Abstract：
:A major tolerance mechanism that functions to replicate damaged genomic DNA across lesions that have escaped elimination by repair mechanism is translesion DNA synthesis (TLS). DNA polymerase kappa (Pol kappa), a specialised low-fidelity DNA polymerase which is able to perform DNA synthesis across several damaged bases, is one of the enzymes involved in the process. The mutagenic nature of Pol kappa implies that its expression must be tightly regulated to prevent the formation of excessive genetic disorders along undamaged parts of the genome. Indeed, Pol kappa overexpression, which is notably observed in lung cancer, results not only in increased spontaneous mutagenesis, but also in pleiotropic alterations such as DNA breaks, genetic exchanges and aneuploidy. This review will discuss both aspects of DNA polymerase kappa, which can be considered as a genomic supervisor participating in genome maintenance and when misregulated as a genetic instability enhancer as well.
journal_name
Biochimiejournal_title
Biochimieauthors
Bavoux C,Hoffmann JS,Cazaux Cdoi
10.1016/j.biochi.2005.02.007keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
637-46issue
7eissn
0300-9084issn
1638-6183pii
S0300-9084(05)00045-3journal_volume
87pub_type
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