Abstract:
PURPOSE OF REVIEW:The review aims to summarize recent data about vascular endothelial growth factor and its implications in the normal endometrium during the menstrual cycle, implantation window and early pregnancy. RECENT FINDINGS:Angiogenesis is crucial for the development of endometrium as well as for embryo implantation and establishment of pregnancy. A number of cytokines and growth factors including vascular endothelial growth factor are known to modulate angiogenesis in human endometrium in vitro and in vivo. Intrauterine vascular endothelial growth factor expression has been shown to be regulated in a cycle-dependent fashion. Recent studies have demonstrated that female sex steroid hormones and gonadotrophins contribute to the regulation of vascular endothelial growth factor by endometrial glandular epithelial and stromal cells. Vascular endothelial growth factor levels increase around the peri-implantation period and in the late secretory and pre-menstrual phases. Further, the production of this angiogenic growth factor appears to be related to decidualization. SUMMARY:Vascular endothelial growth factor is a key regulator of angiogenesis and vascular function in the human endometrium. Aberrant endometrial angiogenesis may result in menstrual dysfunction, failed implantation and first-trimester miscarriage. The possibility of enhancing or inhibiting angiogenic activity in the endometrium will provide a novel approach to the manipulation of reproductive functions.
journal_name
Curr Opin Obstet Gynecoljournal_title
Current opinion in obstetrics & gynecologyauthors
Nardo LGdoi
10.1097/01.gco.0000175362.12470.e0keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
419-23issue
4eissn
1040-872Xissn
1473-656Xpii
00001703-200508000-00018journal_volume
17pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:This article reviews the potential benefits and downsides of early anatomy screening. RECENT FINDINGS:There is increasing evidence that about 50% of severe fetal anomalies can be diagnosed prior to 14 weeks of gestation. 'Red flags' such as an increased nuchal or intracranial translucency, tricuspid ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000161
更新日期:2015-04-01 00:00:00
abstract::Transvaginal ultrasonography is emerging as the newest method for the early detection of structural malformations and markers of chromosomal aberrations. According to a multicenter registry on the onset of fetal anomalies, many defects are potentially detectable at an early transvaginal scan. Moreover, cystic hygroma ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-199504000-00008
更新日期:1995-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize recent advances in oocyte and embryo cryopreservation techniques and outcomes. RECENT FINDINGS:Vitrification is gradually replacing slow freezing due to a better survival rate after thawing. Most units use vitrification for both oocyte and blastocyst cryopreservation, as these two biolog...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e32834874e2
更新日期:2011-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Surgery can be an important treatment option for women with symptomatic endometriosis. This review summarizes the recommended preoperative work up and techniques in minimally invasive surgery for treatment of deeply infiltrating endometriosis (DIE) involving the obliterated posterior cul-de-sac, bowel...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000291
更新日期:2016-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To evaluate the impact of early pregnancy complications involving placentation and early placental development on adverse obstetric outcome in ongoing and subsequent pregnancies. RECENT FINDINGS:We found an increased risk of adverse outcome (odds ratio >2.0) in ongoing pregnancies of preterm delivery...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3283404e44
更新日期:2010-12-01 00:00:00
abstract::In the past decade, neoadjuvant and concomitant multimodality therapies have been studied in patients with cervical cancer. The past year has witnessed more pilot studies confirming the feasibility of multimodality therapy. It is now time to move to prospective randomized clinical trials to determine the effects on di...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1993-02-01 00:00:00
abstract::Human papillomavirus (HPV) infection and HPV-associated diseases pose a considerable health care burden in the United States. The morbidity and mortality associated with HPV infection and HPV-associated diseases, ranging from genital warts to cervical cancer, have prompted both the use of screening measures to monitor...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/01.gco.0000216316.10690.c6
更新日期:2006-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Vitamin D deficiency has been associated with a wide range of human disease states and the global epidemic, particularly in reproductive aged women, has led to a focus on this complex hormones role in human reproduction. Indeed vitamin D receptors are found throughout the reproductive tract in the ova...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000375
更新日期:2017-08-01 00:00:00
abstract::This review concentrates on the structural and functional aspects of lesions of the female genital tract that cause infertility, including cervical changes after treatment for neoplasia, uterine malformations, leiomyoma, endometrial aberrations, infection-related tubal lesions, ovarian disorders (oocyte defects, prema...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1997-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Immune checkpoint blockade (ICB) is a promising area of cancer therapeutic research. Therapies targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) mechanism of tumor immune evasion have resulted in durable responses in many difficult-to-treat tumor types. While these...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章
doi:10.1097/GCO.0000000000000596
更新日期:2020-02-01 00:00:00
abstract::Human papillomavirus-related anogenital neoplasia is an active area of basic and clinical research. The research topics are broad based, but mostly are focused on delineating the clinical utility of human papillomavirus testing, the natural history of human papillomavirus infections and associated premalignancies, cha...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1996-02-01 00:00:00
abstract::The subdermal contraceptive implant etonogestrel (Implanon; NV Organon International, Oss, The Netherlands) exerts complex effects on the endometrium. These include direct effects on the endometrium through endometrial progestin target sites, and indirect effects through suppression of the hypothalamic-pituitary-ovari...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200106000-00015
更新日期:2001-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to outline ovarian conservation and fertility sparing surgery (FSS) in the management of the most common pediatric gynecology malignancies. RECENT FINDINGS:Management of gynecologic malignancies has evolved to have a greater appreciation for adverse late effects from rad...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000484
更新日期:2018-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The clinical utility of sperm DNA fragmentation tests needs to be revisited in light of increasing evidence of detrimental effect of sperm DNA damage on reproductive outcomes. RECENT FINDINGS:Current evidence supports the association between high sperm DNA fragmentation and poor outcomes with regards...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000271
更新日期:2016-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the effect of local injury to the endometrium on the implantation rate in IVF-embryo transfer. RECENT FINDINGS:In 2003, Barash et al. reported that endometrial sampling of IVF patients using a biopsy catheter substantially increases their chances to conceive at the following IVF-embryo tran...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e32832a0654
更新日期:2009-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The management of locally advanced breast cancer requires a combined-modality treatment approach involving surgery, radiotherapy and systemic therapy. In this paper, we review clinical and experimental studies in order to evaluate how basic and clinical research in locally advanced breast cancer has p...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/01.gco.0000192998.04793.ba
更新日期:2006-02-01 00:00:00
abstract::Pelvic floor dysfunction, specifically urinary and fecal incontinence, is thought to be widespread. Prevalence figures for these disorders vary greatly. This review highlights the accepted prevalence and incidence figures for pelvic floor dysfunction and their relative age distribution in women. Remission and natural ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1994-08-01 00:00:00
abstract:PURPOSE OF REVIEW:In the past 10 years, clinicians have become more suspect regarding thromboembolic events and potential thrombosis in children at risk. Although adolescents are not typically considered to be a high-risk group, they are the main seekers of contraception in our society today, thereby placing them at so...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e32830ab83f
更新日期:2008-10-01 00:00:00
abstract::Child sexual abuse is being recognized as a common and serious problem which affects children regardless of their age, sex, socio-economic class, or geographic location. Children of all ages, from infancy to young adulthood, have been victims of abuse. It is well accepted that the number of reported incidents of child...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1993-12-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews new concepts in the aetiology of recurrent miscarriage, presents new outcome data and evaluates new modalities of treatment for unexplained recurrent miscarriage. RECENT FINDINGS:Preimplantation genetic diagnosis has been considered an option for couples who have structural chrom...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/01.gco.0000194112.86051.26
更新日期:2005-12-01 00:00:00
abstract:PURPOSE OF REVIEW:To highlight relevant strategies to overcome poly(ADP-ribose) polymerase (PARP) inhibitor resistance and present key clinical trials. RECENT FINDINGS:The use of PARP inhibition (PARPi) for frontline maintenance offers substantial clinical benefit in patients with homologous recombination-deficient tu...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章
doi:10.1097/GCO.0000000000000678
更新日期:2021-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Expanded carrier screening, which detects carriers for a large number of autosomal recessive and X-linked diseases, is increasing in clinical utilization. A recent joint statement from multiple professional societies, in addition to a growing literature base, offers perspective on rationale, decision ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000256
更新日期:2016-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to summarize the most important and interesting achievements which have recently been made in the field of female sexual dysfunction. RECENT FINDINGS:During the last years, the characterization of the female sexual response has been re-examined, resulting in new approaches ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3282f1c733
更新日期:2007-12-01 00:00:00
abstract::During the period under review (December 1990 through January 1992), the revised World Health Organization Histological Classification of Ovarian Neoplasms and Tumor-like Lesions was completed, and it is presented herein. This system of classification incorporates recent advances and includes newly recognized entities...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1992-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To review current available literature on the relationship between fibroids and infertility with particular emphasis on the benefits of myomectomy. Pregnancy complications related to the presence of these lesions and to their removal are also addressed. RECENT FINDINGS:There is a biological plausibil...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章
doi:10.1097/GCO.0b013e3283073ac9
更新日期:2008-08-01 00:00:00
abstract::Current studies verify the safety of surgery in the elderly. Delirium is a costly complication, but its incidence and severity can be reduced by pre- and postoperative interventions. Avoidance of even mild hypothermia has now been shown to reduce cardiovascular morbidity. New information available on the cardiovascula...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract::Minimally invasive surgery enables the avoidance of, preparation for, participation in, and treatment of complications following assisted reproductive technology (ART). The major recent changes are, the development of surgical techniques to diagnose and treat intrafallopian tubal abnormalities; the use of operative en...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1994-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the recent literature regarding modifications of abdominal radical hysterectomy as well as development of new approaches including laparoscopic, vaginal, and robotic radical hysterectomy. RECENT FINDINGS:Nerve-sparing radical hysterectomy technique allows for significant reduction in postop...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3282f2288a
更新日期:2008-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Fetal and newborn brain injury causes lifelong morbidity for the survivors, with high emotional costs to the individual and the family plus a heavy economic burden for society. This is timely and relevant. Techniques are now available to prevent, detect, and treat those central nervous injuries that r...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3282f734db
更新日期:2008-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Currently, a number of different stress urinary incontinence (SUI) procedures exist. The relatively recent adoption of the midurethral sling into clinical practice has changed the surgical management of SUI. This critical evaluation of the trends in SUI surgery emphasizes the public health burden of S...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3283648cdd
更新日期:2013-10-01 00:00:00