Current and future landscape of poly (ADP-ribose) polymerase inhibition resistance.

abstract：PURPOSE OF REVIEW:Growth hormone (GH) has been used as an adjunct in ovulation induction and IVF for 25 years, particularly as an adjunct to ovarian stimulation for women who had a previous poor response to stimulation in an IVF cycle. It does not have US Food and Drug Administration approval for this use. Unfortunatel...

journal_title：Current opinion in obstetrics & gynecology

authors： Hart RJ,Rombauts L,Norman RJ

更新日期：2017-06-01 00:00:00

abstract：:Urinary tract infections (UTIs) are still one of the most common bacterial infections in pregnant and non-pregnant women. It is estimated that about 10-20% of all women suffer from a UTI at some point in life. The presence of UTI is defined as the existence of urinary symptoms such as frequency of urination and dysuri...

journal_title：Current opinion in obstetrics & gynecology

authors： Weissenbacher ER,Reisenberger K

更新日期：1993-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Venous thromboembolism is the leading cause of maternal death in the UK. Thrombophilia underlies many thrombotic disorders in pregnancy. The high prevalence of thrombophilic defects in the population, the association of defects with venous thromboembolism and the special considerations for management ...

journal_title：Current opinion in obstetrics & gynecology

authors： Robertson L,Greer I

更新日期：2005-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The study of embryonic development through conventional microscopy has contributed significantly to the success of IVF. However, clinical pregnancy rates per transfer remain as low as 30% according to the latest records of European society if human reproduction and society if assisted reproduction. Co...

journal_title：Current opinion in obstetrics & gynecology

authors： Basile N,Elkhatib I,Meseguer M

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Much attention has been paid to the role of immunology in reproductive success or failure. Every step in the establishment of normal pregnancy has been implicated as a possible site of immune-mediated reproductive failure. The widespread testing of antiphospholipid, antinuclear, antithyroid, and antis...

journal_title：Current opinion in obstetrics & gynecology

authors： Kallen CB,Arici A

更新日期：2003-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent advances in oocyte and embryo cryopreservation techniques and outcomes. RECENT FINDINGS:Vitrification is gradually replacing slow freezing due to a better survival rate after thawing. Most units use vitrification for both oocyte and blastocyst cryopreservation, as these two biolog...

journal_title：Current opinion in obstetrics & gynecology

authors： Herrero L,Martínez M,Garcia-Velasco JA

更新日期：2011-08-01 00:00:00

abstract：:During the past year much effort has been focused on defining the DNA content of gestational trophoblastic tumors. Flow cytometric and image analysis studies of molar pregnancies confirmed that the majority of partial hydatidiform moles were triploid, and, as expected, most complete hydatidiform moles were diploid or ...

journal_title：Current opinion in obstetrics & gynecology

authors： Lage JM

更新日期：1994-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The different patterns of autoreactivity that may account for the premature infertility observed in patients with premature ovarian failure are described. RECENT FINDINGS:Animal model studies have detailed fundamental immune dysregulatory patterns that induce ovarian failure in the context of global ...

journal_title：Current opinion in obstetrics & gynecology

authors： Tuohy VK,Altuntas CZ

更新日期：2007-08-01 00:00:00

abstract：:Pelvic floor dysfunction, specifically urinary and fecal incontinence, is thought to be widespread. Prevalence figures for these disorders vary greatly. This review highlights the accepted prevalence and incidence figures for pelvic floor dysfunction and their relative age distribution in women. Remission and natural ...

journal_title：Current opinion in obstetrics & gynecology

authors： Mallett VT,Bump RC

更新日期：1994-08-01 00:00:00

abstract：:Examination of the placenta may be viewed as a diary of the pregnancy. Apart from its immediate diagnostic value, it can also broadly serve two purposes: 1) it provides a method of auditing antenatal clinical judgment by clinicopathologic correlation, and 2) it makes an important contribution in the context of unsolve...

journal_title：Current opinion in obstetrics & gynecology

authors： Gillan JE

更新日期：1992-04-01 00:00:00

abstract：:During the past few years enormous progress has been made in the understanding of the molecular mechanisms involved in parturition; however, the answer to the fundamental question of how labor is initiated remains elusive. This is a very important question because alterations in the timing of birth (preterm and post-t...

journal_title：Current opinion in obstetrics & gynecology

authors： Valenzuela GJ,Germain A,Foster TC

更新日期：1993-10-01 00:00:00

abstract：:This review concentrates on the structural and functional aspects of lesions of the female genital tract that cause infertility, including cervical changes after treatment for neoplasia, uterine malformations, leiomyoma, endometrial aberrations, infection-related tubal lesions, ovarian disorders (oocyte defects, prema...

journal_title：Current opinion in obstetrics & gynecology

authors： Honoré LH

更新日期：1997-02-01 00:00:00

abstract：:Human papillomavirus (HPV) infection and HPV-associated diseases pose a considerable health care burden in the United States. The morbidity and mortality associated with HPV infection and HPV-associated diseases, ranging from genital warts to cervical cancer, have prompted both the use of screening measures to monitor...

journal_title：Current opinion in obstetrics & gynecology

authors： Mayeaux EJ Jr

更新日期：2006-02-01 00:00:00

abstract：:Approximately 2-3% of cervical smears will be reported as showing low-grade changes. Many of these smears are in fact associated with high-grade cervical intraepithelial neoplasia requiring treatment, but a significant number will be associated with an absence of cervical intraepithelial neoplasia, where surveillance ...

journal_title：Current opinion in obstetrics & gynecology

authors： Cruickshank ME,Kitchener HC

更新日期：1995-02-01 00:00:00

abstract：:Ultrasound prenatal diagnosis of structural anomalies has become almost a separate branch of obstetrics. The advantages of performing ultrasound in pregnancies at high risk for fetal structural anomalies are clear. Patients and the news media have placed ever-increasing expectations on persons performing diagnostic ul...

journal_title：Current opinion in obstetrics & gynecology

authors： Gomez KJ,Copel JA

更新日期：1993-04-01 00:00:00

abstract：:The management of advanced ovarian cancer relies on appropriate surgical cytoreduction in conjunction with appropriate adjuvant chemotherapy. In the past year several studies have continued to support aggressive cytoreduction at the initial operation, including for stage IV disease, as well as in a second-look setting...

journal_title：Current opinion in obstetrics & gynecology

authors： Chen LM,Berek JS

更新日期：1998-02-01 00:00:00

abstract：:This review explores the recent experience with, and the basis for, the use of selective estrogen receptor modulators to treat and prevent breast cancer. As new agents are unveiled, they will continue to be tested against tamoxifen. A number of new selective estrogen receptor modulators are in clinical development in ...

journal_title：Current opinion in obstetrics & gynecology

authors： Bentrem DJ,Jordan VC

更新日期：2002-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Examine recent evidence of randomized controlled trials and meta-analyses regarding the effect of maternal vitamin D status and supplementation over obstetrical and offspring outcomes. RECENT FINDINGS:Maternal serum 25-hydroxyvitamin [25(OH)D] progressively declines during pregnancy because of fetal ...

journal_title：Current opinion in obstetrics & gynecology

authors： Pérez-López FR,Pilz S,Chedraui P

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The review aims to summarize recent data about vascular endothelial growth factor and its implications in the normal endometrium during the menstrual cycle, implantation window and early pregnancy. RECENT FINDINGS:Angiogenesis is crucial for the development of endometrium as well as for embryo implan...

journal_title：Current opinion in obstetrics & gynecology

authors： Nardo LG

更新日期：2005-08-01 00:00:00

abstract：:Immune based therapies for ovarian carcinoma continue to evolve. The current status of antibody, antibody conjugates, cytokine, cellular, and vaccine based immunotherapy is reviewed. Novel gene transfer strategies that will play an increasing important role in the evolution of immunotherapy are also discussed. ...

journal_title：Current opinion in obstetrics & gynecology

authors： Vanderkwaak TJ,Alvarez RD

更新日期：1999-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Microarray-based comparative genomic hybridization (array-CGH) which detects aneuploidies and submicroscopic deletions and duplications in one assay is now offered for genetic diagnosis in children and adults. Its application to prenatal diagnosis is still limited, but very promising. We predict that ...

journal_title：Current opinion in obstetrics & gynecology

authors： Van den Veyver IB,Beaudet AL

更新日期：2006-04-01 00:00:00

abstract：:Misoprostol, an orally active prostaglandin E1 analogue, has been used widely by the vaginal and oral routes for labour induction at or near term. Several recent trials have confirmed that it is highly effective. Overall caesarean section rates appear to be reduced, despite a relative increase in caesarean sections fo...

journal_title：Current opinion in obstetrics & gynecology

authors： Hofmeyr GJ

更新日期：2001-12-01 00:00:00

abstract：PURPOSE OF REVIEW:We present an update on amenorrhea in adolescent girls and young women. Amenorrhea may herald the onset of estrogen deficiency, which can adversely affect peak bone mass and ultimate risk of osteoporosis. RECENT FINDINGS:Adolescence is a critical period for bone accretion. Important modifiable factor...

journal_title：Current opinion in obstetrics & gynecology

authors： Gordon CM,Nelson LM

更新日期：2003-10-01 00:00:00

abstract：:The surgical management of hydrosalpinges is a controversial subject. Chronic pathology of the fallopian tube with distal obstruction leads to the formation of a hydrosalpinx, and is associated with very poor pregnancy rates after surgery. In these cases, in-vitro fertilization has proved to be a much better alternati...

journal_title：Current opinion in obstetrics & gynecology

authors： Mansour R,Aboulghar M,Serour GI

更新日期：2000-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The management of uterine fibroids in patients requiring treatment who desire future fertility remains controversial. Myomectomy has been the most common operative procedure to improve pregnancy rates and outcomes. Uterine fibroid embolization is an increasingly popular, minimally invasive treatment f...

journal_title：Current opinion in obstetrics & gynecology

authors： Goldberg J,Pereira L

更新日期：2006-08-01 00:00:00

abstract：:Adolescent pregnancy and its consequences continue as major sources of morbidity in the United States. A teenager who becomes a parent is at a significant disadvantage in becoming a contributing adult, both psychosocially and economically. The physician who cares for adolescents has the responsibility of helping paren...

journal_title：Current opinion in obstetrics & gynecology

authors： Cromer BA,Brown RT

更新日期：1992-12-01 00:00:00

abstract：:Chronic medical problems and the various medications available to treat them represent an enormous volume of information for the practicing obstetrician. The agents commonly encountered are reviewed here and current literature is explored, where available, including the literature on folates in pregnancy. ...

journal_title：Current opinion in obstetrics & gynecology

authors： Colie CF

更新日期：1996-12-01 00:00:00

abstract：:Few randomized studies have addressed the best choice of adjuvant radiation therapy after surgery for stage I endometrial cancer. Although whole pelvic radiation decreases the incidence of pelvic and vaginal cancer recurrence, there is no convincing evidence that it improves survival in women who have been completely ...

journal_title：Current opinion in obstetrics & gynecology

authors： Naumann RW

更新日期：2002-02-01 00:00:00

abstract：:For the majority of women, gynecologic cancer is a survivable disease. A brief overview of the recent findings on the psychological and behavioral aspects of gynecologic cancer is provided. The discussion is organized by disease-relevant time points, from prevention to recovery or death. Recognition of the positive re...

journal_title：Current opinion in obstetrics & gynecology

authors： Andersen BL

更新日期：1995-02-01 00:00:00

abstract：:The battle against the epidemic of sexually transmitted infections continues but the clinician has new diagnostic and therapeutic weapons. This manuscript reviews new technologies, as well as novel applications of newer methodologies, such as utilization of amplified DNA techniques for urine specimens or patient-colle...

journal_title：Current opinion in obstetrics & gynecology

authors： Biro FM

更新日期：1999-10-01 00:00:00