Inhibitory effect of sterigmatocystin and 5,6-dimethoxysterigmatocystin on ATP synthesis in mitochondria.

Abstract:

:The inhibitory effects of sterigmatocystin, O-methylsterigmatocystin, and 5,6-dimethoxysterigmatocystin on the ATP synthesis system in mitochondria were compared with that of aflatoxin B1, which disturbs the respiratory chain in mitochondria. Sterigmatocystin and 5,6-dimethoxysterigmatocystin were found to uncouple the oxidative phosphorylation process without causing depression of state 3 respiration. O-Methylsterigmatocystin did not exhibit uncoupling activity at the limited concentrations tested (due to its low solubility in an aqueous system). These compounds, as well as aflatoxin B1, elicited neither pseudo-energized nor energized swelling of mitochondria and did not inhibit Ca2+-induced swelling of mitochondria.

journal_name

Appl Environ Microbiol

authors

Kawai K,Nakamaru T,Nozawa Y,Maebayashi Y,Yamazaki M,Natori S

doi

10.1128/AEM.48.5.1001-1003.1984

subject

Has Abstract

pub_date

1984-11-01 00:00:00

pages

1001-3

issue

5

eissn

0099-2240

issn

1098-5336

journal_volume

48

pub_type

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