Managing the toxicities of the aromatase inhibitors.

abstract：PURPOSE OF REVIEW:The management of locally advanced breast cancer requires a combined-modality treatment approach involving surgery, radiotherapy and systemic therapy. In this paper, we review clinical and experimental studies in order to evaluate how basic and clinical research in locally advanced breast cancer has p...

journal_title：Current opinion in obstetrics & gynecology

authors： Barni S,Mandalà M

更新日期：2006-02-01 00:00:00

abstract：:The corpus luteum is controlled by luteinizing hormone (LH) and intraovarian morphofunctional specialization and autocrine/paracrine mechanisms. Corpus luteal insufficiency produces luteal phase defects (LPD). The poor precision and validation of endometrial histologic dating and single or random multiple serum proges...

journal_title：Current opinion in obstetrics & gynecology

authors： Dawood MY

更新日期：1994-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review is timely and relevant for several reasons. The incidence of adenomyosis begins to rise from the mid-thirties. Moreover, more women are delaying their first pregnancy until later in their thirties or forties, and consequently adenomyosis is encountered more frequently in the fertility clin...

journal_title：Current opinion in obstetrics & gynecology

authors： Matalliotakis IM,Katsikis IK,Panidis DK

更新日期：2005-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Benefit of micronutrient supplementation on female fertility. RECENT FINDINGS:Reports of randomized trials are rare. Most studies are focused on multivitamin supplementations. For some micronutrients, a positive impact on fertility could be shown. This article reviews the available clinical studies a...

journal_title：Current opinion in obstetrics & gynecology

authors： Buhling KJ,Grajecki D

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the impact of early pregnancy complications involving placentation and early placental development on adverse obstetric outcome in ongoing and subsequent pregnancies. RECENT FINDINGS:We found an increased risk of adverse outcome (odds ratio >2.0) in ongoing pregnancies of preterm delivery...

journal_title：Current opinion in obstetrics & gynecology

authors： Jauniaux E,Van Oppenraaij RH,Burton GJ

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Telomere attrition and dysfunction has become a well established pathway involved in organismal aging, not only because it imposes a limitation to cell division and therefore, tissue regeneration but also because telomere homeostasis influences other pathways involved in aging. However, the implicatio...

journal_title：Current opinion in obstetrics & gynecology

authors： Varela E,Sánchez-de-Puerta I,García-Velasco JA

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Monochorionic compared with dichorionic twins have disproportionately high fetal loss rates, perinatal mortality and morbidity. This is because of the unpredictable vascular anastomoses and the often asymmetrical distribution of the single placenta between both twins. RECENT FINDINGS:The pathophysiol...

journal_title：Current opinion in obstetrics & gynecology

authors： Lewi L,Van Schoubroeck D,Gratacós E,Witters I,Timmerman D,Deprest J

更新日期：2003-04-01 00:00:00

abstract：:Infertility is a common medical problem resulting from one or more defects in the reproductive tract. Of the known causes of infertility, cervico-utero-tubal factors are important because they are generally manageable. Cervical factors include changes in cervical architecture, mucus, or both, resulting in a hostile en...

journal_title：Current opinion in obstetrics & gynecology

authors： Markham S

更新日期：1991-04-01 00:00:00

abstract：:Loss of pelvic support involving the 'middle compartment' is manifested by herniation through the central pelvic floor in proximity to the intersection of an imaginary line from the public symphysis to the coccyx with another from one ischial spine to opposite ischial spine. Loss of middle compartment support may exis...

journal_title：Current opinion in obstetrics & gynecology

authors： Timmons MC,Addison WA

更新日期：1993-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Many minimally invasive techniques have recently been introduced for the management of uterine fibroids. The purpose of this review is to analyse recent data for techniques that are used to manage uterine fibroids. RECENT FINDINGS:Laparoscopic myomectomy has provided a minimally invasive alternative ...

journal_title：Current opinion in obstetrics & gynecology

authors： Falcone T,Bedaiwy MA

更新日期：2002-08-01 00:00:00

abstract：:This review explores the recent experience with, and the basis for, the use of selective estrogen receptor modulators to treat and prevent breast cancer. As new agents are unveiled, they will continue to be tested against tamoxifen. A number of new selective estrogen receptor modulators are in clinical development in ...

journal_title：Current opinion in obstetrics & gynecology

authors： Bentrem DJ,Jordan VC

更新日期：2002-02-01 00:00:00

abstract：:In contrast to the reduction in perinatal mortality in high-risk pregnancies, screening of low-risk pregnancies with umbilical artery Doppler ultrasonography has shown no benefit. Advances in pathophysiology question the assumption that the placenta is hypoxic in fetal growth restriction, with absent end-diastolic fre...

journal_title：Current opinion in obstetrics & gynecology

authors： Burrell SJ,Kingdom JC

更新日期：1997-12-01 00:00:00

abstract：:Doppler ultrasound velocimetry of uteroplacental, umbilical, and fetal vessels provides the clinician with important information on the hemodynamics of the vascular area under study. Transvaginal color Doppler is a new technique that allows precise investigation of fetomaternal circulation in early pregnancy. Doppler ...

journal_title：Current opinion in obstetrics & gynecology

authors： Kurjak A,Kupesic S,Zudenigo D

更新日期：1994-10-01 00:00:00

abstract：PURPOSE OF REVIEW:What controls puberty remains largely unknown and current gene mutations account for only about one-third of the apparently genetic cases of idiopathic hypogonadotropic hypogonadism. Lately important developments have occurred in this field. RECENT FINDINGS:Substantial variation in clinical expressio...

journal_title：Current opinion in obstetrics & gynecology

authors： Topaloglu AK,Kotan LD

更新日期：2010-08-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been increasing interest in developing assisted reproductive technologies to overcome failure at fertilization and early embryonic arrest. Some of the affected patients harbor too few copies of mitochondrial DNA (mtDNA) in their eggs at the time of fertilization, which results in development...

journal_title：Current opinion in obstetrics & gynecology

authors： St John JC,Tsai TS,Cagnone GL

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To avoid both overtreatment and undertreatment accurate risk assessment is mandatory. The present review gives an overview of recently published articles covering prognostic and predictive factors for adjuvant therapy in early breast cancer. RECENT FINDINGS:Gene expression signatures enhance prognost...

journal_title：Current opinion in obstetrics & gynecology

authors： Schmidt M

更新日期：2020-02-01 00:00:00

abstract：:Human embryo cryopreservation is now a fully established adjunct to assisted reproduction, with thawed embryos implanting at a rate approaching that of fresh embryos. As with fresh embryos, the quality of frozen-thawed embryos is affected by patient age at the time of oocyte retrieval, and by culture conditions. Ovari...

journal_title：Current opinion in obstetrics & gynecology

authors： Tucker MJ,Morton PC,Sweitzer CL,Wright G

更新日期：1995-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review important considerations in the counseling and management of women over the age of 40 desiring a myomectomy for symptomatic fibroids. RECENT FINDINGS:Women in the late reproductive and perimenopausal years may choose a myomectomy over a hysterectomy for reasons of fertility preservation or ...

journal_title：Current opinion in obstetrics & gynecology

authors： Pepin K,Reddy H,Clark NV

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence-based women's healthcare is underpinned by systematic reviews and guidelines. Generating an evidence synthesis to support guidance for clinical practice is a time-consuming and labour-intensive activity that delays transfer of research into practice. Artificial intelligence has the potential ...

journal_title：Current opinion in obstetrics & gynecology

authors： Amezcua-Prieto C,Fernández-Luna JM,Huete-Guadix JF,Bueno-Cavanillas A,Khan KS

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Expanded carrier screening, which detects carriers for a large number of autosomal recessive and X-linked diseases, is increasing in clinical utilization. A recent joint statement from multiple professional societies, in addition to a growing literature base, offers perspective on rationale, decision ...

journal_title：Current opinion in obstetrics & gynecology

authors： Lazarin GA,Goldberg JD

更新日期：2016-04-01 00:00:00

abstract：:During the period under review (December 1990 through January 1992), the revised World Health Organization Histological Classification of Ovarian Neoplasms and Tumor-like Lesions was completed, and it is presented herein. This system of classification incorporates recent advances and includes newly recognized entities...

journal_title：Current opinion in obstetrics & gynecology

authors： Talerman A

更新日期：1992-08-01 00:00:00

abstract：PURPOSE OF REVIEW:There is a growing clinical consensus that Medicaid sterilization consent protections should be revisited because they impede desired care for many women. Here, we consider the broad social and ideological contexts for past sterilization abuses, beyond informed consent. RECENT FINDINGS:Throughout the...

journal_title：Current opinion in obstetrics & gynecology

authors： Harris LH,Wolfe T

更新日期：2014-12-01 00:00:00

abstract：:Acquired immunodeficiency virus infections had recently been the leading cause of death in minority women of reproductive age in several urban cities in the United States. In addition, more than 80% of infants with human immunodeficiency virus type 1 infection acquired the infection perinatally. These alarming data ha...

journal_title：Current opinion in obstetrics & gynecology

authors： Sison AV

更新日期：1992-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight relevant strategies to overcome poly(ADP-ribose) polymerase (PARP) inhibitor resistance and present key clinical trials. RECENT FINDINGS:The use of PARP inhibition (PARPi) for frontline maintenance offers substantial clinical benefit in patients with homologous recombination-deficient tu...

journal_title：Current opinion in obstetrics & gynecology

authors： Hinchcliff E,Chelariu-Raicu A,Westin SN

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Apart from histopathology, electrophysiological methods are the only tests to reveal neuromuscular involvement in the absence of gross anatomical lesions. They have played a major role in establishing the neuromuscular lesion due to vaginal delivery as a risk factor for incontinence and pelvic organ p...

journal_title：Current opinion in obstetrics & gynecology

authors： Vodusek DB

更新日期：2002-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Sex trafficking of adolescents and young adults is both a human rights violation and a public health problem, globally and in the United States. Healthcare providers, including obstetricians and gynecologists, interact with victims, often while they remain under their traffickers' control, but because...

journal_title：Current opinion in obstetrics & gynecology

authors： Chaffee T,English A

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to analyze what is known to date about the relation between telomeres and male fertility, and if it is possible for telomeres, or elements related to them, to be used as new prognostic biomarkers in fertility treatment. RECENT FINDINGS:Cells in germ series, including spe...

journal_title：Current opinion in obstetrics & gynecology

authors： Balmori C,Varela E

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the complexity of caring for gynecologic patients who refuse blood transfusion and discusses the importance of early, targeted perioperative and intraoperative medical optimization. We review alternative interventions and the importance of medical management to minimize blood lo...

journal_title：Current opinion in obstetrics & gynecology

authors： Han ES,Arora C,Hur HC,Advincula AP,Kim JHJ

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Pelvic organ prolapse is a common disease that negatively affects the lives of women. To date, basic science research into the pathogenesis of prolapse has been limited. The vagina and its supportive connective tissues provide one of the primary mechanisms of support to the pelvic organs. This review ...

journal_title：Current opinion in obstetrics & gynecology

authors： Alperin M,Moalli PA

更新日期：2006-10-01 00:00:00

abstract：:Urinary incontinence remains a common problem that adversely affects the quality of life of millions of women. In detrusor instability, treatment measures often lack efficacy or are accompanied by unacceptable side effects. In this review, standard treatments are discussed, together with recent pharmacologic advances ...

journal_title：Current opinion in obstetrics & gynecology

authors： Wise B,Cardozo L

更新日期：1991-08-01 00:00:00