Preparation and evaluation of gastroretentive floating tablets of acyclovir.

Abstract:

:The present study performed by preparation and evaluation of floating tablets of Acyclovir as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose K 4M, K 15M, psyllium husk, swelling agent as crospovidone and microcrystalline cellulose and gas generating agent like sodium bicarbonate and citric acid and evaluated for floating properties, swelling characteristics and in vitro drug release studies. Floating noneffervescent tablets were prepared by polypropylene foam powder and different matrix forming polymers like HPMC K 4M, Carbopol 934P, xanthan gum and sodium alginate. In vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was found to follow both the Higuchi and the Korsmeyer and Peppas equation. The drug release mechanism was found fickian type in most of the formulations.

journal_name

Curr Drug Deliv

journal_title

Current drug delivery

authors

Garg R,Gupta GD

doi

10.2174/156720109789941678

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

437-43

issue

5

eissn

1567-2018

issn

1875-5704

pii

CDD-Epub-016

journal_volume

6

pub_type

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