Conformational features of bradykinin. A circular dichroism study of some peptide fragments and structural analogues of bradykinin.

abstract：:Since discovery of high-temperature superconductive (HTS) ceramics by Bednorz and Muller in 1986, there has been an accelerated development of cold technologies in industry, including the domain of NMR detection. The purpose of this paper is to fix ideas about the stage that cryogenic radio frequency (RF) probe techni...

journal_title：Biochimie

authors： Darrasse L,Ginefri JC

更新日期：2003-09-01 00:00:00

abstract：:We are here reporting that calpain-1 is a constitutive component of a distinct lipid raft/caveolin-1 microdomain isolated from bEnd5 cells in association with endothelial nitric oxide synthase (eNOS) and heat shock protein 90 (HSP90). Perturbations in intracellular calcium concentration by Ca2+-ionophore A23187 or pro...

journal_title：Biochimie

authors： Martines A,Stifanese R,Faelli EL,Perasso L,Melloni I,Ruggeri P,Averna M

更新日期：2017-02-01 00:00:00

abstract：:Kinetic parameters characterizing the catalytic activities of enzymes are typically investigated in dilute solutions. However, in reality, these reactions occur in cells that, in addition to water and ions, are full of other macromolecules including proteins, nucleic acids, lipids, and metabolites. Such a crowded envi...

journal_title：Biochimie

authors： Popielec A,Ostrowska N,Wojciechowska M,Feig M,Trylska J

更新日期：2020-09-01 00:00:00

abstract：:Datura stramonium contains a compound that impairs learning retention in mice. It has been purified to homogeneity and its structure has been established as that of a gamma-L-glutamyl-L-aspartate. The biological activity of this pseudodipeptide has been found to be identical with that of the corresponding synthetic on...

journal_title：Biochimie

authors： Schmitz-Bourgeois M,Amiri I,Reinbolt J,Boulanger Y,Ungerer A

更新日期：1988-09-01 00:00:00

abstract：:Lactic acid bacteria provide a model system for the in vivo study of mechanisms pertaining to the regulation of sugar transport and metabolism by microorganisms. Recent studies with resting and growing cells of the homofermentative Streptococci and Lactobacilli have yielded evidence for hitherto unsuspected regulatory...

journal_title：Biochimie

authors： Thompson J

更新日期：1988-03-01 00:00:00

abstract：:Clustered apurinic/apyrimidinic (AP) sites are more cytotoxic than isolated AP lesions because double strand breaks (DSB) can be formed during repair of closely positioned bistranded AP sites. Formation of DSB due to simultaneous cleavage of bistranded AP sites may be regulated by proteins specifically interacting wit...

journal_title：Biochimie

authors： Ilina ES,Khodyreva SN,Lavrik OI

更新日期：2018-07-01 00:00:00

abstract：:An efficient phosphotriester methodology based on the use of condensing agents in the presence of several O-nucleophilic catalysts has been developed. ...

journal_title：Biochimie

authors： Efimov VA,Chakhmakhcheva OG

更新日期：1985-07-01 00:00:00

abstract：:A new apolipoprotein has been identified in VHDL1 and in HDL. This protein is immunologically distinct from already isolated apoproteins. It was isolated by column chromatography on hydroxylapatite. In polyacrylamide gel electrophoresis, its mobility is very close to that of apo D. The amino acid composition differs f...

journal_title：Biochimie

authors： Ayrault-Jarrier M,Alix JF,Polonovski J

更新日期：1978-01-01 00:00:00

abstract：:Certain transcription factors have recently been shown to interact with DNA in living cells, through very short binding cycles, contrasting with the data previously obtained in vitro, and with the view of a stepwise building of transcription initiation complexes. These short cycles are triggered by active dissociation...

journal_title：Biochimie

authors： Michel D

更新日期：2009-07-01 00:00:00

abstract：:In around 10% of SARS-CoV-2 infected patients, coronavirus disease-2019 (Covid-19) symptoms are complicated with a severe lung damage called Acute Respiratory Distress Syndrome (ARDS), which is often lethal. ARDS is mainly associated with an uncontrolled overproduction of immune cells and cytokines, called "cytokine s...

journal_title：Biochimie

authors： Weill P,Plissonneau C,Legrand P,Rioux V,Thibault R

更新日期：2020-12-01 00:00:00

abstract：:Developing a logical and rational methodology for obtaining vaccines, especially against the main parasite causing human malaria (P. falciparum), consists of blocking receptor-ligand interactions. Conserved peptides derived from proteins involved in invasion and having high red blood cell binding ability have thus bee...

journal_title：Biochimie

authors： Patarroyo ME,Salazar LM,Cifuentes G,Lozano JM,Delgado G,Rivera Z,Rosas J,Vargas LE

更新日期：2006-02-01 00:00:00

abstract：:A major tolerance mechanism that functions to replicate damaged genomic DNA across lesions that have escaped elimination by repair mechanism is translesion DNA synthesis (TLS). DNA polymerase kappa (Pol kappa), a specialised low-fidelity DNA polymerase which is able to perform DNA synthesis across several damaged base...

journal_title：Biochimie

authors： Bavoux C,Hoffmann JS,Cazaux C

更新日期：2005-07-01 00:00:00

abstract：:The oncogenic potential of the high-risk human papillomavirus (HPV) relies on the expression of genes specifying the E7 and E6 proteins. To investigate further the variation in oligomeric structure that has been reported for different E7 proteins, an HPV-18 E7 cloned from a Hispanic woman with cervical intraepithelial...

journal_title：Biochimie

authors： Liu S,Tian Y,Greenaway FT,Sun MZ

更新日期：2010-07-01 00:00:00

abstract：:Neuropeptides and hormones, in contrast to constitutive secretory proteins, are sorted to and stored in secretory granules and released upon a stimulus. During the last two decades, signals and mechanisms involved in their sorting to the regulated pathway of protein secretion have been addressed in numerous studies. T...

journal_title：Biochimie

authors： Glombik MM,Gerdes HH

更新日期：2000-04-01 00:00:00

abstract：:L-aromatic aminoacid decarboxylase has been purified more than thousand times from homogenates of rat brain, in several steps : centrifugation, DEAE-cellulose, CM cellulose, hydroxylapatite, DEAE sephadex. Its properties have been studied, most of them on an intermediate fraction of the purification, because of the in...

journal_title：Biochimie

authors： Corgier M,Pacheco H

更新日期：1975-01-01 00:00:00

abstract：:A previous study has shown the effect of individual mineral surfaces on the activity of sweet almond beta-D-glucosidase. We now consider more complex situations likely to occur in soil, such as adsorption onto mixtures of different mineral surfaces, and the effect on enzyme activity of mineral surfaces with organic co...

journal_title：Biochimie

authors： Quiquampoix H

更新日期：1987-06-01 00:00:00

abstract：:Plant vacuolar invertases, which belong to family 32 of glycoside hydrolases (GH32), are key enzymes in sugar metabolism. They hydrolyse sucrose into glucose and fructose. The cDNA encoding a vacuolar invertase from Solanum lycopersicum (TIV-1) was cloned and heterologously expressed in Pichia pastoris. The functional...

journal_title：Biochimie

authors： Tauzin AS,Sulzenbacher G,Lafond M,Desseaux V,Reca IB,Perrier J,Bellincampi D,Fourquet P,Lévêque C,Giardina T

更新日期：2014-06-01 00:00:00

abstract：:The wheat germ translation initiation factor 2 (WGeIF-2) was isolated in a homogeneous state by an efficient procedure and characterized. Its molecular mass, as determined by a gel-filtration method is approximately 150,000 Da. According to SDS-PAGE WGeIF-2 consists of four subunits with M(r) 37,000 (alpha), 40,000 (b...

journal_title：Biochimie

authors： Shaikhin SM,Smailov SK,Lee AV,Kozhanov EV,Iskakov BK

更新日期：1992-05-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae strain LB332 bearing a mutation in the ERG20 gene encoding farnesyl diphosphate synthase (FPPS) synthesizes significantly longer dolichols than the wild type strain FL100 (14-31 and 14-19 isoprene units, respectively). The measurement of the short chain prenyl alcohols excreted into ...

journal_title：Biochimie

authors： Plochocka D,Karst F,Swiezewska E,Szkopińska A

更新日期：2000-08-01 00:00:00

abstract：:Oxidatively modified proteins are continuously produced in cells by reactive oxygen and nitrogen species generated as a consequence of aerobic metabolism. During periods of oxidative stress, protein oxidation is significantly increased and may become a threat to cell survival. In eucaryotic cells the proteasome has be...

journal_title：Biochimie

authors： Davies KJ

更新日期：2001-03-01 00:00:00

abstract：:Hydroxylamine and its derivatives of general formula H2NOR react with aldehydes and aldimines to produce oximes. If R corresponds to the side chain of a natural amino acid, such compounds can be thought of as analogs of the corresponding amino acids, lacking the alpha-carboxylate group. Oximes formed between such comp...

journal_title：Biochimie

authors： Delbaere LT,Kallen J,Markovic-Housley Z,Khomutov AR,Khomutov RM,Karpeisky MY,Jansonius JN

更新日期：1989-04-01 00:00:00

abstract：:Calcium-independent receptor of alpha-latrotoxin (CIRL-1) is an adhesion G protein-coupled receptor implicated in the regulation of exocytosis. CIRL-1 biosynthesis involves constitutive proteolytic processing that takes place in the endoplasmic reticulum, requires the receptor's GPS domain, and yields heterologous two...

journal_title：Biochimie

authors： Deyev IE,Petrenko AG

更新日期：2010-04-01 00:00:00

abstract：:The cell reproduction cycle of parasitic wall-free bacteria, mycoplasma, is reviewed. DNA replication of Mycoplasma capricolum starts at a fixed site neighboring the dnaA gene and proceeds to both directions after a short arrest in one direction. The initiation frequency fits to the slow speed of replication fork and ...

journal_title：Biochimie

authors： Miyata M,Seto S

更新日期：1999-08-01 00:00:00

abstract：:A human replication initiation protein, Cdt1, is a central player in the cell cycle regulation of DNA replication, and geminin down-regulates Cdt1 function by direct binding. It has been demonstrated that Cdt1 hyperfunction resulting from Cdt1-geminin imbalance, for example, by geminin silencing with small interfering...

journal_title：Biochimie

authors： Mizushina Y,Takeuchi T,Hada T,Maeda N,Sugawara F,Yoshida H,Fujita M

更新日期：2008-06-01 00:00:00

abstract：UNLABELLED:Pancreatic cancer (PC) is one of the most lethal human malignancies and a major health problem. Patients diagnosed with PC and treated with conventional approaches have an overall 5-year survival rate of less than 5%. Novel strategies are needed to treat this disease. Herein, we propose a combinatorial strat...

journal_title：Biochimie

authors： Breton CS,Aubry D,Ginet V,Puyal J,Heulot M,Widmann C,Duchosal MA,Nahimana A

更新日期：2015-09-01 00:00:00

abstract：:Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were shown to possess insulin-mimetic properties and to be efficient in lowering post-prandial blood glucose. In addition, abnormalities in inositol metabolism are associated with insulin resistance and with long term microvascula...

journal_title：Biochimie

authors： Croze ML,Soulage CO

更新日期：2013-10-01 00:00:00

abstract：:At least 6 N-acetylglucosaminyltransferases (GlcNAc-T I, II, III, IV, V and VI) are involved in initiating the synthesis of the various branches found in complex asparagine-linked oligosaccharides (N-glycans), as indicated below: GlcNAc beta 1-6 GlcNAc-T V GlcNAc beta 1-4 GlcNAc-T VI GlcNAc beta 1-2Man alpha 1-6 GlcNA...

journal_title：Biochimie

authors： Brockhausen I,Narasimhan S,Schachter H

更新日期：1988-11-01 00:00:00

abstract：:Evidence from clinical, animal and cell culture studies demonstrates that increased autotaxin (ATX) expression is responsible for enhancing tumor progression, cell migration, metastases, angiogenesis and chemo-resistance. These effects depend mainly on the rapid formation of lysophosphatidate (LPA) by ATX. Circulating...

journal_title：Biochimie

authors： Samadi N,Bekele R,Capatos D,Venkatraman G,Sariahmetoglu M,Brindley DN

更新日期：2011-01-01 00:00:00

abstract：:The rate of hydrolysis of long chain triglycerides by pure bovine pancreatic lipase has been determined in the presence of variable amounts of bile salts and colipase. Cofactor-free lipase is strongly inhibited by sodium taurodesoxycholate and by mixed bovine bile salts at concentrations higher than the critical micel...

journal_title：Biochimie

authors： Rathelot J,Julien R,Canioni P,Coeroli C,Sarda L

更新日期：1975-01-01 00:00:00

abstract：:I have been involved in research on oxysterols since 1963 and this review is intended to cover some of the most important aspects of this work. The first project dealed with 7α-hydroxy-4-cholesten-3-one. My successful synthesis of this steroid with high specific radioactivity allowed a demonstration that it is a bile ...

journal_title：Biochimie

authors： Björkhem I

更新日期：2013-03-01 00:00:00