Investigation of in vitro iontophoresis facilitated transdermal delivery of glycine.

abstract：:Several groups have shown that vaccine antigens can be encapsulated within polymeric microparticles and can serve as potent antigen delivery systems. We have recently shown that an alternative approach involving charged polylactide co-glycolide (PLG) microparticles with surface adsorbed antigen(s) can also be used to ...

journal_title：Current drug delivery

authors： Singh M,Kazzaz J,Ugozzoli M,Malyala P,Chesko J,O'Hagan DT

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:In this study, central composite factorial design was used for the preparation and optimization of chitosan/Na-alginate hydrogel films containing metformin via solvent evaporation technique. METHODS:Low and high molecular weight (MW) chitosan was used as a polymer in different concentrations while genipin w...

journal_title：Current drug delivery

authors： Ubaid M,Murtaza G

更新日期：2018-01-01 00:00:00

abstract：:Since its discovery in 1796 by Edward Jenner, vaccines have been an integral aspect of therapeutics, combating a number of infectious diseases with remarkable success. In recent years, due to rapid advances in proteomics, genomics, biotechnology and immunology and the plethora of knowledge amassed in related fields, i...

journal_title：Current drug delivery

authors： Azad N,Rojanasakul Y

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Gemcitabine (GEM) is found effective in the treatment of many solid tumors. However, its use is restricted due to its small circulation half-life, fast metabolism and low capacity for selective tumor uptake. Folate receptors (FRs) have been recognized as cellular surface markers, which can be used for cancer...

journal_title：Current drug delivery

authors： Unnam S,Panduragaiah VM,Sidramappa MA,Muddana Eswara BR

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Betulinic acid (BA) is a lipophilic compound with proven beneficial results in topical inflammation. Nanogels (NG) are carriers of bioactive compounds with properties that make them good candidates to treat skin diseases. OBJECTIVE:The objective of this study was to evaluate the anti-inflammatory activity o...

journal_title：Current drug delivery

authors： Sosa-Gutierrez D,Toro-Vazquez J,Cano-Sarmiento C,Grube-Pagola P,Aparicio-Saguilan A,Torres-Palacios C,Acosta-Osorio A,Garcia H

更新日期：2020-08-17 00:00:00

abstract：:The aim of this present research work was to prepare and evaluate alginate microspheres of aceclofenac by ionic gelation method for targeting the drug release in intestinal region and decrease distinct tissue protection in the stomach. This method offers to prepare microspheres which are important in controlling the r...

journal_title：Current drug delivery

authors： Khandai M,Chakraborty S,Nayak P,Krishna NB,Chakravarthi G,Acharjya B,Ghosh AK

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:A new tumor targeted polymer-coated gold/graphene hybrid has been developed for achieving simultaneously thermoablation and chemoterapy of folate receptor-positive cancer cells. METHODS:The gold/graphene hybrid was prepared by depositing gold nanospheres onto graphene oxide and coating it with an inulin-fola...

journal_title：Current drug delivery

authors： Mauro N,Volsi AL,Scialabba C,Licciardi M,Cavallaro G,Giammona G

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:A ceftiofur hydrochloride long-acting oily suspension with no irritation was prepared by testing and optimizing the types and amounts of organic solvents, suspending agents, and surfactants.

Methods: Its properties, stability, injection site irritation, in vitro release, and pharmacokinetics in pigs were...

journal_title：Current drug delivery

authors： Xie S,Zhang X,Luo W,Meng K,Chen D,Pan Y,Tao Y,Huang L,Liu Z,Wang Y,Yuan Z

更新日期：2020-09-03 00:00:00

abstract：OBJECTIVE:The present study reports the use of MicrofluidizerTM technology to form a stable nanosuspension of atovaquone (ATQ) using quality by design (QbD) approach. METHODS:The patient-centric quality target product profile and critical quality attributes (CQAs) were identified. A Box-Behnken design was employed for...

journal_title：Current drug delivery

authors： Kakade P,Gite S,Patravale V

更新日期：2020-01-01 00:00:00

abstract：:Skin, the most significant protective organ in the body, may face serious problems, including cancer, infectious diseases, etc., requiring different drugs for the treatment. However, most of these drugs have poor chemical and physical stability, and insufficient penetration through the skin layers. In recent years, wi...

journal_title：Current drug delivery

authors： Khailnezhad B,Hadjizadeh A

更新日期：2020-08-20 00:00:00

abstract：:Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulos...

journal_title：Current drug delivery

authors： Duttagupta DS,Jadhav VM,Kadam VJ

更新日期：2015-01-01 00:00:00

abstract：:Asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis, are among the most common chronic diseases and their prevalence is increasing. Each of these diseases is characterized by the secretion of cytokines and pro-inflammatory molecules which are thought to play a critical rol...

journal_title：Current drug delivery

authors： Gioia SD,Sardo C,Castellani S,Porsio B,Belgiovine G,Carbone A,Giammona G,Cavallaro G,Conese M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Wound healing is a biological process that can get in a state of pathologic inflammation, requiring the use of specific medications able to promote proper tissue repair. OBJECTIVE:The study describes the production and characterization of nanoparticle based gel for wound healing treatment designed to delive...

journal_title：Current drug delivery

authors： Esposito E,Pecorelli A,Sguizzato M,Drechsler M,Mariani P,Carducci F,Cervellati F,Nastruzzi C,Cortesi R,Valacchi G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Amphotericin B eye drops are widely used in the treatment of ocular infections. However, amphotericin's toxicity leads to low patient compliance and aggravation of symptoms. This work describes the development of a microemulsion system containing amphotericin B, aiming for its use in ocular applications. ME...

journal_title：Current drug delivery

authors： da Silveira WL,Damasceno BP,Ferreira LF,Ribeiro IL,Silva KS,Silva AL,Giannini MJ,da Silva-Júnior AA,de Oliveira AG,do Egito ES

更新日期：2016-01-01 00:00:00

abstract：:The low bioavailability and consequently the poor therapeutic response of traditional ophthalmic formulations is caused by reduced pre-corneal residence time of the formulation in contact with the ocular surface. The use of colloidal carrier systems, namely lipid nanoparticles in combination with in situ gelling polym...

journal_title：Current drug delivery

authors： Almeida H,Lobão P,Frigerio C,Fonseca J,Silva R,Palmeira-de-Oliveira A,Lobo JM,Amaral MH

更新日期：2016-01-01 00:00:00

abstract：:The objective of present investigation was the characterization of chitosan films after in vivo implantation. Chitosan films were prepared at three dose loadings of paclitaxel by classical casting method. They were implanted subcutaneously in Swiss mice in the neck region and were removed at 7, 15, 21 and 30 days post...

journal_title：Current drug delivery

authors： Panchagnula R,Dhanikula RS,Dhanikula AB

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:In the present work, we report for the first time the therapeutic potential of talazoparib (BMN 673)-SLNs for the treatment of BRCA1 deficient Triple Negative Breast Cancer (TNBC). BMN 673-SLNs were produced by hot-homogenization technique and then characterized. METHODS:The cytotoxic and apoptotic effects o...

journal_title：Current drug delivery

authors： Eskiler GG,Cecener G,Dikmen G,Egeli U,Tunca B

更新日期：2019-01-01 00:00:00

abstract：:Selective targeting of ligand-targeted liposomes containing anticancer drugs or therapeutic genes to cell surface receptors expressed on cancer cells is a recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics or gene therapeutics. Some recent advances in the field of ligand-...

journal_title：Current drug delivery

authors： Sapra P,Tyagi P,Allen TM

更新日期：2005-10-01 00:00:00

abstract：:Tablets are still the most commonly used dosage form because of the ease of manufacturing, convenience in administration, accurate dosing and excellent stability. Direct compression is the preferred method for the preparation of tablets. However, it has been estimated that less than 20 percent of the active pharmaceut...

journal_title：Current drug delivery

authors： Mirani AG,Patankar SP,Borole VS,Pawar AS,Kadam VJ

更新日期：2011-07-01 00:00:00

abstract：:The objective of this investigation was to prepare mucoadhesive microspheres of ketorolac for nasal delivery to avoid gastrointestinal side effects of conventional dosage form. Mucoadhesive microspheres were prepared using carbopol, polycarbophil and chitosan as polymer by spray drying method. The process and formulat...

journal_title：Current drug delivery

authors： Nagda CD,Chotai NP,Nagda DC,Patel SB,Patel UL

更新日期：2012-03-01 00:00:00

abstract：:The objective of this study was to develop and evaluate mucoadhesive microsphere of diclofenac sodium with natural gums for sustained delivery. Guar gum and tragacanth were used along with sodium alginate as mucoadhesive polymers. Microspheres were formulated using orifice-ionic gelation method. Particle size, surface...

journal_title：Current drug delivery

authors： Amin ML,Jesmeen T,Sutradhar KB,Mannan MA

更新日期：2013-12-01 00:00:00

abstract：:The objective of the present research is to prepare stable nano suspensions of Valsartan (VAL) with high solubility and dissolution. VAL is an orally administered anti-hypertensive drug with lower bio-availability of 25%, this is attributed to its lower aqueous solubility (0.082 mg/ml). VAL nano suspensions were prepa...

journal_title：Current drug delivery

authors： Vuppalapati L,Cherukuri S,Neeli V,Yeragamreddy PR,Kesavan BR

更新日期：2016-01-01 00:00:00

abstract：:The use of different drug classes as host modulating agents has been postulated to have significance as an adjunctive remedy curing chronic periodontitis. In this study nano-structured films containing doxycyclin (DOX) were evaluated for such purpose. Nano DOX/chitosan particulate system was prepared using spray dryin...

journal_title：Current drug delivery

authors： Mahmoud MM,Samy WM

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Bupivacaine is the most used local anesthetic in surgical procedures, producing prolonged anesthesia. The major limiting factor for the clinical use of bupivacaine comes from its systemic toxicity. Nanostructured lipid carriers (NLC) are vehicles for sustained drug delivery that are able to minimize the toxi...

journal_title：Current drug delivery

authors： Da Silva GHR,de Morais Ribeiro LN,Guilherme VA,de Castro SR,Breitkreitz MC,de Paula E

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:One of the major abundant proteins in the nucleous is nucleolin that overexpressed on the cytoplasmic membrane of malignant and endothelial cells and makes it as a promising condidate for targeted drug delivery. OBJECTIVES:In this study, doxorubicin (Dox) as a chemotherapy drug was entrapped into the Poly l...

journal_title：Current drug delivery

authors： Mosafer J,Mokhtarzadeh A

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Atenolol has been used to treat angina and hypertension, either alone or with other antihypertensives. Despite its usefulness, it shows some side effects such as diarrhea and nausea in some patients. A method for slow release of atenolol in intestine is helpful to prevent such side effects. METHODS:A facile...

journal_title：Current drug delivery

authors： Mortazavi-Derazkola S,Naimi-Jamal MR,Ghoreishi SM

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Solid lipid nanoparticles (SLNs) represent an affordable, easily scalable, stable and biocompatible drug delivery system with a high drug to lipid ratio which also improves solubility of poorly soluble drugs. OBJECTIVE:SLNs were developed by using glyceryl monostearate as the single lipid in the presence of...

journal_title：Current drug delivery

authors： Bhatt H,Rompicharla SVK,Komanduri N,Aashma S,Paradkar S,Ghosh B,Biswas S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Subarachnoid hemorrhage (SAH) is considered as a violent disease with high rate of morbidity and mortality. Early brain injury (EBI) and delayed vasospasm are the two aspects of this disease that are becoming research hotspots. OBJECTIVE:We aim to update the role of oxidative stress in the development of EB...

journal_title：Current drug delivery

authors： Yang Y,Chen S,Zhang JM

更新日期：2017-09-06 00:00:00

abstract：BACKGROUND:PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE:The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded t...

journal_title：Current drug delivery

authors： De Marco Almeida F,Silva CN,de Araujo Lopes SC,Santos DM,Torres FS,Cardoso FL,Martinelli PM,da Silva ER,de Lima ME,Miranda LAF,Oliveira MC

更新日期：2018-01-01 00:00:00

abstract：AIM:The aim of the study was to formulate, characterize, and evaluate the resveratrol-loaded cubosomes (RC) through topical application. BACKGROUND:Resveratrol (RV) is a nutraceutical compound that has exciting pharmacological potential in different diseases including cancers. Many studies of resveratrol have been rep...

journal_title：Current drug delivery

authors： Kurangi B,Jalalpure S,Jagwani S

更新日期：2020-09-02 00:00:00