Abstract:
PURPOSE OF REVIEW:Targeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may impact significantly patient's life. RECENT FINDINGS:Immune checkpoint inhibition has recently demonstrated promising results in selected CCRCC patients with respect to tumor progression and survival. The decision to treat these patients with immune checkpoint inhibitors (ICI) relies on the immunohistochemical detection of PD-1/PD-L1 positivity in inflammatory cells in the tumor, which makes the role of the pathologist crucial, but clinical concern upon the reliability to use immunohistochemistry (IHC) to predict therapeutic response is increasing. We review the state of the art of the immune checkpoint inhibition in CCRCC, from the basic science and its fundamentals to the daily application in clinical routine.
journal_name
Curr Urol Repjournal_title
Current urology reportsauthors
Nunes-Xavier CE,Angulo JC,Pulido R,López JIdoi
10.1007/s11934-019-0866-8subject
Has Abstractpub_date
2019-01-15 00:00:00pages
1issue
1eissn
1527-2737issn
1534-6285pii
10.1007/s11934-019-0866-8journal_volume
20pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Although benign, renal angiomyolipoma (AML) may lead to serious complications without appropriate management. The purpose of this review is to describe the role of and evidence for interventional radiology techniques in the management of patients with AML. RECENT FINDINGS:For patients with renal mass...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0687-6
更新日期:2017-05-01 00:00:00
abstract::Lipoxygenases oxidatively metabolize polyunsaturated fatty acids to a rich spectrum of biologically active products. One enzyme of the lipoxygenase family, Arachidonate 15-lipoxygenase-1 (arachidonate:oxygen 15-oxidoreductase, EC 1.13.11.33), is implicated in several forms of epithelial cell cancers, and provides a ra...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-002-0066-8
更新日期:2002-06-01 00:00:00
abstract:PURPOSE OF REVIEW:We sought to determine whether infertile men can accurately be identified within a large insurance claims database to validate its use for reproductive health research. RECENT FINDINGS:Prior literature suggests that men coded for infertility are at higher risk for chronic disease though it was previo...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0714-7
更新日期:2017-09-01 00:00:00
abstract::The most common form of prostatitis is National Institutes of Health category III, also known as chronic abacterial prostatitis/chronic pelvic pain syndrome. The search for effective and durable therapy for this condition remains frustrating for both patients and physicians. A new approach incorporating a neurobahavio...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-000-0051-z
更新日期:2000-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Inflatable penile prosthesis (IPP) is a treatment for erectile dysfunction. IPPs have undergone improvements; however, post-surgical infections still occur. Furthermore, the type of pathogens infecting the implants has changed recently from Gram-positive to Gram-negative bacteria and fungi due to adva...
journal_title:Current urology reports
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s11934-019-0874-8
更新日期:2019-01-30 00:00:00
abstract:PURPOSE OF REVIEW:In light of the announcement that the United States Medical Licensing Examination Step 1 exam will transition to pass/fail reporting, we reviewed recent literature on evaluating residency applicants with a focus on identifying objective measurements of applicant potential. RECENT FINDINGS:References ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-020-00993-0
更新日期:2020-08-17 00:00:00
abstract::Nodal staging in prostate cancer is suboptimal both with respect to current imaging modalities and pelvic lymph node dissection, and thus other techniques are being explored. Lymphotropic nanoparticle-enhanced MRI, also called magnetic resonance lymphography (MRL), is a technique that has shown high sensitivity (65-92...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-013-0389-7
更新日期:2014-03-01 00:00:00
abstract::Patients with one or more low-grade bladder tumors of the urinary bladder will often develop a subsequent tumor but these so called "recurrences" are almost always of similar grade and rarely invade beyond the basement membrane. Therefore, the clinician should try to minimize the morbidity associated with treating the...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-015-0555-1
更新日期:2015-12-01 00:00:00
abstract::Surgical techniques to repair hypospadias have undergone remarkable advances in recent years with the development and widespread use of dorsal urethral plate incision to facilitate urethroplasty. Clinical studies of the technique have shown excellent cosmesis and low complication rates for dorsal plate incision (DPI) ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-001-0008-x
更新日期:2001-04-01 00:00:00
abstract::Correct staging of prostate cancer at initial diagnosis, as well as accurate staging and tumor localization with biochemical recurrence, remains generally inaccurate with current imaging techniques. Newer modalities are being investigated to accurately identify patients with prostate cancer at different stages of dise...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-006-0018-9
更新日期:2006-05-01 00:00:00
abstract::Bladder cancer is the second commonest urinary tract malignancy with 70-80 % being non-muscle invasive (NMIBC) at diagnosis. Patients with high-risk NMIBC (T1/Tis, with high grade/G3, or CIS) represent a challenging group as they are at greater risk of recurrence and progression. Intravesical Bacilli Calmette-Guerin (...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-016-0625-z
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Spina bifida is caused by incomplete neural tube closure during the first trimester. This condition may lead to bowel and bladder dysfunction as well as truncal weakness and motor anomalies. Presentations vary between myelomeningoceles and lipomeningoceles and may result in different outcomes. This re...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0684-9
更新日期:2017-05-01 00:00:00
abstract::The prostate-specific antigen (PSA) era has increased the rates of prostate cancer detection and treatment, while reducing the risk of death from prostate cancer in the US. Image-guided prostate biopsy techniques have led to stage migration and the detection and treatment of lower risk prostate cancers. Improved techn...
journal_title:Current urology reports
pub_type: 杂志文章
doi:10.1007/s11934-012-0285-6
更新日期:2012-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Molecular characterization of cancer allows us to understand oncogenesis and clinical prognosis as well as facilitates development of biomarkers and treatment. Our aim was to review the current literature on genomic characterization of bladder cancer, and how far we are in implementing genomics into c...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-020-0960-y
更新日期:2020-03-13 00:00:00
abstract::Phthalates are part of a class of high-volume industrial chemicals used ubiquitously in health care as well as household products. Biomarker studies have confirmed the widespread presence of these chemicals in both humans and animals. As a class, phthalates have been implicated in diseases and birth anomalies of the g...
journal_title:Current urology reports
pub_type: 杂志文章
doi:10.1007/s11934-012-0261-1
更新日期:2012-08-01 00:00:00
abstract::Laparoscopic radical nephrectomy can be efficaciously performed by either the transperitoneal or the retroperitoneal laparoscopic approach. The primary indication for selecting one approach over another has historically depended on the individual surgeon's experience and training. With either technique, laparoscopy ad...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-002-0030-7
更新日期:2002-04-01 00:00:00
abstract::Recent studies have cast doubt on the reliability of serum total prostate-specific antigen as a biomarker for the detection and prognosis of prostate cancer. Biomarkers that can identify those men at risk for clinically significant prostate cancer are desperately needed. The search for biomarkers that may improve the ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-005-0004-7
更新日期:2005-05-01 00:00:00
abstract::Robot-assisted surgery has changed the landscape of surgery. Implementation of robotics into most surgical specialties has left many educators challenged to develop the tools necessary to train and credential surgeons. Advances in robot-assisted surgery have led to the development of simulators and tools to assess ski...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-015-0508-8
更新日期:2015-06-01 00:00:00
abstract::Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent disease for which there is no standardized therapy. Traditional treatments have included antibiotics, α-blockers, and anti-inflammatories, but those have not proven to be efficacious therapies through many clinical trials. Alternative therapies,...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-011-0188-y
更新日期:2011-08-01 00:00:00
abstract::Molecular imaging of prostate cancer is in a dynamic phase of development. Currently approved techniques are limited and researchers have been working on novel agents to improve accuracy in targeting and detecting prostate tumors. In addition, the complexity of various prostate cancer states also contributes to the ch...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-016-0575-5
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal of this paper is to describe the pathophysiology of adult nocturnal enuresis and develop a generalized approach for evaluation and treatment. RECENT FINDINGS:Although nocturnal enuresis (NE) impacts a significant proportion of the adult population, research on this topic remains lacking. In ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-020-00983-2
更新日期:2020-06-06 00:00:00
abstract::The increased detection of incidental renal masses has introduced new challenges into the management of patients with newly discovered renal masses. Much interest has been focused on the diagnostic accuracy and the prognostic ability of imaging studies. These studies have elucidated trends that can guide management bu...
journal_title:Current urology reports
pub_type: 杂志文章
doi:10.1007/s11934-009-0004-0
更新日期:2009-01-01 00:00:00
abstract::The most important change in urology during the past decade was the development of minimally invasive surgery, particularly laparoscopy. However, the main drawback of laparoscopy is a steep learning curve, which results from the significant changes in the surgical environment. Although laparoscopy can provide importan...
journal_title:Current urology reports
pub_type: 杂志文章
doi:10.1007/s11934-003-0040-0
更新日期:2003-04-01 00:00:00
abstract::Author Siamak Daneshmand would like to note that this article published in Current Urology Reports inadvertently did not disclose financial information that could possibly be a conflict of interest. ...
journal_title:Current urology reports
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11934-019-0890-8
更新日期:2019-04-05 00:00:00
abstract::Aging can be associated with an abnormal decline in testosterone production, mainly due to pituitary failure, and is reflected by low serum testosterone concentrations. Manifestations of testosterone deficiency can be subtle, can be misinterpreted as consequences of normal aging, and include lack of libido and energy,...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-000-0013-5
更新日期:2000-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Recurrent urinary tract infections are a common condition that can impact patients' quality of life. The purpose of this review is to summarize and analyze the literature regarding the distress that these infections can cause to patients and provide guidance to clinicians on how to improve care of the...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-018-0849-1
更新日期:2018-10-18 00:00:00
abstract::The quality of functional outcome has become increasingly important in view of improvement in prognosis with colorectal cancer patients. Sexual dysfunction remains a common problem after colorectal cancer treatment, despite the good oncologic outcomes achieved by expert surgeons. Although radiotherapy and chemotherapy...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-013-0341-x
更新日期:2013-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Targeted therapy for genitourinary cancer is being used at an increasing rate. These medications show great survival benefit but are relatively lacking in long-term adverse effect data. With increasing survivability, measures to improve quality of life must be considered for GU cancer and a large prop...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-017-0704-9
更新日期:2017-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Male urethral stricture disease is characterized by the formation of scar tissue within the urethra resulting in lower urinary tract symptoms, infection, and potentially kidney dysfunction. There is significant variability in clinical practice for the treatment of urethral stricture. We sought to summ...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-018-0771-6
更新日期:2018-02-26 00:00:00
abstract::Several minimally invasive approaches to treatment of ureteropelvic junction obstruction are now in the urologist's armamentarium. This review provides in-depth analysis of endopyelotomy, endopyeloplasty, and laparoscopic pyeloplasty and suggests a treatment algorithm for proper patient selection to improve efficacy a...
journal_title:Current urology reports
pub_type: 杂志文章,评审
doi:10.1007/s11934-007-0064-y
更新日期:2007-03-01 00:00:00