Abstract:
:Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environmental, dietary and lifestyle of the person. Treatment options depend on the presence or absence of cirrhosis, number and size of tumors, and degree of hepatic deterioration. The primary option for some of the patients include hepatic resectioning, locoregional ablation, liver transplantation, ultrasound-guided tumor injection with absolute ethanol or tumor thermoablation with radiofrequency. Most common drugs like sorafenib, doxorubicin and daunorubicin have been used widely for treatment of HCC. A number of novel formulations like polymeric nanoparticles, nanocapsules, liposomes, nanoemulsions, microsphere, hydrogels, dendrimers, polymeric micelles has been reported for the treatment of HCC. The advantages of novel drug delivery systems (NDDS) is based on the ability to modify the bio-distribution, pharmacokinetics and pharmacological activity, prolonged efficacy and duration of drug activity, improved patient compliance, drug targeting to the site of action, enhancement of solubility, bioavailability, protection from toxicity, enhancement of stability. The carriers for liver specific drug delivery include liver-specific asialoglycoprotein receptor on mammalian hepatocytes. The natural ligand i.e. asialofeutin, or synthetic ligands with galactosylated or lactosylated polymers have been developed for significant targeting to the liver.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Sharma P,Pandita A,Murthy RSsubject
Has Abstractpub_date
2013-11-24 00:00:00eissn
1567-2018issn
1875-5704pii
CDD-EPUB-57608pub_type
杂志文章abstract:BACKGROUND:The basal ganglia, an important functional integrity of the brain, comprises multiple subcortical nuclei. The area is mainly supplied by the perforating branches of ipsilateral middle cerebral artery (MCA). The unilateral non-traumatic basal ganglia hemorrhage, commonly located in the putamen, most often res...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201813666160607202811
更新日期:2017-09-06 00:00:00
abstract::In this study we developed and evaluated a prototype of an effective occlusive mucoadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan and gelatine models together with nystatin as a prophylactic agent incorporated into the formulation and investigated drug release in-vitro. Results of...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201811310010020
更新日期:2013-02-01 00:00:00
abstract::In recent years, Poloxamers had attracted a particular interest in the design of dermal and transdermal delivery systems in order to improve or retard drug permeation through the skin. In the present study, the influence of different parameters, such as, temperature, storage time, type of polymer (Lutrol(®) F-127 and ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/15672018113109990056
更新日期:2013-12-01 00:00:00
abstract::Motivated by the success and exhaustive research on carbon nanotubes (CNTs) based drug delivery, graphene, a two-dimensional; honey-comb crystal lattice has emerged as the rising star in recent years. Graphene is a flat monolayer of carbon atoms that holds many promising properties such as unparalleled thermal conduct...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811666140605151600
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Solid lipid nanoparticles (SLNs) represent an affordable, easily scalable, stable and biocompatible drug delivery system with a high drug to lipid ratio which also improves solubility of poorly soluble drugs. OBJECTIVE:SLNs were developed by using glyceryl monostearate as the single lipid in the presence of...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180503120113
更新日期:2018-01-01 00:00:00
abstract::The aim of this work is to study liposomes as carriers of nutrients and therapeutic agents in aquaculture with Venerupis decussatus and Venerupis pullastra larvae. Multilamellar (MLVs) and large unilamellar (LUVs) vesicles were prepared from a commercial mixture of soy phosphatidylcholine, rich in unsaturated and poly...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201043479957
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:The scope of nanotechnology has been extended to almost every sphere of our daily life. As a result of this, nanocarriers like Carbon Nanotubes (CNTs) are gaining considerable attention for their use in various therapeutic and diagnostic applications. OBJECTIVE:The objective of the current article is to rev...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200508092821
更新日期:2020-01-01 00:00:00
abstract::The objective of this investigation was to prepare mucoadhesive microspheres of ketorolac for nasal delivery to avoid gastrointestinal side effects of conventional dosage form. Mucoadhesive microspheres were prepared using carbopol, polycarbophil and chitosan as polymer by spray drying method. The process and formulat...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720112800234503
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:A ceftiofur hydrochloride long-acting oily suspension with no irritation was prepared by testing and optimizing the types and amounts of organic solvents, suspending agents, and surfactants.
Methods: Its properties, stability, injection site irritation, in vitro release, and pharmacokinetics in pigs were...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200903165119
更新日期:2020-09-03 00:00:00
abstract::The aim of the present study was to prepare and evaluate hydrogels containing 0.1% isosorbide mononitrate (ISMN) for topical treatment of anal fissure. The hydrogels were prepared on the base of Carbopol 940, Poloxamer 407 or their combination. The highest viscosity and significant thyxotropy were observed for the com...
journal_title:Current drug delivery
pub_type: 杂志文章,随机对照试验
doi:10.2174/156720112802650635
更新日期:2012-09-01 00:00:00
abstract::Paclitaxel (taxol, 1a) and docetaxel (taxotere, 1b) have established themselves as an important class of antitumor drugs currently available to the oncologist. While the great contribution of these drugs to the management of the disease and their effect on the improvement of the patient quality of life could not be ov...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720108783331005
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:In this study, central composite factorial design was used for the preparation and optimization of chitosan/Na-alginate hydrogel films containing metformin via solvent evaporation technique. METHODS:Low and high molecular weight (MW) chitosan was used as a polymer in different concentrations while genipin w...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180409102459
更新日期:2018-01-01 00:00:00
abstract::Metformin (MTF) improves hyperglycemia primarily by suppressing glucose production by the liver. The objective of our investigation was to evaluate nanoemulsion as a promising carrier for MTF for sustained hypoglycemic effect. The drug was incorporated into oil phase of nanoemulsion, which finally improved biopharmace...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720181102140411160817
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Betulinic acid (BA) is a lipophilic compound with proven beneficial results in topical inflammation. Nanogels (NG) are carriers of bioactive compounds with properties that make them good candidates to treat skin diseases. OBJECTIVE:The objective of this study was to evaluate the anti-inflammatory activity o...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200817154003
更新日期:2020-08-17 00:00:00
abstract::The aim of this present research work was to prepare and evaluate alginate microspheres of aceclofenac by ionic gelation method for targeting the drug release in intestinal region and decrease distinct tissue protection in the stomach. This method offers to prepare microspheres which are important in controlling the r...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720112802650725
更新日期:2012-09-01 00:00:00
abstract::The placenta has traditionally been considered as a highly permeable organ for a large variety of substances with diverse molecular structures that are readily able to cross it from the maternal blood to reach the foetus. This has recommended limiting the use of drugs during pregnancy as far as possible. However, our ...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201043334731
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180727145724
更新日期:2018-01-01 00:00:00
abstract::Atherosclerosis is the primary cause of coronary heart disease, which is characterized by a narrowing (stenosis) of the arteries that supply blood to tissues of the heart. Over the past decade, the use of "Bare metallic stents" during Percutaneous Transluminal Coronary Angioplasty (PTCA) has become a common practice f...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720110793566281
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:Present investigation was aimed to fabricate nanocrystal of exemestane, an anticancer drug with poor dissolution properties and oral bioavailability. METHODS:Influence of various process parameters on the formulation of exemestane nanosuspension using media milling technique were investigated in the trial batc...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201818999210112190716
更新日期:2021-01-12 00:00:00
abstract:BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeu...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201814666170712122508
更新日期:2018-01-01 00:00:00
abstract::Camptothecins are a family of alkaloids originally extracted from the Chinese tree Camptotheca acuminata, Nyssaceae, exhibiting a strong activity against colorectal cancer (CRC). CRC is a common malignancy worlwide. Despite significant developments in the treatment of this disease, it still causes considerable morbidi...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720112800234558
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Gemcitabine (GEM) is found effective in the treatment of many solid tumors. However, its use is restricted due to its small circulation half-life, fast metabolism and low capacity for selective tumor uptake. Folate receptors (FRs) have been recognized as cellular surface markers, which can be used for cancer...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666181024112252
更新日期:2019-01-01 00:00:00
abstract::Medicated foams and film forming systems are dosage forms formulated to undergo a controlled metamorphosis when applied on the skin. Indeed, due to the presence of propellant or a particular air-spray foam pump, a liquid can generate foam when applied on the stratum corneum, or a liquid or conventional dosage form can...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201816666190118124439
更新日期:2019-01-01 00:00:00
abstract::The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of potent drug to improve therapeutics. Recently the liposome formulations are targeted to reduce toxicity and increase accumulation ...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720107782151269
更新日期:2007-10-01 00:00:00
abstract::The most common feature for antigen-delivery systems is their particulate nature. Together with a certain depot effect, it is the particulate nature that primarily dictates whether the antigen-delivery system will be successful in inducing a certain type and strength of immune response. In this article, we will summar...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720106778559029
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Tuberculosis is an infection and caused by gentle growing bacteria. The Internet provides opportunities for people with tuberculosis (TB) to connect with one another to address these challenges. OBJECTIVE:The aim of this paper is to introduce readers to the platforms on which Tuberculosis participants inter...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201814666171120125916
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:A new tumor targeted polymer-coated gold/graphene hybrid has been developed for achieving simultaneously thermoablation and chemoterapy of folate receptor-positive cancer cells. METHODS:The gold/graphene hybrid was prepared by depositing gold nanospheres onto graphene oxide and coating it with an inulin-fola...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160520113804
更新日期:2017-01-01 00:00:00
abstract::The aim of the present work is the development and evaluation of solid lipid nanoparticles (SLNs) as carrier system for topical delivery of benzocaine (BZC) improving its local anesthesia aiming to produce a fast acting and long lasting topical formulation. BZC loaded SLNs were prepared using a full factorial design t...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201812666150703115126
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Cabazitaxel (CBZ) is a new taxane approved by FDA for treatment of castration- resistant prostate cancer not responding to docetaxel. However, CBZ is not a suitable substrate for p-glycoprotein 60, an efflux pump which transports anticancer drugs out of malignant cells and is therefore a promising drug for t...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201814666161122150302
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Amphotericin B eye drops are widely used in the treatment of ocular infections. However, amphotericin's toxicity leads to low patient compliance and aggravation of symptoms. This work describes the development of a microemulsion system containing amphotericin B, aiming for its use in ocular applications. ME...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1570159x14666151109110734
更新日期:2016-01-01 00:00:00