Thrombophilias in adolescents: the past, present and future.

Abstract:

PURPOSE OF REVIEW:In the past 10 years, clinicians have become more suspect regarding thromboembolic events and potential thrombosis in children at risk. Although adolescents are not typically considered to be a high-risk group, they are the main seekers of contraception in our society today, thereby placing them at some risk due to exogenous estrogen administration. RECENT FINDINGS:Certain thrombophilic states increase the risk of thromboembolism significantly. Because estrogen-containing hormonal contraceptives also increase the risk of thrombosis, inherited thrombophilias are a contraindication to the use of these contraceptives. Current guidelines support laboratory screening for inherited and acquired thrombophilias when personal history of deep venous thrombosis exists, unexplained spontaneous thrombosis occurs, recurrent thrombosis arises, there is a family history of thrombosis, or thrombosis in unusual sites, such as central nervous system, abdominal veins or upper limbs. Prophylactic anticoagulation is not necessary in the setting of certain thrombophilias; however, consultation with a hematologist may be helpful when making decisions on acute and long-term management of these patients. SUMMARY:Although some thrombophilic conditions are a contraindication to combined hormonal contraception, not all thrombophilias maintain the same level of risk. Routine history-taking to assess the risk of an inherited thrombophilia on the basis of family history is important prior to prescribing oral contraceptives and should be documented in a patient's chart. Laboratory screening is recommended in specific risk scenarios; however, routine screening is not presently recommended prior to oral contraceptive initiation.

authors

Dietrich JE,Hertweck SP

doi

10.1097/GCO.0b013e32830ab83f

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

470-4

issue

5

eissn

1040-872X

issn

1473-656X

journal_volume

20

pub_type

杂志文章,评审
  • Human papillomavirus.

    abstract::In the past year, new data have been published on the molecular biology of human papillomavirus infections and their relationship to cervical neoplasia. As molecular techniques have become more sophisticated and as the molecular knowledge of human papilloma-virus infections has been pursued in greater depth, it is inc...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Richart RM,Wright TC Jr

    更新日期:1992-10-01 00:00:00

  • Pathology of female infertility.

    abstract::This review concentrates on the structural and functional aspects of lesions of the female genital tract that cause infertility, including cervical changes after treatment for neoplasia, uterine malformations, leiomyoma, endometrial aberrations, infection-related tubal lesions, ovarian disorders (oocyte defects, prema...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Honoré LH

    更新日期:1997-02-01 00:00:00

  • Surgical techniques and outcome in the management of submucous fibroids.

    abstract:PURPOSE OF REVIEW:Hysteroscopic myomectomy was a revolution for surgical treatment of symptomatic submucosal myoma. RECENT FINDINGS:A new International Federation of Gynecology and Obstetrics classification for myoma was recently described. Type 0, 1 and 2 are submucosal like in the European Society for Human Reproduc...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e3283630e10

    authors: Capmas P,Levaillant JM,Fernandez H

    更新日期:2013-08-01 00:00:00

  • Cystic fibrosis and fertility.

    abstract:PURPOSE OF REVIEW:As the life expectancy of cystic fibrosis (CF) patients continues to increase, and more patients become adults with a chronic disease, researching the impact of the disorder on male and female infertility has become increasingly important. Studies suggest that the prevalence of CF mutations may be hig...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e32835f1745

    authors: Ahmad A,Ahmed A,Patrizio P

    更新日期:2013-06-01 00:00:00

  • Delayed puberty in the female patient.

    abstract:PURPOSE OF REVIEW:The purpose is to review current recommendations for the evaluation and management of delayed puberty in the female patient. RECENT FINDINGS:Kisspeptin activation has emerged as an important factor for initiation of pubertal development. Causes of delayed puberty can be considered in four main catego...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000303

    authors: Trotman GE

    更新日期:2016-10-01 00:00:00

  • Doppler ultrasound in all three trimesters of pregnancy.

    abstract::Doppler ultrasound velocimetry of uteroplacental, umbilical, and fetal vessels provides the clinician with important information on the hemodynamics of the vascular area under study. Transvaginal color Doppler is a new technique that allows precise investigation of fetomaternal circulation in early pregnancy. Doppler ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Kurjak A,Kupesic S,Zudenigo D

    更新日期:1994-10-01 00:00:00

  • Pelvic relaxation involving the middle compartment.

    abstract::Loss of pelvic support involving the 'middle compartment' is manifested by herniation through the central pelvic floor in proximity to the intersection of an imaginary line from the public symphysis to the coccyx with another from one ischial spine to opposite ischial spine. Loss of middle compartment support may exis...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Timmons MC,Addison WA

    更新日期:1993-08-01 00:00:00

  • Thromboembolism in pregnancy.

    abstract:PURPOSE OF REVIEW:Venous thromboembolism is the leading cause of maternal death in the UK. Thrombophilia underlies many thrombotic disorders in pregnancy. The high prevalence of thrombophilic defects in the population, the association of defects with venous thromboembolism and the special considerations for management ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000162177.30607.59

    authors: Robertson L,Greer I

    更新日期:2005-04-01 00:00:00

  • Tumor markers and molecular biological markers in gynecologic malignancies.

    abstract::Gynecologic oncology is a rapidly growing field due to constant advances in immunohistochemistry and molecular biology. This review serves as an overview of new studies promoting the use of tumor markers and molecular biological prognostic factors in malignancies affecting women. The majority of studies focus on eithe...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200102000-00005

    authors: Geisler JP,Geisler HE

    更新日期:2001-02-01 00:00:00

  • Eating disorders in children and adolescents: what does the gynecologist need to know?

    abstract:PURPOSE OF REVIEW:The purpose of this review is to discuss the diagnosis, medical complications, and treatment of eating disorders as defined by the newly released Diagnostic and Statistical Manual, 5th edition. RECENT FINDINGS:With the introduction of the Diagnostic and Statistical Manual, 5th edition, the diagnostic...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000317

    authors: Sieke EH,Rome ES

    更新日期:2016-10-01 00:00:00

  • Prediction of spontaneous preterm birth: no good test for predicting a spontaneous preterm birth.

    abstract:PURPOSE OF REVIEW:Spontaneous preterm birth complicates 3-11% of pregnancies and is a major cause of neonatal mortality and morbidity worldwide. If accurate tests can be identified, a potentially effective screening strategy with an adjunct preventive therapy may be trialled to reduce the rate of spontaneous preterm bi...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章

    doi:10.1097/GCO.0b013e328359823a

    authors: Honest H,Hyde CJ,Khan KS

    更新日期:2012-12-01 00:00:00

  • Hormone replacement therapy update: who should we be prescribing this to now?

    abstract:PURPOSE OF REVIEW:To summarize results from the Women's Health Initiative trial and other recent randomized placebo-controlled trials of hormone replacement therapy, which fundamentally changed our understanding of its risks and benefits. RECENT FINDINGS:The Women's Health Initiative study for the first time provided ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200312000-00001

    authors: Kocjan T,Prelevic GM

    更新日期:2003-12-01 00:00:00

  • Vitamin D supplementation during pregnancy: an overview.

    abstract:PURPOSE OF REVIEW:Examine recent evidence of randomized controlled trials and meta-analyses regarding the effect of maternal vitamin D status and supplementation over obstetrical and offspring outcomes. RECENT FINDINGS:Maternal serum 25-hydroxyvitamin [25(OH)D] progressively declines during pregnancy because of fetal ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章

    doi:10.1097/GCO.0000000000000641

    authors: Pérez-López FR,Pilz S,Chedraui P

    更新日期:2020-10-01 00:00:00

  • Anabolic effects of androgens on muscles of female pelvic floor and lower urinary tract.

    abstract:PURPOSE OF REVIEW:This review discusses recently published data concerning the anabolic effects of androgens on muscle and the mechanism by which testosterone regulates body composition with special emphasis on the anabolic effects of androgens on the muscles of the pelvic floor and lower urinary tract. RECENT FINDING...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200410000-00009

    authors: Ho MH,Bhatia NN,Bhasin S

    更新日期:2004-10-01 00:00:00

  • Current trends in minilaparoscopy.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to understand the current use of minilaparoscopy in the field and how minilaparoscopy compares with traditional laparoscopy in terms of operative times, complications, pain, and cosmesis. RECENT FINDINGS:Although there are few randomized controlled trials comparing minil...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000290

    authors: Small Layne A,Pinkard L,Shepherd J

    更新日期:2016-08-01 00:00:00

  • Endometriosis and assisted reproductive technologies: are outcomes affected?

    abstract::The preponderance of recent data suggests that endometriosis does not adversely affect in-vitro fertilization pregnancy rates. However, many studies demonstrate impaired oocyte quality, decreased fertilization, and compromised implantation rates. Such findings give insight into the mechanisms by which endometriosis ma...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200106000-00005

    authors: Mahutte NG,Arici A

    更新日期:2001-06-01 00:00:00

  • Thromboembolism in pregnancy: recurrence risks, prevention and management.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize the epidemiology of thromboembolism in pregnancy and describe strategies to prevent and treat it. RECENT FINDINGS:The main reason for the increased risk of thrombosis in pregnancy is hypercoagulability. Other risk factors include a history of thrombosis, inh...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e328317a427

    authors: James AH

    更新日期:2008-12-01 00:00:00

  • Laparoscopic treatment of early ovarian cancer.

    abstract:PURPOSE OF REVIEW:Recently some studies have reinforced the arguments supporting the laparoscopic management of early ovarian cancer. These studies and reports questioning the use of laparoscopy in patients with early ovarian cancer will be reviewed. RECENT FINDINGS:Advances in laparoscopic techniques have enabled the...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000175352.95436.fc

    authors: Tozzi R,Schneider A

    更新日期:2005-08-01 00:00:00

  • Ethical and practical challenges in providing noninvasive prenatal testing for chromosome abnormalities: an update.

    abstract:PURPOSE OF REVIEW:Noninvasive prenatal testing (NIPT) through the analysis of cell-free DNA in maternal plasma has rapidly changed screening for fetal chromosome abnormalities. We review practical and ethical challenges associated with the transition, progress in their resolution, and identify new emerging difficulties...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000254

    authors: Benn P,Chapman AR

    更新日期:2016-04-01 00:00:00

  • Ethical consideration of maternal participation in clinical research.

    abstract::This review explores some of the implications for a balanced approach to the ethics of maternal participation in clinical research, from the perspective of the fetus as a patient, which is a central concept in obstetric ethics. The review therefore begins with an account of this topic, followed by an examination of so...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-199912000-00002

    authors: Chervenak FA,McCullough LB

    更新日期:1999-12-01 00:00:00

  • A review of laparoscopic uterine suspension procedures for uterine preservation.

    abstract:PURPOSE OF REVIEW:The most appropriate surgical approach for uterine preservation still remains the subject of ongoing controversy. Uterine suspension procedures can be performed abdominally, vaginally, or laparoscopically. This article focuses on the three different laparoscopic approaches of uterine suspension for ut...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000179664.83154.9c

    authors: Lin LL,Ho MH,Haessler AL,Betson LH,Alinsod RM,Liu CY,Bhatia NN

    更新日期:2005-10-01 00:00:00

  • Borderline ovarian tumours: a review of the recent literature.

    abstract:PURPOSE OF REVIEW:Borderline tumors of the ovary are seen commonly in obstetrics and gynecology practices. This review will outline the most recent information regarding the epidemiology, molecular pathogenesis, pathology, and clinical management of these tumors. RECENT FINDINGS:In the past, borderline ovarian tumors ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200302000-00006

    authors: Crispens MA

    更新日期:2003-02-01 00:00:00

  • Consequences of fetal growth restriction.

    abstract::An increasing number of diseases in child and adult life are now thought to have their origins in the fetal period. Central to this predisposition is restriction of fetal growth. During the period reviewed in this article, the associations between adult hypertension and low birthweight were confirmed, and numerous stu...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-199804000-00011

    authors: Newnham J

    更新日期:1998-04-01 00:00:00

  • Managing symptoms and maximizing quality of life after preventive interventions for cancer risk reduction.

    abstract:PURPOSE OF REVIEW:The prevention of breast, ovarian and endometrial cancer frequently involves hormonal or surgical interventions. Each of these may have noncancerous sequelae and can affect quality of life in women with hereditary cancer syndromes. The purpose of this review is to discuss the medical management of hor...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000146

    authors: Chapman JS,Jacoby V,Chen LM

    更新日期:2015-02-01 00:00:00

  • Neoadjuvant chemotherapy in cervical cancer: a new trend.

    abstract:PURPOSE OF REVIEW:Although there is effective screening for cervical cancer, it continues to be a healthcare problem in developing countries. To increase survival rates, different strategies with neoadjuvant chemotherapy have been developed. Nearly all trials that analysed neoadjuvant chemotherapy plus surgery demonstr...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200502000-00008

    authors: Sardi JE,Boixadera MA,Sardi JJ

    更新日期:2005-02-01 00:00:00

  • Obstetric and perinatal outcome in pregnancies after assisted reproduction.

    abstract::Infertile couples who seek medical advice have one single hope: to have one or more children. Therefore, pregnancy rates per cycle of any assisted reproductive technique that include early miscarriages and ectopic pregnancies are of little interest to them. They want to know their chances of having a baby. When counse...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Tanbo T,Abyholm T

    更新日期:1996-06-01 00:00:00

  • Changing trends in surgery for stress urinary incontinence.

    abstract:PURPOSE OF REVIEW:Currently, a number of different stress urinary incontinence (SUI) procedures exist. The relatively recent adoption of the midurethral sling into clinical practice has changed the surgical management of SUI. This critical evaluation of the trends in SUI surgery emphasizes the public health burden of S...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e3283648cdd

    authors: Geller EJ,Wu JM

    更新日期:2013-10-01 00:00:00

  • Controversies in the surgical management of hydrosalpinx.

    abstract::The surgical management of hydrosalpinges is a controversial subject. Chronic pathology of the fallopian tube with distal obstruction leads to the formation of a hydrosalpinx, and is associated with very poor pregnancy rates after surgery. In these cases, in-vitro fertilization has proved to be a much better alternati...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200008000-00006

    authors: Mansour R,Aboulghar M,Serour GI

    更新日期:2000-08-01 00:00:00

  • Amenorrhea and bone health in adolescents and young women.

    abstract:PURPOSE OF REVIEW:We present an update on amenorrhea in adolescent girls and young women. Amenorrhea may herald the onset of estrogen deficiency, which can adversely affect peak bone mass and ultimate risk of osteoporosis. RECENT FINDINGS:Adolescence is a critical period for bone accretion. Important modifiable factor...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200310000-00005

    authors: Gordon CM,Nelson LM

    更新日期:2003-10-01 00:00:00

  • Comparative genomic hybridization and prenatal diagnosis.

    abstract:PURPOSE OF REVIEW:Microarray-based comparative genomic hybridization (array-CGH) which detects aneuploidies and submicroscopic deletions and duplications in one assay is now offered for genetic diagnosis in children and adults. Its application to prenatal diagnosis is still limited, but very promising. We predict that ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000192986.22718.cc

    authors: Van den Veyver IB,Beaudet AL

    更新日期:2006-04-01 00:00:00