New Thermoresponsive Eyedrop Formulation Containing Ibuprofen Loaded-Nanostructured Lipid Carriers (NLC): Development, Characterization and Biocompatibility Studies.

Abstract:

:The low bioavailability and consequently the poor therapeutic response of traditional ophthalmic formulations is caused by reduced pre-corneal residence time of the formulation in contact with the ocular surface. The use of colloidal carrier systems, namely lipid nanoparticles in combination with in situ gelling polymers, is an excellent strategy which results in the exponential increase of the bioavailability of ophthalmic drugs. In the present study, we have developed thermoresponsive eyedrops prepared with nanostructured lipid carriers (NLC) dispersions for the controlled delivery of ibuprofen. Lipid solubility studies and DSC measurements have proved that the lipids solubilise ibuprofen and present a good compatibility. NLC were prepared based on the melt-emulsification and ultrasonication technique and lipid nanoparticles with a Z-average of 120-150 nm, polydispersity index below 0.3, highly positive zeta potential and an efficacy of encapsulation of ~87% were obtained. The cytotoxicity of NLC was evaluated by the Alamar Blue reduction assay using the Y-79 human retinoblastoma cell line, and no relevant toxicity was observed after exposure to 0-100 μg/mL NLC for up to 72 hours. The HET-CAM assay was used to assess the product eye compatibility, confirming that the developed product does not exhibit irritant potential. The in vitro release studies showed ibuprofen release over several hours.

journal_name

Curr Drug Deliv

journal_title

Current drug delivery

authors

Almeida H,Lobão P,Frigerio C,Fonseca J,Silva R,Palmeira-de-Oliveira A,Lobo JM,Amaral MH

doi

10.2174/1567201813666151111143434

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

953-70

issue

6

eissn

1567-2018

issn

1875-5704

pii

CDD-EPUB-71329

journal_volume

13

pub_type

杂志文章
  • Pain control via opioid analgesic-local anesthetic loaded IPNs.

    abstract::Relief of chronic pain is an important clinical problem requiring special care and approaches. The present study was designed for the construction of a controlled release system for local application of analgesics (hydromorphone (HM), morphine (M), and codeine (C)) and a local anesthetic, bupivacaine (BP). An interpen...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201043480081

    authors: Keskin DS,Wise DL,Hasirci V

    更新日期:2004-01-01 00:00:00

  • Consensus Guideline Based Therapeutic Drug Monitoring (TDM) in Psychiatry and Neurology.

    abstract::Therapeutic drug monitoring (TDM) is a valuable tool for tailoring the dosage of the prescribed medication(s) to the individual pharmacokinetic characteristics of a patient. In psychiatry and neurology, however, proven evidence that TDM should be used for treatment with the multiple neuropsychiatric medications is res...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201812666151029100909

    authors: Hiemke C

    更新日期:2016-01-01 00:00:00

  • Nanoparticle coated emulsions as novel dermal delivery vehicles.

    abstract::The dermal delivery characteristics of hydrophilic silica nanoparticle coated medium chain triglyceride oil-in-water emulsions are reported and correlated with the physicochemical and interfacial properties of the emulsion based drug carriers. The synergistic drug/stabiliser/nanoparticle interactions are demonstrated ...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/156720109789000456

    authors: Eskandar NG,Simovic S,Prestidge CA

    更新日期:2009-08-01 00:00:00

  • Analysis of carcinogenic Polycyclic Aromatic Hydrocarbons (PAHS): an overview of modern electroanalytical techniques and their applications.

    abstract::A number of Polycyclic Aromatic Hydrocarbons (PAHs) have been shown to be toxicants, and induce carcinogenic and immunotoxic effects. Since PAHs are often present in low concentrations and it may be difficult to determine them in complex matrices, it is therefore essential to use powerful analytical tools to separate ...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201811310010014

    authors: Şentürk Z

    更新日期:2013-02-01 00:00:00

  • Formulation and evaluation of resveratrol loaded cubosomal nanoformulation for topical delivery.

    abstract:AIM:The aim of the study was to formulate, characterize, and evaluate the resveratrol-loaded cubosomes (RC) through topical application. BACKGROUND:Resveratrol (RV) is a nutraceutical compound that has exciting pharmacological potential in different diseases including cancers. Many studies of resveratrol have been rep...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201817666200902150646

    authors: Kurangi B,Jalalpure S,Jagwani S

    更新日期:2020-09-02 00:00:00

  • Fast dissolving films: a review.

    abstract::Fast-dissolving drug delivery systems have been developed as an alternative to conventional dosage form as an oral means of drug delivery in case of chronic conditions. Now a day's fast dissolving films are preferred over conventional tablets and capsules for masking the taste of bitter drugs to increase the patient c...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/156720111795768022

    authors: Chaturvedi A,Srivastava P,Yadav S,Bansal M,Garg G,Sharma PK

    更新日期:2011-07-01 00:00:00

  • Enhanced Periodontal Regeneration by Novel Single Application Sustained Release Nano-Structured Doxycycline Films.

    abstract::The use of different drug classes as host modulating agents has been postulated to have significance as an adjunctive remedy curing chronic periodontitis. In this study nano-structured films containing doxycyclin (DOX) were evaluated for such purpose. Nano DOX/chitosan particulate system was prepared using spray dryin...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201813666151113122752

    authors: Mahmoud MM,Samy WM

    更新日期:2016-01-01 00:00:00

  • Dextran Microparticulate Inhalable Dry Powder for the Treatment of Cystic Fibrosis and Mucopolysaccharidosis.

    abstract:BACKGROUND:Cystic Fibrosis (CF) is a genetic disease which affects the patient's lungs, pancreas, liver, kidney and intestine and lacks sulfatase enzyme, leading to mucopolysaccharidosis. Colistin sulfate acts by interacting with phospholipids of bacterial cell membranes. Sulfatase enzyme reduces the high levels of sul...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201817666200122160110

    authors: Solanki NR,Patel DH,Talele DR

    更新日期:2020-01-01 00:00:00

  • Optimization of Performance Variables of Exemestane Nanosuspension Using Box-Behnken Design to Improve Dissolution and Oral Bioavailability.

    abstract:PURPOSE:Present investigation was aimed to fabricate nanocrystal of exemestane, an anticancer drug with poor dissolution properties and oral bioavailability. METHODS:Influence of various process parameters on the formulation of exemestane nanosuspension using media milling technique were investigated in the trial batc...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201818999210112190716

    authors: Parmar K,Shah J

    更新日期:2021-01-12 00:00:00

  • A review on the molecular mechanisms involved in the placental barrier for drugs.

    abstract::The placenta has traditionally been considered as a highly permeable organ for a large variety of substances with diverse molecular structures that are readily able to cross it from the maternal blood to reach the foetus. This has recommended limiting the use of drugs during pregnancy as far as possible. However, our ...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201043334731

    authors: Marin JJ,Briz O,Serrano MA

    更新日期:2004-07-01 00:00:00

  • Anti-lung Cancer and Anti-angiogenic Activities of New Designed Boronated Phenylalanine Metal Complexes.

    abstract:BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201815666180727145724

    authors: Varol M,Koparal AT,Benkli K,Bostancioglu RB

    更新日期:2018-01-01 00:00:00

  • In vitro Evaluation of Genipin-crosslinked Na-alginate/Chitosan Hydrogel Films for Delivery of Metformin: Effect of Chitosan Molecular Weight.

    abstract:OBJECTIVES:In this study, central composite factorial design was used for the preparation and optimization of chitosan/Na-alginate hydrogel films containing metformin via solvent evaporation technique. METHODS:Low and high molecular weight (MW) chitosan was used as a polymer in different concentrations while genipin w...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201815666180409102459

    authors: Ubaid M,Murtaza G

    更新日期:2018-01-01 00:00:00

  • Physicochemical Characterization and Skin Permeation of Cationic Transfersomes Containing the Synthetic Peptide PnPP-19.

    abstract:BACKGROUND:PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE:The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded t...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201815666180108170206

    authors: De Marco Almeida F,Silva CN,de Araujo Lopes SC,Santos DM,Torres FS,Cardoso FL,Martinelli PM,da Silva ER,de Lima ME,Miranda LAF,Oliveira MC

    更新日期:2018-01-01 00:00:00

  • Intranasal Delivery of Microspheres Loaded with 20 (R)-ginsenoside Rg3 Enhances Anti-Fatigue Effect in Mice.

    abstract:BACKGROUND:Nasal delivery of 20 (R) -ginsenoside Rg3 (Rg3) has a short-lived anti-fatigue effect owing to rapid clearance by nasal cilia. Thus, in order to extend the residence time of Rg3 in the nasal cavity, a new drug delivery system is needed. METHODS:Chitosan microspheres loaded with Rg3 were prepared using a mul...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201814666161109121151

    authors: Zhang W,Wang X,Zhang M,Xu M,Tang W,Zhang Y,Lu L,Gao J,Gao S

    更新日期:2017-09-06 00:00:00

  • Synthesis, Characterization, and Atenolol Delivery Application of Functionalized Mesoporous Hydroxyapatite Nanoparticles Prepared by Microwave-Assisted Co-precipitation Method.

    abstract:BACKGROUND:Atenolol has been used to treat angina and hypertension, either alone or with other antihypertensives. Despite its usefulness, it shows some side effects such as diarrhea and nausea in some patients. A method for slow release of atenolol in intestine is helpful to prevent such side effects. METHODS:A facile...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201813666160321115543

    authors: Mortazavi-Derazkola S,Naimi-Jamal MR,Ghoreishi SM

    更新日期:2016-01-01 00:00:00

  • Photothermal Ablation of Cancer Cells Using Folate-Coated Gold/ Graphene Oxide Composite.

    abstract:OBJECTIVE:A new tumor targeted polymer-coated gold/graphene hybrid has been developed for achieving simultaneously thermoablation and chemoterapy of folate receptor-positive cancer cells. METHODS:The gold/graphene hybrid was prepared by depositing gold nanospheres onto graphene oxide and coating it with an inulin-fola...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201813666160520113804

    authors: Mauro N,Volsi AL,Scialabba C,Licciardi M,Cavallaro G,Giammona G

    更新日期:2017-01-01 00:00:00

  • Preparation and evaluation of isosorbide mononitrate hydrogels for topical fissure treatment.

    abstract::The aim of the present study was to prepare and evaluate hydrogels containing 0.1% isosorbide mononitrate (ISMN) for topical treatment of anal fissure. The hydrogels were prepared on the base of Carbopol 940, Poloxamer 407 or their combination. The highest viscosity and significant thyxotropy were observed for the com...

    journal_title:Current drug delivery

    pub_type: 杂志文章,随机对照试验

    doi:10.2174/156720112802650635

    authors: Yoncheva K,Doytchinova I,Tankova L

    更新日期:2012-09-01 00:00:00

  • Doxorubicin-Loaded Micelle Targeting MUC1: A Potential Therapeutic for MUC1 Triple Negative Breast Cancer Treatment.

    abstract:BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeu...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201814666170712122508

    authors: Khondee S,Chittasupho C,Tima S,Anuchapreeda S

    更新日期:2018-01-01 00:00:00

  • Production and Characterization of Nanoparticle Based Hyaluronate Gel Containing Retinyl Palmitate for Wound Healing.

    abstract:BACKGROUND:Wound healing is a biological process that can get in a state of pathologic inflammation, requiring the use of specific medications able to promote proper tissue repair. OBJECTIVE:The study describes the production and characterization of nanoparticle based gel for wound healing treatment designed to delive...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201815666180518123926

    authors: Esposito E,Pecorelli A,Sguizzato M,Drechsler M,Mariani P,Carducci F,Cervellati F,Nastruzzi C,Cortesi R,Valacchi G

    更新日期:2018-01-01 00:00:00

  • Killing Rates of Caspofungin in 50 Percent Serum Correlate with Caspofungin Efficacy Against Candida albicans in a Neutropenic Murine Model.

    abstract::Previous studies suggested that caspofungin dose escalation against Candida species is more beneficial than currently used lower daily doses. Thus, we determined in vitro and in vivo activity of caspofungin against six wild-type C. albicans clinical isolates, the ATCC 10231 strain and an echinocandin resistant strain....

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201812666150623091336

    authors: Domán M,Kovács R,Kardos G,Gesztelyi R,Juhász B,Bozó A,Kardos T,Saleh Q,Majoros L

    更新日期:2016-01-01 00:00:00

  • Sterically stabilized polyionic complex nanogels of chitosan lysate and PEG-b-polyglutamic acid copolymer for delivery of irinotecan active metabolite (SN-38).

    abstract:BACKGROUND:Polyionic Complex (PIC) nanogels are promising delivery systems with numerous attractions such as simple, fast, and organic solvent-free particle formation and mild drug loading conditions. Among polyelectrolytes, poly (L-amino acid) copolymers such as poly (ethylene glycol)-block-poly (L-glutamic acid) copo...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201817999201103195846

    authors: Salmanpour M,Saeed-Vaghefi M,Abolmaali SS,Tamaddon A

    更新日期:2020-11-03 00:00:00

  • Drug eluting coronary artery stents.

    abstract::Atherosclerosis is the primary cause of coronary heart disease, which is characterized by a narrowing (stenosis) of the arteries that supply blood to tissues of the heart. Over the past decade, the use of "Bare metallic stents" during Percutaneous Transluminal Coronary Angioplasty (PTCA) has become a common practice f...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/156720110793566281

    authors: Hirlekar R,Patel M,Jain S,Kadam V

    更新日期:2010-12-01 00:00:00

  • Advanced Drug Delivery Systems for Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs: A Review.

    abstract:BACKGROUND:Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption, and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). Transdermal route is also beneficial for dru...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201815666180605114131

    authors: Kumar L,Verma S,Singh M,Chalotra T,Utreja P

    更新日期:2018-01-01 00:00:00

  • Influence of drug incorporation, temperature and storage time on the pH, textural and rheological properties of different poloxamer hydrogels.

    abstract::In recent years, Poloxamers had attracted a particular interest in the design of dermal and transdermal delivery systems in order to improve or retard drug permeation through the skin. In the present study, the influence of different parameters, such as, temperature, storage time, type of polymer (Lutrol(®) F-127 and ...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/15672018113109990056

    authors: Almeida H,Amaral MH,Lobão P,Lobo JM

    更新日期:2013-12-01 00:00:00

  • Simultaneous Bilateral Basal Ganglia Hemorrhage.

    abstract:BACKGROUND:The basal ganglia, an important functional integrity of the brain, comprises multiple subcortical nuclei. The area is mainly supplied by the perforating branches of ipsilateral middle cerebral artery (MCA). The unilateral non-traumatic basal ganglia hemorrhage, commonly located in the putamen, most often res...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201813666160607202811

    authors: Yang Z,Chen J,Mu J

    更新日期:2017-09-06 00:00:00

  • Polylactide-co-glycolide microparticles with surface adsorbed antigens as vaccine delivery systems.

    abstract::Several groups have shown that vaccine antigens can be encapsulated within polymeric microparticles and can serve as potent antigen delivery systems. We have recently shown that an alternative approach involving charged polylactide co-glycolide (PLG) microparticles with surface adsorbed antigen(s) can also be used to ...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/156720106775197565

    authors: Singh M,Kazzaz J,Ugozzoli M,Malyala P,Chesko J,O'Hagan DT

    更新日期:2006-01-01 00:00:00

  • Design and Development of Novel Transdermal Nanoemulgel for Alzheimer's Disease: Pharmacokinetic, Pharmacodynamic and Biochemical Investigations.

    abstract:BACKGROUND:Alzheimer's disease is a chronic progressive neurodegenerative disorder associated with depletion of acetylcholine. Oral treatment with tacrine hydrochloride; a reversible inhibitor of acetylcholinesterase, finds limited use in Alzheimer's disease due to frequent dosing, hepatotoxicity and extensive pre-syst...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201816666191022105036

    authors: Setya S,Madaan T,Razdan BK,Farswan M,Talegaonkar S

    更新日期:2019-01-01 00:00:00

  • Phospholipid vesicles as carriers in aquaculture: preparation and stability study of thiamine hydrochloride-loaded liposomes.

    abstract::The aim of this work is to study liposomes as carriers of nutrients and therapeutic agents in aquaculture with Venerupis decussatus and Venerupis pullastra larvae. Multilamellar (MLVs) and large unilamellar (LUVs) vesicles were prepared from a commercial mixture of soy phosphatidylcholine, rich in unsaturated and poly...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201043479957

    authors: Lai F,Valenti D,Sinico C,Manconi M,Mendez JB,Fadda AM

    更新日期:2004-04-01 00:00:00

  • Tuberculosis Treated by Multiple Drugs: An Overview.

    abstract:BACKGROUND:Tuberculosis is an infection and caused by gentle growing bacteria. The Internet provides opportunities for people with tuberculosis (TB) to connect with one another to address these challenges. OBJECTIVE:The aim of this paper is to introduce readers to the platforms on which Tuberculosis participants inter...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201814666171120125916

    authors: Singh G,Kesharwani P,Srivastava AK

    更新日期:2018-01-01 00:00:00

  • Cancer targeting potential of folate targeted nanocarrier under comparative influence of tretinoin and dexamethasone.

    abstract::The objective of this investigation was aimed to explore the cancer targeting potential of folate conjugated dendrimer (polypropylene imine, PPI) under strategic influence of folate receptor up-regulators (all trans Retinoic acid, ATRA and Dexamethasone, DEXA). The folate conjugated dendrimer nanoconjugate (FPPI) was ...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201811310040012

    authors: Dhakad RS,Tekade RK,Jain NK

    更新日期:2013-08-01 00:00:00