Abstract:
:Paclitaxel (taxol, 1a) and docetaxel (taxotere, 1b) have established themselves as an important class of antitumor drugs currently available to the oncologist. While the great contribution of these drugs to the management of the disease and their effect on the improvement of the patient quality of life could not be overemphasized, a great deal of research has been ongoing to improve two key pharmacologic factors, antitumor activity and systemic toxicity. Both physical and chemical means have been employed towards the enhancement of antitumor activity and at the same time, lowering the inherent toxicity and side effects of these drugs. This mini-review compiles the recent reported works on the design and development of taxane delivery systems through tumor cell surface receptor-targeted delivery mechanisms such as small-molecule peptides and monoclonal antibodies, as well as those on non-targeted procedures such as liposomes, nanostructures, and natural and synthetic polymers.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Safavy Adoi
10.2174/156720108783331005subject
Has Abstractpub_date
2008-01-01 00:00:00pages
42-54issue
1eissn
1567-2018issn
1875-5704journal_volume
5pub_type
杂志文章,评审abstract::The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The present study was carried out to develop a gastroretentive drug delivery system using isabgol as an exci...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/15672018113106660065
更新日期:2014-01-01 00:00:00
abstract::In recent years, Poloxamers had attracted a particular interest in the design of dermal and transdermal delivery systems in order to improve or retard drug permeation through the skin. In the present study, the influence of different parameters, such as, temperature, storage time, type of polymer (Lutrol(®) F-127 and ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/15672018113109990056
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:In the present work, we report for the first time the therapeutic potential of talazoparib (BMN 673)-SLNs for the treatment of BRCA1 deficient Triple Negative Breast Cancer (TNBC). BMN 673-SLNs were produced by hot-homogenization technique and then characterized. METHODS:The cytotoxic and apoptotic effects o...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201816666190515105532
更新日期:2019-01-01 00:00:00
abstract::A palpable need for the optimization of therapeutic agents, due to challenges tackled by them such as poor pharmacokinetics and chemoresistance, has steered the journey towards novel interdisciplinary scientific field for emergence of nanostructure materials as a carrier for targeted delivery of therapeutic agents. Am...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666141229104304
更新日期:2015-01-01 00:00:00
abstract::The stratum corneum (SC) is a primary rate limiting barrier to permeation of drug molecules through the skin. Small molecular weight lipophilic drugs that are effective at low doses can be effectively delivered by passive transdermal delivery. The SC does not permit passage of polar/hydrophilic and macromolecules. Pas...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720110791011765
更新日期:2010-04-01 00:00:00
abstract::Cutaneous gene therapy and DNA vaccination are potential applications of plasmid delivery methods where a gene for an antigen or a therapeutic protein is inserted in the plasmid and applied to the skin. However, the delivery of the DNA plasmid is a major challenge due to the unusual physicochemical properties of the D...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720106775197493
更新日期:2006-01-01 00:00:00
abstract::There are still so-called unmet needs in the treatment of epithelial and cutaneous lesions. Mucositis, ocular lesions, chronic skin wounds represent typical examples. These pathologies do not yet afford a satisfactory treatment. In particular chronic wounds represent a major health care burden, likely to increase as t...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811310010005
更新日期:2013-02-01 00:00:00
abstract::Metformin (MTF) improves hyperglycemia primarily by suppressing glucose production by the liver. The objective of our investigation was to evaluate nanoemulsion as a promising carrier for MTF for sustained hypoglycemic effect. The drug was incorporated into oil phase of nanoemulsion, which finally improved biopharmace...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720181102140411160817
更新日期:2014-01-01 00:00:00
abstract::The objective of this investigation was aimed to explore the cancer targeting potential of folate conjugated dendrimer (polypropylene imine, PPI) under strategic influence of folate receptor up-regulators (all trans Retinoic acid, ATRA and Dexamethasone, DEXA). The folate conjugated dendrimer nanoconjugate (FPPI) was ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201811310040012
更新日期:2013-08-01 00:00:00
abstract::Hydrogels can constitute reliable delivery systems of drugs, including those based on nucleic acids (NABDs) such as small interfering ribonucleic acid (siRNA). Their nature, structure, and response to physiological or external stimuli strongly influence the delivery mechanisms of entrapped active molecules, and, in tu...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160721142202
更新日期:2017-01-01 00:00:00
abstract::The objective of this investigation was to prepare mucoadhesive microspheres of ketorolac for nasal delivery to avoid gastrointestinal side effects of conventional dosage form. Mucoadhesive microspheres were prepared using carbopol, polycarbophil and chitosan as polymer by spray drying method. The process and formulat...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720112800234503
更新日期:2012-03-01 00:00:00
abstract::Camptothecins are a family of alkaloids originally extracted from the Chinese tree Camptotheca acuminata, Nyssaceae, exhibiting a strong activity against colorectal cancer (CRC). CRC is a common malignancy worlwide. Despite significant developments in the treatment of this disease, it still causes considerable morbidi...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720112800234558
更新日期:2012-03-01 00:00:00
abstract::The use of different drug classes as host modulating agents has been postulated to have significance as an adjunctive remedy curing chronic periodontitis. In this study nano-structured films containing doxycyclin (DOX) were evaluated for such purpose. Nano DOX/chitosan particulate system was prepared using spray dryin...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666151113122752
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Amphotericin B eye drops are widely used in the treatment of ocular infections. However, amphotericin's toxicity leads to low patient compliance and aggravation of symptoms. This work describes the development of a microemulsion system containing amphotericin B, aiming for its use in ocular applications. ME...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1570159x14666151109110734
更新日期:2016-01-01 00:00:00
abstract::Relief of chronic pain is an important clinical problem requiring special care and approaches. The present study was designed for the construction of a controlled release system for local application of analgesics (hydromorphone (HM), morphine (M), and codeine (C)) and a local anesthetic, bupivacaine (BP). An interpen...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201043480081
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate Quality by Design (QbD) principle for the preparation of hydrogel products to prove both practicability and utility of executing QbD concept to hydrogel based controlled release systems. Product and process understanding will help in decreasing the variability of ...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666150817122506
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The scope of nanotechnology has been extended to almost every sphere of our daily life. As a result of this, nanocarriers like Carbon Nanotubes (CNTs) are gaining considerable attention for their use in various therapeutic and diagnostic applications. OBJECTIVE:The objective of the current article is to rev...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200508092821
更新日期:2020-01-01 00:00:00
abstract::The aim of this study was to design a silica-supported solid dispersion of lacidipine (LCDP) to enhance the dissolution rate and oral absorption using supercritical CO2 (scCO2) as a solvent. The formulation was characterized using differential scanning calorimetry, powder X-ray diffraction, scanning electron microscop...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666151203233232
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Levofloxacin is a potent antibiotic with severe side effects due to its high doses. Bacterial resistance may be due to frequent use of antibiotics. Biogenic gold nanoparticles conjugated levofloxacin (Au-HSA-LvN-NPs) were developed by Human Serum Albumin (HSA) and nitrate reductasemediated pathways. METHODS...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201814666170316113432
更新日期:2017-01-01 00:00:00
abstract:AIM:This study was focused on the formulation of the multi-unit extended-release peroral delivery device of lamotrigine for better management of epilepsy. BACKGROUND:The single-unit extended-release peroral preparations often suffer from all-or-none effect. A significant number of multi-unit delivery systems have been...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200317124022
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to design an efficient delivery system with an anticipated swelling and drug release properties for a prolonged drug release as well as to target colon for various hydrophilic drugs. METHOD:For this purpose, the pH-responsive hydrogel comprising a combination of Eudragit and ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201816666190208165511
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:One of the major abundant proteins in the nucleous is nucleolin that overexpressed on the cytoplasmic membrane of malignant and endothelial cells and makes it as a promising condidate for targeted drug delivery. OBJECTIVES:In this study, doxorubicin (Dox) as a chemotherapy drug was entrapped into the Poly l...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180724104451
更新日期:2018-01-01 00:00:00
abstract::The interaction of a series of amphiphilic 2-alkyl aminoacids (lipoamino acids, LAAs) with different cell cultures and biomembrane models was investigated. LAAs can be useful promoieties to modify the physico-chemical properties of many drugs, and in particular their lipophilicity. Tests were performed in vitro on mam...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720107780362348
更新日期:2007-04-01 00:00:00
abstract::Methylene blue (MB) has been shown to slow down the progression of the Alzheimer's disease (AD) and other tauopathies; however distribution of MB into the brain is limited due its high hydrophilicity. In this study, we aimed to prepare novel hydrophobic glutathione coated PLGA nanoparticles to improve bioavailability ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201810666131113102037
更新日期:2014-01-01 00:00:00
abstract::Reactive oxygen species (ROS) and free radicals have been implicated in a number of diseases and disorders, and the skin, for its localization, is exposed to a large number of environmental threats. Free radical scavengers and antioxidants have thus been proposed as protective or therapeutic agents against ROS-mediate...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720111797635487
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Solid lipid nanoparticles (SLNs) represent an affordable, easily scalable, stable and biocompatible drug delivery system with a high drug to lipid ratio which also improves solubility of poorly soluble drugs. OBJECTIVE:SLNs were developed by using glyceryl monostearate as the single lipid in the presence of...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180503120113
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The present work aimed to develop an ethosomal gel of naproxen sodium for the amelioration of rheumatoid arthritis. OBJECTIVE:In the present work, we have explored the potential of ethosomes to deliver naproxen into deeper skin strata. Further, the anti-inflammatory efficacy of naproxen ethosomal formulatio...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200724170203
更新日期:2020-01-01 00:00:00
abstract::Alternative formulations of paclitaxel were developed in order to improve its aqueous solubility, and characterized in vitro. A methacrylic acid based nanoconjugate of paclitaxel was synthesized by a simple esterification reaction with molecular weight of 1657 Da. The in vitro hydrolysis study on the prodrug of paclit...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201052772861
更新日期:2005-01-01 00:00:00
abstract::Polar lipids and various surfactants exhibit rich phase behavior depending on the composition of the lipids and the physicochemical conditions. Lamellar (L(alpha)), hexagonal (Inverted [H(II)]) and normal or inverted cubic (bicontinuous or micellar) structures are some of the most common lyotropic liquid crystalline p...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720110790396526
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Colloidal systems are most prominent delivery systems mainly used as vehicles for the transportation, targeting the various types of biomolecules, proteins, peptides, synthetic medicinal agents. OBJECTIVE:To provide concise information on patents that are directly or indirectly related to the nanoemulsions....
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666150901111930
更新日期:2016-01-01 00:00:00