Abstract：
:The beneficial effect of trans-resveratrol (RESV) on health is well documented. Our aim was to study the putative preventive effect of RESV on the cytotoxicity of frequently used herbicides (alachlor, acetochlor). Estrogen receptor positive (ER+) MCF-7 human mammary carcinoma, HepG2 (ER+) human hepatocellular carcinoma and VERO estrogen receptor negative (ER-) non-transformed monkey fibroblast cell lines were treated with alachlor and acetochlor (2-500 microg/ml) as toxic agents, and RESV (10 microM) as preventive agent. The MTT dye reduction assay was performed to test cytotoxicity, and flow cytometry to test cell proliferation and apoptosis. RESV is not cytotoxic in the concentration range of 1-100 microM on neither cell lines examined after 24 h, but cytotoxic on Vero and MCF-7 cells at 100 microM after 48h, and on all three cell lines after 72 h. On both ER+ cell lines a stimulation of viability occurs in the low concentration range (0.5-12.5 microM) as detected by the MTT assay. Cell cycle analysis of the culture shows a significant increase of S-phase cells at low concentrations of RESV (10-50 microM) and a decrease in the 100-200 microM concentration range. The ratio of apoptotic cells significantly increases after the administration of 50 microM RESV, depending on the incubation time. The cytotoxicity of 20-65 microg/ml alachlor and 10-65 microg/ml acetochlor was significantly decreased by the addition of 10 microM RESV in Vero ER- cells whereas no significant change was detected on ER+ cell lines MCF-7 and HepG2. These results show that RESV protects non-transformed ER- cells, but has no such effect on ER+ tumor cells.
journal_name
Int J Hyg Environ Healthauthors
Kocsis Z,Marcsek ZL,Jakab MG,Szende B,Tompa Adoi
10.1016/j.ijheh.2005.01.021keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
211-8issue
3eissn
1438-4639issn
1618-131Xpii
S1438-4639(05)00022-2journal_volume
208pub_type
杂志文章abstract：:Under-five children diarrhea remains a major public health problem in resource-limited areas, including Ethiopia, due to multiple risk factors. This study aimed to identify individual and community-level risk factors affecting under-five children diarrhea (UFCD) in five districts of the Bench Maji Zone, southwestern E...
journal_title：International journal of hygiene and environmental health
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abstract：:Mental disorders were often reported following hazardous substance exposure. The present study analyses this association in relation to a work-related exposure to PCBs (polychlorinated biphenyls). Specifically, the aim was to investigate (a) the relationship of inner PCB burden and the severity of mental symptoms and ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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journal_title：International journal of hygiene and environmental health
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abstract：:Helicobacter pylori (H. pylori) is one of the world's most widespread microorganisms. Its acquisition in humans remains poorly understood, however, epidemiological studies have identified drinking water as reservoir for the bacterium. The aim of this study was to investigate the prevalence of H. pylori infection among...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,多中心研究
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abstract：:School facility conditions, environment, and perceptions of safety and learning have been investigated for their impact on child development. However, it is important to consider how the environment separately influences academic performance and attendance after controlling for school and community factors. Using resu...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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abstract：:Adequate access to water, sanitation, and hygiene (WaSH) in schools impacts health, educational outcomes, and gender disparities. Little multi-country research has been published on WaSH in rural schools in Sub-Saharan Africa. In this multi-national cross-sectional WaSH study, we document WaSH access, continuity, qual...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2017.03.015
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abstract：:Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease (COPD), asthma and lung cancer. Evaluation and understanding of tobacco health effects are of major interest worldwide and answer to...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2016.12.010
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abstract：:The aim of this study was to examine the survival dynamics of several epidemic healthcare (HA) and community-associated (CA) meticillin-resistant Staphylococcus aureus (MRSA) in river, sea and swimming pool waters. Six different phage-types of HA-MRSA (Irish 1, Irish 2, EMRSA 15, EMRSA 16, distinct type and non-typabl...
journal_title：International journal of hygiene and environmental health
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doi：10.1016/j.ijheh.2007.06.003
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abstract：:Reference values (RV95) are statistically derived values comprising the rounded 95th percentiles within the 95% confidence interval and indicate the upper margin of background exposure to chemical substances in a population at a given time period. Based on representative national human biomonitoring data on several ur...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2018.06.001
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND AND AIM:Epidemiological studies linking insecticide exposure to childhood neurodevelopment have been gaining global attention. Despite the rapid development of the central nervous system in early childhood, studies regarding the biological monitoring of insecticide exposure in diapered children are limited. ...
journal_title：International journal of hygiene and environmental health
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abstract：:Human biomonitoring (HBM) has proven an extremely valuable tool for determining which chemicals are getting into people, detecting trends in population exposures over time, and identifying populations with exposures above background. The potential significance of the HBM data in the context of existing toxicology data...
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更新日期：2012-02-01 00:00:00
abstract：:The production and use of the plasticisers Hexamoll® DINCH (di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate) and DPHP (di-(2-propylheptyl) phthalate) have increased after both chemicals were introduced into the market in the early 2000s as substitutes for restricted high molecular weight phthalates. During the population...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2019.09.004
更新日期：2020-08-01 00:00:00
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00162
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abstract：:Water, sanitation, and hygiene (WASH) in schools are important for child health, development, and educational performance; yet coverage in Indonesian schools remains low. To address this deficiency, UNICEF and partners conducted a WASH intervention in 450 schools across three provinces in Indonesia. A survey evaluatin...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2017.02.001
更新日期：2017-05-01 00:00:00
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00291
更新日期：2004-07-01 00:00:00
abstract：:A multiparametric analysis of immune components was performed in blood and serum of 61 voluntary persons before and after (1 day, 3 days, 4-6 months, 10-12 months) a professional pest control operation (PCO) using pyrethroids. Following parameters were included in the study (1) immunological parameters of the humoral ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00201
更新日期：2003-03-01 00:00:00
abstract：:This paper reviews the existing literature on human exposure to polybrominated diphenyl ethers (PBDEs), with particular focus on external exposure routes (e.g. dust, diet, and air) and the resulting internal exposure to PBDEs (e.g. breast milk and blood). Being lipophilic and persistent organic compounds, PBDEs accumu...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,评审
doi：10.1016/j.ijheh.2008.04.005
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abstract：UNLABELLED:The objective of the study was to measure the indoor air quality in classrooms with special emphasis on particulate matter (PM 10) and carbon dioxide (CO(2)) and the impact of cleaning and ventilation. MATERIAL AND METHOD:PM 10 was analysed via gravimetric method and by laser beam technology. CO(2) was anal...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2007.09.011
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2006.09.001
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pub_type： 杂志文章
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2017.10.006
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更新日期：2020-07-01 00:00:00
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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更新日期：2016-03-01 00:00:00
abstract：:Exposure to some phthalate diesters and bisphenol A in the general population is a cause of increasing concern because of their potential adverse effects on the reproductive and endocrine systems and their broad presence in foodstuff and consumer products. The aims of this work are to assess patterns of exposure to ph...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2014.07.005
更新日期：2015-01-01 00:00:00
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2017.07.007
更新日期：2017-10-01 00:00:00
abstract：:In this study, the concentrations of disinfection byproducts (DBPs), including trihalomethanes (THMs; chloroform, bromodichloromethane, dibromochloromethane, and bromoform), haloacetic acids (HAAs; dichloroacetic acid and trichloroacetic acid), haloacetonitriles (HANs; dichloroacetonitrile, trichloroacetonitrile, brom...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2010.09.005
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Refugees from Burma who consume fish caught from local waterbodies have increased risk of exposure to environmental contaminants. We used respondent driven sampling (RDS) to sample this hard-to-reach population for the first Biomonitoring of Great Lakes Populations program. In the current study, we examined ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2018.04.014
更新日期：2018-06-01 00:00:00
abstract：AIM:The focus of our study was the assessment of the effects of spatial relocation on office staff. Our aim was to investigate whether psychosocial or personal factors are better predictors of the occurrence of impaired well-being. METHODS:Before relocation the administration of the university hospital of Ulm (Germany...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2006.03.005
更新日期：2006-07-01 00:00:00
