Overcoming the Challenges of siRNA Delivery: Nanoparticle Strategies.

abstract：:Asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis, are among the most common chronic diseases and their prevalence is increasing. Each of these diseases is characterized by the secretion of cytokines and pro-inflammatory molecules which are thought to play a critical rol...

journal_title：Current drug delivery

authors： Gioia SD,Sardo C,Castellani S,Porsio B,Belgiovine G,Carbone A,Giammona G,Cavallaro G,Conese M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Polyionic Complex (PIC) nanogels are promising delivery systems with numerous attractions such as simple, fast, and organic solvent-free particle formation and mild drug loading conditions. Among polyelectrolytes, poly (L-amino acid) copolymers such as poly (ethylene glycol)-block-poly (L-glutamic acid) copo...

journal_title：Current drug delivery

authors： Salmanpour M,Saeed-Vaghefi M,Abolmaali SS,Tamaddon A

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption, and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). Transdermal route is also beneficial for dru...

journal_title：Current drug delivery

authors： Kumar L,Verma S,Singh M,Chalotra T,Utreja P

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present work is the development and evaluation of solid lipid nanoparticles (SLNs) as carrier system for topical delivery of benzocaine (BZC) improving its local anesthesia aiming to produce a fast acting and long lasting topical formulation. BZC loaded SLNs were prepared using a full factorial design t...

journal_title：Current drug delivery

authors： Basha M,Abd El-Alim SH,Kassem AA,El Awdan S,Awad G

更新日期：2015-01-01 00:00:00

abstract：:The low bioavailability and consequently the poor therapeutic response of traditional ophthalmic formulations is caused by reduced pre-corneal residence time of the formulation in contact with the ocular surface. The use of colloidal carrier systems, namely lipid nanoparticles in combination with in situ gelling polym...

journal_title：Current drug delivery

authors： Almeida H,Lobão P,Frigerio C,Fonseca J,Silva R,Palmeira-de-Oliveira A,Lobo JM,Amaral MH

更新日期：2016-01-01 00:00:00

abstract：:The dermal delivery characteristics of hydrophilic silica nanoparticle coated medium chain triglyceride oil-in-water emulsions are reported and correlated with the physicochemical and interfacial properties of the emulsion based drug carriers. The synergistic drug/stabiliser/nanoparticle interactions are demonstrated ...

journal_title：Current drug delivery

authors： Eskandar NG,Simovic S,Prestidge CA

更新日期：2009-08-01 00:00:00

abstract：:Tablets are still the most commonly used dosage form because of the ease of manufacturing, convenience in administration, accurate dosing and excellent stability. Direct compression is the preferred method for the preparation of tablets. However, it has been estimated that less than 20 percent of the active pharmaceut...

journal_title：Current drug delivery

authors： Mirani AG,Patankar SP,Borole VS,Pawar AS,Kadam VJ

更新日期：2011-07-01 00:00:00

abstract：:A review with 93 references. Heparins are high molecular weight, hydrophilic polyanions, which are unstable under acidic conditions; and therefore they exhibit poor oral bioavailability. Consequently they must be administered via the parenteral route which is expensive, inconvenient, and limits use by outpatients. The...

journal_title：Current drug delivery

authors： Ross BP,Toth I

更新日期：2005-07-01 00:00:00

abstract：:Fast-dissolving drug delivery systems have been developed as an alternative to conventional dosage form as an oral means of drug delivery in case of chronic conditions. Now a day's fast dissolving films are preferred over conventional tablets and capsules for masking the taste of bitter drugs to increase the patient c...

journal_title：Current drug delivery

authors： Chaturvedi A,Srivastava P,Yadav S,Bansal M,Garg G,Sharma PK

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Cabazitaxel (CBZ) is a new taxane approved by FDA for treatment of castration- resistant prostate cancer not responding to docetaxel. However, CBZ is not a suitable substrate for p-glycoprotein 60, an efflux pump which transports anticancer drugs out of malignant cells and is therefore a promising drug for t...

journal_title：Current drug delivery

authors： Khoeeniha MK,Esfandyari-Manesh M,Behrouz H,Amini M,Varnamkhasti BS,Atyabi F,Dinarvand R

更新日期：2017-01-01 00:00:00

abstract：:Alternative formulations of paclitaxel were developed in order to improve its aqueous solubility, and characterized in vitro. A methacrylic acid based nanoconjugate of paclitaxel was synthesized by a simple esterification reaction with molecular weight of 1657 Da. The in vitro hydrolysis study on the prodrug of paclit...

journal_title：Current drug delivery

authors： Dhanikula AB,Panchagnula R

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:One of the major abundant proteins in the nucleous is nucleolin that overexpressed on the cytoplasmic membrane of malignant and endothelial cells and makes it as a promising condidate for targeted drug delivery. OBJECTIVES:In this study, doxorubicin (Dox) as a chemotherapy drug was entrapped into the Poly l...

journal_title：Current drug delivery

authors： Mosafer J,Mokhtarzadeh A

更新日期：2018-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) and free radicals have been implicated in a number of diseases and disorders, and the skin, for its localization, is exposed to a large number of environmental threats. Free radical scavengers and antioxidants have thus been proposed as protective or therapeutic agents against ROS-mediate...

journal_title：Current drug delivery

authors： Ascenso A,Ribeiro HM,Marques HC,Simoes S

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:To develop and evaluate the suitability of lecithin organogels containing aceclofenac for topical application and compare its In vitro and In vivo effects with conventionally used hydrogels. METHODS:The components and their concentration necessary for organogels formation were evaluated using phase diagram. So...

journal_title：Current drug delivery

authors： Shaikh IM,Jadhav SL,Jadhav KR,Kadam VJ,Pisal SS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeu...

journal_title：Current drug delivery

authors： Khondee S,Chittasupho C,Tima S,Anuchapreeda S

更新日期：2018-01-01 00:00:00

abstract：:In the present study, cross linked sodium carboxymethylated pea starch (SCPS) was synthesized and evaluated as tablet superdisintegrant in diclofenac sodium based tablets. SCPS was synthesized using native pea starch with monochloroacetic acid and NaOH in microwave radiation environment. Finally the dried product was ...

journal_title：Current drug delivery

authors： Singh AV,Singh A,Nath LK

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Essential oils are poor aqueous solubility and high volatility compounds. The encapsulation of essential oils with cyclodextrins (CDs) can protect them from the adverse environmental conditions and improve their stability. Therefore, increasing the functional capabilities of essential oils when they were use...

journal_title：Current drug delivery

authors： Li Z,Wen W,Chen X,Zhu L,Cheng G,Liao Z,Huang H,Ming L

更新日期：2020-07-31 00:00:00

abstract：:Atherosclerosis is the primary cause of coronary heart disease, which is characterized by a narrowing (stenosis) of the arteries that supply blood to tissues of the heart. Over the past decade, the use of "Bare metallic stents" during Percutaneous Transluminal Coronary Angioplasty (PTCA) has become a common practice f...

journal_title：Current drug delivery

authors： Hirlekar R,Patel M,Jain S,Kadam V

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:The label free ultrasmall fluorescent ferrite clusters have been engineered in a controlled fashion which was stabilized by serum protein and functionalized by folic acid for the application of targeted multimodal optical and Magnetic Resonance (MR) cancer imaging. METHODS:The ultra-small manganese ferrite n...

journal_title：Current drug delivery

authors： Haribabu V,Sharmiladevi P,Akhtar N,Farook AS,Girigoswami K,Girigoswami A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is considered as a violent disease with high rate of morbidity and mortality. Early brain injury (EBI) and delayed vasospasm are the two aspects of this disease that are becoming research hotspots. OBJECTIVE:We aim to update the role of oxidative stress in the development of EB...

journal_title：Current drug delivery

authors： Yang Y,Chen S,Zhang JM

更新日期：2017-09-06 00:00:00

abstract：:New technologies are currently investigated with the aim to improve the quality of foods by enhancing their nutritional value, freshness, safety and shelf-life, as well as by improving their tastes, flavours and textures. Moreover, new technological approaches are being explored, in this field, to address nutritional ...

journal_title：Current drug delivery

authors： Trombino S,Curcio F,Roberta C

更新日期：2020-11-25 00:00:00

abstract：:Medicated foams and film forming systems are dosage forms formulated to undergo a controlled metamorphosis when applied on the skin. Indeed, due to the presence of propellant or a particular air-spray foam pump, a liquid can generate foam when applied on the stratum corneum, or a liquid or conventional dosage form can...

journal_title：Current drug delivery

authors： Gennari CGM,Selmin F,Minghetti P,Cilurzo F

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Gemcitabine (GEM) is found effective in the treatment of many solid tumors. However, its use is restricted due to its small circulation half-life, fast metabolism and low capacity for selective tumor uptake. Folate receptors (FRs) have been recognized as cellular surface markers, which can be used for cancer...

journal_title：Current drug delivery

authors： Unnam S,Panduragaiah VM,Sidramappa MA,Muddana Eswara BR

更新日期：2019-01-01 00:00:00

abstract：:The objective of this study was to investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant. The result showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HCl from aged PEO matri...

journal_title：Current drug delivery

authors： Shojaee S,Nokhodchi A,Cumming I,Alhalaweh A,Kaialy W

更新日期：2015-01-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) is a valuable tool for tailoring the dosage of the prescribed medication(s) to the individual pharmacokinetic characteristics of a patient. In psychiatry and neurology, however, proven evidence that TDM should be used for treatment with the multiple neuropsychiatric medications is res...

journal_title：Current drug delivery

authors： Hiemke C

更新日期：2016-01-01 00:00:00

abstract：:Cutaneous gene therapy and DNA vaccination are potential applications of plasmid delivery methods where a gene for an antigen or a therapeutic protein is inserted in the plasmid and applied to the skin. However, the delivery of the DNA plasmid is a major challenge due to the unusual physicochemical properties of the D...

journal_title：Current drug delivery

authors： Foldvari M,Babiuk S,Badea I

更新日期：2006-01-01 00:00:00

abstract：:ADMET Chemoinformatics multi-output models are useful for a parallel prediction of multiple experimental parameters related the absorption (A), distribution (D), metabolism (M), excretion (E), and toxicity (T) process of drugs, pollutants, and NPs with a single QSPR model. Here we present one state-of-art review about...

journal_title：Current drug delivery

authors： González-Díaz H

更新日期：2016-04-19 00:00:00

abstract：:The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of potent drug to improve therapeutics. Recently the liposome formulations are targeted to reduce toxicity and increase accumulation ...

journal_title：Current drug delivery

authors： Samad A,Sultana Y,Aqil M

更新日期：2007-10-01 00:00:00

abstract：:Recent studies have focused on the potential use of metal-based complexes for the treatment of cancer. However, there are some limitations of metal-based ligands for the treatment of cancer due to their toxic effects. In the present study, a novel bimetallic Cu(II) complex, [Cu2(μ-(C6H5)2CHCOO)3 (bipy)2)](ClO4), has f...

journal_title：Current drug delivery

authors： Kani I,Dikmen G,Eskiler GG,Cecener G,Tunca B,Egeli U

更新日期：2016-01-01 00:00:00

abstract：:Relief of chronic pain is an important clinical problem requiring special care and approaches. The present study was designed for the construction of a controlled release system for local application of analgesics (hydromorphone (HM), morphine (M), and codeine (C)) and a local anesthetic, bupivacaine (BP). An interpen...

journal_title：Current drug delivery

authors： Keskin DS,Wise DL,Hasirci V

更新日期：2004-01-01 00:00:00