Abstract:
OBJECTIVE:An injectable long acting In-Situ Forming Gel (ISFG) of human Growth Hormone (hGH) was prepared by using triblock PCL-PEG-PCL (Mw 1500-1500-1500). Ring-Opening Polymerization (ROP) of triblock using microwave was applied. METHODS:The BCA protein assay Kit was used to determine the concentration of hGH in the in-vitro release medium. Finally, Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE) tests and Circular Dichroism (CD) spectrum were done to approve the stability of released hGH. The result of ROP demonstrated that the proportion of PCL to PEG accorded with the initial molar ratio of the monomers. The cross-section of the Surface Electron Microscopy (SEM) indicated the porous framework of the hydrogel could load the drug into its tridimensional matrixes structure. There is the low initial burst release of hGH from the supramolecular hydrogel. RESULTS:The maximum in-vitro release of hGH was 71.2 % ± 1.5 that were due to hGH degrading after this time (21 days). The CD spectrum and SDS-PAGE results confirmed the stability of hGH during invitro release evaluation. CONCLUSION:The results suggest that the sustained-release formulation using PCL-PEG-PCL can be applied to control the release of hGH.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Khodaverdi E,Delroba K,Mohammadpour F,Khameneh B,Sajadi Tabassi SA,Tafaghodi M,Kamali H,Hadizadeh Fdoi
10.2174/1567201817666200120120105subject
Has Abstractpub_date
2020-01-01 00:00:00pages
174-183issue
2eissn
1567-2018issn
1875-5704pii
CDD-EPUB-103768journal_volume
17pub_type
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journal_title:Current drug delivery
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journal_title:Current drug delivery
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journal_title:Current drug delivery
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journal_title:Current drug delivery
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journal_title:Current drug delivery
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journal_title:Current drug delivery
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journal_title:Current drug delivery
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journal_title:Current drug delivery
pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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更新日期:2016-01-01 00:00:00
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journal_title:Current drug delivery
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更新日期:2010-04-01 00:00:00
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