Abstract:
:Medicated foams and film forming systems are dosage forms formulated to undergo a controlled metamorphosis when applied on the skin. Indeed, due to the presence of propellant or a particular air-spray foam pump, a liquid can generate foam when applied on the stratum corneum, or a liquid or conventional dosage form can form on the skin a continuous film as a consequence of the solvent evaporation. Thanks to these controlled modifications, the drug thermodynamic activity increases favoring the skin penetration and, therefore, the bioavailability with respect to conventional semi-solid and liquid dosage forms. Furthermore, the available clinical data also evidence that these dosage forms improve the patient's compliance. The main formulative aspects of medicated foams and film forming systems are reviewed with the aim to underline the possible advantages in terms of biopharmaceutical performances and patient's adherence.
journal_name
Curr Drug Delivjournal_title
Current drug deliveryauthors
Gennari CGM,Selmin F,Minghetti P,Cilurzo Fdoi
10.2174/1567201816666190118124439subject
Has Abstractpub_date
2019-01-01 00:00:00pages
461-471issue
5eissn
1567-2018issn
1875-5704pii
CDD-EPUB-95897journal_volume
16pub_type
杂志文章,评审abstract::Reactive oxygen species (ROS) and free radicals have been implicated in a number of diseases and disorders, and the skin, for its localization, is exposed to a large number of environmental threats. Free radical scavengers and antioxidants have thus been proposed as protective or therapeutic agents against ROS-mediate...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720111797635487
更新日期:2011-11-01 00:00:00
abstract::The research presented in this paper discusses the potential of iontophoresis facilitated transdermal delivery of glycine. Iontophoresis has been widely investigated as a noninvasive transdermal drug delivery system. Iontophoresis is the use of a low electric current to carry ionized as well as unionized drug molecule...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720109787846207
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Essential oils are poor aqueous solubility and high volatility compounds. The encapsulation of essential oils with cyclodextrins (CDs) can protect them from the adverse environmental conditions and improve their stability. Therefore, increasing the functional capabilities of essential oils when they were use...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200731164902
更新日期:2020-07-31 00:00:00
abstract::The use of nanoparticles as platforms or vehicles for applications in nanomedicine, such as drug delivery and medical imaging, has been widely reported in the literature. A key area of potential improvement in the development and implementation of nanoparticles is the design of surface treatments to maximize residence...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720111795256165
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to design an efficient delivery system with an anticipated swelling and drug release properties for a prolonged drug release as well as to target colon for various hydrophilic drugs. METHOD:For this purpose, the pH-responsive hydrogel comprising a combination of Eudragit and ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201816666190208165511
更新日期:2019-01-01 00:00:00
abstract::The use of different drug classes as host modulating agents has been postulated to have significance as an adjunctive remedy curing chronic periodontitis. In this study nano-structured films containing doxycyclin (DOX) were evaluated for such purpose. Nano DOX/chitosan particulate system was prepared using spray dryin...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666151113122752
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:The main objective of this novel study was to develop midazolam hydrochloride fast dissolving oral films (FDFs) using solvent casting method and to evaluate the characteristics of the optimum formulation through in vitro and in vivo analysis. The FDFs are new favorable solid dosage forms that deliver drugs r...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180723115600
更新日期:2018-01-01 00:00:00
abstract::Motivated by the success and exhaustive research on carbon nanotubes (CNTs) based drug delivery, graphene, a two-dimensional; honey-comb crystal lattice has emerged as the rising star in recent years. Graphene is a flat monolayer of carbon atoms that holds many promising properties such as unparalleled thermal conduct...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201811666140605151600
更新日期:2014-01-01 00:00:00
abstract::Tablets are still the most commonly used dosage form because of the ease of manufacturing, convenience in administration, accurate dosing and excellent stability. Direct compression is the preferred method for the preparation of tablets. However, it has been estimated that less than 20 percent of the active pharmaceut...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720111795767960
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Atenolol has been used to treat angina and hypertension, either alone or with other antihypertensives. Despite its usefulness, it shows some side effects such as diarrhea and nausea in some patients. A method for slow release of atenolol in intestine is helpful to prevent such side effects. METHODS:A facile...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666160321115543
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Present investigation was aimed to fabricate nanocrystal of exemestane, an anticancer drug with poor dissolution properties and oral bioavailability. METHODS:Influence of various process parameters on the formulation of exemestane nanosuspension using media milling technique were investigated in the trial batc...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201818999210112190716
更新日期:2021-01-12 00:00:00
abstract::The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The present study was carried out to develop a gastroretentive drug delivery system using isabgol as an exci...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/15672018113106660065
更新日期:2014-01-01 00:00:00
abstract::The objective of this study was to develop and evaluate mucoadhesive microsphere of diclofenac sodium with natural gums for sustained delivery. Guar gum and tragacanth were used along with sodium alginate as mucoadhesive polymers. Microspheres were formulated using orifice-ionic gelation method. Particle size, surface...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/15672018113109990054
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The scope of nanotechnology has been extended to almost every sphere of our daily life. As a result of this, nanocarriers like Carbon Nanotubes (CNTs) are gaining considerable attention for their use in various therapeutic and diagnostic applications. OBJECTIVE:The objective of the current article is to rev...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200508092821
更新日期:2020-01-01 00:00:00
abstract::Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulos...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201812666150310151657
更新日期:2015-01-01 00:00:00
abstract::Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validate...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201812666150130161736
更新日期:2015-01-01 00:00:00
abstract::Methylene blue (MB) has been shown to slow down the progression of the Alzheimer's disease (AD) and other tauopathies; however distribution of MB into the brain is limited due its high hydrophilicity. In this study, we aimed to prepare novel hydrophobic glutathione coated PLGA nanoparticles to improve bioavailability ...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201810666131113102037
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Betulinic acid (BA) is a lipophilic compound with proven beneficial results in topical inflammation. Nanogels (NG) are carriers of bioactive compounds with properties that make them good candidates to treat skin diseases. OBJECTIVE:The objective of this study was to evaluate the anti-inflammatory activity o...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999200817154003
更新日期:2020-08-17 00:00:00
abstract::Cutaneous gene therapy and DNA vaccination are potential applications of plasmid delivery methods where a gene for an antigen or a therapeutic protein is inserted in the plasmid and applied to the skin. However, the delivery of the DNA plasmid is a major challenge due to the unusual physicochemical properties of the D...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720106775197493
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Realgar, a traditional Chinese medicine, has shown antitumor efficacy in several tumor types. We previously showed that realgar nanoparticles (nano-realgar) had significant antileukemia, anti-lung cancer and anti-liver cancer effects. In addition, the anti-tumor effects of nanorealgar were significantly bett...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817666200115105633
更新日期:2020-01-01 00:00:00
abstract::Selective targeting of ligand-targeted liposomes containing anticancer drugs or therapeutic genes to cell surface receptors expressed on cancer cells is a recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics or gene therapeutics. Some recent advances in the field of ligand-...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/156720105774370159
更新日期:2005-10-01 00:00:00
abstract::Phase-sensitive in situ gel forming controlled release formulations of cyclosporine were prepared using poly (lactide-co-glycolide) and a solvent system consisting of various proportions of benzyl benzoate and benzyl alcohol. Uniformity of content of cyclosporine in the formulation and in vitro release samples was det...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720109789941669
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:PnPP-19 is a 19-amino-acid synthetic peptide previously described as a novel drug for the treatment of erectile dysfunction. OBJECTIVE:The aim of this work was to evaluate the physicochemical properties of cationic transfersomes containing PnPP-19 and the skin permeation of free PnPP-19 and PnPP-19-loaded t...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201815666180108170206
更新日期:2018-01-01 00:00:00
abstract::The objective of this study was to investigate the influence of drug type on the release of drug from PEO matrix tablets accompanied with the impact of vitamin E succinate as antioxidant. The result showed that the presence of vitamin E promoted a stable release rate of soluble drug propranolol HCl from aged PEO matri...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201812666150326113052
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Polyionic Complex (PIC) nanogels are promising delivery systems with numerous attractions such as simple, fast, and organic solvent-free particle formation and mild drug loading conditions. Among polyelectrolytes, poly (L-amino acid) copolymers such as poly (ethylene glycol)-block-poly (L-glutamic acid) copo...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201817999201103195846
更新日期:2020-11-03 00:00:00
abstract::Curcumin as an antioxidative agent which has been widely used medicinally in India and China. However, rapid metabolism coupled with the instability of curcumin under physiological conditions has greatly limited its applications in vivo. In the present study, a thermosensitive hydrogel with high payload of curcumin wa...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201813666151109102532
更新日期:2016-01-01 00:00:00
abstract::Biphenyl Dimethyl Dicarboxylate (BDD) is insoluble in aqueous solution and the bioavailability after oral administration is low. Self-nanoemulsifying drug delivery system (SNEDDS) containing BDD has been successfully prepared using carefully selected ingredients which are less affected by pH and ionic strength changes...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720108784911695
更新日期:2008-07-01 00:00:00
abstract::The placenta has traditionally been considered as a highly permeable organ for a large variety of substances with diverse molecular structures that are readily able to cross it from the maternal blood to reach the foetus. This has recommended limiting the use of drugs during pregnancy as far as possible. However, our ...
journal_title:Current drug delivery
pub_type: 杂志文章,评审
doi:10.2174/1567201043334731
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Levofloxacin is a potent antibiotic with severe side effects due to its high doses. Bacterial resistance may be due to frequent use of antibiotics. Biogenic gold nanoparticles conjugated levofloxacin (Au-HSA-LvN-NPs) were developed by Human Serum Albumin (HSA) and nitrate reductasemediated pathways. METHODS...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/1567201814666170316113432
更新日期:2017-01-01 00:00:00
abstract::The objective of this work was to investigate the main theological features of vaginal hydrophilic polymer gels and to elucidate about the relationship between these characteristics and gels composition, and their general influence in therapeutic/usage purpose. Flow and dynamic oscillatory properties of four commercia...
journal_title:Current drug delivery
pub_type: 杂志文章
doi:10.2174/156720109787048294
更新日期:2009-01-01 00:00:00