Isolation and structure of a pseudopeptide gamma-L-glutamyl-L-aspartic acid from Datura stramonium that impairs learning retention in mice.

Abstract:

:Datura stramonium contains a compound that impairs learning retention in mice. It has been purified to homogeneity and its structure has been established as that of a gamma-L-glutamyl-L-aspartate. The biological activity of this pseudodipeptide has been found to be identical with that of the corresponding synthetic one. It has also been compared to those of various synthetic di- and tripeptides containing L- and/or D-enantiomers of the constitutive amino acids. The results show that the activity is associated with a peptidic structure containing only one type of enantiomer.

journal_name

Biochimie

journal_title

Biochimie

authors

Schmitz-Bourgeois M,Amiri I,Reinbolt J,Boulanger Y,Ungerer A

doi

10.1016/0300-9084(88)90183-6

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

1179-84

issue

9

eissn

0300-9084

issn

1638-6183

pii

0300-9084(88)90183-6

journal_volume

70

pub_type

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