Abstract:
PURPOSE OF REVIEW:As the life expectancy of cystic fibrosis (CF) patients continues to increase, and more patients become adults with a chronic disease, researching the impact of the disorder on male and female infertility has become increasingly important. Studies suggest that the prevalence of CF mutations may be higher than previously thought and that many mutations are yet to be identified. RECENT FINDINGS:Assisted reproductive technologies can help both infertile male and female patients with CF in achieving successful parenthood. In addition, for women more health characteristics including baseline pulmonary function have been evaluated as predictors of health and pregnancy outcomes. SUMMARY:Mutations in the CF Transmembrane Conductance Regulator (CFTR) gene affect both male and female fertility; however, not all CFTR mutations appear to cause infertility. Although most men with CF have significant anatomical abnormalities of the reproductive tract causing infertility, most women with CF have anatomically normal reproductive tracts and up to half may be able to conceive spontaneously. Less is known about how CF affects female fertility or the treatment options available.
journal_name
Curr Opin Obstet Gynecoljournal_title
Current opinion in obstetrics & gynecologyauthors
Ahmad A,Ahmed A,Patrizio Pdoi
10.1097/GCO.0b013e32835f1745subject
Has Abstractpub_date
2013-06-01 00:00:00pages
167-72issue
3eissn
1040-872Xissn
1473-656Xjournal_volume
25pub_type
杂志文章,评审abstract::Mifepristone is an orally active progesterone antagonist. It can be used for both contraceptive and non-contraceptive clinical indications. It is a very effective drug for emergency contraception with a low incidence of side effects. There is a potential for mifepristone to be used as a once-a-month pill. There is a n...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200206000-00013
更新日期:2002-06-01 00:00:00
abstract::Ultrasound prenatal diagnosis of structural anomalies has become almost a separate branch of obstetrics. The advantages of performing ultrasound in pregnancies at high risk for fetal structural anomalies are clear. Patients and the news media have placed ever-increasing expectations on persons performing diagnostic ul...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1993-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Gonadotrophin in IVF increases the number of oocytes retrieved, and many doctors regard a high number of oocytes as a measurement of success in IVF. Thus, the dogma of more oocytes provides better IVF success has been broadly accepted. However, some European fertility specialists have argued against t...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000460
更新日期:2018-06-01 00:00:00
abstract::Recent advances in seemingly remote areas of investigation, i.e. yeast cell cycle research and DNA amplifications, have opened spectacular avenues for understanding reproduction. The new insights on the single cell and subcellular level of processes, such as egg maturation, sperm-egg interaction and implantation enhan...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1994-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to understand the current use of minilaparoscopy in the field and how minilaparoscopy compares with traditional laparoscopy in terms of operative times, complications, pain, and cosmesis. RECENT FINDINGS:Although there are few randomized controlled trials comparing minil...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000290
更新日期:2016-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the beneficial effects of micronutrient supplementation on male fertility. RECENT FINDINGS:Several micronutrients have beneficial effects on sperm quality, as well on male fertility (e.g. pregnancy rate). A deliberate use of micronutrients might be helpful for infertile patients. Healthca...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000063
更新日期:2014-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Traditionally, ovarian stimulation for IVF/intracytoplasmic sperm injection is performed by healthcare professionals, requiring the patient to make frequent visits to these centres. We describe the rationale, research findings and early clinical experience with home-based sonography for IVF patients. ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000363
更新日期:2017-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the current role of radiation therapy and specific types of radiation therapy used in the management of early stage, locoregionally advanced, and metastatic breast cancer. RECENT FINDINGS:The role of radiation therapy in the management of breast cancer has not changed in recent decades, h...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3283425401
更新日期:2011-02-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize recent advances in oocyte and embryo cryopreservation techniques and outcomes. RECENT FINDINGS:Vitrification is gradually replacing slow freezing due to a better survival rate after thawing. Most units use vitrification for both oocyte and blastocyst cryopreservation, as these two biolog...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e32834874e2
更新日期:2011-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Venous thromboembolism is the leading cause of maternal death in the UK. Thrombophilia underlies many thrombotic disorders in pregnancy. The high prevalence of thrombophilic defects in the population, the association of defects with venous thromboembolism and the special considerations for management ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/01.gco.0000162177.30607.59
更新日期:2005-04-01 00:00:00
abstract:PURPOSE OF REVIEW:More than 50% of all gynecologic cancers can be classified as rare tumors (defined as an incidence of <6 per 100 000) and as such represent a major challenge for clinicians. RECENT FINDINGS:The rapidly increasing number of targeted therapies provides a unique opportunity to improve treatment options ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000144
更新日期:2015-02-01 00:00:00
abstract:PURPOSE OF REVIEW:To review updated information on the influence of endometrial scratching on IVF. RECENT FINDINGS:Endometrial receptivity remains an important rate-limiting step affecting the success of IVF. The current evidence on the effect of endometrial scratching on IVF ranges from marked improvement, no differe...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000264
更新日期:2016-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To evaluate the role of fluorodeoxyglucose (FDG) PET/CT as cancer response testing in gynecological malignancies. RECENT FINDINGS:The application of FDG PET/CT in patients with endometrial and ovarian cancer to evaluate treatment response was found to have no clinical benefits.Patients with cervical ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e32835a7e96
更新日期:2013-02-01 00:00:00
abstract::Voiding disorders are frequently associated with urinary incontinence and other lower urinary tract dysfunction in women, but the cause of these disorders is not well understood and treatment options are limited. Little has changed in the treatment and evaluation of voiding disorders. New approaches to the study of de...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1996-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Prescribing habits for the treatment of symptomatic hypogonadism have recently stirred controversy surrounding testosterone replacement therapy. As a result, the gynecologist will need to recognize this iatrogenic form of decreased sperm production in couples seeking fertility advice. We have compiled...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000192
更新日期:2015-08-01 00:00:00
abstract::Advances in perinatal and neonatal health care over the past few decades have resulted in a substantial reduction in perinatal mortality. Some of this improvement has been attributed to antepartum fetal surveillance techniques. The primary objective of antepartum fetal surveillance techniques is to avoid fetal deaths....
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1997-04-01 00:00:00
abstract::Outpatient hysteroscopy has shown good correlation of findings compared with inpatient hysteroscopy, but one limitation is pain and discomfort in some women, and vasovagal reaction. Various forms of local anaesthesia have been evaluated in the past year, with controversial results, and a narrow 3.5 mm sheath hysterosc...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200108000-00003
更新日期:2001-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide a concise review of advances in prediction of preeclampsia, highlighting the most important and interesting articles among the many published within the past months, making a clear distinction between early and late clinical forms of the condition. RECENT FINDINGS:The performance of matern...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e328344579c
更新日期:2011-04-01 00:00:00
abstract:PURPOSE OF REVIEW:With the recent advancements in reproductive medicine, many infertile couples now have the opportunity to conceive their own biological children. Although some medication protocols, such as clomiphene citrate, have been utilized for decades, other treatment modalities have evolved over the recent year...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000064
更新日期:2014-06-01 00:00:00
abstract::Gynecologic oncology is a rapidly growing field due to constant advances in immunohistochemistry and molecular biology. This review serves as an overview of new studies promoting the use of tumor markers and molecular biological prognostic factors in malignancies affecting women. The majority of studies focus on eithe...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200102000-00005
更新日期:2001-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The aromatase inhibitors are increasingly used as adjuvant therapy in postmenopausal women with hormone receptor positive breast cancer. With additional experience using these agents, unanticipated side effects have become apparent. Women who experience side effects from adjuvant endocrine therapy are...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e328334e44e
更新日期:2010-02-01 00:00:00
abstract:PURPOSE OF REVIEW:There is a growing clinical consensus that Medicaid sterilization consent protections should be revisited because they impede desired care for many women. Here, we consider the broad social and ideological contexts for past sterilization abuses, beyond informed consent. RECENT FINDINGS:Throughout the...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 历史文章,杂志文章,评审
doi:10.1097/GCO.0000000000000121
更新日期:2014-12-01 00:00:00
abstract::This review discusses studies documenting an increase in birth rate associated with in vitro fertilization and gamete intrafallopian transfer. The results of zygote intrafallopian transfer are also encouraging. The rates of chromosomal and congenital abnormalities in assisted reproduction are similar to the rates at w...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1991-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Monochorionic compared with dichorionic twins have disproportionately high fetal loss rates, perinatal mortality and morbidity. This is because of the unpredictable vascular anastomoses and the often asymmetrical distribution of the single placenta between both twins. RECENT FINDINGS:The pathophysiol...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200304000-00013
更新日期:2003-04-01 00:00:00
abstract:PURPOSE OF REVIEW:We present an update on amenorrhea in adolescent girls and young women. Amenorrhea may herald the onset of estrogen deficiency, which can adversely affect peak bone mass and ultimate risk of osteoporosis. RECENT FINDINGS:Adolescence is a critical period for bone accretion. Important modifiable factor...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200310000-00005
更新日期:2003-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The management of uterine fibroids in patients requiring treatment who desire future fertility remains controversial. Myomectomy has been the most common operative procedure to improve pregnancy rates and outcomes. Uterine fibroid embolization is an increasingly popular, minimally invasive treatment f...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/01.gco.0000233934.13684.cb
更新日期:2006-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Abortion services are essential in sexual and reproductive health and should be held to the same standards as other health services. Patient (or person)-centeredness is a key dimension of healthcare quality that incorporates the perspectives of patients in care provision. The purpose of this review is...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000492
更新日期:2018-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The most common method of antepartum fetal surveillance is the nonstress test (NST). Although it has satisfactory false-negative rates, dubious nonreactive results may challenge the physician. Any method or factor increasing the reactive NST results or shortening the time to attain a reactive test may...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000050
更新日期:2014-04-01 00:00:00
abstract::Doppler ultrasound velocimetry of uteroplacental, umbilical, and fetal vessels provides the clinician with important information on the hemodynamics of the vascular area under study. Transvaginal color Doppler is a new technique that allows precise investigation of fetomaternal circulation in early pregnancy. Doppler ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1994-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The recovery of immature oocytes followed by in-vitro maturation (IVM) and in-vitro fertilization is an attractive alternative to conventional in-vitro fertilization treatment in which controlled ovarian stimulation with gonadotropins is used to increase the number of available oocytes and embryos. Si...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200406000-00003
更新日期:2004-06-01 00:00:00