New Thermoresponsive Eyedrop Formulation Containing Ibuprofen Loaded-Nanostructured Lipid Carriers (NLC): Development, Characterization and Biocompatibility Studies.

Abstract:

:The low bioavailability and consequently the poor therapeutic response of traditional ophthalmic formulations is caused by reduced pre-corneal residence time of the formulation in contact with the ocular surface. The use of colloidal carrier systems, namely lipid nanoparticles in combination with in situ gelling polymers, is an excellent strategy which results in the exponential increase of the bioavailability of ophthalmic drugs. In the present study, we have developed thermoresponsive eyedrops prepared with nanostructured lipid carriers (NLC) dispersions for the controlled delivery of ibuprofen. Lipid solubility studies and DSC measurements have proved that the lipids solubilise ibuprofen and present a good compatibility. NLC were prepared based on the melt-emulsification and ultrasonication technique and lipid nanoparticles with a Z-average of 120-150 nm, polydispersity index below 0.3, highly positive zeta potential and an efficacy of encapsulation of ~87% were obtained. The cytotoxicity of NLC was evaluated by the Alamar Blue reduction assay using the Y-79 human retinoblastoma cell line, and no relevant toxicity was observed after exposure to 0-100 μg/mL NLC for up to 72 hours. The HET-CAM assay was used to assess the product eye compatibility, confirming that the developed product does not exhibit irritant potential. The in vitro release studies showed ibuprofen release over several hours.

journal_name

Curr Drug Deliv

journal_title

Current drug delivery

authors

Almeida H,Lobão P,Frigerio C,Fonseca J,Silva R,Palmeira-de-Oliveira A,Lobo JM,Amaral MH

doi

10.2174/1567201813666151111143434

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

953-70

issue

6

eissn

1567-2018

issn

1875-5704

pii

CDD-EPUB-71329

journal_volume

13

pub_type

杂志文章
  • Local delivery of therapeutics for percutaneous coronary intervention.

    abstract::Percutaneous coronary intervention (PCI) has become a highly effective alternative for the treatment of coronary artery disease. The use of stents has reduced the rates of restenosis by preventing elastic recoil and negative remodeling, however neointima formation still remains an issue. Local drug delivery is an attr...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/156720111796642282

    authors: Kennedy KL,Lucas AR,Wan W

    更新日期:2011-09-01 00:00:00

  • Insights on the Use of Nanocarriers for Acne Alleviation.

    abstract::Among the common myths in the cosmetics industry is the perception that acne only happens to teenagers, and specifically to females. However, acne is neither limited to a specific age, nor to a certain gender, it creates a stressful problem for many people. Many chemical treatments for acne were proven to be successfu...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201815666180913144145

    authors: Amer SS,Nasr M,Mamdouh W,Sammour O

    更新日期:2019-01-01 00:00:00

  • A Microstructural Study of the O/W Primary Emulsion on the Formation of Oil-in-Water-in-Oil Multiple Emulsion.

    abstract:AIM:This study aimed to investigate the influence of the preparation process and composition on the microstructure of the O/W primary emulsions and the corresponding impact on the formation of oil-in-water-in-oil (O/W/O) multiple emulsions. OBJECTIVES:Multiple emulsions were prepared by a two-step emulsification metho...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201818666210101114517

    authors: Zhang Q,Qin Y,Duan G,Ou W,Wang Y,Zhang W

    更新日期:2020-12-31 00:00:00

  • Phospholipid vesicles as carriers in aquaculture: preparation and stability study of thiamine hydrochloride-loaded liposomes.

    abstract::The aim of this work is to study liposomes as carriers of nutrients and therapeutic agents in aquaculture with Venerupis decussatus and Venerupis pullastra larvae. Multilamellar (MLVs) and large unilamellar (LUVs) vesicles were prepared from a commercial mixture of soy phosphatidylcholine, rich in unsaturated and poly...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201043479957

    authors: Lai F,Valenti D,Sinico C,Manconi M,Mendez JB,Fadda AM

    更新日期:2004-04-01 00:00:00

  • Ligand-targeted liposomes for cancer treatment.

    abstract::Selective targeting of ligand-targeted liposomes containing anticancer drugs or therapeutic genes to cell surface receptors expressed on cancer cells is a recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics or gene therapeutics. Some recent advances in the field of ligand-...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/156720105774370159

    authors: Sapra P,Tyagi P,Allen TM

    更新日期:2005-10-01 00:00:00

  • A review on exploring better safety prospects in managing cancer using liposomal combinations of food bioactive compounds and anticancer drugs: Combisomes.

    abstract::Nowadays, cancer is one of the deadliest diseases affecting an annually enormous number of people. Around 9.6 million people had died from different cancer types in 2018. Chemotherapy is considered to be a mainline treatment, and systemic administration of a single anticancer agent is also considered as vital clinical...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201818999210120203904

    authors: Dubey A,Shriram RG,El-Zahaby SA

    更新日期:2021-01-20 00:00:00

  • Microwave assisted synthesis and evaluation of modified pea starch as tablet superdisintegrant.

    abstract::In the present study, cross linked sodium carboxymethylated pea starch (SCPS) was synthesized and evaluated as tablet superdisintegrant in diclofenac sodium based tablets. SCPS was synthesized using native pea starch with monochloroacetic acid and NaOH in microwave radiation environment. Finally the dried product was ...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/156720111794479853

    authors: Singh AV,Singh A,Nath LK

    更新日期:2011-03-01 00:00:00

  • Overcoming the Challenges of siRNA Delivery: Nanoparticle Strategies.

    abstract:BACKGROUND:Despite therapeutics based on siRNA have an immense potential for the treatment of incurable diseases such as cancers. However, the in vivo utilization of siRNA and also the delivery of this agent to the target site is one of the most controversial challenges. The helpful assistance by nanoparticles can impr...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201813666160816105408

    authors: Shajari N,Mansoori B,Davudian S,Mohammadi A,Baradaran B

    更新日期:2017-01-01 00:00:00

  • Liposomal drug delivery systems: an update review.

    abstract::The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of potent drug to improve therapeutics. Recently the liposome formulations are targeted to reduce toxicity and increase accumulation ...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/156720107782151269

    authors: Samad A,Sultana Y,Aqil M

    更新日期:2007-10-01 00:00:00

  • Chitosan and gelatin based prototype delivery systems for the treatment of oral mucositis: from material to performance in vitro.

    abstract::In this study we developed and evaluated a prototype of an effective occlusive mucoadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and gelatine models together with nystatin as a prophylactic agent incorporated into the formulation and investigated drug release in-vitro. Results of...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201811310010020

    authors: Perchyonok VT,Zhang S,Oberholzer T

    更新日期:2013-02-01 00:00:00

  • Direct compression high functionality excipient using coprocessing technique: a brief review.

    abstract::Tablets are still the most commonly used dosage form because of the ease of manufacturing, convenience in administration, accurate dosing and excellent stability. Direct compression is the preferred method for the preparation of tablets. However, it has been estimated that less than 20 percent of the active pharmaceut...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/156720111795767960

    authors: Mirani AG,Patankar SP,Borole VS,Pawar AS,Kadam VJ

    更新日期:2011-07-01 00:00:00

  • Confectionery-based dose forms.

    abstract::Conventional dosage forms such as tablets, capsules and syrups are prescribed in the normal course of practice. However, concerns about patient preferences and market demands have given rise to the exploration of novel unconventional dosage forms. Among these, confectionery-based dose forms have strong potential to ov...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201811666140821112637

    authors: Tangso KJ,Ho QP,Boyd BJ

    更新日期:2015-01-01 00:00:00

  • The Updated Role of Oxidative Stress in Subarachnoid Hemorrhage.

    abstract:BACKGROUND:Subarachnoid hemorrhage (SAH) is considered as a violent disease with high rate of morbidity and mortality. Early brain injury (EBI) and delayed vasospasm are the two aspects of this disease that are becoming research hotspots. OBJECTIVE:We aim to update the role of oxidative stress in the development of EB...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201813666161025115531

    authors: Yang Y,Chen S,Zhang JM

    更新日期:2017-09-06 00:00:00

  • The Anticancer Activity of Complex [Cu2(μ-(C6H5)2CHCOO)3(bipy)2)] (ClO4) -Solid Lipid Nanoparticles on MCF-7 Cells.

    abstract::Recent studies have focused on the potential use of metal-based complexes for the treatment of cancer. However, there are some limitations of metal-based ligands for the treatment of cancer due to their toxic effects. In the present study, a novel bimetallic Cu(II) complex, [Cu2(μ-(C6H5)2CHCOO)3 (bipy)2)](ClO4), has f...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201813666160111123739

    authors: Kani I,Dikmen G,Eskiler GG,Cecener G,Tunca B,Egeli U

    更新日期:2016-01-01 00:00:00

  • Influence of drug incorporation, temperature and storage time on the pH, textural and rheological properties of different poloxamer hydrogels.

    abstract::In recent years, Poloxamers had attracted a particular interest in the design of dermal and transdermal delivery systems in order to improve or retard drug permeation through the skin. In the present study, the influence of different parameters, such as, temperature, storage time, type of polymer (Lutrol(®) F-127 and ...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/15672018113109990056

    authors: Almeida H,Amaral MH,Lobão P,Lobo JM

    更新日期:2013-12-01 00:00:00

  • Development and in vitro evaluation of diclofenac sodium loaded mucoadhesive microsphere with natural gum for sustained delivery.

    abstract::The objective of this study was to develop and evaluate mucoadhesive microsphere of diclofenac sodium with natural gums for sustained delivery. Guar gum and tragacanth were used along with sodium alginate as mucoadhesive polymers. Microspheres were formulated using orifice-ionic gelation method. Particle size, surface...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/15672018113109990054

    authors: Amin ML,Jesmeen T,Sutradhar KB,Mannan MA

    更新日期:2013-12-01 00:00:00

  • Carbon Nanotubes: An Emerging Drug Delivery Carrier in Cancer Therapeutics.

    abstract:BACKGROUND:The scope of nanotechnology has been extended to almost every sphere of our daily life. As a result of this, nanocarriers like Carbon Nanotubes (CNTs) are gaining considerable attention for their use in various therapeutic and diagnostic applications. OBJECTIVE:The objective of the current article is to rev...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201817999200508092821

    authors: Panigrahi BK,Nayak AK

    更新日期:2020-01-01 00:00:00

  • Design and Development of Thermoreversible Ophthalmic In Situ Hydrogel of Moxifloxacin HCl.

    abstract::Conventional eye drops show relatively low bioavailability due to poor precorneal contact time. In situ hydrogels are of great importance in providing sustained ocular drug delivery. By exhibiting elastic properties they resist ocular drainage of the drug leading to longer contact times. In the present study an in sit...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/156720110791560928

    authors: Shastri DH,Prajapati ST,Patel LD

    更新日期:2010-07-01 00:00:00

  • Concepts and Strategies for the Site Specific Delivery of Nanocarrier Based Delivery Systems for Treating Hepatocellular Carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environment...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:

    authors: Sharma P,Pandita A,Murthy RS

    更新日期:2013-11-24 00:00:00

  • Realgar Nanoparticles Inhibit Migration, Invasion and Metastasis in a Mouse Model of Breast Cancer by Suppressing Matrix Metalloproteinases and Angiogenesis.

    abstract:BACKGROUND:Realgar, a traditional Chinese medicine, has shown antitumor efficacy in several tumor types. We previously showed that realgar nanoparticles (nano-realgar) had significant antileukemia, anti-lung cancer and anti-liver cancer effects. In addition, the anti-tumor effects of nanorealgar were significantly bett...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201817666200115105633

    authors: Xiaoxia X,Jing S,Dongbin X,Yonggang T,Jingke Z,Yanying Z,Hulai W

    更新日期:2020-01-01 00:00:00

  • Doxorubicin-Loaded Micelle Targeting MUC1: A Potential Therapeutic for MUC1 Triple Negative Breast Cancer Treatment.

    abstract:BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeu...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201814666170712122508

    authors: Khondee S,Chittasupho C,Tima S,Anuchapreeda S

    更新日期:2018-01-01 00:00:00

  • Emerging role of immunoPET in receptor targeted cancer therapy.

    abstract::ImmunoPET is a non-invasive imaging technology based on tracking and quantification of radiolabeled monoclonal antibodies, antibody fragments and peptides in vivo. The knowledge of distribution and expression levels of a given receptor is a key for successful receptor targeted cancer therapy. ImmunoPET performed with ...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/156720111793663589

    authors: Marik J,Junutula JR

    更新日期:2011-01-01 00:00:00

  • Formulation and evaluation of resveratrol loaded cubosomal nanoformulation for topical delivery.

    abstract:AIM:The aim of the study was to formulate, characterize, and evaluate the resveratrol-loaded cubosomes (RC) through topical application. BACKGROUND:Resveratrol (RV) is a nutraceutical compound that has exciting pharmacological potential in different diseases including cancers. Many studies of resveratrol have been rep...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201817666200902150646

    authors: Kurangi B,Jalalpure S,Jagwani S

    更新日期:2020-09-02 00:00:00

  • Topical delivery of antioxidants.

    abstract::Reactive oxygen species (ROS) and free radicals have been implicated in a number of diseases and disorders, and the skin, for its localization, is exposed to a large number of environmental threats. Free radical scavengers and antioxidants have thus been proposed as protective or therapeutic agents against ROS-mediate...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/156720111797635487

    authors: Ascenso A,Ribeiro HM,Marques HC,Simoes S

    更新日期:2011-11-01 00:00:00

  • Preparation and in vitro in vivo evaluation of aceclofenac loaded alginate microspheres: an investigation of effects of polymer using multiple comparison analysis.

    abstract::The aim of this present research work was to prepare and evaluate alginate microspheres of aceclofenac by ionic gelation method for targeting the drug release in intestinal region and decrease distinct tissue protection in the stomach. This method offers to prepare microspheres which are important in controlling the r...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/156720112802650725

    authors: Khandai M,Chakraborty S,Nayak P,Krishna NB,Chakravarthi G,Acharjya B,Ghosh AK

    更新日期:2012-09-01 00:00:00

  • Gastrointestinal absorption of heparin by lipidization or coadministration with penetration enhancers.

    abstract::A review with 93 references. Heparins are high molecular weight, hydrophilic polyanions, which are unstable under acidic conditions; and therefore they exhibit poor oral bioavailability. Consequently they must be administered via the parenteral route which is expensive, inconvenient, and limits use by outpatients. The...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201054367968

    authors: Ross BP,Toth I

    更新日期:2005-07-01 00:00:00

  • Drug eluting coronary artery stents.

    abstract::Atherosclerosis is the primary cause of coronary heart disease, which is characterized by a narrowing (stenosis) of the arteries that supply blood to tissues of the heart. Over the past decade, the use of "Bare metallic stents" during Percutaneous Transluminal Coronary Angioplasty (PTCA) has become a common practice f...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/156720110793566281

    authors: Hirlekar R,Patel M,Jain S,Kadam V

    更新日期:2010-12-01 00:00:00

  • Nanodiamonds as a new horizon for pharmaceutical and biomedical applications.

    abstract::A palpable need for the optimization of therapeutic agents, due to challenges tackled by them such as poor pharmacokinetics and chemoresistance, has steered the journey towards novel interdisciplinary scientific field for emergence of nanostructure materials as a carrier for targeted delivery of therapeutic agents. Am...

    journal_title:Current drug delivery

    pub_type: 杂志文章,评审

    doi:10.2174/1567201812666141229104304

    authors: Chaudhary HM,Duttagupta AS,Jadhav KR,Chilajwar SV,Kadam VJ

    更新日期:2015-01-01 00:00:00

  • Anti-lung Cancer and Anti-angiogenic Activities of New Designed Boronated Phenylalanine Metal Complexes.

    abstract:BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/1567201815666180727145724

    authors: Varol M,Koparal AT,Benkli K,Bostancioglu RB

    更新日期:2018-01-01 00:00:00

  • A gastroretentive drug delivery system of lisinopril imbibed on isabgol-husk.

    abstract::The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The present study was carried out to develop a gastroretentive drug delivery system using isabgol as an exci...

    journal_title:Current drug delivery

    pub_type: 杂志文章

    doi:10.2174/15672018113106660065

    authors: Semwal R,Semwal RB,Semwal DK

    更新日期:2014-01-01 00:00:00