Mitochondrial DNA supplementation as an enhancer of female reproductive capacity.

Abstract:

PURPOSE OF REVIEW:There has been increasing interest in developing assisted reproductive technologies to overcome failure at fertilization and early embryonic arrest. Some of the affected patients harbor too few copies of mitochondrial DNA (mtDNA) in their eggs at the time of fertilization, which results in developmental failure. RECENT FINDINGS:In the last 3-5 years, there has been a drive to overcome mtDNA deficiency through mitochondrial supplementation protocols using autologous populations of mitochondrial DNA so as not to perturb the offspring's genetic identity or mediate a series of side-effects because of the mixing of two distinct populations of mitochondrial DNA. It is evident that there is strict regulation of mitochondrial DNA copy number from the primordial germ cell through to the time when tissues are specified during organogenesis. Supplementation of oocytes can give rise to better quality embryos, enhanced blastocyst rates, and ongoing pregnancies. It utilizes a key mitochondrial DNA replication event that takes place shortly after fertilization to stabilize the embryonic genome. SUMMARY:These findings provide a rationale for undertaking mitochondrial supplementation and propose a mechanism to explain why the process can enhance embryo development. They also take the approach a step closer to clinical practice.

authors

St John JC,Tsai TS,Cagnone GL

doi

10.1097/GCO.0000000000000265

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

211-6

issue

3

eissn

1040-872X

issn

1473-656X

pii

00001703-201606000-00013

journal_volume

28

pub_type

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