Abstract:
PURPOSE OF REVIEW:Immune checkpoint blockade (ICB) is a promising area of cancer therapeutic research. Therapies targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) mechanism of tumor immune evasion have resulted in durable responses in many difficult-to-treat tumor types. While these inhibitors are being actively investigated in clinical trials for ovarian cancer, most patients fail to respond to initial treatment with immune therapy. This review focuses on biomarkers for predicting response to treatment, and discusses clinical trials using ICB for recurrent ovarian cancer. RECENT FINDINGS:While PD-L1 detection by immunohistochemistry (IHC) is approved as a companion or complementary diagnostic in some cancers, there are many limitations with its use as a predictive marker. Recent research has explored biomarkers beyond PD-L1 that assess for somatic mutations, immune cell infiltrate, and gene signatures. SUMMARY:With improved understanding of the tumor microenvironment and genomic classifications of ovarian tumors, new diagnostics and biomarkers that supplement conventional IHC may help predict response to therapy.
journal_name
Curr Opin Obstet Gynecoljournal_title
Current opinion in obstetrics & gynecologyauthors
Chin CD,Fares CM,Konecny GE,Rao Jdoi
10.1097/GCO.0000000000000596subject
Has Abstractpub_date
2020-02-01 00:00:00pages
84-90issue
1eissn
1040-872Xissn
1473-656Xpii
00001703-202002000-00013journal_volume
32pub_type
杂志文章abstract:PURPOSE OF REVIEW:To review updated information on the influence of endometrial scratching on IVF. RECENT FINDINGS:Endometrial receptivity remains an important rate-limiting step affecting the success of IVF. The current evidence on the effect of endometrial scratching on IVF ranges from marked improvement, no differe...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000264
更新日期:2016-06-01 00:00:00
abstract::During the past few years enormous progress has been made in the understanding of the molecular mechanisms involved in parturition; however, the answer to the fundamental question of how labor is initiated remains elusive. This is a very important question because alterations in the timing of birth (preterm and post-t...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1993-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To analyse the reasons why foetal heart rate (FHR) monitoring failed to fulfil the initial expectations of unequivocally decreasing perinatal morbidity and mortality, and to summarize the most recent advances in this field. RECENT FINDINGS:It is now clear that expectations towards FHR monitoring at t...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e328337233c
更新日期:2010-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The past 15 years have seen a five-fold increase in the incidence of acquired heart disease as a cause of maternal mortality in the UK, and advances in the surgical correction of congenital heart disease have enabled many more women to survive childhood and present at the antenatal clinic. This review...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e328332a762
更新日期:2009-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Sex trafficking of adolescents and young adults is both a human rights violation and a public health problem, globally and in the United States. Healthcare providers, including obstetricians and gynecologists, interact with victims, often while they remain under their traffickers' control, but because...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000198
更新日期:2015-10-01 00:00:00
abstract:PURPOSE OF REVIEW:In the past 10 years, clinicians have become more suspect regarding thromboembolic events and potential thrombosis in children at risk. Although adolescents are not typically considered to be a high-risk group, they are the main seekers of contraception in our society today, thereby placing them at so...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e32830ab83f
更新日期:2008-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews new concepts in the aetiology of recurrent miscarriage, presents new outcome data and evaluates new modalities of treatment for unexplained recurrent miscarriage. RECENT FINDINGS:Preimplantation genetic diagnosis has been considered an option for couples who have structural chrom...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/01.gco.0000194112.86051.26
更新日期:2005-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The different patterns of autoreactivity that may account for the premature infertility observed in patients with premature ovarian failure are described. RECENT FINDINGS:Animal model studies have detailed fundamental immune dysregulatory patterns that induce ovarian failure in the context of global ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e328220e90c
更新日期:2007-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the role of mullerian inhibiting substance in the context of female reproduction. RECENT FINDINGS:Serum and follicular fluid mullerian inhibiting substance can be measured by commercially available enzyme-linked immunosorbent assay kits. Mullerian inhibiting substance is secreted from small...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3282fe99f2
更新日期:2008-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to discuss the diagnosis, medical complications, and treatment of eating disorders as defined by the newly released Diagnostic and Statistical Manual, 5th edition. RECENT FINDINGS:With the introduction of the Diagnostic and Statistical Manual, 5th edition, the diagnostic...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000317
更新日期:2016-10-01 00:00:00
abstract::Congenital heart disease in pregnancy is increasingly common because of the advances in surgery and medical therapy which have taken place over the last 30 years, which means that more affected women are surviving into the reproductive age. Antenatal counselling needs to be tailored to the specific lesion, with pulmon...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200204000-00006
更新日期:2002-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses recently published data concerning the anabolic effects of androgens on muscle and the mechanism by which testosterone regulates body composition with special emphasis on the anabolic effects of androgens on the muscles of the pelvic floor and lower urinary tract. RECENT FINDING...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200410000-00009
更新日期:2004-10-01 00:00:00
abstract::The failure to store urine resulting from bladder outflow incompetence requires a method to increase outflow resistance. Peri- and intraurethral injection is one form of treatment capable of accomplishing this need. The best results are obtained in those women who do not have detrusor abnormalities, who have adequate ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1995-10-01 00:00:00
abstract::In the past year, new data have been published on the molecular biology of human papillomavirus infections and their relationship to cervical neoplasia. As molecular techniques have become more sophisticated and as the molecular knowledge of human papilloma-virus infections has been pursued in greater depth, it is inc...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1992-10-01 00:00:00
abstract::Urinary incontinence remains a common problem that adversely affects the quality of life of millions of women. In detrusor instability, treatment measures often lack efficacy or are accompanied by unacceptable side effects. In this review, standard treatments are discussed, together with recent pharmacologic advances ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1991-08-01 00:00:00
abstract::This review discusses studies documenting an increase in birth rate associated with in vitro fertilization and gamete intrafallopian transfer. The results of zygote intrafallopian transfer are also encouraging. The rates of chromosomal and congenital abnormalities in assisted reproduction are similar to the rates at w...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1991-10-01 00:00:00
abstract::The principles of managed care are more difficult to apply to preventive medical treatments, such as hormone replacement therapy, than to the investigation and treatment of established disease. In addition to an ageing society with increased health demands, the use of hormone replacement therapy is increasing in most ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1997-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Benefit of micronutrient supplementation on female fertility. RECENT FINDINGS:Reports of randomized trials are rare. Most studies are focused on multivitamin supplementations. For some micronutrients, a positive impact on fertility could be shown. This article reviews the available clinical studies a...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3283609138
更新日期:2013-06-01 00:00:00
abstract:PURPOSE OF REVIEW:We review the techniques recently tested in both animal models and humans to provide a state-of-the-art on adult stem cell ovarian transplant to achieve ovarian rejuvenation in patients with diminished ovarian reserves. RECENT FINDINGS:As the firsts reports of spontaneous pregnancies achieved after b...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000531
更新日期:2019-06-01 00:00:00
abstract::Ultrasound prenatal diagnosis of structural anomalies has become almost a separate branch of obstetrics. The advantages of performing ultrasound in pregnancies at high risk for fetal structural anomalies are clear. Patients and the news media have placed ever-increasing expectations on persons performing diagnostic ul...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1993-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide clinicians with a review of recent research and clinically applicable tools regarding teen pregnancy. RECENT FINDINGS:Teen pregnancy rates have declined but still remain a significant problem in the USA. Teen pregnancy prevention was identified by Centers for Disease Control and Prevention...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000102
更新日期:2014-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews the potential benefits and downsides of early anatomy screening. RECENT FINDINGS:There is increasing evidence that about 50% of severe fetal anomalies can be diagnosed prior to 14 weeks of gestation. 'Red flags' such as an increased nuchal or intracranial translucency, tricuspid ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000161
更新日期:2015-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Selective intrauterine growth restriction (sIUGR) in twin pregnancies presents a complex management problem for the fetal medicine specialist. This review summarizes what is currently known about sIUGR pathophysiology, particularly in monochorionic pregnancies and looks at the results of early trials ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000326
更新日期:2016-12-01 00:00:00
abstract::Various malignant neoplasms, either primary or secondary, can affect the vagina. The most common primary malignant tumors of the vagina are squamous cell cancers; however, they are among the most uncommon of all primary gynecologic cancers. Vaginal intraepithelial neoplasia is being diagnosed with increasing frequency...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1991-02-01 00:00:00
abstract::Current ultrasound equipment allows the antenatal identification of many central nervous system anomalies from early gestation. In selected cases, special techniques (transvaginal sonography, three-dimensional ultrasound, colour Doppler) may enhance the diagnostic potential. Diagnostic accuracy, however, remains heavi...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/00001703-200004000-00007
更新日期:2000-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The last several years have seen a number of important clinical and academic advances in long-acting reversible contraceptive (LARC) methods, such that many professional medical organizations now recommend these methods as first-line contraception for all women. RECENT FINDINGS:Recent data support th...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000227
更新日期:2015-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The prevalence and impact of elective deliveries occurring prior to 39 weeks' gestation has been the focus of several important studies published in recent medical literature. Defined as scheduled deliveries in the absence of medical or obstetrical indications, concern has been raised that many of the...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3283404eb4
更新日期:2010-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Therapeutics targeting the ErbB protein family receptors have not always yielded favorable or successful results in present cancer therapy. This review discusses the possibility of the clinical adaptation of targeting against heparin-binding epidermal growth factor-like growth factor (HB-EGF), one of ...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0b013e3283409c91
更新日期:2011-02-01 00:00:00
abstract::Loss of pelvic support involving the 'middle compartment' is manifested by herniation through the central pelvic floor in proximity to the intersection of an imaginary line from the public symphysis to the coccyx with another from one ischial spine to opposite ischial spine. Loss of middle compartment support may exis...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:
更新日期:1993-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The clinical utility of sperm DNA fragmentation tests needs to be revisited in light of increasing evidence of detrimental effect of sperm DNA damage on reproductive outcomes. RECENT FINDINGS:Current evidence supports the association between high sperm DNA fragmentation and poor outcomes with regards...
journal_title:Current opinion in obstetrics & gynecology
pub_type: 杂志文章,评审
doi:10.1097/GCO.0000000000000271
更新日期:2016-06-01 00:00:00