BJ

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The label free ultrasmall fluorescent ferrite clusters have been engineered in a controlled fashion which was stabilized by serum protein and functionalized by folic acid for the application of targeted multimodal optical and Magnetic Resonance (MR) cancer imaging. METHODS:The ultra-small manganese ferrite n...

journal_title：Current drug delivery

authors： Haribabu V,Sharmiladevi P,Akhtar N,Farook AS,Girigoswami K,Girigoswami A

更新日期：2019-01-01 00:00:00

abstract：:In recent years, Poloxamers had attracted a particular interest in the design of dermal and transdermal delivery systems in order to improve or retard drug permeation through the skin. In the present study, the influence of different parameters, such as, temperature, storage time, type of polymer (Lutrol(®) F-127 and ...

journal_title：Current drug delivery

authors： Almeida H,Amaral MH,Lobão P,Lobo JM

更新日期：2013-12-01 00:00:00

abstract：:The interaction of a series of amphiphilic 2-alkyl aminoacids (lipoamino acids, LAAs) with different cell cultures and biomembrane models was investigated. LAAs can be useful promoieties to modify the physico-chemical properties of many drugs, and in particular their lipophilicity. Tests were performed in vitro on mam...

journal_title：Current drug delivery

authors： Pignatello R,Noce C,Campisi A,Acquaviva R,Bucolo C,Puglisi G,Toth I

更新日期：2007-04-01 00:00:00

abstract：:The objective of this investigation was to prepare mucoadhesive microspheres of ketorolac for nasal delivery to avoid gastrointestinal side effects of conventional dosage form. Mucoadhesive microspheres were prepared using carbopol, polycarbophil and chitosan as polymer by spray drying method. The process and formulat...

journal_title：Current drug delivery

authors： Nagda CD,Chotai NP,Nagda DC,Patel SB,Patel UL

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVES:This study aimed to develop and evaluate chitosan (CTS) solid dispersion particulate matrix (SDPM) for sustained oral delivery of ketorolac tromethamine (KT). METHODS:SDPM formulations were prepared by freeze drying method and characterized for their effectiveness and biological activities via in vitro and ...

journal_title：Current drug delivery

authors： Rasool BK,Aziz US,Abu-Gharbieh E,Khan SA

更新日期：2016-01-01 00:00:00

abstract：:Alternative formulations of paclitaxel were developed in order to improve its aqueous solubility, and characterized in vitro. A methacrylic acid based nanoconjugate of paclitaxel was synthesized by a simple esterification reaction with molecular weight of 1657 Da. The in vitro hydrolysis study on the prodrug of paclit...

journal_title：Current drug delivery

authors： Dhanikula AB,Panchagnula R

更新日期：2005-01-01 00:00:00

abstract：:Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulos...

journal_title：Current drug delivery

authors： Duttagupta DS,Jadhav VM,Kadam VJ

更新日期：2015-01-01 00:00:00

abstract：:The aim of this present research work was to prepare and evaluate alginate microspheres of aceclofenac by ionic gelation method for targeting the drug release in intestinal region and decrease distinct tissue protection in the stomach. This method offers to prepare microspheres which are important in controlling the r...

journal_title：Current drug delivery

authors： Khandai M,Chakraborty S,Nayak P,Krishna NB,Chakravarthi G,Acharjya B,Ghosh AK

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Nanoparticles (NPs) suffer from rapid clearance from body and require frequent dosing if long treatment is required. METHOD:In order to solve this problem for solid lipid nanoparticles (SLN) and prolong their action, SLNs were incorporated into thermo-responsive Poloxamer sol-gels and their fate was investi...

journal_title：Current drug delivery

authors： Dorraj G,Dadashzadeh S,Erfan M,Moghimi HR

更新日期：2018-01-01 00:00:00

abstract：:Since its discovery in 1796 by Edward Jenner, vaccines have been an integral aspect of therapeutics, combating a number of infectious diseases with remarkable success. In recent years, due to rapid advances in proteomics, genomics, biotechnology and immunology and the plethora of knowledge amassed in related fields, i...

journal_title：Current drug delivery

authors： Azad N,Rojanasakul Y

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease is a chronic progressive neurodegenerative disorder associated with depletion of acetylcholine. Oral treatment with tacrine hydrochloride; a reversible inhibitor of acetylcholinesterase, finds limited use in Alzheimer's disease due to frequent dosing, hepatotoxicity and extensive pre-syst...

journal_title：Current drug delivery

authors： Setya S,Madaan T,Razdan BK,Farswan M,Talegaonkar S

更新日期：2019-01-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 has spread rapidly since its discovery in December 2019 in the Chinese province of Hubei, reaching this day, all the continents. This scourge is, unfortunately, in lineage with various dangerous outbreaks such as Ebola, Cholera, Spanish flu, American seasonal flu. Until ...

journal_title：Current drug delivery

authors： Sofiane F,Lamia T,Mohamed S,Mokrane IO

更新日期：2020-09-17 00:00:00

abstract：:Skin, the most significant protective organ in the body, may face serious problems, including cancer, infectious diseases, etc., requiring different drugs for the treatment. However, most of these drugs have poor chemical and physical stability, and insufficient penetration through the skin layers. In recent years, wi...

journal_title：Current drug delivery

authors： Khailnezhad B,Hadjizadeh A

更新日期：2020-08-20 00:00:00