Targeting the heparin-binding epidermal growth factor-like growth factor in ovarian cancer therapy.

Abstract:

PURPOSE OF REVIEW:Therapeutics targeting the ErbB protein family receptors have not always yielded favorable or successful results in present cancer therapy. This review discusses the possibility of the clinical adaptation of targeting against heparin-binding epidermal growth factor-like growth factor (HB-EGF), one of the ligands of the ErbB system, in ovarian cancer therapy. RECENT FINDINGS:We have previously described the results of studies concerning roles of HB-EGF in tumor formation in ovarian cancer. In brief, lisophosphatidic acid (LPA) and HB-EGF are predominantly expressed in advanced ovarian cancer, and LPA-induced, a disintegrin and metalloprotease-mediated ectodomain shedding of HB-EGF was found to be critical to tumor formation. We also noted that exogenous expression of HB-EGF enhanced tumor formation but inhibition blocked both extracellular signal-related kinase and serine/threonine protein kinase activation. Finally we investigated the antitumor effects of CRM197 - a specific HB-EGF inhibitor - on ovarian cancer cells by evaluating human ovarian cancer cell proliferation. SUMMARY:We discuss alternative strategies to develop the chemotherapeutic agent based on targeting ErbB family ligands rather than their receptors. A phase I study of CRM197 for advanced ovarian cancer has already begun, which is the first approved trial of ErbB-ligand-targeted therapy. We also discuss clinical adaptations based on combination of CRM197 with other conventional chemotherapeutic agents.

authors

Tsujioka H,Yotsumoto F,Hikita S,Ueda T,Kuroki M,Miyamoto S

doi

10.1097/GCO.0b013e3283409c91

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

24-30

issue

1

eissn

1040-872X

issn

1473-656X

journal_volume

23

pub_type

杂志文章,评审
  • Minimally invasive surgery in assisted conception.

    abstract::Minimally invasive surgery enables the avoidance of, preparation for, participation in, and treatment of complications following assisted reproductive technology (ART). The major recent changes are, the development of surgical techniques to diagnose and treat intrafallopian tubal abnormalities; the use of operative en...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Wood C

    更新日期:1994-06-01 00:00:00

  • Physiology of uterine activity in pregnancy.

    abstract::During the past few years enormous progress has been made in the understanding of the molecular mechanisms involved in parturition; however, the answer to the fundamental question of how labor is initiated remains elusive. This is a very important question because alterations in the timing of birth (preterm and post-t...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Valenzuela GJ,Germain A,Foster TC

    更新日期:1993-10-01 00:00:00

  • Management of benign ovarian lesions in girls: a trend toward fewer oophorectomies.

    abstract:PURPOSE OF REVIEW:The management of benign ovarian lesions in girls is currently a controversial topic in the pediatric surgical literature. The purpose of this review is to highlight the epidemiology of benign ovarian masses, outline preoperative risk stratification strategies, review the indications and importance of...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000400

    authors: Gonzalez DO,Minneci PC,Deans KJ

    更新日期:2017-10-01 00:00:00

  • Cardiac disease in pregnancy.

    abstract:PURPOSE OF REVIEW:The past 15 years have seen a five-fold increase in the incidence of acquired heart disease as a cause of maternal mortality in the UK, and advances in the surgical correction of congenital heart disease have enabled many more women to survive childhood and present at the antenatal clinic. This review...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e328332a762

    authors: Curry R,Swan L,Steer PJ

    更新日期:2009-12-01 00:00:00

  • Medications in pregnancy.

    abstract::Chronic medical problems and the various medications available to treat them represent an enormous volume of information for the practicing obstetrician. The agents commonly encountered are reviewed here and current literature is explored, where available, including the literature on folates in pregnancy. ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Colie CF

    更新日期:1996-12-01 00:00:00

  • Changing trends in surgery for stress urinary incontinence.

    abstract:PURPOSE OF REVIEW:Currently, a number of different stress urinary incontinence (SUI) procedures exist. The relatively recent adoption of the midurethral sling into clinical practice has changed the surgical management of SUI. This critical evaluation of the trends in SUI surgery emphasizes the public health burden of S...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e3283648cdd

    authors: Geller EJ,Wu JM

    更新日期:2013-10-01 00:00:00

  • Induction of labour with misoprostol.

    abstract::Misoprostol, an orally active prostaglandin E1 analogue, has been used widely by the vaginal and oral routes for labour induction at or near term. Several recent trials have confirmed that it is highly effective. Overall caesarean section rates appear to be reduced, despite a relative increase in caesarean sections fo...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200112000-00005

    authors: Hofmeyr GJ

    更新日期:2001-12-01 00:00:00

  • State of the art in in-vitro oocyte maturation.

    abstract:PURPOSE OF REVIEW:The recovery of immature oocytes followed by in-vitro maturation (IVM) and in-vitro fertilization is an attractive alternative to conventional in-vitro fertilization treatment in which controlled ovarian stimulation with gonadotropins is used to increase the number of available oocytes and embryos. Si...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200406000-00003

    authors: Chian RC,Lim JH,Tan SL

    更新日期:2004-06-01 00:00:00

  • Emergency contraception, efficacy and public health impact.

    abstract:PURPOSE OF REVIEW:Emergency contraception in the past two decades had been proven to be effective and well tolerated. Counseling and advance provision and prescription of emergency contraception have been embraced by professional organizations in practice guidelines for its potential to reduce the number of unintended ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e32832e0772

    authors: Broekhuizen FF

    更新日期:2009-08-01 00:00:00

  • Early fetal anatomy screening: who, what, when and why?

    abstract:PURPOSE OF REVIEW:This article reviews the potential benefits and downsides of early anatomy screening. RECENT FINDINGS:There is increasing evidence that about 50% of severe fetal anomalies can be diagnosed prior to 14 weeks of gestation. 'Red flags' such as an increased nuchal or intracranial translucency, tricuspid ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000161

    authors: Van Mieghem T,Hindryckx A,Van Calsteren K

    更新日期:2015-04-01 00:00:00

  • Quality of life for women with gynecologic cancer.

    abstract::For the majority of women, gynecologic cancer is a survivable disease. A brief overview of the recent findings on the psychological and behavioral aspects of gynecologic cancer is provided. The discussion is organized by disease-relevant time points, from prevention to recovery or death. Recognition of the positive re...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Andersen BL

    更新日期:1995-02-01 00:00:00

  • Common prepubertal vulvar conditions.

    abstract:PURPOSE OF REVIEW:The purpose of this article is to provide an update for the GP on selected common vulvar concerns in prepubertal girls. Presentation, diagnostic criteria, and management of common vulvar conditions will be described. The following conditions are frequently encountered and may pose diagnostic or manage...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000309

    authors: Vilano SE,Robbins CL

    更新日期:2016-10-01 00:00:00

  • Forceps and vacuum extraction.

    abstract::The proper use of forceps or vacuum extractor, or both, remains a safe and effective modality in achieving the universal goal of a healthy mother and baby. Their use requires continued experience, sharing of information, and possibly attention to subtleties of design. This review looks at the current situation with sp...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Robinson JC

    更新日期:1994-10-01 00:00:00

  • Ultrasound screening for fetal structural anomalies.

    abstract::Ultrasound prenatal diagnosis of structural anomalies has become almost a separate branch of obstetrics. The advantages of performing ultrasound in pregnancies at high risk for fetal structural anomalies are clear. Patients and the news media have placed ever-increasing expectations on persons performing diagnostic ul...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Gomez KJ,Copel JA

    更新日期:1993-04-01 00:00:00

  • Amenorrhea and bone health in adolescents and young women.

    abstract:PURPOSE OF REVIEW:We present an update on amenorrhea in adolescent girls and young women. Amenorrhea may herald the onset of estrogen deficiency, which can adversely affect peak bone mass and ultimate risk of osteoporosis. RECENT FINDINGS:Adolescence is a critical period for bone accretion. Important modifiable factor...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200310000-00005

    authors: Gordon CM,Nelson LM

    更新日期:2003-10-01 00:00:00

  • Neoadjuvant chemotherapy in cervical cancer: a new trend.

    abstract:PURPOSE OF REVIEW:Although there is effective screening for cervical cancer, it continues to be a healthcare problem in developing countries. To increase survival rates, different strategies with neoadjuvant chemotherapy have been developed. Nearly all trials that analysed neoadjuvant chemotherapy plus surgery demonstr...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200502000-00008

    authors: Sardi JE,Boixadera MA,Sardi JJ

    更新日期:2005-02-01 00:00:00

  • Ureteral stents and retrograde studies: a primer for the gynecologist.

    abstract:PURPOSE OF REVIEW:To review basic techniques and recent advances in endourology for the practicing gynecologist. RECENT FINDINGS:New ureteral stent designs are available to improve comfort and reduce some of the complications of indwelling ureteral stents. A large prospective study failed to show a significant benefit...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e32832fd23a

    authors: Aungst MJ,Sears CL,Fischer JR

    更新日期:2009-10-01 00:00:00

  • Aromatase inhibition for ovarian stimulation: future avenues for infertility management.

    abstract::Ovarian stimulation is applied during infertility management either alone or in conjunction with intrauterine insemination and assisted reproductive technologies. At the present time, the two main medications used for ovarian stimulation include an oral antiestrogen, clomiphene citrate, and injectable gonadotropins. I...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200206000-00003

    authors: Mitwally MF,Casper RF

    更新日期:2002-06-01 00:00:00

  • The role of radiation therapy in early endometrial cancer.

    abstract::Few randomized studies have addressed the best choice of adjuvant radiation therapy after surgery for stage I endometrial cancer. Although whole pelvic radiation decreases the incidence of pelvic and vaginal cancer recurrence, there is no convincing evidence that it improves survival in women who have been completely ...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200202000-00012

    authors: Naumann RW

    更新日期:2002-02-01 00:00:00

  • Fertility, IVF and reproductive genetics.

    abstract:PURPOSE OF REVIEW:Telomere attrition and dysfunction has become a well established pathway involved in organismal aging, not only because it imposes a limitation to cell division and therefore, tissue regeneration but also because telomere homeostasis influences other pathways involved in aging. However, the implicatio...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000456

    authors: Varela E,Sánchez-de-Puerta I,García-Velasco JA

    更新日期:2018-06-01 00:00:00

  • Adolescent androgen abnormalities.

    abstract:PURPOSE OF REVIEW:Polycystic ovary syndrome is one of the most common endocrinopathies affecting premenopausal women. This review focuses on this major cause of hyperandrogenism in adolescents and young women, highlighting new diagnostic and therapeutic strategies that are under investigation. The pathophysiologic role...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200210000-00002

    authors: Stafford DE,Gordon CM

    更新日期:2002-10-01 00:00:00

  • Adenomyosis: what is the impact on fertility?

    abstract:PURPOSE OF REVIEW:This review is timely and relevant for several reasons. The incidence of adenomyosis begins to rise from the mid-thirties. Moreover, more women are delaying their first pregnancy until later in their thirties or forties, and consequently adenomyosis is encountered more frequently in the fertility clin...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.gco.0000169103.85128.c0

    authors: Matalliotakis IM,Katsikis IK,Panidis DK

    更新日期:2005-06-01 00:00:00

  • Vitamin D in human reproduction.

    abstract:PURPOSE OF REVIEW:Vitamin D deficiency has been associated with a wide range of human disease states and the global epidemic, particularly in reproductive aged women, has led to a focus on this complex hormones role in human reproduction. Indeed vitamin D receptors are found throughout the reproductive tract in the ova...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000375

    authors: Franasiak JM,Lara EE,Pellicer A

    更新日期:2017-08-01 00:00:00

  • Sex trafficking of adolescents and young adults in the United States: healthcare provider's role.

    abstract:PURPOSE OF REVIEW:Sex trafficking of adolescents and young adults is both a human rights violation and a public health problem, globally and in the United States. Healthcare providers, including obstetricians and gynecologists, interact with victims, often while they remain under their traffickers' control, but because...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000198

    authors: Chaffee T,English A

    更新日期:2015-10-01 00:00:00

  • Roles and types of radiation in breast cancer treatment: early breast cancer, locoregionally advanced, and metastatic disease.

    abstract:PURPOSE OF REVIEW:To describe the current role of radiation therapy and specific types of radiation therapy used in the management of early stage, locoregionally advanced, and metastatic breast cancer. RECENT FINDINGS:The role of radiation therapy in the management of breast cancer has not changed in recent decades, h...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0b013e3283425401

    authors: McCloskey SA,Lee SP,Steinberg ML

    更新日期:2011-02-01 00:00:00

  • Controversies in the surgical management of hydrosalpinx.

    abstract::The surgical management of hydrosalpinges is a controversial subject. Chronic pathology of the fallopian tube with distal obstruction leads to the formation of a hydrosalpinx, and is associated with very poor pregnancy rates after surgery. In these cases, in-vitro fertilization has proved to be a much better alternati...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-200008000-00006

    authors: Mansour R,Aboulghar M,Serour GI

    更新日期:2000-08-01 00:00:00

  • Cryopreservation of human embryos and oocytes.

    abstract::Human embryo cryopreservation is now a fully established adjunct to assisted reproduction, with thawed embryos implanting at a rate approaching that of fresh embryos. As with fresh embryos, the quality of frozen-thawed embryos is affected by patient age at the time of oocyte retrieval, and by culture conditions. Ovari...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/00001703-199506000-00006

    authors: Tucker MJ,Morton PC,Sweitzer CL,Wright G

    更新日期:1995-06-01 00:00:00

  • Prediction of spontaneous preterm birth: no good test for predicting a spontaneous preterm birth.

    abstract:PURPOSE OF REVIEW:Spontaneous preterm birth complicates 3-11% of pregnancies and is a major cause of neonatal mortality and morbidity worldwide. If accurate tests can be identified, a potentially effective screening strategy with an adjunct preventive therapy may be trialled to reduce the rate of spontaneous preterm bi...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章

    doi:10.1097/GCO.0b013e328359823a

    authors: Honest H,Hyde CJ,Khan KS

    更新日期:2012-12-01 00:00:00

  • Laparoscopic oophorectomy.

    abstract::Laparoscopic oophorectomy is one of the most controversial and challenging areas of endoscopic surgery. Judicious preoperative evaluation along with careful patient selection can reduce the risk of operating on an unsuspected ovarian malignancy. Appropriate patient consent and planning should be obtained before the pr...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:

    authors: Russell JB

    更新日期:1995-08-01 00:00:00

  • A Strength, Weaknesses, Opportunities and Threats analysis on time lapse.

    abstract:PURPOSE OF REVIEW:The study of embryonic development through conventional microscopy has contributed significantly to the success of IVF. However, clinical pregnancy rates per transfer remain as low as 30% according to the latest records of European society if human reproduction and society if assisted reproduction. Co...

    journal_title:Current opinion in obstetrics & gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/GCO.0000000000000534

    authors: Basile N,Elkhatib I,Meseguer M

    更新日期:2019-06-01 00:00:00