An ex vivo characterization of Paclitaxel loaded chitosan films after implantation in mice.

abstract：:The objective of this study was to develop and evaluate mucoadhesive microsphere of diclofenac sodium with natural gums for sustained delivery. Guar gum and tragacanth were used along with sodium alginate as mucoadhesive polymers. Microspheres were formulated using orifice-ionic gelation method. Particle size, surface...

journal_title：Current drug delivery

authors： Amin ML,Jesmeen T,Sutradhar KB,Mannan MA

更新日期：2013-12-01 00:00:00

abstract：:The blood brain barrier protects the brain from harmful substances in the blood stream and has stopped the development of many powerful and interesting drugs candidates for central nervous system due to the low poor distribution and by efflux mechanisms. Many different approaches have been developed in order to overco...

journal_title：Current drug delivery

authors： Khalil NM,Mainardes RM

更新日期：2009-07-01 00:00:00

abstract：:The use of nanoparticles as platforms or vehicles for applications in nanomedicine, such as drug delivery and medical imaging, has been widely reported in the literature. A key area of potential improvement in the development and implementation of nanoparticles is the design of surface treatments to maximize residence...

journal_title：Current drug delivery

authors： Meerasa A,Huang JG,Gu FX

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Solid lipid nanoparticles (SLNs) represent an affordable, easily scalable, stable and biocompatible drug delivery system with a high drug to lipid ratio which also improves solubility of poorly soluble drugs. OBJECTIVE:SLNs were developed by using glyceryl monostearate as the single lipid in the presence of...

journal_title：Current drug delivery

authors： Bhatt H,Rompicharla SVK,Komanduri N,Aashma S,Paradkar S,Ghosh B,Biswas S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The aim of this research was to engineer solid dispersion lipid particles (SDSLs) in which a solid dispersion (SD) was encapsulated to form the core of solid lipid particles (SLs), thereby achieving an efficient enhancement in the dissolution of a poorly water-soluble drug. METHODS:Ultrasonication was intro...

journal_title：Current drug delivery

authors： My Tran KT,Vo TV,Lee BJ,Duan W,Ha-Lien Tran P,Truong-Dinh Tran T

更新日期：2018-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environment...

journal_title：Current drug delivery

authors： Sharma P,Pandita A,Murthy RS

更新日期：2013-11-24 00:00:00

abstract：:psyllium, a medicinally active gel forming natural polysaccharide and a dietary fiber has been used as a medicine in myriad of conditions such as constipation and inflammatory bowel syndrome. One of its more recent uses that have received attention has been its ability to reduce blood sugar levels in diabetics. Theref...

journal_title：Current drug delivery

authors： Rathnanand M,Narkhede R,Udupa N,Kalra A

更新日期：2013-06-01 00:00:00

abstract：:The research presented in this paper discusses the potential of iontophoresis facilitated transdermal delivery of glycine. Iontophoresis has been widely investigated as a noninvasive transdermal drug delivery system. Iontophoresis is the use of a low electric current to carry ionized as well as unionized drug molecule...

journal_title：Current drug delivery

authors： Dasgupta R,Banthia AK,Tibarewala DN

更新日期：2009-04-01 00:00:00

abstract：:Gelrite is an ion-activated polymer prepared by partial acetylation of gellan gum, an exogeneous polysaccharide present in Pseudomonas elodea. Its unique cation-dependent gelling property at 33 degrees C has been exploited for the formulation of in situ gelling hydrogels for ophthalmic and oral drug delivery. Gelrite ...

journal_title：Current drug delivery

authors： Rastogi R,Aqil M,Ali A,Sultana Y

更新日期：2008-04-01 00:00:00

abstract：:The aim of the present study was to prepare and evaluate hydrogels containing 0.1% isosorbide mononitrate (ISMN) for topical treatment of anal fissure. The hydrogels were prepared on the base of Carbopol 940, Poloxamer 407 or their combination. The highest viscosity and significant thyxotropy were observed for the com...

journal_title：Current drug delivery

authors： Yoncheva K,Doytchinova I,Tankova L

更新日期：2012-09-01 00:00:00

abstract：:The aim of this work is to study liposomes as carriers of nutrients and therapeutic agents in aquaculture with Venerupis decussatus and Venerupis pullastra larvae. Multilamellar (MLVs) and large unilamellar (LUVs) vesicles were prepared from a commercial mixture of soy phosphatidylcholine, rich in unsaturated and poly...

journal_title：Current drug delivery

authors： Lai F,Valenti D,Sinico C,Manconi M,Mendez JB,Fadda AM

更新日期：2004-04-01 00:00:00

abstract：:A palpable need for the optimization of therapeutic agents, due to challenges tackled by them such as poor pharmacokinetics and chemoresistance, has steered the journey towards novel interdisciplinary scientific field for emergence of nanostructure materials as a carrier for targeted delivery of therapeutic agents. Am...

journal_title：Current drug delivery

authors： Chaudhary HM,Duttagupta AS,Jadhav KR,Chilajwar SV,Kadam VJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...

journal_title：Current drug delivery

authors： Varol M,Koparal AT,Benkli K,Bostancioglu RB

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Tuberculosis is an infection and caused by gentle growing bacteria. The Internet provides opportunities for people with tuberculosis (TB) to connect with one another to address these challenges. OBJECTIVE:The aim of this paper is to introduce readers to the platforms on which Tuberculosis participants inter...

journal_title：Current drug delivery

authors： Singh G,Kesharwani P,Srivastava AK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteo...

journal_title：Current drug delivery

authors： Gera S,Sampathi S,Dodoala S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Chrysin is a strong inhibitor of breast cancer resistance protein (BCRP) but it is practically insoluble in water. Effective solubilization of chrysin is critical for its pharmaceutical application as an absorption enhancer via inhibition of BCRP-mediated drug efflux. OBJECTIVE:This study aimed to develop a...

journal_title：Current drug delivery

authors： Lee SH,Lee YS,Song JG,Han HK

更新日期：2019-01-01 00:00:00

abstract：:Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validate...

journal_title：Current drug delivery

authors： de Almeida PA,Alves MC,Polonini HC,Calixto SL,Braga Gomes TB,Barros Lataliza AA,da Silveira Ramos CD,Barbosa Raposo NR,de Oliveira Ferreira A,Fernandes Brandão A

更新日期：2015-01-01 00:00:00

abstract：:Skin, the most significant protective organ in the body, may face serious problems, including cancer, infectious diseases, etc., requiring different drugs for the treatment. However, most of these drugs have poor chemical and physical stability, and insufficient penetration through the skin layers. In recent years, wi...

journal_title：Current drug delivery

authors： Khailnezhad B,Hadjizadeh A

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Nasal delivery of 20 (R) -ginsenoside Rg3 (Rg3) has a short-lived anti-fatigue effect owing to rapid clearance by nasal cilia. Thus, in order to extend the residence time of Rg3 in the nasal cavity, a new drug delivery system is needed. METHODS:Chitosan microspheres loaded with Rg3 were prepared using a mul...

journal_title：Current drug delivery

authors： Zhang W,Wang X,Zhang M,Xu M,Tang W,Zhang Y,Lu L,Gao J,Gao S

更新日期：2017-09-06 00:00:00

abstract：:Relief of chronic pain is an important clinical problem requiring special care and approaches. The present study was designed for the construction of a controlled release system for local application of analgesics (hydromorphone (HM), morphine (M), and codeine (C)) and a local anesthetic, bupivacaine (BP). An interpen...

journal_title：Current drug delivery

authors： Keskin DS,Wise DL,Hasirci V

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The basal ganglia, an important functional integrity of the brain, comprises multiple subcortical nuclei. The area is mainly supplied by the perforating branches of ipsilateral middle cerebral artery (MCA). The unilateral non-traumatic basal ganglia hemorrhage, commonly located in the putamen, most often res...

journal_title：Current drug delivery

authors： Yang Z,Chen J,Mu J

更新日期：2017-09-06 00:00:00

abstract：OBJECTIVE:The present study reports the use of MicrofluidizerTM technology to form a stable nanosuspension of atovaquone (ATQ) using quality by design (QbD) approach. METHODS:The patient-centric quality target product profile and critical quality attributes (CQAs) were identified. A Box-Behnken design was employed for...

journal_title：Current drug delivery

authors： Kakade P,Gite S,Patravale V

更新日期：2020-01-01 00:00:00

abstract：:Atherosclerosis is the primary cause of coronary heart disease, which is characterized by a narrowing (stenosis) of the arteries that supply blood to tissues of the heart. Over the past decade, the use of "Bare metallic stents" during Percutaneous Transluminal Coronary Angioplasty (PTCA) has become a common practice f...

journal_title：Current drug delivery

authors： Hirlekar R,Patel M,Jain S,Kadam V

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:An injectable long acting In-Situ Forming Gel (ISFG) of human Growth Hormone (hGH) was prepared by using triblock PCL-PEG-PCL (Mw 1500-1500-1500). Ring-Opening Polymerization (ROP) of triblock using microwave was applied. METHODS:The BCA protein assay Kit was used to determine the concentration of hGH in the...

journal_title：Current drug delivery

authors： Khodaverdi E,Delroba K,Mohammadpour F,Khameneh B,Sajadi Tabassi SA,Tafaghodi M,Kamali H,Hadizadeh F

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease is a chronic progressive neurodegenerative disorder associated with depletion of acetylcholine. Oral treatment with tacrine hydrochloride; a reversible inhibitor of acetylcholinesterase, finds limited use in Alzheimer's disease due to frequent dosing, hepatotoxicity and extensive pre-syst...

journal_title：Current drug delivery

authors： Setya S,Madaan T,Razdan BK,Farswan M,Talegaonkar S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hesperetin (HSP) is a low water-soluble flavanone aglycone with low bioavailability. OBJECTIVES:This study aimed at enhancing the hepatoprotective effects of HSP by a combinatory technique based on solid dispersions of co-crystals of HSP. METHODS:Co-crystals were prepared using citric acid, tartaric acid, ...

journal_title：Current drug delivery

authors： Varshosaz J,Jalali M,Hosseini-Sharifabad A

更新日期：2018-01-01 00:00:00

abstract：:The mucosal administration of vaccines is an area currently receiving a high level of interest due to potential advantages offered by this technique. These advantages include the ability to administer vaccines without need for needles, thus improving patient compliance with vaccination schedules, and the capacity to i...

journal_title：Current drug delivery

authors： Moyle PM,McGeary RP,Blanchfield JT,Toth I

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:A ceftiofur hydrochloride long-acting oily suspension with no irritation was prepared by testing and optimizing the types and amounts of organic solvents, suspending agents, and surfactants.

Methods: Its properties, stability, injection site irritation, in vitro release, and pharmacokinetics in pigs were...

journal_title：Current drug delivery

authors： Xie S,Zhang X,Luo W,Meng K,Chen D,Pan Y,Tao Y,Huang L,Liu Z,Wang Y,Yuan Z

更新日期：2020-09-03 00:00:00

abstract：:Curcumin as an antioxidative agent which has been widely used medicinally in India and China. However, rapid metabolism coupled with the instability of curcumin under physiological conditions has greatly limited its applications in vivo. In the present study, a thermosensitive hydrogel with high payload of curcumin wa...

journal_title：Current drug delivery

authors： Lu C

更新日期：2016-01-01 00:00:00

abstract：:ImmunoPET is a non-invasive imaging technology based on tracking and quantification of radiolabeled monoclonal antibodies, antibody fragments and peptides in vivo. The knowledge of distribution and expression levels of a given receptor is a key for successful receptor targeted cancer therapy. ImmunoPET performed with ...

journal_title：Current drug delivery

authors： Marik J,Junutula JR

更新日期：2011-01-01 00:00:00