Molecular analysis of mutations induced in the vermilion gene of Drosophila melanogaster by methyl methanesulfonate.

abstract：:A causal link between deficiency of the cytochrome respiratory pathway and life span was previously shown in the filamentous fungus Podospora anserina. To gain more insight into the relationship between mitochondrial function and life span, we have constructed a strain carrying a thermosensitive mutation of the gene o...

journal_title：Genetics

authors： Sellem CH,Lemaire C,Lorin S,Dujardin G,Sainsard-Chanet A

更新日期：2005-03-01 00:00:00

abstract：:In experiments with directional selection on a quantitative character a "reversed response" to selection is occasionally observed, when selection of individuals for a higher (lower) value of the character results in a lower (higher) value of the character among their offspring. A sudden change in environments or rando...

journal_title：Genetics

authors： Gimelfarb A

更新日期：1986-09-01 00:00:00

abstract：:In hybrids between Drosophila simulans and D. mauritiana, males are sterile and females are fertile, in compliance with HALDANE's rule. The genetic basis of this phenomenon was investigated by introgression of segments of the mauritiana genome into a simulans background. A total of 87 positions throughout the mauritia...

journal_title：Genetics

authors： True JR,Weir BS,Laurie CC

更新日期：1996-03-01 00:00:00

abstract：:We introduce an approach to revealing the likelihood of different population histories that utilizes an explicit model of sequence evolution for the DNA segment under study. Based on a phylogenetic tree reconstruction method we show that a Tamura-Nei model with heterogeneous mutation rates is a fair description of the...

journal_title：Genetics

authors： Weiss G,von Haeseler A

更新日期：1998-07-01 00:00:00

abstract：:The Thomas Hunt Morgan Medal is awarded to an individual Genetics Society of America member for lifetime achievement in the field of genetics. It recognizes the full body of work of an exceptional geneticist. The 2016 recipient is Nancy Kleckner, who has made many significant contributions to our understanding of chro...

journal_title：Genetics

authors： Kleckner N

更新日期：2016-12-01 00:00:00

abstract：:Directed open reading frame (ORF) disruption and a serial selection technique in Escherichia coli and the extremely thermophilic archaeon Sulfolobus solfataricus allowed the identification of otherwise cryptic crucial and noncrucial viral open reading frames in the genome of the archaeal virus SSV1. It showed that the...

journal_title：Genetics

authors： Stedman KM,Schleper C,Rumpf E,Zillig W

更新日期：1999-08-01 00:00:00

abstract：:Adaptive introgression is common in nature and can be driven by selection acting on multiple, linked genes. We explore the effects of polygenic selection on introgression under the infinitesimal model with linkage. This model assumes that the introgressing block has an effectively infinite number of loci, each with an...

journal_title：Genetics

authors： Sachdeva H,Barton NH

更新日期：2018-08-01 00:00:00

abstract：:The consequences of a discontinuity in the migration rate and of a geographical barrier in the habitat are studied in a diffusion model of migration and selection. The treatment is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is supposed further that...

journal_title：Genetics

authors： Nagylaki T

更新日期：1976-08-01 00:00:00

abstract：:Positive selection on a new mutant allele can increase the frequencies of closely linked alleles (through hitchhiking), as well as create linkage disequilibrium between them. Because this disequilibrium is induced by the selected allele, one may be able to identify loci under selection by measuring the influence of a ...

journal_title：Genetics

authors： Grote MN,Klitz W,Thomson G

更新日期：1998-11-01 00:00:00

abstract：:Much of the material taken into cells by endocytosis is rapidly returned to the plasma membrane by the endocytic recycling pathway. Although recycling is vital for the correct localization of cell membrane receptors and lipids, the molecular mechanisms that regulate recycling are only partially understood. Here we sho...

journal_title：Genetics

authors： Nilsson L,Conradt B,Ruaud AF,Chen CC,Hatzold J,Bessereau JL,Grant BD,Tuck S

更新日期：2008-05-01 00:00:00

abstract：:We have studied a genome-wide set of single-nucleotide polymorphism (SNP) allele frequency measures for African-American, East Asian, and European-American samples. For this analysis we derived a simple, closed mathematical formulation for the spectrum of expected allele frequencies when the sampled populations have e...

journal_title：Genetics

authors： Marth GT,Czabarka E,Murvai J,Sherry ST

更新日期：2004-01-01 00:00:00

abstract：:The additive genomic variance in linear models with random marker effects can be defined as a random variable that is in accordance with classical quantitative genetics theory. Common approaches to estimate the genomic variance in random-effects linear models based on genomic marker data can be regarded as estimating ...

journal_title：Genetics

authors： Schreck N,Piepho HP,Schlather M

更新日期：2019-10-01 00:00:00

abstract：:The N-terminal tail of Ndc80 is essential for kinetochore-microtubule binding in human cells but is not required for viability in yeast. We show that the yeast Ndc80 tail is required for timely mitotic progression and accurate chromosome segregation. The tail is essential when cells are limited for Dam1, demonstrating...

journal_title：Genetics

authors： Demirel PB,Keyes BE,Chaterjee M,Remington CE,Burke DJ

更新日期：2012-10-01 00:00:00

abstract：:An exact sampling formula for a Wright-Fisher population of fixed size N under the infinitely many neutral alleles model is deduced. This extends the Ewens formula for the configuration of a random sample to the case where the sample is drawn from a population of small size, that is, without the usual large-N and smal...

journal_title：Genetics

authors： Lessard S

更新日期：2007-10-01 00:00:00

abstract：:We examined the effect of a single variant repeat on the stability of a 51-base pair (bp) microsatellite (poly GT). We found that the insertion stabilizes the microsatellite about fivefold in wild-type strains. The stabilizing effect of the variant base was also observed in strains with mutations in the DNA mismatch r...

journal_title：Genetics

authors： Petes TD,Greenwell PW,Dominska M

更新日期：1997-06-01 00:00:00

abstract：:The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, thus the consequences of sequence variation in rDNA remain unexplored. However, renewed interest in the role that rDNA variation may play in diverse cellular functions, aside from ribosome production, hig...

journal_title：Genetics

authors： Sanchez JC,Ollodart A,Large CRL,Clough C,Alvino GM,Tsuchiya M,Crane M,Kwan EX,Kaeberlein M,Dunham MJ,Raghuraman MK,Brewer BJ

更新日期：2019-09-01 00:00:00

abstract：:Two replications of a complete diallel cross experiment were performed among four partially inbred lines of mice. These inbred lines originated from a random-bred ICR strain and were produced by 12 generations of full sibbing (F congruent to 92%). Individual body weight was recorded for each animal at 12, 21, 42 and 5...

journal_title：Genetics

authors： Jamison MG,White JM,Vinson WE,Hinkelmann K

更新日期：1975-10-01 00:00:00

abstract：:The Drosophila piwi gene is the founding member of the only known family of genes whose function in stem cell maintenance is highly conserved in both animal and plant kingdoms. piwi mutants fail to maintain germline stem cells in both male and female gonads. The identification of piwi-interacting genes is essential fo...

journal_title：Genetics

authors： Smulders-Srinivasan TK,Lin H

更新日期：2003-12-01 00:00:00

abstract：:CarD is the only reported prokaryotic protein showing structural and functional features typical of eukaryotic high-mobility group A transcription factors. In prokaryotes, proteins similar to CarD appear to be confined primarily to myxobacteria. In Myxococcus xanthus, CarD has been previously shown to act as a positiv...

journal_title：Genetics

authors： Galbis-Martínez M,Fontes M,Murillo FJ

更新日期：2004-08-01 00:00:00

abstract：:Centromeres control chromosome inheritance in eukaryotes, yet their DNA structure and primary sequence are hypervariable. Most animals and plants have megabases of tandem repeats at their centromeres, unlike yeast with unique centromere sequences. Centromere function requires the centromere-specific histone CENH3 (CEN...

journal_title：Genetics

authors： Ravi M,Kwong PN,Menorca RM,Valencia JT,Ramahi JS,Stewart JL,Tran RK,Sundaresan V,Comai L,Chan SW

更新日期：2010-10-01 00:00:00

abstract：:The Caenorhabditis elegans gene gld-1 is essential for oocyte development; in gld-1 (null) hermaphrodites, a tumor forms where oogenesis would normally occur. We use genetic epistasis analysis to demonstrate that tumor formation is dependent on the sexual fate of the germline. When the germline sex determination pathw...

journal_title：Genetics

authors： Francis R,Maine E,Schedl T

更新日期：1995-02-01 00:00:00

abstract：:The hitchhiking model of population genetics predicts that an allele favored by Darwinian selection can replace haplotypes from the same locus previously established at a neutral mutation-drift equilibrium. This process, known as "selective sweep," was studied by comparing molecular variation between the polymorphic I...

journal_title：Genetics

authors： Depaulis F,Brazier L,Veuille M

更新日期：1999-07-01 00:00:00

abstract：:Population structure leads to systematic patterns in measures of mean relatedness between individuals in large genomic data sets, which are often discovered and visualized using dimension reduction techniques such as principal component analysis (PCA). Mean relatedness is an average of the relationships across locus-s...

journal_title：Genetics

authors： Li H,Ralph P

更新日期：2019-01-01 00:00:00

abstract：:There have been several attempts to estimate the average dominance (ratio of heterozygous to homozygous effects) of spontaneous deleterious mutations in Drosophila melanogaster, but these have given inconsistent results. We investigated whether transposable element (TE) insertions have higher average dominance for egg...

journal_title：Genetics

authors： Fry JD,Nuzhdin SV

更新日期：2003-04-01 00:00:00

abstract：:The Drosophila PS1 and PS2 integrins are required to maintain the connection between the dorsal and ventral wing epithelia. If alphaPS subunits are inappropriately expressed during early pupariation, the epithelia separate, causing a wing blister. Two lines of evidence indicate that this apparent loss-of-function phen...

journal_title：Genetics

authors： Baker SE,Lorenzen JA,Miller SW,Bunch TA,Jannuzi AL,Ginsberg MH,Perkins LA,Brower DL

更新日期：2002-09-01 00:00:00

abstract：:In response to an external source of adenine, yeast cells repress the expression of purine biosynthesis pathway genes. To identify necessary components of this signalling mechanism, we have isolated mutants that are constitutively active for expression. These mutants were named bra (for bypass of repression by adenine...

journal_title：Genetics

authors： Guetsova ML,Lecoq K,Daignan-Fornier B

更新日期：1997-10-01 00:00:00

abstract：:Damaged DNA-binding proteins 1 and 2 (DDB1 and DDB2) are subunits of the damaged DNA-binding protein complex (DDB). DDB1 is also found in the same complex as DE-ETIOLATED 1 (DET1), a negative regulator of light-mediated responses in plants. Arabidopsis has two DDB1 homologs, DDB1A and DDB1B. ddb1a single mutants have ...

journal_title：Genetics

authors： Al Khateeb WM,Schroeder DF

更新日期：2007-05-01 00:00:00

abstract：:An inbreeding matrix is defined for populations with overlapping generations. In the short term it can be expressed in terms of a matrix specifying the passage of genes between the different age groups (and sexes) and a diagonal matrix whose elements depend on the number of individuals in each age group. Formulae for ...

journal_title：Genetics

authors： Johnson DL

更新日期：1977-11-01 00:00:00

abstract：:Insulin-like growth factors (IGFs) control cell and organism growth through evolutionarily conserved signaling pathways. The mammalian acid-labile subunit (ALS) is a secreted protein that complexes with IGFs to modulate their activity. Recent work has shown that a Drosophila homolog of ALS, dALS, can also complex with...

journal_title：Genetics

authors： Swanson LE,Yu M,Nelson KS,Laprise P,Tepass U,Beitel GJ

更新日期：2009-04-01 00:00:00

abstract：:Correlation and regression analyses indicate that isofemale strains extracted from a population of the parasitic wasp, Nasonia vitripennis, differ in the fit of their second sex ratios (those produced in previously parasitized hosts) to the predictions of the theory of optimal facultative sex ratio adjustment. Under t...

journal_title：Genetics

authors： Orzack SH

更新日期：1990-02-01 00:00:00