Abstract：
:In the past year, new data have been published on the molecular biology of human papillomavirus infections and their relationship to cervical neoplasia. As molecular techniques have become more sophisticated and as the molecular knowledge of human papilloma-virus infections has been pursued in greater depth, it is increasingly apparent that this human tumor DNA virus is similar to a number of other oncogenic DNA viruses that have been described and well studied. These viruses appear to act through a common pathway of producing oncogenic proteins that interfere with key signalling elements that normally control the process of cell division. With a better mechanistic knowledge, it should be possible to design new therapeutic approaches to treating human papillomavirus-associated disease that are directed toward specific cellular events such as turning off the production of E6 and E7 proteins or restoring the activity of pRB or p53. Increased attention has also been turned to immunologic aspects of HPV infections, and a number of groups are eagerly pursuing the possibility of using simple office-based procedures to detect specific proteins encoded for by the human papillomavirus open reading frames in an attempt to determine who has been infected, is actively infected, and has proteins being produced that are indicative of neoplasia. From the clinical point of view, the use of outpatient excisional techniques such as the loop electrosurgical excision procedure is rapidly supplanting ablative techniques because of their superior ability to identify early invasive carcinomas and adenocarcinomas in situ that have not been detected by colposcopy.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Curr Opin Obstet Gynecoljournal_title
Current opinion in obstetrics & gynecologyauthors
Richart RM,Wright TC Jrkeywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
662-9issue
5eissn
1040-872Xissn
1473-656Xjournal_volume
4pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:Telomere attrition and dysfunction has become a well established pathway involved in organismal aging, not only because it imposes a limitation to cell division and therefore, tissue regeneration but also because telomere homeostasis influences other pathways involved in aging. However, the implicatio...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0000000000000456
更新日期：2018-06-01 00:00:00
abstract：PURPOSE OF REVIEW:To provide an overview of the latest views and evidence available to clinicians managing couples with recurrent early pregnancy loss (RPL). RECENT FINDINGS:RPL is a heterogeneous condition associated with many pathologies, none of which is found in more than 50% of couples after routine investigation...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0b013e32833e124e
更新日期：2010-12-01 00:00:00
abstract：PURPOSE OF REVIEW:To review recent literature on medical accuracy, program effectiveness, and ethical concerns related to abstinence-only policies for adolescent sexuality education. RECENT FINDINGS:The federal government invests over 175 million dollars annually in 'abstinence-only-until-marriage' programs. These pro...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0b013e3282efdc0b
更新日期：2007-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The last several years have seen a number of important clinical and academic advances in long-acting reversible contraceptive (LARC) methods, such that many professional medical organizations now recommend these methods as first-line contraception for all women. RECENT FINDINGS:Recent data support th...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0000000000000227
更新日期：2015-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Vitamin D deficiency has been associated with a wide range of human disease states and the global epidemic, particularly in reproductive aged women, has led to a focus on this complex hormones role in human reproduction. Indeed vitamin D receptors are found throughout the reproductive tract in the ova...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0000000000000375
更新日期：2017-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Although there is effective screening for cervical cancer, it continues to be a healthcare problem in developing countries. To increase survival rates, different strategies with neoadjuvant chemotherapy have been developed. Nearly all trials that analysed neoadjuvant chemotherapy plus surgery demonstr...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/00001703-200502000-00008
更新日期：2005-02-01 00:00:00
abstract：:During the past few years enormous progress has been made in the understanding of the molecular mechanisms involved in parturition; however, the answer to the fundamental question of how labor is initiated remains elusive. This is a very important question because alterations in the timing of birth (preterm and post-t...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1993-10-01 00:00:00
abstract：:During the period under review (December 1990 through January 1992), the revised World Health Organization Histological Classification of Ovarian Neoplasms and Tumor-like Lesions was completed, and it is presented herein. This system of classification incorporates recent advances and includes newly recognized entities...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1992-08-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to discuss the diagnosis, medical complications, and treatment of eating disorders as defined by the newly released Diagnostic and Statistical Manual, 5th edition. RECENT FINDINGS:With the introduction of the Diagnostic and Statistical Manual, 5th edition, the diagnostic...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0000000000000317
更新日期：2016-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The review aims to summarize recent data about vascular endothelial growth factor and its implications in the normal endometrium during the menstrual cycle, implantation window and early pregnancy. RECENT FINDINGS:Angiogenesis is crucial for the development of endometrium as well as for embryo implan...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/01.gco.0000175362.12470.e0
更新日期：2005-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Genetic variation plays a crucial role in modification of normal or disease pathophysiology. Follicle stimulating hormone receptor (FSHR) signaling is necessary for normal development and function of the ovaries and testes. Here, we review the associations between FSHR polymorphisms and fertility or s...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0b013e3283455288
更新日期：2011-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Neonatal herpes simplex virus infection is often severe, if not fatal. What is our understanding of the epidemiology of this disease? How is it diagnosed? Would maternal screening for herpes simplex virus-2 (HSV-2) in pregnancy make a difference? Does maternal HSV alter transmission of HIV vertically ...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0b013e3283294840
更新日期：2009-04-01 00:00:00
abstract：:The management of advanced ovarian cancer relies on appropriate surgical cytoreduction in conjunction with appropriate adjuvant chemotherapy. In the past year several studies have continued to support aggressive cytoreduction at the initial operation, including for stage IV disease, as well as in a second-look setting...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/00001703-199802000-00010
更新日期：1998-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The most common method of antepartum fetal surveillance is the nonstress test (NST). Although it has satisfactory false-negative rates, dubious nonreactive results may challenge the physician. Any method or factor increasing the reactive NST results or shortening the time to attain a reactive test may...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0000000000000050
更新日期：2014-04-01 00:00:00
abstract：:Ovarian stimulation is applied during infertility management either alone or in conjunction with intrauterine insemination and assisted reproductive technologies. At the present time, the two main medications used for ovarian stimulation include an oral antiestrogen, clomiphene citrate, and injectable gonadotropins. I...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/00001703-200206000-00003
更新日期：2002-06-01 00:00:00
abstract：:This review explores some of the implications for a balanced approach to the ethics of maternal participation in clinical research, from the perspective of the fetus as a patient, which is a central concept in obstetric ethics. The review therefore begins with an account of this topic, followed by an examination of so...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/00001703-199912000-00002
更新日期：1999-12-01 00:00:00
abstract：:Mifepristone is an orally active progesterone antagonist. It can be used for both contraceptive and non-contraceptive clinical indications. It is a very effective drug for emergency contraception with a low incidence of side effects. There is a potential for mifepristone to be used as a once-a-month pill. There is a n...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/00001703-200206000-00013
更新日期：2002-06-01 00:00:00
abstract：PURPOSE OF REVIEW:To evaluate the role of fluorodeoxyglucose (FDG) PET/CT as cancer response testing in gynecological malignancies. RECENT FINDINGS:The application of FDG PET/CT in patients with endometrial and ovarian cancer to evaluate treatment response was found to have no clinical benefits.Patients with cervical ...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0b013e32835a7e96
更新日期：2013-02-01 00:00:00
abstract：:Selective oestrogen receptor modulators are a range of compounds which mimic some, but not all, agonist actions of oestrogen in different tissues. They were developed with the aim of maximizing the benefits of oestrogen-like drugs in a number of important conditions whilst reducing adverse side-effects. The molecular ...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/00001703-199806000-00002
更新日期：1998-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Therapeutics targeting the ErbB protein family receptors have not always yielded favorable or successful results in present cancer therapy. This review discusses the possibility of the clinical adaptation of targeting against heparin-binding epidermal growth factor-like growth factor (HB-EGF), one of ...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0b013e3283409c91
更新日期：2011-02-01 00:00:00
abstract：PURPOSE OF REVIEW:To review important considerations in the counseling and management of women over the age of 40 desiring a myomectomy for symptomatic fibroids. RECENT FINDINGS:Women in the late reproductive and perimenopausal years may choose a myomectomy over a hysterectomy for reasons of fertility preservation or ...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0000000000000551
更新日期：2019-08-01 00:00:00
abstract：:Congenital heart disease in pregnancy is increasingly common because of the advances in surgery and medical therapy which have taken place over the last 30 years, which means that more affected women are surviving into the reproductive age. Antenatal counselling needs to be tailored to the specific lesion, with pulmon...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/00001703-200204000-00006
更新日期：2002-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Fetal and newborn brain injury causes lifelong morbidity for the survivors, with high emotional costs to the individual and the family plus a heavy economic burden for society. This is timely and relevant. Techniques are now available to prevent, detect, and treat those central nervous injuries that r...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0b013e3282f734db
更新日期：2008-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The utility of positron emission tomography (PET) in gynecologic malignancy has increased rapidly in recent years. This review examines publications in this area. RECENT FINDINGS:PET scans are mostly performed using 18-fluorodeoxyglucose (FDG-PET). It is valuable in primary staging of untreated advan...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0b013e32801195c9
更新日期：2007-02-01 00:00:00
abstract：:Recent advances in seemingly remote areas of investigation, i.e. yeast cell cycle research and DNA amplifications, have opened spectacular avenues for understanding reproduction. The new insights on the single cell and subcellular level of processes, such as egg maturation, sperm-egg interaction and implantation enhan...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1994-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review was to summarize recently published clinical and animal-based studies of antenatal corticosteroids, describe current recommendations for practice, and suggest priority areas for future research. RECENT FINDINGS:A single course of antenatal corticosteroids is known to improv...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/00001703-200212000-00006
更新日期：2002-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this article is to provide an update for the GP on selected common vulvar concerns in prepubertal girls. Presentation, diagnostic criteria, and management of common vulvar conditions will be described. The following conditions are frequently encountered and may pose diagnostic or manage...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1097/GCO.0000000000000309
更新日期：2016-10-01 00:00:00
abstract：:In 1991, the abortion literature was characterized by articles relating to 1) epidemiologic issues in abortion care, 2) advances in knowledge and experience with medical abortifacients such as mifepristone (RU 486), and 3) cervical ripening prior to abortion with the use of both mifepristone and prostaglandins. Techni...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1992-08-01 00:00:00
abstract：:The field of preimplantation genetic diagnosis has undergone significant advances since the report of the first birth from this method in 1990. The first birth in the USA was reported in 1992, as was the first successful diagnosis and delivery of a baby free of a single gene defect disorder (cystic fibrosis and then T...
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1996-04-01 00:00:00
abstract：:Advances in perinatal and neonatal health care over the past few decades have resulted in a substantial reduction in perinatal mortality. Some of this improvement has been attributed to antepartum fetal surveillance techniques. The primary objective of antepartum fetal surveillance techniques is to avoid fetal deaths....
journal_title：Current opinion in obstetrics & gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1997-04-01 00:00:00
