Development of novel floating delivery system based on psyllium: application on metformin hydrochloride.

abstract：:The mucosal administration of vaccines is an area currently receiving a high level of interest due to potential advantages offered by this technique. These advantages include the ability to administer vaccines without need for needles, thus improving patient compliance with vaccination schedules, and the capacity to i...

journal_title：Current drug delivery

authors： Moyle PM,McGeary RP,Blanchfield JT,Toth I

更新日期：2004-10-01 00:00:00

abstract：:Cutaneous gene therapy and DNA vaccination are potential applications of plasmid delivery methods where a gene for an antigen or a therapeutic protein is inserted in the plasmid and applied to the skin. However, the delivery of the DNA plasmid is a major challenge due to the unusual physicochemical properties of the D...

journal_title：Current drug delivery

authors： Foldvari M,Babiuk S,Badea I

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Polyionic Complex (PIC) nanogels are promising delivery systems with numerous attractions such as simple, fast, and organic solvent-free particle formation and mild drug loading conditions. Among polyelectrolytes, poly (L-amino acid) copolymers such as poly (ethylene glycol)-block-poly (L-glutamic acid) copo...

journal_title：Current drug delivery

authors： Salmanpour M,Saeed-Vaghefi M,Abolmaali SS,Tamaddon A

更新日期：2020-11-03 00:00:00

abstract：:ADMET Chemoinformatics multi-output models are useful for a parallel prediction of multiple experimental parameters related the absorption (A), distribution (D), metabolism (M), excretion (E), and toxicity (T) process of drugs, pollutants, and NPs with a single QSPR model. Here we present one state-of-art review about...

journal_title：Current drug delivery

authors： González-Díaz H

更新日期：2016-04-19 00:00:00

abstract：:The aim of the present work was to evaluate alginate hydrogels in the form of spherical beads as carrier for antithrombotic drugs for future use in artificial grafts. The ionotropic gelation technique was employed to prepare beads from the L. hyperborea stipe of alginate with two different alginate concentrations and ...

journal_title：Current drug delivery

authors： Jämstorp E,Bodin A,Gatenholm P,Jeppsson A,Strømme M

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteo...

journal_title：Current drug delivery

authors： Gera S,Sampathi S,Dodoala S

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:In the present work, we report for the first time the therapeutic potential of talazoparib (BMN 673)-SLNs for the treatment of BRCA1 deficient Triple Negative Breast Cancer (TNBC). BMN 673-SLNs were produced by hot-homogenization technique and then characterized. METHODS:The cytotoxic and apoptotic effects o...

journal_title：Current drug delivery

authors： Eskiler GG,Cecener G,Dikmen G,Egeli U,Tunca B

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The basal ganglia, an important functional integrity of the brain, comprises multiple subcortical nuclei. The area is mainly supplied by the perforating branches of ipsilateral middle cerebral artery (MCA). The unilateral non-traumatic basal ganglia hemorrhage, commonly located in the putamen, most often res...

journal_title：Current drug delivery

authors： Yang Z,Chen J,Mu J

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:Hesperetin (HSP) is a low water-soluble flavanone aglycone with low bioavailability. OBJECTIVES:This study aimed at enhancing the hepatoprotective effects of HSP by a combinatory technique based on solid dispersions of co-crystals of HSP. METHODS:Co-crystals were prepared using citric acid, tartaric acid, ...

journal_title：Current drug delivery

authors： Varshosaz J,Jalali M,Hosseini-Sharifabad A

更新日期：2018-01-01 00:00:00

abstract：:Nowadays, cancer is one of the deadliest diseases affecting an annually enormous number of people. Around 9.6 million people had died from different cancer types in 2018. Chemotherapy is considered to be a mainline treatment, and systemic administration of a single anticancer agent is also considered as vital clinical...

journal_title：Current drug delivery

authors： Dubey A,Shriram RG,El-Zahaby SA

更新日期：2021-01-20 00:00:00

abstract：:The development of oral insulin using the eligen technology represents a significant advance in insulin administration which is expected to improve the quality of life of diabetic patients. As clinical studies progress, a great deal of interest has focused on the process by which this technology enables insulin absorp...

journal_title：Current drug delivery

authors： Malkov D,Angelo R,Wang HZ,Flanders E,Tang H,Gomez-Orellana I

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Solid lipid nanoparticles (SLNs) represent an affordable, easily scalable, stable and biocompatible drug delivery system with a high drug to lipid ratio which also improves solubility of poorly soluble drugs. OBJECTIVE:SLNs were developed by using glyceryl monostearate as the single lipid in the presence of...

journal_title：Current drug delivery

authors： Bhatt H,Rompicharla SVK,Komanduri N,Aashma S,Paradkar S,Ghosh B,Biswas S

更新日期：2018-01-01 00:00:00

abstract：:The blood brain barrier protects the brain from harmful substances in the blood stream and has stopped the development of many powerful and interesting drugs candidates for central nervous system due to the low poor distribution and by efflux mechanisms. Many different approaches have been developed in order to overco...

journal_title：Current drug delivery

authors： Khalil NM,Mainardes RM

更新日期：2009-07-01 00:00:00

abstract：:The use of different drug classes as host modulating agents has been postulated to have significance as an adjunctive remedy curing chronic periodontitis. In this study nano-structured films containing doxycyclin (DOX) were evaluated for such purpose. Nano DOX/chitosan particulate system was prepared using spray dryin...

journal_title：Current drug delivery

authors： Mahmoud MM,Samy WM

更新日期：2016-01-01 00:00:00

abstract：:The interaction of a series of amphiphilic 2-alkyl aminoacids (lipoamino acids, LAAs) with different cell cultures and biomembrane models was investigated. LAAs can be useful promoieties to modify the physico-chemical properties of many drugs, and in particular their lipophilicity. Tests were performed in vitro on mam...

journal_title：Current drug delivery

authors： Pignatello R,Noce C,Campisi A,Acquaviva R,Bucolo C,Puglisi G,Toth I

更新日期：2007-04-01 00:00:00

abstract：:In this study we developed and evaluated a prototype of an effective occlusive mucoadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and gelatine models together with nystatin as a prophylactic agent incorporated into the formulation and investigated drug release in-vitro. Results of...

journal_title：Current drug delivery

authors： Perchyonok VT,Zhang S,Oberholzer T

更新日期：2013-02-01 00:00:00

abstract：:A number of Polycyclic Aromatic Hydrocarbons (PAHs) have been shown to be toxicants, and induce carcinogenic and immunotoxic effects. Since PAHs are often present in low concentrations and it may be difficult to determine them in complex matrices, it is therefore essential to use powerful analytical tools to separate ...

journal_title：Current drug delivery

authors： Şentürk Z

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The scope of nanotechnology has been extended to almost every sphere of our daily life. As a result of this, nanocarriers like Carbon Nanotubes (CNTs) are gaining considerable attention for their use in various therapeutic and diagnostic applications. OBJECTIVE:The objective of the current article is to rev...

journal_title：Current drug delivery

authors： Panigrahi BK,Nayak AK

更新日期：2020-01-01 00:00:00

abstract：:A review with 93 references. Heparins are high molecular weight, hydrophilic polyanions, which are unstable under acidic conditions; and therefore they exhibit poor oral bioavailability. Consequently they must be administered via the parenteral route which is expensive, inconvenient, and limits use by outpatients. The...

journal_title：Current drug delivery

authors： Ross BP,Toth I

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:An injectable long acting In-Situ Forming Gel (ISFG) of human Growth Hormone (hGH) was prepared by using triblock PCL-PEG-PCL (Mw 1500-1500-1500). Ring-Opening Polymerization (ROP) of triblock using microwave was applied. METHODS:The BCA protein assay Kit was used to determine the concentration of hGH in the...

journal_title：Current drug delivery

authors： Khodaverdi E,Delroba K,Mohammadpour F,Khameneh B,Sajadi Tabassi SA,Tafaghodi M,Kamali H,Hadizadeh F

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Nanoparticles (NPs) suffer from rapid clearance from body and require frequent dosing if long treatment is required. METHOD:In order to solve this problem for solid lipid nanoparticles (SLN) and prolong their action, SLNs were incorporated into thermo-responsive Poloxamer sol-gels and their fate was investi...

journal_title：Current drug delivery

authors： Dorraj G,Dadashzadeh S,Erfan M,Moghimi HR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeu...

journal_title：Current drug delivery

authors： Khondee S,Chittasupho C,Tima S,Anuchapreeda S

更新日期：2018-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environment...

journal_title：Current drug delivery

authors： Sharma P,Pandita A,Murthy RS

更新日期：2013-11-24 00:00:00

abstract：BACKGROUND:Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption, and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). Transdermal route is also beneficial for dru...

journal_title：Current drug delivery

authors： Kumar L,Verma S,Singh M,Chalotra T,Utreja P

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Colloidal systems are most prominent delivery systems mainly used as vehicles for the transportation, targeting the various types of biomolecules, proteins, peptides, synthetic medicinal agents. OBJECTIVE:To provide concise information on patents that are directly or indirectly related to the nanoemulsions....

journal_title：Current drug delivery

authors： Patel RB,Thakore SD,Patel MR

更新日期：2016-01-01 00:00:00

abstract：:The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The present study was carried out to develop a gastroretentive drug delivery system using isabgol as an exci...

journal_title：Current drug delivery

authors： Semwal R,Semwal RB,Semwal DK

更新日期：2014-01-01 00:00:00

abstract：:The placenta has traditionally been considered as a highly permeable organ for a large variety of substances with diverse molecular structures that are readily able to cross it from the maternal blood to reach the foetus. This has recommended limiting the use of drugs during pregnancy as far as possible. However, our ...

journal_title：Current drug delivery

authors： Marin JJ,Briz O,Serrano MA

更新日期：2004-07-01 00:00:00

abstract：:Asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis, are among the most common chronic diseases and their prevalence is increasing. Each of these diseases is characterized by the secretion of cytokines and pro-inflammatory molecules which are thought to play a critical rol...

journal_title：Current drug delivery

authors： Gioia SD,Sardo C,Castellani S,Porsio B,Belgiovine G,Carbone A,Giammona G,Cavallaro G,Conese M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is considered as a violent disease with high rate of morbidity and mortality. Early brain injury (EBI) and delayed vasospasm are the two aspects of this disease that are becoming research hotspots. OBJECTIVE:We aim to update the role of oxidative stress in the development of EB...

journal_title：Current drug delivery

authors： Yang Y,Chen S,Zhang JM

更新日期：2017-09-06 00:00:00

abstract：:The present study performed by preparation and evaluation of floating tablets of Acyclovir as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose K 4M, K 15M, psyllium husk, swelling agent as crospovidone and micro...

journal_title：Current drug delivery

authors： Garg R,Gupta GD

更新日期：2009-10-01 00:00:00