Testosterone supplementation in men: a practical guide for the gynecologist and obstetrician.

Abstract:

PURPOSE OF REVIEW:Prescribing habits for the treatment of symptomatic hypogonadism have recently stirred controversy surrounding testosterone replacement therapy. As a result, the gynecologist will need to recognize this iatrogenic form of decreased sperm production in couples seeking fertility advice. We have compiled a review of the current literature on testosterone supplementation pertaining to the gynecologic practice. RECENT FINDINGS:Over the last decade, testosterone use has seen a recent increase including in men desiring to become fathers. Many physicians and hypogonadal men do not recognize that testosterone replacement therapy can have a detrimental effect on spermatogenesis. Fortunately, the cessation of treatment will yield predictable recovery of sperm production for most men. A growing body of evidence supports the use of selective estrogen receptor modulators, such as clomiphene citrate, or human chorionic gonadotropin for the treatment of hypogonadism in men who wish to maintain fertility potential. Recently, the Food and Drug Administration has recommended a labeling update on testosterone products to warn of possible increased risk of venous thromboembolism, cardiovascular events and stroke. SUMMARY:Clinicians should be familiar with current practices involving testosterone replacement therapy and the implications on male factor fertility.

authors

Owen RC,Elkelany OO,Kim ED

doi

10.1097/GCO.0000000000000192

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

258-64

issue

4

eissn

1040-872X

issn

1473-656X

journal_volume

27

pub_type

杂志文章,评审
  • Male sterilization.

    abstract::Reflective of increasing attention to male sterilization are the development in China of the so-called "no scalpel" vasectomy technique, experiments with predicting reversibility through measurement of the cytometry of testicular aspirates, and research on issues such as the effects of vasectomy on spermatogenesis...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Davis JE

    更新日期:1990-08-01 00:00:00

  • Adolescent androgen abnormalities.

    abstract:PURPOSE OF REVIEW:Polycystic ovary syndrome is one of the most common endocrinopathies affecting premenopausal women. This review focuses on this major cause of hyperandrogenism in adolescents and young women, highlighting new diagnostic and therapeutic strategies that are under investigation. The pathophysiologic role...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200210000-00002

    authors: Stafford DE,Gordon CM

    更新日期:2002-10-01 00:00:00

  • Thromboembolism in pregnancy: recurrence risks, prevention and management.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize the epidemiology of thromboembolism in pregnancy and describe strategies to prevent and treat it. RECENT FINDINGS:The main reason for the increased risk of thrombosis in pregnancy is hypercoagulability. Other risk factors include a history of thrombosis, inh...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e328317a427

    authors: James AH

    更新日期:2008-12-01 00:00:00

  • Laboratory models for studying ectopic pregnancy.

    abstract:PURPOSE OF REVIEW:Understanding the cause of tubal ectopic pregnancy (tEP) remains incomplete. We aim to summarize the latest advances in laboratory models of tEP that we believe will, ultimately, contribute to improving the diagnosis and management of the condition. RECENT FINDINGS:Progress in proteome prefractionati...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e3283481212

    authors: Brown JK,Horne AW

    更新日期:2011-08-01 00:00:00

  • Physiology of uterine activity in pregnancy.

    abstract::During the past few years enormous progress has been made in the understanding of the molecular mechanisms involved in parturition; however, the answer to the fundamental question of how labor is initiated remains elusive. This is a very important question because alterations in the timing of birth (preterm and post-t...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Valenzuela GJ,Germain A,Foster TC

    更新日期:1993-10-01 00:00:00

  • Uncomplicated urinary tract infections in pregnant and non-pregnant women.

    abstract::Urinary tract infections (UTIs) are still one of the most common bacterial infections in pregnant and non-pregnant women. It is estimated that about 10-20% of all women suffer from a UTI at some point in life. The presence of UTI is defined as the existence of urinary symptoms such as frequency of urination and dysuri...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Weissenbacher ER,Reisenberger K

    更新日期:1993-08-01 00:00:00

  • Amenorrhea and bone health in adolescents and young women.

    abstract:PURPOSE OF REVIEW:We present an update on amenorrhea in adolescent girls and young women. Amenorrhea may herald the onset of estrogen deficiency, which can adversely affect peak bone mass and ultimate risk of osteoporosis. RECENT FINDINGS:Adolescence is a critical period for bone accretion. Important modifiable factor...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200310000-00005

    authors: Gordon CM,Nelson LM

    更新日期:2003-10-01 00:00:00

  • Magnetic resonance imaging of the fetal brain.

    abstract:PURPOSE OF REVIEW:Fetal magnetic resonance imaging (MRI) is a relatively new clinical application but is becoming increasingly used in fetal medicine in combination with the established technique of antenatal ultrasound. A review of the literature to date provides information for clinicians to help assess which patient...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e32832947ab

    authors: Rutherford MA

    更新日期:2009-04-01 00:00:00

  • Update on pregnancy, condom use, and prevalence of selected sexually transmitted diseases in adolescents.

    abstract::Adolescent pregnancy and its consequences continue as major sources of morbidity in the United States. A teenager who becomes a parent is at a significant disadvantage in becoming a contributing adult, both psychosocially and economically. The physician who cares for adolescents has the responsibility of helping paren...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Cromer BA,Brown RT

    更新日期:1992-12-01 00:00:00

  • The feasibility of laparoscopic bowel resection performed by a gynaecologist to treat endometriosis.

    abstract:PURPOSE OF REVIEW:Intestinal endometriosis is commonly diagnosed in the setting of deeply infiltrating endometriosis. A multidisciplinary team that includes gynaecologists and general surgeons traditionally performs laparoscopic bowel resections for symptomatic patients. Recently, Pereira et al. has published the resul...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e32833beae0

    authors: Pereira RM,Zanatta A,Serafini PC,Redwine D

    更新日期:2010-08-01 00:00:00

  • Implantation failure of endometrial origin: what is new?

    abstract:PURPOSE OF REVIEW:To review recent findings related to possible causes of recurrent implantation failure of endometrial origin in normal uterus. RECENT FINDINGS:Recent evidences suggest that in apparently normal endometria, RIF may associate with molecular and functional changes in the uterus such as abnormal endometr...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000468

    authors: Bellver J,Simón C

    更新日期:2018-08-01 00:00:00

  • Important considerations for women in the late reproductive and perimenopausal years desiring myomectomy.

    abstract:PURPOSE OF REVIEW:To review important considerations in the counseling and management of women over the age of 40 desiring a myomectomy for symptomatic fibroids. RECENT FINDINGS:Women in the late reproductive and perimenopausal years may choose a myomectomy over a hysterectomy for reasons of fertility preservation or ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000551

    authors: Pepin K,Reddy H,Clark NV

    更新日期:2019-08-01 00:00:00

  • Minimally invasive management of uterine fibroids.

    abstract:PURPOSE OF REVIEW:Many minimally invasive techniques have recently been introduced for the management of uterine fibroids. The purpose of this review is to analyse recent data for techniques that are used to manage uterine fibroids. RECENT FINDINGS:Laparoscopic myomectomy has provided a minimally invasive alternative ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200208000-00007

    authors: Falcone T,Bedaiwy MA

    更新日期:2002-08-01 00:00:00

  • Should we consider telomere length and telomerase activity in male factor infertility?

    abstract:PURPOSE OF REVIEW:The purpose of this review is to analyze what is known to date about the relation between telomeres and male fertility, and if it is possible for telomeres, or elements related to them, to be used as new prognostic biomarkers in fertility treatment. RECENT FINDINGS:Cells in germ series, including spe...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000451

    authors: Balmori C,Varela E

    更新日期:2018-06-01 00:00:00

  • Vulvar malignancy.

    abstract::Treatment of invasive vulvar malignancy has become more individualized during the past decade. In the past, radical vulvectomy with bilateral inguinofemoral lymphadenectomy was the standard therapy for invasive squamous cell carcinoma and melanoma of the vulva. This is no longer always the case. The treatment of stage...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Girtanner RE,Kaufman RH

    更新日期:1991-02-01 00:00:00

  • Pregnancy outcomes following treatment for fibroids: uterine fibroid embolization versus laparoscopic myomectomy.

    abstract:PURPOSE OF REVIEW:The management of uterine fibroids in patients requiring treatment who desire future fertility remains controversial. Myomectomy has been the most common operative procedure to improve pregnancy rates and outcomes. Uterine fibroid embolization is an increasingly popular, minimally invasive treatment f...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000233934.13684.cb

    authors: Goldberg J,Pereira L

    更新日期:2006-08-01 00:00:00

  • Elective delivery at less than 39 weeks.

    abstract:PURPOSE OF REVIEW:The prevalence and impact of elective deliveries occurring prior to 39 weeks' gestation has been the focus of several important studies published in recent medical literature. Defined as scheduled deliveries in the absence of medical or obstetrical indications, concern has been raised that many of the...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e3283404eb4

    authors: Ashton DM

    更新日期:2010-12-01 00:00:00

  • Obstetric and perinatal outcome in pregnancies after assisted reproduction.

    abstract::Infertile couples who seek medical advice have one single hope: to have one or more children. Therefore, pregnancy rates per cycle of any assisted reproductive technique that include early miscarriages and ectopic pregnancies are of little interest to them. They want to know their chances of having a baby. When counse...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Tanbo T,Abyholm T

    更新日期:1996-06-01 00:00:00

  • Consequences of fetal growth restriction.

    abstract::An increasing number of diseases in child and adult life are now thought to have their origins in the fetal period. Central to this predisposition is restriction of fetal growth. During the period reviewed in this article, the associations between adult hypertension and low birthweight were confirmed, and numerous stu...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-199804000-00011

    authors: Newnham J

    更新日期:1998-04-01 00:00:00

  • Prolonged pregnancy: when should we intervene?

    abstract:PURPOSE OF REVIEW:Prolonged (postterm) pregnancies are associated with both fetal and maternal complications. A variety of management practices can be utilized to mitigate the risk of these complications. RECENT FINDINGS:In addition to routine induction of labor at 41 weeks, a number of alternative management strategi...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/gco.0b013e328314b6f8

    authors: Doherty L,Norwitz ER

    更新日期:2008-12-01 00:00:00

  • Vitamin D in human reproduction.

    abstract:PURPOSE OF REVIEW:Vitamin D deficiency has been associated with a wide range of human disease states and the global epidemic, particularly in reproductive aged women, has led to a focus on this complex hormones role in human reproduction. Indeed vitamin D receptors are found throughout the reproductive tract in the ova...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000375

    authors: Franasiak JM,Lara EE,Pellicer A

    更新日期:2017-08-01 00:00:00

  • Towards optimal management of the mildly abnormal smear.

    abstract::Approximately 2-3% of cervical smears will be reported as showing low-grade changes. Many of these smears are in fact associated with high-grade cervical intraepithelial neoplasia requiring treatment, but a significant number will be associated with an absence of cervical intraepithelial neoplasia, where surveillance ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Cruickshank ME,Kitchener HC

    更新日期:1995-02-01 00:00:00

  • Harnessing the power of prevention: human papillomavirus vaccines.

    abstract::Human papillomavirus (HPV) infection and HPV-associated diseases pose a considerable health care burden in the United States. The morbidity and mortality associated with HPV infection and HPV-associated diseases, ranging from genital warts to cervical cancer, have prompted both the use of screening measures to monitor...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000216316.10690.c6

    authors: Mayeaux EJ Jr

    更新日期:2006-02-01 00:00:00

  • Injectables in the treatment of female stress incontinence.

    abstract::The failure to store urine resulting from bladder outflow incompetence requires a method to increase outflow resistance. Peri- and intraurethral injection is one form of treatment capable of accomplishing this need. The best results are obtained in those women who do not have detrusor abnormalities, who have adequate ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Appell RA

    更新日期:1995-10-01 00:00:00

  • Impact of follicle stimulating hormone receptor variants in fertility.

    abstract:PURPOSE OF REVIEW:Genetic variation plays a crucial role in modification of normal or disease pathophysiology. Follicle stimulating hormone receptor (FSHR) signaling is necessary for normal development and function of the ovaries and testes. Here, we review the associations between FSHR polymorphisms and fertility or s...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e3283455288

    authors: Lalioti MD

    更新日期:2011-06-01 00:00:00

  • Advances in the management of endometriosis in the adolescent.

    abstract:PURPOSE OF REVIEW:The present article provides an overview of the molecular mechanisms underlying adolescent endometriosis and advances in both medical and surgical management. RECENT FINDINGS:Molecular and cellular features of endometriotic lesions differ from eutopic endometrium. There is altered estrogen-mediated c...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000483

    authors: Mama ST

    更新日期:2018-10-01 00:00:00

  • Update in preimplantation genetic diagnosis: successes, advances, and problems.

    abstract::The field of preimplantation genetic diagnosis has undergone significant advances since the report of the first birth from this method in 1990. The first birth in the USA was reported in 1992, as was the first successful diagnosis and delivery of a baby free of a single gene defect disorder (cystic fibrosis and then T...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Grifo JA,Tang YX,Munne S,Krey L

    更新日期:1996-04-01 00:00:00

  • Early fetal anatomy screening: who, what, when and why?

    abstract:PURPOSE OF REVIEW:This article reviews the potential benefits and downsides of early anatomy screening. RECENT FINDINGS:There is increasing evidence that about 50% of severe fetal anomalies can be diagnosed prior to 14 weeks of gestation. 'Red flags' such as an increased nuchal or intracranial translucency, tricuspid ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000161

    authors: Van Mieghem T,Hindryckx A,Van Calsteren K

    更新日期:2015-04-01 00:00:00

  • Severe virilization in a postmenopausal woman.

    abstract::Virilization occurring in the postmenopausal woman may be either adrenal or ovarian in origin. We describe the case of a 74-year-old postmenopausal woman with severe virilization and a serum testosterone level elevated into the male range who was found to have a non-malignant aetiology for her condition. ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章

    doi:

    authors: Conn JJ,Conway GS

    更新日期:1996-10-01 00:00:00

  • The persistent challenge of foetal heart rate monitoring.

    abstract:PURPOSE OF REVIEW:To analyse the reasons why foetal heart rate (FHR) monitoring failed to fulfil the initial expectations of unequivocally decreasing perinatal morbidity and mortality, and to summarize the most recent advances in this field. RECENT FINDINGS:It is now clear that expectations towards FHR monitoring at t...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e328337233c

    authors: Bernardes J,Ayres-de-Campos D

    更新日期:2010-04-01 00:00:00