Characteristics of the interaction of a treponemal hemolysin with rabbit erythrocytes.

Abstract:

:The mechanism of action on rabbit red cells of Treponema hyodysenteriae hemolysin was studied using volume analysis and release of hemoglobin. While fixation of the hemolysin on the erythrocytes is temperature independent, it appears that hemolysis is temperature dependent. The kinetics of hemolysis proceed according to a sigmoid curve characterized by a prelytic lag. The duration of the prelytic lag varies inversely with the quantity of hemolysin but the rate and the maximum value of hemolysis are directly proportional to the quantity of hemolysin. The effect of sucrose and trypan blue on the hemolysin and the the red cells suggest that erythrocyte lysis is likely to be induced by the hemolysin in a way different from that known for other hemolytic agents.

journal_name

Biochimie

journal_title

Biochimie

authors

Saheb SA,Lafleur L

doi

10.1016/s0300-9084(80)80134-9

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

787-93

issue

11-12

eissn

0300-9084

issn

1638-6183

pii

S0300-9084(80)80134-9

journal_volume

62

pub_type

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