Abstract:
BACKGROUND:Colloidal systems are most prominent delivery systems mainly used as vehicles for the transportation, targeting the various types of biomolecules, proteins, peptides, synthetic medicinal agents. OBJECTIVE:To provide concise information on patents that are directly or indirectly related to the nanoemulsions. METHODS:The ample of research work going on with such system, in which small insoluble particle/droplets are dispersed within the immiscible secondary liquid referred to as continuous phase, is enormous. A highly praised colloidal system is nanoemulsion which possesses 'nano' sized droplets of one phase dispersed within second continuous phase. RESULTS:The characteristic features of nanoemulsion are their optical clarity, clear or bluish tint appearance and small globule size (20-200 nm) which makes them insensitive to gravitational instability, dilution and temperature. Above of all, achieving said properties using lower surfactant concentration and by supplying external energy differentiate them from microemulsion, which uses higher amount of surfactant thereby making them toxic for human body. Due to such variable advantages, researchers are engaged in going for the protecting their ideas in nanoemulsions by filling various patents. CONCLUSION:Patents in this review, covers various areas (types of drug delivery and applications) where nanoemulsion are used. Literature revealed that filing of patents on nanoemulsion increased tremendously during last 5 years and will increase in upcoming time as 21st century will be called as the century of nanomedicine.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Patel RB,Thakore SD,Patel MRdoi
10.2174/1567201812666150901111930subject
Has Abstractpub_date
2016-01-01 00:00:00pages
857-81issue
6eissn
1567-2018issn
1875-5704pii
CDD-EPUB-70076journal_volume
13pub_type
杂志文章,评审abstract::Recent studies have focused on the potential use of metal-based complexes for the treatment of cancer. However, there are some limitations of metal-based ligands for the treatment of cancer due to their toxic effects. In the present study, a novel bimetallic Cu(II) complex, [Cu2(μ-(C6H5)2CHCOO)3 (bipy)2)](ClO4), has f...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160111123739
更新日期:2016-01-01 00:00:00
abstract::New technologies are currently investigated with the aim to improve the quality of foods by enhancing their nutritional value, freshness, safety and shelf-life, as well as by improving their tastes, flavours and textures. Moreover, new technological approaches are being explored, in this field, to address nutritional ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999201125205025
更新日期:2020-11-25 00:00:00
abstract:BACKGROUND:Amphotericin B eye drops are widely used in the treatment of ocular infections. However, amphotericin's toxicity leads to low patient compliance and aggravation of symptoms. This work describes the development of a microemulsion system containing amphotericin B, aiming for its use in ocular applications. ME...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1570159x14666151109110734
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Mesoporous bioactive glass (MBG) has been widely studied because of its excellent histocompatibility and degradability. However, due to the lack of good osteoinductive activity, the pure MBG scaffold is not effective in repairing large-scale bone defects. OBJECTIVE:To observe the repair effect of MBG scaffo...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200916091253
更新日期:2020-09-15 00:00:00
abstract::In this study we developed and evaluated a prototype of an effective occlusive mucoadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and gelatine models together with nystatin as a prophylactic agent incorporated into the formulation and investigated drug release in-vitro. Results of...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201811310010020
更新日期:2013-02-01 00:00:00
abstract::Polar lipids and various surfactants exhibit rich phase behavior depending on the composition of the lipids and the physicochemical conditions. Lamellar (L(alpha)), hexagonal (Inverted [H(II)]) and normal or inverted cubic (bicontinuous or micellar) structures are some of the most common lyotropic liquid crystalline p...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720110790396526
更新日期:2010-01-01 00:00:00
abstract::A palpable need for the optimization of therapeutic agents, due to challenges tackled by them such as poor pharmacokinetics and chemoresistance, has steered the journey towards novel interdisciplinary scientific field for emergence of nanostructure materials as a carrier for targeted delivery of therapeutic agents. Am...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666141229104304
更新日期:2015-01-01 00:00:00
abstract::Gene therapy has the potential to treat both acquired and inherited genetic diseases. Generally, two types of gene delivery vectors are used - viral vectors and non-viral vectors. Non-viral gene delivery systems have attracted significant interest (e.g. 115 gene therapies approved for clinical trials in 2018; clinical...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201816666190529072914
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Tuberculosis is an infection and caused by gentle growing bacteria. The Internet provides opportunities for people with tuberculosis (TB) to connect with one another to address these challenges. OBJECTIVE:The aim of this paper is to introduce readers to the platforms on which Tuberculosis participants inter...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201814666171120125916
更新日期:2018-01-01 00:00:00
abstract::The mucosal administration of vaccines is an area currently receiving a high level of interest due to potential advantages offered by this technique. These advantages include the ability to administer vaccines without need for needles, thus improving patient compliance with vaccination schedules, and the capacity to i...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201043334588
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180727145724
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Gemcitabine (GEM) is found effective in the treatment of many solid tumors. However, its use is restricted due to its small circulation half-life, fast metabolism and low capacity for selective tumor uptake. Folate receptors (FRs) have been recognized as cellular surface markers, which can be used for cancer...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666181024112252
更新日期:2019-01-01 00:00:00
abstract::The use of nanoparticles as platforms or vehicles for applications in nanomedicine, such as drug delivery and medical imaging, has been widely reported in the literature. A key area of potential improvement in the development and implementation of nanoparticles is the design of surface treatments to maximize residence...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720111795256165
更新日期:2011-05-01 00:00:00
abstract::Phase-sensitive in situ gel forming controlled release formulations of cyclosporine were prepared using poly (lactide-co-glycolide) and a solvent system consisting of various proportions of benzyl benzoate and benzyl alcohol. Uniformity of content of cyclosporine in the formulation and in vitro release samples was det...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720109789941669
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Realgar, a traditional Chinese medicine, has shown antitumor efficacy in several tumor types. We previously showed that realgar nanoparticles (nano-realgar) had significant antileukemia, anti-lung cancer and anti-liver cancer effects. In addition, the anti-tumor effects of nanorealgar were significantly bett...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200115105633
更新日期:2020-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environment...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:
更新日期:2013-11-24 00:00:00
abstract::The low bioavailability and consequently the poor therapeutic response of traditional ophthalmic formulations is caused by reduced pre-corneal residence time of the formulation in contact with the ocular surface. The use of colloidal carrier systems, namely lipid nanoparticles in combination with in situ gelling polym...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666151111143434
更新日期:2016-01-01 00:00:00
abstract::The aim of this present research work was to prepare and evaluate alginate microspheres of aceclofenac by ionic gelation method for targeting the drug release in intestinal region and decrease distinct tissue protection in the stomach. This method offers to prepare microspheres which are important in controlling the r...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720112802650725
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption, and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). Transdermal route is also beneficial for dru...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201815666180605114131
更新日期:2018-01-01 00:00:00
abstract::The objective of this investigation was to prepare mucoadhesive microspheres of ketorolac for nasal delivery to avoid gastrointestinal side effects of conventional dosage form. Mucoadhesive microspheres were prepared using carbopol, polycarbophil and chitosan as polymer by spray drying method. The process and formulat...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720112800234503
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Fluoroquinolones, the synthetic antibacterial agents are being successfully utilized against bacterial infections, since the time immemorial. Despite of enormous useful features, these drugs are associated with some limitations also. Large number of efforts has been made by various scientists to improve phar...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666161018153852
更新日期:2018-02-14 00:00:00
abstract::psyllium, a medicinally active gel forming natural polysaccharide and a dietary fiber has been used as a medicine in myriad of conditions such as constipation and inflammatory bowel syndrome. One of its more recent uses that have received attention has been its ability to reduce blood sugar levels in diabetics. Theref...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201811310030010
更新日期:2013-06-01 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 has spread rapidly since its discovery in December 2019 in the Chinese province of Hubei, reaching this day, all the continents. This scourge is, unfortunately, in lineage with various dangerous outbreaks such as Ebola, Cholera, Spanish flu, American seasonal flu. Until ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200917124241
更新日期:2020-09-17 00:00:00
abstract::Osteoarthritis is usually regarded as a localized disease whose optimal treatment is a therapy applied directly to the affected joint. Unfortunately, current local therapies such as repeated intraarticular injections or constant infusions are associated with a higher risk of infection. One way to overcome this would b...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720107779314839
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE:The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded t...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180108170206
更新日期:2018-01-01 00:00:00
abstract::Skin, the most significant protective organ in the body, may face serious problems, including cancer, infectious diseases, etc., requiring different drugs for the treatment. However, most of these drugs have poor chemical and physical stability, and insufficient penetration through the skin layers. In recent years, wi...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200820161438
更新日期:2020-08-20 00:00:00
abstract::There are still so-called unmet needs in the treatment of epithelial and cutaneous lesions. Mucositis, ocular lesions, chronic skin wounds represent typical examples. These pathologies do not yet afford a satisfactory treatment. In particular chronic wounds represent a major health care burden, likely to increase as t...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811310010005
更新日期:2013-02-01 00:00:00
abstract::Conventional dosage forms such as tablets, capsules and syrups are prescribed in the normal course of practice. However, concerns about patient preferences and market demands have given rise to the exploration of novel unconventional dosage forms. Among these, confectionery-based dose forms have strong potential to ov...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811666140821112637
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:The main objective of this novel study was to develop midazolam hydrochloride fast dissolving oral films (FDFs) using solvent casting method and to evaluate the characteristics of the optimum formulation through in vitro and in vivo analysis. The FDFs are new favorable solid dosage forms that deliver drugs r...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180723115600
更新日期:2018-01-01 00:00:00
abstract::Motivated by the success and exhaustive research on carbon nanotubes (CNTs) based drug delivery, graphene, a two-dimensional; honey-comb crystal lattice has emerged as the rising star in recent years. Graphene is a flat monolayer of carbon atoms that holds many promising properties such as unparalleled thermal conduct...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811666140605151600
更新日期:2014-01-01 00:00:00