The Anticancer Activity of Complex [Cu2(μ-(C6H5)2CHCOO)3(bipy)2)] (ClO4) -Solid Lipid Nanoparticles on MCF-7 Cells.

abstract：BACKGROUND:Levofloxacin is a potent antibiotic with severe side effects due to its high doses. Bacterial resistance may be due to frequent use of antibiotics. Biogenic gold nanoparticles conjugated levofloxacin (Au-HSA-LvN-NPs) were developed by Human Serum Albumin (HSA) and nitrate reductasemediated pathways. METHODS...

journal_title：Current drug delivery

authors： Bagga P,Siddiqui HH,Akhtar J,Mahmood T,Zahera M,Khan MS

更新日期：2017-01-01 00:00:00

abstract：:A palpable need for the optimization of therapeutic agents, due to challenges tackled by them such as poor pharmacokinetics and chemoresistance, has steered the journey towards novel interdisciplinary scientific field for emergence of nanostructure materials as a carrier for targeted delivery of therapeutic agents. Am...

journal_title：Current drug delivery

authors： Chaudhary HM,Duttagupta AS,Jadhav KR,Chilajwar SV,Kadam VJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Mesoporous bioactive glass (MBG) has been widely studied because of its excellent histocompatibility and degradability. However, due to the lack of good osteoinductive activity, the pure MBG scaffold is not effective in repairing large-scale bone defects. OBJECTIVE:To observe the repair effect of MBG scaffo...

journal_title：Current drug delivery

authors： Wu L,Wei Z,He S,Bi Y,Cao Y,Wang W

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:The management of TB is difficult due to the resistance developed by Mycobacterium tuberculosis against anti-tubercular drugs causes the new challenges for treating and managing the disease. OBJECTIVE:The objective of the study was to combat multiple drug resistance (MDR) exhibited by mycobacterium species ...

journal_title：Current drug delivery

authors： Moin A,Raizaday A,Hussain T,Nagshubha B

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Fluoroquinolones, the synthetic antibacterial agents are being successfully utilized against bacterial infections, since the time immemorial. Despite of enormous useful features, these drugs are associated with some limitations also. Large number of efforts has been made by various scientists to improve phar...

journal_title：Current drug delivery

authors： Sharma PC,Piplani M,Rajak H

更新日期：2018-02-14 00:00:00

abstract：:Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an e...

journal_title：Current drug delivery

authors： Mishra N,Singh D,Sharma S,Baldi A

更新日期：2014-01-01 00:00:00

abstract：:Metformin (MTF) improves hyperglycemia primarily by suppressing glucose production by the liver. The objective of our investigation was to evaluate nanoemulsion as a promising carrier for MTF for sustained hypoglycemic effect. The drug was incorporated into oil phase of nanoemulsion, which finally improved biopharmace...

journal_title：Current drug delivery

authors： Akhtar J,Siddiqui HH,Badruddeen,Fareed S,Aqil M

更新日期：2014-01-01 00:00:00

abstract：:A review with 93 references. Heparins are high molecular weight, hydrophilic polyanions, which are unstable under acidic conditions; and therefore they exhibit poor oral bioavailability. Consequently they must be administered via the parenteral route which is expensive, inconvenient, and limits use by outpatients. The...

journal_title：Current drug delivery

authors： Ross BP,Toth I

更新日期：2005-07-01 00:00:00

abstract：AIM:The aim of the study was to formulate, characterize, and evaluate the resveratrol-loaded cubosomes (RC) through topical application. BACKGROUND:Resveratrol (RV) is a nutraceutical compound that has exciting pharmacological potential in different diseases including cancers. Many studies of resveratrol have been rep...

journal_title：Current drug delivery

authors： Kurangi B,Jalalpure S,Jagwani S

更新日期：2020-09-02 00:00:00

abstract：BACKGROUND:Amphotericin B eye drops are widely used in the treatment of ocular infections. However, amphotericin's toxicity leads to low patient compliance and aggravation of symptoms. This work describes the development of a microemulsion system containing amphotericin B, aiming for its use in ocular applications. ME...

journal_title：Current drug delivery

authors： da Silveira WL,Damasceno BP,Ferreira LF,Ribeiro IL,Silva KS,Silva AL,Giannini MJ,da Silva-Júnior AA,de Oliveira AG,do Egito ES

更新日期：2016-01-01 00:00:00

abstract：:Alternative formulations of paclitaxel were developed in order to improve its aqueous solubility, and characterized in vitro. A methacrylic acid based nanoconjugate of paclitaxel was synthesized by a simple esterification reaction with molecular weight of 1657 Da. The in vitro hydrolysis study on the prodrug of paclit...

journal_title：Current drug delivery

authors： Dhanikula AB,Panchagnula R

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Chrysin is a strong inhibitor of breast cancer resistance protein (BCRP) but it is practically insoluble in water. Effective solubilization of chrysin is critical for its pharmaceutical application as an absorption enhancer via inhibition of BCRP-mediated drug efflux. OBJECTIVE:This study aimed to develop a...

journal_title：Current drug delivery

authors： Lee SH,Lee YS,Song JG,Han HK

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the longterm side effects. OBJECTIVE:A series of mononuclear gold (III) and platinum (II) complexes based on 4-dihydroxyboryl- DL-phenylala...

journal_title：Current drug delivery

authors： Varol M,Koparal AT,Benkli K,Bostancioglu RB

更新日期：2018-01-01 00:00:00

abstract：:Nowadays, cancer is one of the deadliest diseases affecting an annually enormous number of people. Around 9.6 million people had died from different cancer types in 2018. Chemotherapy is considered to be a mainline treatment, and systemic administration of a single anticancer agent is also considered as vital clinical...

journal_title：Current drug delivery

authors： Dubey A,Shriram RG,El-Zahaby SA

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:Osteoporosis is a disease characterized by progressive bone loss due to aging and menopause in women leading to bone fragility with increased susceptibility towards fractures. The silent disease weakens the bone by altering its microstructure and mass. Therapy is based on either promoting strength (via osteo...

journal_title：Current drug delivery

authors： Gera S,Sampathi S,Dodoala S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeu...

journal_title：Current drug delivery

authors： Khondee S,Chittasupho C,Tima S,Anuchapreeda S

更新日期：2018-01-01 00:00:00

abstract：:Cutaneous gene therapy and DNA vaccination are potential applications of plasmid delivery methods where a gene for an antigen or a therapeutic protein is inserted in the plasmid and applied to the skin. However, the delivery of the DNA plasmid is a major challenge due to the unusual physicochemical properties of the D...

journal_title：Current drug delivery

authors： Foldvari M,Babiuk S,Badea I

更新日期：2006-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is most common lethal malignancy worldwide. About 80% of liver cancer cases are attributed to the combined effects of Hepatitis B and C virus infections. The factors affecting development of HCC include cirrhosis and histological markers of increased liver cell proliferation, environment...

journal_title：Current drug delivery

authors： Sharma P,Pandita A,Murthy RS

更新日期：2013-11-24 00:00:00

abstract：:The objective of the present study was to fabricate and evaluate a multiparticulate oral gastroretentive dosage form of baclofen characterized by a central large cavity (hollow core) promoting unmitigated floatation with practical applications to alleviate the signs and symptoms of spasticity and muscular rigidity. So...

journal_title：Current drug delivery

authors： Dube TS,Ranpise NS,Ranade AN

更新日期：2014-01-01 00:00:00

abstract：:ImmunoPET is a non-invasive imaging technology based on tracking and quantification of radiolabeled monoclonal antibodies, antibody fragments and peptides in vivo. The knowledge of distribution and expression levels of a given receptor is a key for successful receptor targeted cancer therapy. ImmunoPET performed with ...

journal_title：Current drug delivery

authors： Marik J,Junutula JR

更新日期：2011-01-01 00:00:00

abstract：AIM:This study aimed to investigate the influence of the preparation process and composition on the microstructure of the O/W primary emulsions and the corresponding impact on the formation of oil-in-water-in-oil (O/W/O) multiple emulsions. OBJECTIVES:Multiple emulsions were prepared by a two-step emulsification metho...

journal_title：Current drug delivery

authors： Zhang Q,Qin Y,Duan G,Ou W,Wang Y,Zhang W

更新日期：2020-12-31 00:00:00

abstract：:Previous studies suggested that caspofungin dose escalation against Candida species is more beneficial than currently used lower daily doses. Thus, we determined in vitro and in vivo activity of caspofungin against six wild-type C. albicans clinical isolates, the ATCC 10231 strain and an echinocandin resistant strain....

journal_title：Current drug delivery

authors： Domán M,Kovács R,Kardos G,Gesztelyi R,Juhász B,Bozó A,Kardos T,Saleh Q,Majoros L

更新日期：2016-01-01 00:00:00

abstract：:Among the common myths in the cosmetics industry is the perception that acne only happens to teenagers, and specifically to females. However, acne is neither limited to a specific age, nor to a certain gender, it creates a stressful problem for many people. Many chemical treatments for acne were proven to be successfu...

journal_title：Current drug delivery

authors： Amer SS,Nasr M,Mamdouh W,Sammour O

更新日期：2019-01-01 00:00:00

abstract：AIM:This study was focused on the formulation of the multi-unit extended-release peroral delivery device of lamotrigine for better management of epilepsy. BACKGROUND:The single-unit extended-release peroral preparations often suffer from all-or-none effect. A significant number of multi-unit delivery systems have been...

journal_title：Current drug delivery

authors： Jain D,Sodani A,Ray S,Ghosh P,Nandi G

更新日期：2020-01-01 00:00:00

abstract：:A number of Polycyclic Aromatic Hydrocarbons (PAHs) have been shown to be toxicants, and induce carcinogenic and immunotoxic effects. Since PAHs are often present in low concentrations and it may be difficult to determine them in complex matrices, it is therefore essential to use powerful analytical tools to separate ...

journal_title：Current drug delivery

authors： Şentürk Z

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Cabazitaxel (CBZ) is a new taxane approved by FDA for treatment of castration- resistant prostate cancer not responding to docetaxel. However, CBZ is not a suitable substrate for p-glycoprotein 60, an efflux pump which transports anticancer drugs out of malignant cells and is therefore a promising drug for t...

journal_title：Current drug delivery

authors： Khoeeniha MK,Esfandyari-Manesh M,Behrouz H,Amini M,Varnamkhasti BS,Atyabi F,Dinarvand R

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:An injectable long acting In-Situ Forming Gel (ISFG) of human Growth Hormone (hGH) was prepared by using triblock PCL-PEG-PCL (Mw 1500-1500-1500). Ring-Opening Polymerization (ROP) of triblock using microwave was applied. METHODS:The BCA protein assay Kit was used to determine the concentration of hGH in the...

journal_title：Current drug delivery

authors： Khodaverdi E,Delroba K,Mohammadpour F,Khameneh B,Sajadi Tabassi SA,Tafaghodi M,Kamali H,Hadizadeh F

更新日期：2020-01-01 00:00:00

abstract：:The objective of this work was to investigate the main theological features of vaginal hydrophilic polymer gels and to elucidate about the relationship between these characteristics and gels composition, and their general influence in therapeutic/usage purpose. Flow and dynamic oscillatory properties of four commercia...

journal_title：Current drug delivery

authors： das Neves J,da Silva MV,Gonçalves MP,Amaral MH,Bahia MF

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:A ceftiofur hydrochloride long-acting oily suspension with no irritation was prepared by testing and optimizing the types and amounts of organic solvents, suspending agents, and surfactants.

Methods: Its properties, stability, injection site irritation, in vitro release, and pharmacokinetics in pigs were...

journal_title：Current drug delivery

authors： Xie S,Zhang X,Luo W,Meng K,Chen D,Pan Y,Tao Y,Huang L,Liu Z,Wang Y,Yuan Z

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate Quality by Design (QbD) principle for the preparation of hydrogel products to prove both practicability and utility of executing QbD concept to hydrogel based controlled release systems. Product and process understanding will help in decreasing the variability of ...

journal_title：Current drug delivery

authors： Dalwadi C,Patel G

更新日期：2016-01-01 00:00:00