Perinatal infections and fetal/neonatal brain injury.

Abstract:

PURPOSE OF REVIEW:Fetal and newborn brain injury causes lifelong morbidity for the survivors, with high emotional costs to the individual and the family plus a heavy economic burden for society. This is timely and relevant. Techniques are now available to prevent, detect, and treat those central nervous injuries that result from infection. If instituted, these would have beneficial results for both newborn survival and morbidity. RECENT FINDINGS:The new developments and prevention of adverse impacts of maternal infections due to Rubella, Group B Streptococcus, cytomegalovirus, toxoplasmosis, and chorioamnionitis are discussed. SUMMARY:Rubella immunization has been a success in the USA with virtual elimination of wild virus infection. Broader screening policies need to be instituted to lower the morbidities associated with cytomegalovirus and toxoplasmosis. Alternatives to maternal antibiotic prophylaxis in newborn Group B Streptococcus infection need to be evaluated and implemented when proven effective. The most beneficial treatment protocol for chorioamnionitis needs to be determined by prospective study and then instituted. To date, the combination of maternal antibiotics and steroids appears most promising.

authors

Ledger WJ

doi

10.1097/GCO.0b013e3282f734db

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

120-4

issue

2

eissn

1040-872X

issn

1473-656X

pii

00001703-200804000-00009

journal_volume

20

pub_type

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