Trichothecene Biosynthesis in Fusarium sporotrichioides: Origin of the Oxygen Atoms of T-2 Toxin.

Abstract:

:Mass spectral analysis of T-2 toxin formed during the growth of Fusarium sporotrichioides (ATCC 24043) in the presence of H(2)O showed incorporation of up to three O atoms per toxin molecule. The carbonyl oxygens of the acetates at C-4 and C-15 and of the isovalerate at C-8 were derived from H(2)O. Toxin formed in the presence of O molecular oxygen incorporated up to six O atoms per toxin molecule. The overall incorporation was 78 and 92% of toxin molecules labeled for H(2)O and O(2) labeled samples, respectively. The oxygens of position 1, the 12,13-epoxide, and the hydroxyl groups at C-3, C-4, C-8, and C-15 were all derived from molecular oxygen.

journal_name

Appl Environ Microbiol

authors

Desjardins AE,Plattner RD,Vanmiddlesworth F

doi

10.1128/AEM.51.3.493-497.1986

keywords:

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

493-7

issue

3

eissn

0099-2240

issn

1098-5336

journal_volume

51

pub_type

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