Abstract:
:Methylene blue (MB) has been shown to slow down the progression of the Alzheimer's disease (AD) and other tauopathies; however distribution of MB into the brain is limited due its high hydrophilicity. In this study, we aimed to prepare novel hydrophobic glutathione coated PLGA nanoparticles to improve bioavailability of MB in the brain. Glutathione coated poly-(lactide-co-glycolide) (PLGA-b-PEG) nanoparticles (NPs) were prepared and tested in two different cell culture models of AD expressing microtubule associated protein tau (tau). The NPs showed a particle size averaging 136.5±4.4nm, which is suitable for the blood brain barrier (BBB) permeation. The in vitro release profile of the NPs exhibited no initial burst release and showed sustained drug release for up to 144 hours. Interestingly, treatment of newly formulated MB-NPs showed a potent reduction in both endogenous and over expressed tau protein levels in human neuroblastoma SHSY-5Y cells expressing endogenous tau and transfected HeLa cells over-expressing tau protein, respectively. Furthermore, in vitro BBB Transwell™ study showed significantly higher permeation of MB-NP compared to the MB solution through the co culture of rat brain endothelial 4 (RBE4) and C6 astrocytoma cells (p<0.05). The proposed MB loaded nanoparticles could provide a more effective treatment option for AD and many other related disorders.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Jinwal UK,Groshev A,Zhang J,Grover A,Sutariya VBdoi
10.2174/1567201810666131113102037subject
Has Abstractpub_date
2014-01-01 00:00:00pages
541-50issue
4eissn
1567-2018issn
1875-5704pii
CDD-EPUB-57417journal_volume
11pub_type
杂志文章abstract::The stratum corneum (SC) is a primary rate limiting barrier to permeation of drug molecules through the skin. Small molecular weight lipophilic drugs that are effective at low doses can be effectively delivered by passive transdermal delivery. The SC does not permit passage of polar/hydrophilic and macromolecules. Pas...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720110791011765
更新日期:2010-04-01 00:00:00
abstract::Selective targeting of ligand-targeted liposomes containing anticancer drugs or therapeutic genes to cell surface receptors expressed on cancer cells is a recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics or gene therapeutics. Some recent advances in the field of ligand-...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720105774370159
更新日期:2005-10-01 00:00:00
abstract:AIM:This study aimed to investigate the influence of the preparation process and composition on the microstructure of the O/W primary emulsions and the corresponding impact on the formation of oil-in-water-in-oil (O/W/O) multiple emulsions. OBJECTIVES:Multiple emulsions were prepared by a two-step emulsification metho...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201818666210101114517
更新日期:2020-12-31 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 has spread rapidly since its discovery in December 2019 in the Chinese province of Hubei, reaching this day, all the continents. This scourge is, unfortunately, in lineage with various dangerous outbreaks such as Ebola, Cholera, Spanish flu, American seasonal flu. Until ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200917124241
更新日期:2020-09-17 00:00:00
abstract:BACKGROUND:The basal ganglia, an important functional integrity of the brain, comprises multiple subcortical nuclei. The area is mainly supplied by the perforating branches of ipsilateral middle cerebral artery (MCA). The unilateral non-traumatic basal ganglia hemorrhage, commonly located in the putamen, most often res...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201813666160607202811
更新日期:2017-09-06 00:00:00
abstract::The objective of present investigation was the characterization of chitosan films after in vivo implantation. Chitosan films were prepared at three dose loadings of paclitaxel by classical casting method. They were implanted subcutaneously in Swiss mice in the neck region and were removed at 7, 15, 21 and 30 days post...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720106777731028
更新日期:2006-07-01 00:00:00
abstract::Paclitaxel (taxol, 1a) and docetaxel (taxotere, 1b) have established themselves as an important class of antitumor drugs currently available to the oncologist. While the great contribution of these drugs to the management of the disease and their effect on the improvement of the patient quality of life could not be ov...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720108783331005
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE:The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded t...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180108170206
更新日期:2018-01-01 00:00:00
abstract::The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The present study was carried out to develop a gastroretentive drug delivery system using isabgol as an exci...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/15672018113106660065
更新日期:2014-01-01 00:00:00
abstract::Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an e...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811666140709112040
更新日期:2014-01-01 00:00:00
abstract::Recent studies have focused on the potential use of metal-based complexes for the treatment of cancer. However, there are some limitations of metal-based ligands for the treatment of cancer due to their toxic effects. In the present study, a novel bimetallic Cu(II) complex, [Cu2(μ-(C6H5)2CHCOO)3 (bipy)2)](ClO4), has f...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160111123739
更新日期:2016-01-01 00:00:00
abstract::Nowadays, cancer is one of the deadliest diseases affecting an annually enormous number of people. Around 9.6 million people had died from different cancer types in 2018. Chemotherapy is considered to be a mainline treatment, and systemic administration of a single anticancer agent is also considered as vital clinical...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201818999210120203904
更新日期:2021-01-20 00:00:00
abstract:BACKGROUND:Alzheimer's disease is a chronic progressive neurodegenerative disorder associated with depletion of acetylcholine. Oral treatment with tacrine hydrochloride; a reversible inhibitor of acetylcholinesterase, finds limited use in Alzheimer's disease due to frequent dosing, hepatotoxicity and extensive pre-syst...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201816666191022105036
更新日期:2019-01-01 00:00:00
abstract::Phase-sensitive in situ gel forming controlled release formulations of cyclosporine were prepared using poly (lactide-co-glycolide) and a solvent system consisting of various proportions of benzyl benzoate and benzyl alcohol. Uniformity of content of cyclosporine in the formulation and in vitro release samples was det...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720109789941669
更新日期:2009-10-01 00:00:00
abstract::Conventional dosage forms such as tablets, capsules and syrups are prescribed in the normal course of practice. However, concerns about patient preferences and market demands have given rise to the exploration of novel unconventional dosage forms. Among these, confectionery-based dose forms have strong potential to ov...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811666140821112637
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The aim of this research was to engineer solid dispersion lipid particles (SDSLs) in which a solid dispersion (SD) was encapsulated to form the core of solid lipid particles (SLs), thereby achieving an efficient enhancement in the dissolution of a poorly water-soluble drug. METHODS:Ultrasonication was intro...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201814666170606101138
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:One of the major abundant proteins in the nucleous is nucleolin that overexpressed on the cytoplasmic membrane of malignant and endothelial cells and makes it as a promising condidate for targeted drug delivery. OBJECTIVES:In this study, doxorubicin (Dox) as a chemotherapy drug was entrapped into the Poly l...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180724104451
更新日期:2018-01-01 00:00:00
abstract::Osteoarthritis is usually regarded as a localized disease whose optimal treatment is a therapy applied directly to the affected joint. Unfortunately, current local therapies such as repeated intraarticular injections or constant infusions are associated with a higher risk of infection. One way to overcome this would b...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720107779314839
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Colloidal systems are most prominent delivery systems mainly used as vehicles for the transportation, targeting the various types of biomolecules, proteins, peptides, synthetic medicinal agents. OBJECTIVE:To provide concise information on patents that are directly or indirectly related to the nanoemulsions....
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666150901111930
更新日期:2016-01-01 00:00:00
abstract::Asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis, are among the most common chronic diseases and their prevalence is increasing. Each of these diseases is characterized by the secretion of cytokines and pro-inflammatory molecules which are thought to play a critical rol...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201813666160824142843
更新日期:2017-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environment...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:
更新日期:2013-11-24 00:00:00
abstract:BACKGROUND:Realgar, a traditional Chinese medicine, has shown antitumor efficacy in several tumor types. We previously showed that realgar nanoparticles (nano-realgar) had significant antileukemia, anti-lung cancer and anti-liver cancer effects. In addition, the anti-tumor effects of nanorealgar were significantly bett...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200115105633
更新日期:2020-01-01 00:00:00
abstract::Cutaneous gene therapy and DNA vaccination are potential applications of plasmid delivery methods where a gene for an antigen or a therapeutic protein is inserted in the plasmid and applied to the skin. However, the delivery of the DNA plasmid is a major challenge due to the unusual physicochemical properties of the D...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720106775197493
更新日期:2006-01-01 00:00:00
abstract::The development of oral insulin using the eligen technology represents a significant advance in insulin administration which is expected to improve the quality of life of diabetic patients. As clinical studies progress, a great deal of interest has focused on the process by which this technology enables insulin absorp...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201053586001
更新日期:2005-04-01 00:00:00
abstract::Alternative formulations of paclitaxel were developed in order to improve its aqueous solubility, and characterized in vitro. A methacrylic acid based nanoconjugate of paclitaxel was synthesized by a simple esterification reaction with molecular weight of 1657 Da. The in vitro hydrolysis study on the prodrug of paclit...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201052772861
更新日期:2005-01-01 00:00:00
abstract::Fast-dissolving drug delivery systems have been developed as an alternative to conventional dosage form as an oral means of drug delivery in case of chronic conditions. Now a day's fast dissolving films are preferred over conventional tablets and capsules for masking the taste of bitter drugs to increase the patient c...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720111795768022
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Mesoporous bioactive glass (MBG) has been widely studied because of its excellent histocompatibility and degradability. However, due to the lack of good osteoinductive activity, the pure MBG scaffold is not effective in repairing large-scale bone defects. OBJECTIVE:To observe the repair effect of MBG scaffo...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200916091253
更新日期:2020-09-15 00:00:00
abstract:BACKGROUND:Solid lipid nanoparticles (SLNs) represent an affordable, easily scalable, stable and biocompatible drug delivery system with a high drug to lipid ratio which also improves solubility of poorly soluble drugs. OBJECTIVE:SLNs were developed by using glyceryl monostearate as the single lipid in the presence of...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180503120113
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:In this study, central composite factorial design was used for the preparation and optimization of chitosan/Na-alginate hydrogel films containing metformin via solvent evaporation technique. METHODS:Low and high molecular weight (MW) chitosan was used as a polymer in different concentrations while genipin w...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180409102459
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Bupivacaine is the most used local anesthetic in surgical procedures, producing prolonged anesthesia. The major limiting factor for the clinical use of bupivacaine comes from its systemic toxicity. Nanostructured lipid carriers (NLC) are vehicles for sustained drug delivery that are able to minimize the toxi...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201814666170726101113
更新日期:2018-01-01 00:00:00