Abstract:
:Recent studies have cast doubt on the reliability of serum total prostate-specific antigen as a biomarker for the detection and prognosis of prostate cancer. Biomarkers that can identify those men at risk for clinically significant prostate cancer are desperately needed. The search for biomarkers that may improve the detection of biologically consequential prostate cancer is one of the most active areas under current investigation. In this review, we highlight some of these ongoing efforts. Proper validation of newly discovered biomarkers is of paramount importance.
journal_name
Curr Urol Repjournal_title
Current urology reportsauthors
Hernandez J,Canby-Hagino E,Thompson IMdoi
10.1007/s11934-005-0004-7keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
171-6issue
3eissn
1527-2737issn
1534-6285journal_volume
6pub_type
杂志文章,评审abstract::Neoadjuvant cisplatin-based combination chemotherapy is an established standard for resectable muscle-invasive bladder cancer, a disease with a pattern of predominantly distant and early recurrences. Pathologic complete remission appears to be an intermediate surrogate for survival when employing combination chemother...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-012-0236-2
更新日期:2012-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Patient-reported outcome measures (PROMs) are tools that are widely used by clinicians and researchers across different medical specialties. In this review, we examine the use of PROMs in the evaluation of female pelvic floor disorders (PFD). RECENT FINDINGS:PROM development in the assessment of urin...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-019-0888-2
更新日期:2019-03-27 00:00:00
abstract:PURPOSE OF REVIEW:Laparoscopic kidney surgery is commonly used for living donor, partial, and total tumor nephrectomy. The successful emergence of laparoscopic technique was justified by the many benefits offered such as reduced blood loss, tissue trauma, pain, and hospital stay. However, this comes at the expense of p...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-018-0757-4
更新日期:2018-01-18 00:00:00
abstract:PURPOSE OF REVIEW:We reviewed the literature to determine what role, if any, radical prostatectomy should play in the treatment of high-risk and/or node-positive prostate cancer. RECENT FINDINGS:The AUA, NCCN, and EAU all include radical prostatectomy as a treatment option for high-risk prostate cancer based on eviden...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0703-x
更新日期:2017-07-01 00:00:00
abstract::For many years, estrogen has been used to treat lower urinary tract dysfunction in postmenopausal women. The data supporting this practice vary. Large multi-institutional studies have shown little role for systemic estrogens in the treatment of urinary incontinence. Vaginal estrogen preparations show superiority to sy...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-011-0208-y
更新日期:2011-10-01 00:00:00
abstract::Complementary and alternative medicine (CAM) has recently attracted national attention in the United States because of its widespread use and associated cost. CAM covers a broad spectrum of healing philosophies and approaches. Despite its widespread use, little is known about its safety, efficacy, cost effectiveness, ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-001-0084-y
更新日期:2001-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal of this chapter is to review the recent epidemiologic trends of kidney stone disease and discuss the impact of the increasing incidence of nephrolithiasis among children on adults with respect to extra-renal manifestations, surgical management, and secondary prevention. RECENT FINDINGS:Among...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0691-x
更新日期:2017-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to describe the preoperative evaluation, surgical techniques, and postoperative management of patients with renal cell carcinoma (RCC) undergoing radical nephrectomy (RN) and inferior vena cava (IVC) thrombectomy. RECENT FINDINGS:RN and IVC thrombectomy remains the standard ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-020-01007-9
更新日期:2020-10-22 00:00:00
abstract::Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in men. Patients with BPH often present with a combination of obstructive and overactive bladder (OAB) symptoms. It is postulated that bladder outlet obstruction (BOO) from BPH results in concomitant OAB symptoms through ischem...
journal_title:Current urology reports
pub_type: 杂志文章
doi:10.1007/s11934-013-0363-4
更新日期:2013-12-01 00:00:00
abstract::Significant clinical and basic science advances in the field of sexual medicine have facilitated investigation of the link between endothelial dysfunction and erectile dysfunction. Most sexual medicine practitioners accept the premise that in aging men with risk factors such as increased waist circumference, diabetes,...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-007-0054-0
更新日期:2007-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Targeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may i...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-019-0866-8
更新日期:2019-01-15 00:00:00
abstract::Pediatric urolithiasis is on the rise globally and incidence rates have risen by 6-10% annually over the past couple of decades. Given the increasing incidence, high likelihood of recurrence, and long life expectancy of children, the use of ionizing radiation in the diagnosis, management, and follow up of pediatric ur...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0669-8
更新日期:2017-03-01 00:00:00
abstract::Overactive bladder syndrome continues to be a significant burden for the general population. Current first-line medical therapy often includes antimuscarinic medications designed for overactive bladder. Poor efficacy and significant side effects of these antimuscarinic medications have left patients and physicians loo...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-010-0134-4
更新日期:2010-09-01 00:00:00
abstract::Androgen deprivation therapy (ADT) is a well-established treatment for locally advanced, biochemically recurrent and metastatic prostate cancer. However, it is associated with significant side effects including hot flashes, loss of libido and erectile function, muscular atrophy, metabolic abnormalities, and osteoporos...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-015-0481-2
更新日期:2015-03-01 00:00:00
abstract::Preservation of postoperative urinary continence remains the primary concern of all men and their surgeons following robot-assisted radical prostatectomy (RARP). Without doubt, continence is the most important quality of life issue following radical prostatectomy. Identification of difficulties and lessons learned ove...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-012-0295-4
更新日期:2013-02-01 00:00:00
abstract::Molecular imaging of prostate cancer is in a dynamic phase of development. Currently approved techniques are limited and researchers have been working on novel agents to improve accuracy in targeting and detecting prostate tumors. In addition, the complexity of various prostate cancer states also contributes to the ch...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-016-0575-5
更新日期:2016-03-01 00:00:00
abstract::Health information technology (HIT) is expected to transform the delivery of health care in the United States, but implementation and adoption vary widely across settings, specialties, and geographies. Significant barriers to high-level adoption persist despite federal incentives to hospitals and health-care providers...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-013-0356-3
更新日期:2013-12-01 00:00:00
abstract::Peyronie's disease is an acquired condition that presents clinically with a palpable induration, a distinct plaque, or a curvature of the erect penis. At times, the erections are painful. Erectile dysfunction (ED) often is associated with Peyronie's disease. The current era of phosphodiesterase therapy for the treatme...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-005-0041-2
更新日期:2005-11-01 00:00:00
abstract::Bladder outlet obstruction (BOO) in women can be either anatomic or functional. Anatomic causes for BOO are often readily apparent by history and physical exam. On the other hand, causes for functional obstruction, including dysfunctional voiding, primary bladder neck obstruction, and detrusor-external sphincter dyssy...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-012-0267-8
更新日期:2012-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The classification of morphologically normal sperm has been progressively redefined. Concurrently, our understanding of the significance of sperm morphology in relation to male factor infertility has evolved. In this review, we will discuss the evolution of sperm morphology assessment and factors that...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-019-0911-7
更新日期:2019-06-15 00:00:00
abstract::The conservative treatment of stress urinary incontinence for women has many facets. Each intervention may have value and patients may benefit from simple, reversible recommendations and techniques versus invasive surgery. Starting with a thorough history, lifestyle modifications may lead to decreased incontinence. De...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-005-0056-8
更新日期:2005-09-01 00:00:00
abstract::Adrenal cortical carcinoma is a relatively uncommon malignancy that represents a significant clinical challenge for the development of optimal treatment strategies. Historically, successful treatment has relied upon rapid identification of the lesion, accurate staging with diagnostic imaging, and complete surgical ext...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-007-0024-6
更新日期:2007-01-01 00:00:00
abstract::Numerous surgeries have been proposed for the treatment of genuine stress incontinence, with the goals to improve functional outcome and decrease complications and their associated morbidity. Two new, minimally invasive procedures, transvaginal retropubic urethropexy and transvaginal Cooper's ligament sling, are revie...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-996-0018-9
更新日期:2001-10-01 00:00:00
abstract::Adrenal hemorrhage is a rare yet potentially life-threatening event that occurs both in traumatic conditions and in a variety of nontraumatic conditions. Clinical manifestations of adrenal hemorrhage can vary widely depending on the degree and rate of hemorrhage, as well as the amount of adrenal cortex compromised by ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-009-0014-y
更新日期:2009-01-01 00:00:00
abstract::The quality of functional outcome has become increasingly important in view of improvement in prognosis with colorectal cancer patients. Sexual dysfunction remains a common problem after colorectal cancer treatment, despite the good oncologic outcomes achieved by expert surgeons. Although radiotherapy and chemotherapy...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-013-0341-x
更新日期:2013-08-01 00:00:00
abstract::Symptoms such as overactive bladder represent disorders of bladder control. Functional brain scanning by positron emission tomography and functional magnetic resonance imaging suggest that normal control is exerted by a network of regions in the emotional nervous system, including periaqueductal gray, thalamus, insula...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-004-0081-z
更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Inflatable penile prosthesis (IPP) is a treatment for erectile dysfunction. IPPs have undergone improvements; however, post-surgical infections still occur. Furthermore, the type of pathogens infecting the implants has changed recently from Gram-positive to Gram-negative bacteria and fungi due to adva...
journal_title:Current urology reports
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s11934-019-0874-8
更新日期:2019-01-30 00:00:00
abstract:PURPOSE OF THE REVIEW:To update the most relevant literature regarding complex vascular cases in kidney transplant setting involving the graft, especially during the harvesting procedure and back-table preparation from the subsequent implant. RECENT FINDINGS:Challenging situations affecting the kidney graft such as mu...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-020-0955-8
更新日期:2020-01-31 00:00:00
abstract:PURPOSE OF REVIEW:Therapeutic options for the management of lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement (BPE) have considerably increased in recent years. However, the ideal timing to initiate medical treatment of LUTS/BPE has not been fully established. The aim of this review was to s...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-018-0823-y
更新日期:2018-07-09 00:00:00
abstract::With the advent of intracytoplasmic injection, the management of azoospermia has become ever more important. Gametic manipulation to produce biological offspring is not feasible unless sperm from the azoospermic male patient is obtainable. This article provides an overview of the diagnosis and treatment of azoospermia...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-001-0038-4
更新日期:2001-12-01 00:00:00