Abstract:
PURPOSE OF REVIEW:To avoid both overtreatment and undertreatment accurate risk assessment is mandatory. The present review gives an overview of recently published articles covering prognostic and predictive factors for adjuvant therapy in early breast cancer. RECENT FINDINGS:Gene expression signatures enhance prognostic accuracy with a high level of evidence. These signatures can be further improved by incorporating traditional pathological factors like tumor size. Newer genomic techniques like next-generation sequencing lead to a deeper understanding of the relationship between somatic mutations and prognosis or prediction of therapeutic efficacy. Furthermore, circulating tumor cells, and circulating cell-free or tumor DNA can lead to a better estimation of the risk of recurrence in early breast cancer. In addition, recent results underscore the prognostic and predictive importance of tumor-infiltrating lymphocytes and subtyping of immune cell infiltrates especially in triple-negative breast cancer. SUMMARY:The current review highlights recent studies improving prognostication and prediction of therapeutic efficacy in early breast cancer. These advances should lead to a better risk stratification and thereby to an improved tailoring of therapies.
journal_name
Curr Opin Obstet Gynecoljournal_title
Current opinion in obstetrics & gynecologyauthors
Schmidt Mdoi
10.1097/GCO.0000000000000594subject
Has Abstractpub_date
2020-02-01 00:00:00pages
100-105issue
1eissn
1040-872Xissn
1473-656Xpii
00001703-202002000-00015journal_volume
32pub_type
杂志文章abstract:PURPOSE OF REVIEW:More than 50% of all gynecologic cancers can be classified as rare tumors (defined as an incidence of <6 per 100 000) and as such represent a major challenge for clinicians. RECENT FINDINGS:The rapidly increasing number of targeted therapies provides a unique opportunity to improve treatment options ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000144
更新日期:2015-02-01 00:00:00
abstract::The advent of the AIDS epidemic coupled with enhanced recognition of the morbidity and mortality associated with occupationally acquired hepatitis B virus infection has resulted in a great interest in the epidemiologic characteristics of contact of surgical personnel with patient's blood and other bodily fluids in ass...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1993-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Ductal carcinoma in situ (DCIS) accounts for approximately 20% of mammographically diagnosed breast cancers. Currently, there is a trend to consider DCIS as a lesion for which treatment deescalation is advocated to avoid overtreatment, that is, radiotherapy in addition to breast-conserving surgery or ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000237
更新日期:2016-02-01 00:00:00
abstract:PURPOSE OF REVIEW:To review basic techniques and recent advances in endourology for the practicing gynecologist. RECENT FINDINGS:New ureteral stent designs are available to improve comfort and reduce some of the complications of indwelling ureteral stents. A large prospective study failed to show a significant benefit...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e32832fd23a
更新日期:2009-10-01 00:00:00
abstract::Reflective of increasing attention to male sterilization are the development in China of the so-called "no scalpel" vasectomy technique, experiments with predicting reversibility through measurement of the cytometry of testicular aspirates, and research on issues such as the effects of vasectomy on spermatogenesis...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1990-08-01 00:00:00
abstract::Magnetic resonance imaging represents a new method of imaging the pelvic viscera and pelvic floor musculature. Rapid sequences allow us to perform magnetic resonance imaging dynamically during straining or pelvic floor contraction, which can elegantly demonstrate the patterns of pelvic floor prolapse. The technique is...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-199808000-00003
更新日期:1998-08-01 00:00:00
abstract::Infertility is a common medical problem resulting from one or more defects in the reproductive tract. Of the known causes of infertility, cervico-utero-tubal factors are important because they are generally manageable. Cervical factors include changes in cervical architecture, mucus, or both, resulting in a hostile en...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1991-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses recently published data concerning the anabolic effects of androgens on muscle and the mechanism by which testosterone regulates body composition with special emphasis on the anabolic effects of androgens on the muscles of the pelvic floor and lower urinary tract. RECENT FINDING...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200410000-00009
更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Robotic surgery is rapidly taking the place of laparoscopy in many gynecologic oncology practices. Numerous practitioners have published their experience with this new technology. A review of their findings is timely and relevant. RECENT FINDINGS:The majority of case series of robotic surgery for hys...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e32831ffe8e
更新日期:2009-02-01 00:00:00
abstract::In the past year, new data have been published on the molecular biology of human papillomavirus infections and their relationship to cervical neoplasia. As molecular techniques have become more sophisticated and as the molecular knowledge of human papilloma-virus infections has been pursued in greater depth, it is inc...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1992-10-01 00:00:00
abstract::Loss of pelvic support involving the 'middle compartment' is manifested by herniation through the central pelvic floor in proximity to the intersection of an imaginary line from the public symphysis to the coccyx with another from one ischial spine to opposite ischial spine. Loss of middle compartment support may exis...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1993-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Polycystic ovary syndrome is one of the most common endocrinopathies affecting premenopausal women. This review focuses on this major cause of hyperandrogenism in adolescents and young women, highlighting new diagnostic and therapeutic strategies that are under investigation. The pathophysiologic role...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200210000-00002
更新日期:2002-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Benefit of micronutrient supplementation on female fertility. RECENT FINDINGS:Reports of randomized trials are rare. Most studies are focused on multivitamin supplementations. For some micronutrients, a positive impact on fertility could be shown. This article reviews the available clinical studies a...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3283609138
更新日期:2013-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Fetal and newborn brain injury causes lifelong morbidity for the survivors, with high emotional costs to the individual and the family plus a heavy economic burden for society. This is timely and relevant. Techniques are now available to prevent, detect, and treat those central nervous injuries that r...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3282f734db
更新日期:2008-04-01 00:00:00
abstract::Virilization occurring in the postmenopausal woman may be either adrenal or ovarian in origin. We describe the case of a 74-year-old postmenopausal woman with severe virilization and a serum testosterone level elevated into the male range who was found to have a non-malignant aetiology for her condition. ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Laparoscopy is the gold standard for the diagnosis of endometriosis but the need for visual evidence of the disease is a major stumbling-block for both effective clinical management of affected patients as well as for research into this common and debilitating reproductive disease. Laparoscopy is inva...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200312000-00011
更新日期:2003-12-01 00:00:00
abstract::Voiding disorders are frequently associated with urinary incontinence and other lower urinary tract dysfunction in women, but the cause of these disorders is not well understood and treatment options are limited. Little has changed in the treatment and evaluation of voiding disorders. New approaches to the study of de...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1996-10-01 00:00:00
abstract::Acquired immunodeficiency virus infections had recently been the leading cause of death in minority women of reproductive age in several urban cities in the United States. In addition, more than 80% of infants with human immunodeficiency virus type 1 infection acquired the infection perinatally. These alarming data ha...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1992-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Confidential enquiries of maternal deaths in the UK for 1997-1999 revealed that the number of indirect deaths from medical conditions exacerbated by pregnancy was greater than deaths from conditions directly caused by pregnancy. Indirect maternal deaths accounted for 36% of all deaths. Although neopla...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200304000-00003
更新日期:2003-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Pelvic organ prolapse is a common disease that negatively affects the lives of women. To date, basic science research into the pathogenesis of prolapse has been limited. The vagina and its supportive connective tissues provide one of the primary mechanisms of support to the pelvic organs. This review ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/01.gco.0000242958.25244.ff
更新日期:2006-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize recent advances in oocyte and embryo cryopreservation techniques and outcomes. RECENT FINDINGS:Vitrification is gradually replacing slow freezing due to a better survival rate after thawing. Most units use vitrification for both oocyte and blastocyst cryopreservation, as these two biolog...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e32834874e2
更新日期:2011-08-01 00:00:00
abstract::Specialized fetal echocardiography at 18 to 22 weeks for high-risk groups is well established as being sensitive and specific for most cardiac abnormalities. Early fetal echocardiography (< 16(+0) weeks, i.e. 16 weeks and 0 days) is a feasible alternative to mid second trimester scanning for families at risk of congen...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200104000-00010
更新日期:2001-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Neonatal herpes simplex virus infection is often severe, if not fatal. What is our understanding of the epidemiology of this disease? How is it diagnosed? Would maternal screening for herpes simplex virus-2 (HSV-2) in pregnancy make a difference? Does maternal HSV alter transmission of HIV vertically ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3283294840
更新日期:2009-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Endometriosis is a frequent gynaecological disorder in young women. Colorectal endometriosis accounts for about 90% of all intestinal locations. The effectiveness of medical therapies is poor, and surgery, including colorectal resection, is therefore often required. Since the first description of lapa...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e328216f6bc
更新日期:2007-08-01 00:00:00
abstract::Adolescent pregnancy and its consequences continue as major sources of morbidity in the United States. A teenager who becomes a parent is at a significant disadvantage in becoming a contributing adult, both psychosocially and economically. The physician who cares for adolescents has the responsibility of helping paren...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1992-12-01 00:00:00
abstract::The proper use of forceps or vacuum extractor, or both, remains a safe and effective modality in achieving the universal goal of a healthy mother and baby. Their use requires continued experience, sharing of information, and possibly attention to subtleties of design. This review looks at the current situation with sp...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1994-10-01 00:00:00
abstract::Doppler ultrasound velocimetry of uteroplacental, umbilical, and fetal vessels provides the clinician with important information on the hemodynamics of the vascular area under study. Transvaginal color Doppler is a new technique that allows precise investigation of fetomaternal circulation in early pregnancy. Doppler ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1994-10-01 00:00:00
abstract::Chronic medical problems and the various medications available to treat them represent an enormous volume of information for the practicing obstetrician. The agents commonly encountered are reviewed here and current literature is explored, where available, including the literature on folates in pregnancy. ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1996-12-01 00:00:00
abstract::Current studies verify the safety of surgery in the elderly. Delirium is a costly complication, but its incidence and severity can be reduced by pre- and postoperative interventions. Avoidance of even mild hypothermia has now been shown to reduce cardiovascular morbidity. New information available on the cardiovascula...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract::Approximately 2-3% of cervical smears will be reported as showing low-grade changes. Many of these smears are in fact associated with high-grade cervical intraepithelial neoplasia requiring treatment, but a significant number will be associated with an absence of cervical intraepithelial neoplasia, where surveillance ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1995-02-01 00:00:00